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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=202201</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[Characteristic analysis of DWI and HRMR-VWI in patients with symptomatic middle cerebral atherosclerotic stenosis: comparison between the young group and middle-aged and elderly group]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.001</link>
<description><![CDATA[Objective: To investigate the differences of the characteristics of responsible vessel wall between young and middle-aged and elderly patients with symptomatic middle cerebral atherosclerotic stenosis (sMCAS) based on high resolution magnetic resonance vessel wall imaging (HRMR-VWI). Materials and Methods: From August 2019 to April 2021,consecutive patients with ischemic stroke or transient ischemic attack caused by sMCAS were selected and divided into young group (≤45 years old) and middle-aged and elderly group (＞45 years old). The mechanism of sMCAS stroke was determined according to the distribution pattern of acute cerebral infarction on DWI, including parent artery occluding penetrating artery, hypoperfusion, artery-artery embolization and multiple mechanism. The differences of risk factors between the two groups and the differences of HRMR-VWI wall characteristics of responsible vessels were analyzed, including plaque area, plaque burden, length, enhancement pattern, intraplaque bleeding, plaque distribution pattern, stenosis rate of responsible vessels, remodeling index and remodeling pattern. Results: One hundred and three patients with sMCAS were included, including 30 young patients and 73 middle-aged and elderly patients. There were significant differences in hypertension and coronary heart disease between the two groups (P＜0.05); there was no significant difference in the mechanism of sMCAS stroke between the two groups (P＞0.05).The plaque area, plaque burden and vascular remodeling index of the middle-aged and elderly group were higher than those of the young group (P＜0.05); there was no significant difference in plaque length, plaque enhancement pattern, intraplaque bleeding, plaque distribution, stenosis rate and remodeling pattern between the two groups (P＞0.05). Conclusions: There are differences in plaque area, plaque burden and vascular remodeling index between young and middle aged-elderly patients with sMCAS, suggesting that the pathophysiological changes of young patients with sMCAS are different, and their intervention strategies may be different from those of middle-aged and elderly patients.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study of pseudo-continuous arterial spin labeling perfusion MRI on the evaluation of cerebral hemodynamics in patients with hemorrhagic moyamoya disease]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.002</link>
<description><![CDATA[Objective: To investigate hemodynamic changes in adult patients with hemorrhagic moyamoya disease based on pseudo-continuous artery spin labeling (pCASL) imaging. Materials and Methods: A total of 32 patients (38 hemispheres) with hemorrhagic or ischemic moyamoya diasease in Xuanwu Hospital were enrolled from December 2016 to April 2019, including 21 hemorrhagic hemispheres and 17 ischemic hemispheres. All patients underwent pCASL exams within 3 months after the onset. Mean perfusion parameters of cerebral blood flow (CBF), pCASL-arterial cerebral blood volume (aCBV) and pCASL-arterial transit time (ATT) derived using pCASL were measured within peripheral region of the lesion, ipsilateral frontal lobe and temporal lobe on the semi-oval layer and positive lesion layer. Inter-group comparison between hemorrhage and infarction was carried out through t-test of two independent samples and Mann-Whitney U test of two independent samples. Results: A total of 21 hemorrhagic hemispheres were involved. In the peripheral region of the lesion, mean aCBV, ATT and CBF values were (1.01±0.22) mL/100g, (1.53±0.98) s and (37.88± 6.19) mL/ (100 g·min), respectively. In the frontal lobe, mean aCBV, ATT and CBF values were (1.23±0.31) mL/100g, (1.55±0.15) s and (47.03±13.78) mL/(100 g·min), respectively. In the temporal lobe, mean aCBV, ATT and CBF values were (1.28±0.30) mL/100g, (1.54± 0.12) s and (51.91±13.96) mL/(100 g·min), respectively. For the 17 ischemic cerebral hemispheres, mean aCBV, ATT and CBF values were (1.11±0.24) mL/100g, (1.46±0.35) s and (49.27±14.13) mL/(100 g·min) in the lesion peripheral region, (1.17±0.30) mL/100g,(1.51±0.37) s and (43.17±14.63) mL/(100 g·min) in the frontal lobe, and (1.21±0.35) mL/100g, (1.50±0.40) s and (49.25±20.85) mL/(100 g·min) in the temporal lobe. Compared with ischemic hemispheres, the hemorrhagic hemispheres showed significantly lower CBF in the peripheral region of the lesion (P<0.05). However, there<sup><sup>,</sup></sup>s no statistical difference between two groups in term of aCBV and ATT. No evident statistical difference was seen in statistics of perfusion parameters of the frontal lobe and temporal lobe. Conclusions: Hemorrhagic moyamoya disease has the lower perfusion than ischemic moyamoya. pCASL can detect the grade of blood flow failure in adults with hemorrhagic moyamoya disease, monitor tiny ischemic changes in peripheral frontal and temporal lobes, which can provide a basis for further research on early detection of rebleeding by monitoring hemodynamics.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Three-dimensional arterial spin labeling perfusion imaging shows cerebral blood flow decline in some brain regions in preschool autistic children]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.003</link>
<description><![CDATA[Objective: To explore the feasibility of three-dimensional arterial spin labeling (3D-ASL) perfusion imaging in the brain of children with preschool autism. Materials and Meythods: Each 40 autistic children aged 2, 3, 4, 5 were selected, and 40 healthy children aged 2, 3, 4, 5 were control groups, and all children underwent routine MR and 3D-T1, 3D-ASL scans. The value of cerebral blood perfusion (CBF) was obtained by software posttreatment, compared the value of autistic children of the same age and healthy children, and found the characteristics of CBF in autistic children of all ages. Results: In the 2 years old group, the CBF values of temporal lobe, hippocampus and putamen in autistic children were lower than those in healthy children; in the 3 years old group, the CBF values of frontal lobe, temporal lobe, parietal lobe, hippocampus and putamen of autistic children were lower than those of healthy children; in the 4 years old group, the CBF values of temporal lobe, frontal lobe, parietal lobe, hippocampus, putamen and caudate nucleus in autistic children were lower than those in healthy children; in the 5 years old group, the CBF values of temporal lobe, parietal lobe, hippocampus, putamen and caudate nucleus in autistic children were lower than those in healthy children. Conclusions: 3D-ASL technology can reflect cerebral blood flow perfusion and more comprehensively reflect the pathological process in children with autism.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of magnetic resonance imaging in differentiating grade Ⅱ solitary fibrous tumor/hemangiopericytoma from angiomatous meningioma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.004</link>
<description><![CDATA[Objective: To investigate the value of radiomics features with multi-parameter MRI images in differential diagnosis between intracranial grade Ⅱ solitary fibrous tumor/hemangiopericytoma (SFT/HPC) and angiomatous meningioma (AM). Materials and Methods: A total of 68 patients with grade Ⅱ SFT/HPC and 41 patients with AM confirmed by surgery or pathology were retrospectively analyzed from the First Affiliated Hospital of Qingdao University and Guangxi Medical University, all of the patients were performed T1WI, FLAIR and contrasted TIWI scan. The patients were randomly divided into training set (n=77) and validation set (n=32) in a ratio of 7∶3. After a normalization approach applied on the image, the region of interest (ROI) along the tumor edge step by step based on the axial image with 3D slicer software were sketched, then the radiomics features were extracted in the ROI with 3D slicer software. Minimum redundancy maximum relevance (mRMR) and least absolute shrinkage and selection operator (LASSO) regression were applied to reduce the dimension, then the radiomics features with the most diagnostic value were selected to build a binary Logistic regression model. The receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the model. Results: 16, 13 and 12 radiomics features were extracted from T1WI, FLAIR and contrasted T1WI scan, respectively; additional 9 radiomics features were extracted from the combined sequence for modeling. The ROC analyses on four models resulted in an area under the curve (AUC) of 0.98 (sensitivity 100%, specificity 92.86%) for T1WI model, 0.92 (73.47%, 100%) for FLAIR model, 0.89 (79.59%, 85.19%) for contrasted T1WI model, and 0.99 (98.04%, 96.15%) for the combined sequence model and were enough to correctly distinguish the two groups in 87.50%、 75.00%、 68.75% and 90.63% of cases in test set, respectively. Conclusions: The differentiation efficiency of multi-parameter MRI images radiomics features between intracranial grade Ⅱ SFT/HPC and AM was better than single sequence. T1WI was the highest diagnosis efficacy sequence among single sequence.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[A preliminary study on the efficacy of tumor necrosis factor alpha antagonists in the treatment of axial spondyloarthropathy by T1-mapping technique]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.005</link>
<description><![CDATA[Objective: To explore the use of MRI T1-mapping technique to evaluate the efficacy of tumor necrosis factor-α antagonists in the treatment of axial spondyloarthropathy (axSpA), in order to provide effective quantitative indicators for the evaluation of axSpA treatment. Materials and Methods: One hundred and fourteen study subjects were included, of which 15 normal sacroiliac joint subjects excluded from the diagnosis of axSpA were the control group, and 99 clinically confirmed axSpA patients were the case group, twenty patients in the case group were treated with systemic TNF-α antagonists as the treatment group. The case group was divided into active group and inactive group. The active group was divided into three subgroups: moderate activity group, high activity group and very high activity group. The treatment group was divided into pre-treatment group and 3 weeks treatment group, 6 weeks treatment group and 12 weeks treatment group according to the different time of treatment. All subjects underwent T1-mapping sequence examination to compare the differences in T1-mapping values of the sacroiliac joint subchondral bone marrow area between the control group, the case group, and the subgroups of the case group, using ROC curve to analyze the diagnostic efficacy and monitoring of therapeutic efficacy of different treatment cycles in the treatment group. Results: (1) There was no significant difference in the T1-mapping value of the subchondral bone marrow area of the sacroiliac joint and iliac joint in each group, all P＞0.05; (2) Compared with the control group, the T1-mapping value of the bone marrow area under the sacroiliac articular cartilage of the case group increased to varying degrees, T1-mapping value had a good diagnostic efficiency for the high activity group and the very high activity group; (3) The decrease rate of T1-mapping value in the subchondral bone marrow area of sacroiliac joint in different treatment cycles in the treatment group could effectively monitor the curative effect. Conclusions: T1-mapping technology can quantitatively evaluate axSpA inflammatory activity, and effectively monitor the efficacy, which is beneficial to clinical individualized treatment and timely adjustment of treatment plans.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Quantitative assessment of paraspinal muscle fat infiltration in early stage ankylosing spondylitis patients by using MRI IDEAL sequence]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.006</link>
<description><![CDATA[Objective: To evaluate fat infiltration of the multifidus and erector spinal muscles of the lower waist (L3/4, L4/5 levels) of ankylosing spondylitis (AS) patients in early stage, and explore the correlation between them and clinical indicators. Materials and Methods: Using a prospective study, 40 clinically diagnosed AS patients in early stage (AS group) 41 healthy volunteers (control group) matched in age, sex, and body mass index, all subjects were evaluated using iterative decomposition of water and fat with echo asymmetric and leastsquares estimation (IDEAL) sequence examination, the fat fraction values (ƞ) of multifidus and erector muscles at the levels of L3/4 and L4/5 were measured respectively. The clinical indicators such as the course of disease, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in AS group were collected during the same period. The independent samples t test (or Mann-Whitney U test) was used to compare the quantitative data between the two groups. Spearman correlation was used to evaluate the correlation between ƞ values of multifidus, erector spinae at the levels of L3/4 and L4/5 and clinical indicators. Results: The average ƞ values of erector spinae and multifidus muscles at the levels of L3/4 and L4/5 in AS group were higher than those in the control group [(0.28±0.09) vs. (0.24±0.05); (0.32±0.07) vs.(0.26±0.05); (0.31±0.07) vs. (0.28±0.06); (0.36±0.08) vs. (0.30±0.06)], the differences were statistically significant (P＜0.05). The average ƞ values of erector spinae and multifidus muscles at the levels of L3/4 and L4/5 in AS group were positively correlated with the course of the disease (P＜0.05), but were not significantly correlated with ESR, CRP, and BASDAI scores (P＞0.05). Conclusions: IDEAL sequence could be used in the quantitative analysis of fat infiltration in lower lumbar paraspinal muscles in early AS patients with good evaluation value for clinical treatment.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Preliminary study of CMR tissue feature tracking technology on left ventricular function in patients with hypertrophic cardiomyopathy with ejection fraction preservation]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.007</link>
<description><![CDATA[Objective: To explore the value of CMR tissue feature tracking technology for left ventricular strain in patients with hypertrophic cardiomyopathy (HCMpEF) with ejection fraction preserved. Materials and Methods: Seventy HCMpEF patients and 42 normal subjects (control group) were scanned with 3.0 T CMR steady-state free precession sequence, and the images were imported into CVI42 post-processing software to measure the basic function parameters of the left heart and the overall 3D strain parameters of the left ventricle. Including: radial, circumferential and longitudinal peak strain (PS), peak systolic strain rate (PSSR), peak diastolic strain rate (PDSR). The SPSS 26.0 software was used for statistical analysis of the two groups of parameters. Results: The peak strain in all directions of the HCMpEF group was lower than that of the control group [radial: 26.00 (14.63) vs. 32.39 (10.55), circumferential: (-17.30±4.55) vs. (-19.67±3.73), longitudinal: (-8.14±3.25) vs. (-10.74±3.26), HCMpEF group vs. control group, unit: %], the difference was statistically significant (P＜0.005); the PSSR and PDSR in each direction of HCMpEF group both are lower than the control group [PSSR radial: 1.55 (0.94) vs. 1.85 (0.61), circumferential: -0.99 (0.39) vs. -1.13 (0.29), longitudinal: -0.49 (0.38) vs. -0.67 (0.28), unit: s-1, P＜0.05; PDSR radial: -1.37 (-0.86) vs. -2.17 (1.35), circumferential: 0.87 (2.44) vs. 1.16 (0.53), longitudinal: 0.46 (0.24) vs. 0.68 (0.33), unit: s-1], the difference was statistically significant (P＜0.001). Conclusion: Although the ejection fraction is preserved in HCMpEF patients, the systolic and diastolic functions have been impaired. The CMR-FT quantitative analysis technology can provide a new basis for evaluating cardiac function.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study on the relationship between signal intensity parameters of liver lobes and albumin-bilirubin grades in magnetic resonance images enhanced with Gd-EOB-DTPA]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.008</link>
<description><![CDATA[Objective: To investigate the relationship between lobar based signal intensity parameters and Albumin - Bilirubin (ALBI) grade in patients with chronic hepatitis B-related liver cirrhosis on gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) enhanced MRI. Materials and Methods: Gd-EOB-DTPA enhanced MRI images of 62 patients with normal liver (n=15), ALBI grade 1 (n=23), ALBI grade 2 (n=18), and ALBI grade 3 (n=6) with chronic hepatitis B associated cirrhosis were analyzed. Liver parenchyma relative enhancement (LRE) and liver-to-muscle ratio (LMR) of right lobe, left medial lobe, left lateral lobe and caudate lobe were calculated, and compared between normal group and different ALBI grading groups. The relationship between LRE, LMR and ALBI grading of liver lobes in patients with chronic hepatitis B-related cirrhosis was quantitatively analyzed, and the accuracy of ALBI grade 1 and ALBI grade 2-3 were evaluated by ROC curve. Results: The LRE and LMR values of each liver lobe were significantly different between the normal group and different ALBI grading groups (P＜0.05). The pairings of each group showed that there was no significant difference in LRE value of each liver lobe between ALBI 2 and ALBI 3 groups (P＞0.05), and there was a significant difference in LMR value of each liver lobe between any two groups (P＜0.001). The LRE and LMR of each lobe of liver in patients with chronic hepatitis B-related liver cirrhosis were negatively correlated with ALBI grade (P＜0.001). LRE in the right lobe of the liver had the highest accuracy in distinguishing ALBI grade 1 from ALBI grade 2-3, and the area under the receiver operating characteristic curve is 0.913. Conclusions: There is a correlation between LRE and LMR based on liver lobe and ALBI grade of liver function in patients with chronic hepatitis B related cirrhosis in Gd-EOB-DTPA enhanced MRI. LRE and LMR are expected to be imaging methods to evaluate liver lobe function.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application study of MRI T2WI texture baseline predicting the efficacy of advanced rectal cancer transformation therapy for primary tumors]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.009</link>
<description><![CDATA[Objective: To explore the predictive value of baseline magnetic resonance imaging (MRI) T2WI image texture analysis in the treatment of advanced rectal cancer for the primary tumor. Materials and Methods: Retrospective analysis of 66 patients with advanced rectal cancer confirmed clinically and pathologically. All patients underwent pelvic MRI scan, enhancement and diffusion weighted imaging (DWI) examinations before operation. According to the plain scan and enhanced images, the location and range of the tumor were identified, and the Mazda software was used to extract the region of interest (ROI) texture in the T2WI image, and linear discriminant analysis (LDA) and nonlinear discriminant analysis (linear discriminant analysis) were used respectively. Discriminant analysis (NDA) and principal component analysis (PCA) are three extraction methods for discriminative classification, and the best method is selected for texture extraction. Combined with postoperative pathology, the baseline morphological characteristics of the primary focus of patients with advanced rectal cancer were compared between the sensitive group and the insensitive group, and the texture characteristics of the T2WI sequence images of the two groups were compared to construct a curative effect prediction model. Results: The pathological tumor regression grade (pTRG) of 66 patients with advanced rectal cancer showed that 9 cases were pTRG 0, 8 cases were pTRG 1, 35 cases were pTRG 2, and 14 cases were pTRG 3. Among them, 52 cases were in the sensitive group (pTRG 0～2) and 14 cases were in the insensitive group (pTRG 3). There was no significant difference between the two groups of patients between the primary tumor involving the intestinal segment, the relationship with the peritoneum reflexion, the length of the longitudinal involvement, the proportion of the circumference of the intestinal cavity, the maximum thickness of the oblique axis, and the distance between the lower edge of the tumor and the anal edge (all P＞0.05); the NDA classification method under the Fisher texture feature extraction method has the lowest misjudgment rate, so this method is used to extract the image texture. The univariate analysis of texture characteristics in different treatment groups of the primary tumor of advanced rectal cancer showed: the first percentile (Perc 1%), S (2, 0) DifEntrp, S (3, 0) InvDfMom, S (3, -3) SumAverg, S (4, 0) InvDfMom, S (4, -4) SumAverg, S (5, 0) InvDfMom, S (5, -5) SumAverg, S (2, 2) SumVarnc, all indicators were statistically different (P＜0.05), S (2, 2) SumVarnc, S (3, 0) DifEntrp were not statistically different (P=0.05, 0.052); the indicators with differences in univariate analysis were included in Logistic multivariate analysis of the model showed that Perc 1% and S (5, 0) InvDfMom were independent predictors of insensitivity to transformation treatment of primary tumors of advanced rectal cancer, and the above factors were used to construct the prediction of insensitivity of primary tumors of advanced rectal cancer to transformation therapy. The area under the curve (AUC) of the model is 0.812, the sensitivity is 92.90%, and the specificity was 60.80%. Conclusions: T2WI image texture features extracted based on MRIFisher extraction method can help predict the efficacy of primary tumor transformation therapy for advanced rectal cancer, and provide valuable reference information for the formulation of individualized treatment plans for patients.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The clinical application value of DWI in quantitative evaluation of Crohn′s disease lesions]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.010</link>
<description><![CDATA[Objective: To explore the value of magnetic resonance diffusion weighted imaging (DWI) to quantitatively assess the activity of intestinal Crohn<sup><sup>,</sup></sup>s disease (CD) lesions. Materials and Methods: A total of 51 patients diagnosed with CD were retrospectively analyzed, all of those were underwent magnetic resonance enterography (MRE), DWI and enteroscopy within 2 weeks. The lesions of bowel segments were graded as inactive (0-2), mild (3-6), and moderate-severe group (＞6) based on simplified endoscopic activity score for Crohn′s disease (SES-CD). To observe the performance of MRE and DWI, and calculate the magnetic resonance index of activity (MaRIA) and the apparent diffusion coefficient (ADC) value of the lesions. The Kruskal-Wallis rank sum test was applied to compare the differences in MaRIA and ADC values among different activity groups, and the receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficiency of MaRIA and ADC values to distinguish different active lesions. Spearman analysis was used to evaluate the correlation between SES-CD and MaRIA, ADC values. Results: A total of 127 intestinal segments were included in the study. There were 15 inactive, 45 mild, and 67 moderate-severe. The SES-CD score ranged from 1.0 to 11.0. There were significant differences in MaRIA and ADC values among different groups (P＜0.01). The correlations between SES-CD and MaRIA, ADC values were 0.793 (P＜0.01) and -0.742 (P＜0.01), respectively. ROC curve analysis found that when the MaRIA was the threshold at 9.1 and the ADC value was the threshold at -1.585×10-3 mm2/s, the maximum of area under the curves (AUCs) to distinguish the inactive from the active were 0.962 (P＜0.01) and 0.957 (P＜0.01), respectively. When the MaRIA was the threshold at 11.1 and the ADC value was the threshold at -1.345×10-3 mm2/s, the maximum of AUCs to distinguish the inactive-mild from the moderate-severe were 0.942 (P＜0.01) and 0.920 (P＜0.01), respectively. Conclusions: DWI can quantitatively and accurately distinguish the lesions in different active stages of CD.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study of PI-RADS v2.1 and PI-RADS v2 for diagnostic value of transition zone prostate cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.011</link>
<description><![CDATA[Objective: To study the diagnostic value of PI-RADS v2.1 and PI-RADS v2 (prostate imaging reporting and data system version 2.1 and version 2) in diagnosing transition zone prostate cancer (PCa) and clinically significant prostate cancer (csPCa). Materials and Methods: The clinical and imaging data of 108 patients with transitional zone lesions (53 cases of PCa, 55 cases of benign prostatic hyperplasia and/or inflammation) confirmed by pathology were analyzed retrospectively. Two radiologists independently scored the lesions according to PI-RADS v2.1 and PI-RADS v2. Kappa test was used to assess the consistency of the scoring results between two radiologists; ROC curve was used to evaluate and calculate the diagnostic efficiency of PI-RADS v2.1 and PI-RADS v2 for PCa and csPCa. Spearman correlation analysis was used to analyze the correlation between the scoring results and Gleason score. Results: The consistency of PI-RADS v2.1 was improved compared with PI-RADS v2 (Kappa value was 0.794 vs. 0.724 for all lesions, 0.826 vs. 0.758 for csPCa lesions, 0.734 vs. 0.678 for PCa lesions); the sensitivity, accuracy and AUC value of PI-RADS v2.1 in diagnosing PCa and csPCa and specificity of PI-RADS v2.1 in diagnosing PCa were slightly higher than those of PI-RADS v2 (AUC: 0.949 vs. 0.922 for PCa, 0.955 vs. 0.931 for csPCa; sensitivity: 0.981 vs. 0.943 for PCa, 0.978 vs. 0.956 for csPCa; specificity: 0.764 vs. 0.745 for PCa), but the difference was not significant (all P＞0.05); the scoring results of PI-RADS v2.1 and PI-RADS v2 were moderately positively correlated with Gleason score (r=0.552 vs. r=0.507, P＜0.05). Conclusions: PI-RADS v2.1 has better consistency and the diagnostic efficiency is not lower than PI-RADS v2 for transition zone PCa and csPCa; the PI-RADS score can guide the puncture and help assess the aggressiveness of the tumor.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of multimodal MRI combined with clinical indexes in predicting the short-term effect of neoadjuvant therapy for stage ⅠB1-ⅡA2 cervical cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.012</link>
<description><![CDATA[Objective: To access the value of multimodal MRI combined with clinical indexes to predict the efficacy of neoadjuvant therapy for stage ⅠB1- ⅡA2 cervical cancer. Materials and Methods: Sixty-four cases of cervical cancer patient who received neoadjuvant therapy were retrospectively analyzed. According to the treatment response, the patients were divided into significant response group and non-significant response group. The clinical indexes, ADC value and DCE-MRI parameters (Ktrans, Kep, Ve) of the two groups were analyzed and compared. The correlation between clinical and imaging indexes of the two groups and the neoadjuvant therapy effect was analyzed to establish a reliable model for predicting treatment effect. Results: Univariate analysis showed that there was no significant difference in age, tumor diameter, clinical stage [International Federation of Gynecology and Obstetrics (FIGO) 2009], squamous carcinoma antigen, pathological type. and neoadjuvant therapy methods between the two groups (P=0.092, 0.500, 0.299, 1.000, 0.101, 0.092), and there was no significant difference in ADC and Ve values between the two groups before treatment (P=0.830, 0.891, 0.853, 0.883, 0.859, 0.170, 0.159, 0.637, 0.404, 0.934). Ktrans and Kep before treatment in the significant response group were higher than those in the non-significant response group (P=0.001, 0.037). Multivariate analysis showed that the predictive model constructed by age, pathological type and the 50th percentile of Kep had the highest diagnostic efficiency, with an AUC of 0.891 (0.812, 0.971), a specificity of 86.3% and a sensitivity of 91.3%. Conclusions: MRI parameters combined with clinical indexes have a certain value in predicting short-term efficacy of neoadjuvant therapy for cervical cancer.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Functional imaging analysis of the whole brain ALFF and DC in MDD after medication treatment]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.013</link>
<description><![CDATA[Objective: To evaluate the altered functional change in patients with major depressive disorder (MDD) before and after medication treatment using the whole brain amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) levels, and investigate the potential mechanism of brain functional change. Materials and Methods: Seventeen participants (male 8/female 9) diagnosed with MDD were included in the study and underwent one brain functional image scan. The same rs-fMRI scan was undergone again after 8-week medication treatment. The progression of disease of patients was measured by 17-item Hamilton Rating Scale for Depression (HAMD17) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) following each MRI scan. The significant difference of clinical scales and ALFF and DC levels before and after medication treatment were determined using paired t-test. The relationship between ALFF and DC levels in the whole brain regions and HAMD17 and RBANS scores were based on Pearson correlation coefficient. All data were corrected by Gaussian random field theory (GRF, voxel-wise P＜0.01, cluster-wise P＜0.05, and two-tailed test). Results: The paired t-test found that the scores of HAMD17 after medication treatment were significantly lower than that before (P＜0.001), while immediate memory and attention scores were significantly higher than before (P＜0.001). Moreover, the ALFF values after medication treatment were higher than that before in the Putamen_L (AAL) and Frontal_Mid_R/Frontal_Sup_R (AAL) (GRF correction, voxel level P＜0.01, cluster level P＜0.05). The DC values after medication treatment were higher in the Calcarine_L/Cerebelum_6_R and lower in the Frontal_Sup_R/Frontal_Mid_R (AAL) (GRF correction, voxel level P＜0.01, cluster level P＜0.05). Pearson correlation showed that there was a positive correlation found between ALFF values and education (r2=0.27, P=0.03) in the Frontal_Mid_R (AAL) (GRF correction, voxel level P＜0.01, cluster level P＜0.05). The after treatment DC values were negatively corelated with RBANS-delayed memory score (r2=0.672, P＜0.0001) in the Temporal_Sup_R (AAL), and RBANS-Immediate Memory score (r2=0.668, P＜0.0001) in the SupraMarginal_R/Temporal_Sup_R (GRF correction, voxel level P＜0.01, cluster level P＜0.05), respectively. Conclusions: The present study demonstrated that the resting-state functional brain activity (ALFF, DC) had strong relationship with cognitive ability (RBANS scores) in patients with MDD after medication treatment, which might provide new imaging markers as progression of MDD. Our results indicated that the ALFF and DC might help detect the underlying pathological mechanism in MDD continuum.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Instant brain effect of transcutaneous auricular vagus nerve stimulation in treating the treatment-resistant depression by resting rtate functional magnetic resonance imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.014</link>
<description><![CDATA[Objective: Resting state functional magnetic resonance imaging (rs-fMRI) was used to investigate the instant brain effect of transcutaneous auricular vagus nerve stimulation (taVNS) on treatment-resistant depression (TRD), in order to lay a foundation for revealing the brain mechanism of taVNS<sup><sup>,</sup></sup>s therapeutic effect. Materials and Methods: Thirty-four TRD and 34 healthy volunteers were enrolled, and the data of scale<sup><sup>,</sup></sup>s scores were recorded for every subject. TRD were stimulated by taVNS for 30 minutes, and the rs-fMRI data were collected twice before and after stimulation immediately. Healthy volunteers were not stimulated and only scanned once with rs-fMRI. After comparing the amplitude of low frequency fluctuation (ALFF), functional connectivity (FC) values between TRD and HC, the ALFF values of different brain regions were further extracted and analyzed for partial correlation with scale<sup><sup>,</sup></sup>s scores. Results: In baseline, the ALFF values in the left pallidus/hypothalamus/caudate, the left precentral/middle frontal gyrus in the TRD group were significantly higher. ALFF values of left precentral /middle frontal gyrus were positively correlated with HAMD-17, SDS scores of TRD patients, respectively [(P=0.013, r=0.442), (P=0.026, r=0.400)]. It found that the FC value between left precentral gyrus/middle frontal gyrus and bilateral middle cingulate gyrus, support motor areas, left medial superior frontal gyrus and left lenticulate nucleus (including pallidus and putamen) was significantly higher. In TRD, the ALFF values of pre-treatment were significantly lower than that in post-treatment in the bilateral cerebellar area 1 and left cerebellar area 2 in the left inferior middle frontal gyrus orbital region. Conclusions: TRD showed the abnormal brain functional activities in limbic system-cortical-striatus-globus-pallidus-thalamus neural circuit, in which motor cortex and cognition-related brain regions may be related to the negative emotion. TaVNS can immediately regulate brain spontaneous activities in TRD patients, which involves brain regions related to emotion and cognition, and may be a potential functional brain target of taVNS therapy on TRD.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[A preliminary study of cerebral blood flow perfusion based on the ASL in patients with tension type headache in the resting states]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.015</link>
<description><![CDATA[Objective: To investigate the alteration patterns of cerebral blood flow (CBF) based on arterial spin labeling (ASL) and its correlation with the degree of pain in patients with tension type headache in the resting states. Materials and Methods: Thirty-one cases of tension-type headache patients and 33 cases of matched healthy control volunteers were collected from May 2018 to July 2019 in Affiliated Hospital of Weifang Medical University. A three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) imaging was performed to measure CBF in the resting-states. The difference of CBF between tension headache group and healthy control group was analyzed, visual analogue scale (VAS) was used to evaluate the degree of pain in TTH group, and the correlation between the brain region with altered CBF values and pain degree was evaluated in tension headache patients. Results: Compared with the healthy control group, the CBF values of bilateral parahippocampal gyrus, left thalamus, left putamen, right hippocampus, left caudate nucleus, left insular lobe in TTH group increased, while the CBF values of right central posterior gyrus, right inferior frontal gyrus of insular tectum and left middle frontal gyrus decreased (P＜0.05, family-wise error, FWE correction). In addition, the CBF values of left lenticular putamen, left caudate nucleus and right hippocampus were positively correlated with VAS scores (r=0.374, r=0.416, r=0.358, P＜0.05), while the CBF values of right inferior frontal gyrus were negatively correlated with VAS scores (r=-0.444, P＜0.05). Conclusion: Tension-type headache patients had multiple brain regions with altered CBF value, which may be involved in the central pathophysiological mechanism of tension type headache.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[A pilot study of resting-state brain function in naive patients with primary hypothyroidism]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.016</link>
<description><![CDATA[Objective: To explore the neurophysiological mechanisms of the brain damage in naive patients with primary hypothyroidism by using the fractional amplitude of low-frequency fluctuations (fALFF) of the resting-state functional magnetic resonance imaging (rs-fMRI). Meterials and Methods: Twenty-five untreated patient with hypothyroidism (hypothyroidism group) and 19 healthy volunteers (healthy control group) were assessed with cognitive psychological scales and cranial rs-fMRI scan. The two-sample t test was used to compare the difference of whole brain fALFF value between groups and Pearson correlation analysis with clinical variables and cognitive psychological scores. Results: In the hypothyroidism group, the cognitive scores of Montreal Cognitive Assessment (P=0.009), and the scores of Hamilton Depression Scale-24 and Hamilton Anxiety Scale increased (P=0.013; P=0.041). Compared to controls, the fALFF values in the hypothyroidism group were decreased in the left inferior occipital gyrus, lingual gyrus and right fusiform gyrus, superior occipital gyrus,insula, and central posterior gyrus (GRF correction, voxel level P＜0.005, mass level P＜0.05). Meanwhile, the fALFF values of left inferior occipital gyrus, lingual gyrus and right fusiform gyrus were positively correlated with cognitive scores (r= 0.514, P=0.009; r=0.468, P=0.018; r=0.400, P=0.048). When the voxel decreased to P＜0.001, the fALFF of the left lingual gyrus still decreased significantly and was positively correlated with Montreal Cognitive Assessment scores (r=0.547, P=0.005). Additionally, thyroxine was negatively correlated with depression scores in hypothyroidism group (r=-0.363, P=0.005). Conclusions: Patients with hypothyroidism have cognitive impairment, depression and anxiety. In the resting state, the spontaneous neuronal activity is decreased in multiple brain regions closely related to cognitive function and emotion, which may be a crucially neurophysiological mechanism of cognitive impairment and emotional abnormality in patients with hypothyroidism.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The correlation between brain gray matter volume changes and executive function in patients with end-stage renal disease]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.017</link>
<description><![CDATA[Objective: To investigate the brain gray matter volume changes and its relationship with executive function in patients with end stage renal disease (ESRD) by using voxel-based morphometry (VBM). Materials and Methods: Forty-one patients with ESRD (ESRD group) and 41 gender- , age- and education- matched healthy volunteers (normal control group) were performed by 3D-T1WI MRI scans and executive function tests. To calculate the brain gray matter volume of two groups with VBM, the two-sample independent t-test was performed to test the differences of brain gray matter volume between the two groups. Pearson correlation analysis was performed between different brain gray matter volume and executive function test scores in the ESRD group. Results: Compared with normal control group, brain regions of the significantly decreased gray matter volume in ESRD group included anterior cingulate gyrus, bilateral middle cingulate gyrus, bilateral insula, left middle frontal gyrus, left transverse temporal gyrus, left hippocampus and left caudate (P＜0.05, FWE corrected). The gray matter volume in anterior cingulate gyrus, left middle cingulate gyrus and left insula were negatively correlated with trail making test A (TMT-A) score (P＜0.05), the gray matter volume in anterior cingulate gyrus, bilateral insula, left middle frontal gyrus, left transverse temporal gyrus and left hippocampus were positively correlated with digit symbol substitution test(DSST) score (P＜0.05). Conclusion: There are abnormal gray matter structures in ESRD patients, and the gray matter atrophy in cingulate gyrus, prefrontal lobe and temporal lobe were associated with the degree of executive dysfunction.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Experimental study of Gd-EOB-DTPA dynamic contrast-enhanced magnetic resonance imaging quantitative assessment of moderate liver fibrosis value in rats]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.018</link>
<description><![CDATA[Objective: To investigate the value of ethoxybenzyl diethylene-triamine-pentaacetic-acid (Gd-EOB-DTPA) -dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to quantify the value of moderate hepatic fibrosis (HF) in rats. Materials and Methods: A total of 40 male Wistar rats (10 in the control group and 30 in the experimental group) were intraperitoneally injected with CCl4 to construct HF models of different stages, and axial T1WI and DCE-MRI scans of liver were performed to obtain the following parameters: Volume transport constant (Ktrans), rate constant (Kep), percentage of extracellular space volume (Ve), and initial area under curve (iAUC). All rats were blooded intravenously to determine the content of hyaluronic acid (HA) and layer adhesive protein (LN) in the serum. The liver tissue of rats was taken for HF pathology stage. The difference between DCE-MRI parameters and serological indicators in normal group, normal group and mild HF group and moderate HF group was compared with independent sample t-test; the difference between DCE-MRI parameters and serological index in different HF stages was compared by using the single-factor variance analysis, the correlation between DCE-MRI parameter and serological indicators and HF stage were analyzed by using the Spearman correlation test;the value of moderate HF for diagnosis of each parameter is compared by using the ROC curve. Results: A total of 26 rats were included in the study, of which 6 were pathologically staged for normal group, 7 were mild HF (F1) and 13 were moderate HF (F2—F3), all of DCE-MRI parameters (Ktrans, Ve, Kep and iAUC) decreased with HF (r=-0.665, P<0.001; r=-0.395, P=0.046; r=-0.565, P=0.003; r=-0.538, P=0.005), serum LN and HA content increased with HF (r=0.606, P=0.001; r=0.601, P=0.001); Ktrans, Ve and iAUC had statistical differences between the experimental group and the normal group, the normal group and the mild HF group and the moderate HF group, the normal group and the moderate HF group, the mild HF and the moderate HF group (P＜0.05); the differences in serum LN and HA content between the control group and the moderate HF group were statistically significant (P＜0.05); and the ROC curve shows that Ktrans and LN diagnose moderate HF with the highest efficiency. Conclusions: Gd-EOB-DTPA DCE-MRI quantitative evaluation has good diagnostic value for moderate HF staged, of which Krans has the best diagnostic efficiency in DCE-MRI parameters.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The effect of bandwidth on evaluation of T1, T2 relaxation times and proton density using synthetic MRI: A phantom study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.019</link>
<description><![CDATA[Objective: To evaluate the effect of bandwidth on quantification of T1, T2 relaxation times and proton density using multi-dynamic multi-echo sequence. Materials and Methods: Phantoms consisting of 3 kinds of materials with different T1, T2 and PD [gray matter (GM), white matter (WM), cerebrospinal fluid (CSF)] were included in the study. The phantoms were scanned 9 times using MDME sequence with 7 sets of scan parameters with different bandwidths (19.23 kHz—100.00 kHz). T1, T2, and PD maps were acquired and processed using MAGiC (magnetic resonance imaging compilation) post-processing software, and T1, T2, PD values were acquired. Intragroup coefficient of variation (CV) was performed to evaluate the reproducibility of measured values. Intergroup CV was used to evaluate the discrepancy of measured values across all the groups. The T1, T2 values between GM and WM were compared with paired-samples t test. The PD values between GM and WM were compared with Wilcoxon singled Rank test. Statistical analysis was performed using SPSS software (SPSS for Windows, 23.0.0.0, IBM). Results: The highest intragroup CVs of T1, T2 and PD were 2.09%, 8.73%, 10.61%, respectively. The highest intergroup CVs of T1, T2 and PD values were 1.36%, 2.85%, 3.72%, respectively. Significant differences were revealed when comparing T1 and T2 values between GM and WM (P＜0.01) and no significant differences were found when comparing PD values between GM and WM (P＞0.05). Conclusions: T1 and T2 measurements are not affected by bandwidth within range of 19.23 kHz—100.00 kHz. Repeatability of PD measurements is reduced when the bandwidth is below 50 kHz.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of in-phase and out-of-phase imaging in the grading of gliomas]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.020</link>
<description><![CDATA[Objective: To evaluate the diagnostic value of in-phase and out-of-phase imaging in in grading gliomas. Materials and Methods: A total of 74 patients with glioma confirmed by pathology were retrospectively analyzed. All patient underwent contrast enhanced imaging and in-phase and out-of-phase before the operation. The signal loss ratio (SLR) of the solid part of the glioma was calculated on the in-phase and out-of-phase imaging. The difference of SLR between high-grade glioma (HGG) and low-grade glioma (LGG) was compared, and receiver operating characteristic (ROC) curve was used to evaluate the grading performance of SLR value. Results: The SLR value of HGG was higher than that of LGG, which was statistically different (P＜0.05). The area under curve (AUC) value of SLR to differentiate HGG and LGG was 0.895. Conclusions: In-phase and out-of-phase imaging can help the grading of gliomas. It is simple and easy to implement, and has good clinical practical value.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Functional connectivity of paraventricular thalamus in nocturnal enuresis: a rs-fMRI study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.021</link>
<description><![CDATA[Objective: To find the brain mechanism of awakening disorder and cognitive deficits in children with nocturnal enuresis (NE) by analyzing changes of functional connectivity (FC) between bilateral paraventricular thalamus (PVT) and whole brain voxel. Materials and Methods: In this study, twenty-two children with NE and thirty-three healthy children as the controls were collected. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Bilateral PVT were selected as the regions of interest after pretreatment. Voxel-based functional connectivity (voxel-FC) analysis were used to evaluate the differences in brain function between the two groups. Results: Compared with the children in normal control group, the left PVT of NE group exhibited lower FC with brainstem (t=-3.76, P＜0.05) and left middle temporal gyrus (t=-4.35, P＜0.05) but higher FC with the left cerebellum crus Ⅰ, Ⅱ (t=4.18, P＜0.05) and the right posterior central gyrus (t=3.90, P＜0.05). The right PVT of NE group exhibited lower FC with the left superior temporal gyrus (t=-3.73, P＜0.05) but higher FC with the right precentral gyrus (t=4.09, P＜0.05). Conclusions: The present study revealed that there were spontaneous FC changes in bilateral PVT in children with NE, which maybe one of the mechanisms of central nervous system in the occurrence and development of the awakening disorder and cognitive deficits in children with NE.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Magnetic resonance imaging study of olfactory bulb volume in normal children]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.022</link>
<description><![CDATA[Objective: To investigate the magnetic resonance scanning sequence and volume measurement method of olfactory bulb in normal children, and to establish the volume range of olfactory bulb in normal children. Materials and Methods: One hundred and twenty children who underwent physical examination in Xuzhou Central Hospital and Xuzhou Children<sup><sup>,</sup></sup>s Hospital were retrospectively divided into 4 groups according to their age, including 60 boys and 60 girls, olfactory bulb images were obtained by GE Discovery MR750 3.0 T coronal T2-weighted fast spin echo (FSE) sequence scan, and bilateral olfactory bulb volumes were calculated by manually delineating the boundary and adding layer by layer. Results: The olfactory bulb volumes of normal boys were (21.97±0.50) mm3 on the left,(22.51±0.49) mm3 on the right, and (44.78±0.95) mm3 in total, respectively. The olfactory bulb volumes of normal girls were (23.08± 0.82) mm3 on the left, (22.33±0.76) mm3 on the right, and (45.41±1.55) mm3 in total, respectively. There was no significant difference in the left and right olfactory bulbs volume between boys and girls (P＞0.05). There were significant differences in left and right olfactory bulb volume and total olfactory bulb volume in different age groups (P＜0.05). Conclusions: The coronal T2-weighted FSE sequence of 3.0 T magnetic resonance can clearly display the contour of olfactory bulb and can be used to measure the volume of olfactory bulb. There was no difference in the volume of left and right olfactory bulbs between boys and girls. The olfactory bulb volumes in both boys and girls tended to decrease with the increase of age. The measurement of olfactory bulb volume range in normal children may be used as one of the references to evaluate olfactory bulb lesions in children.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The study of different kinds of primary glaucoma by diffusion tensor imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.023</link>
<description><![CDATA[Objective: To evaluate the microscopic changes of optic pathway in different kinds of primary glaucoma by diffusion tensor imaging (DTI), and investigate the relationship to the severity of glaucoma. Materials and Methods: There were 10 cases (20 eyes in each group) in each group of chronic angle-closure glaucoma (CACG), acute angle-closure glaucoma (AACG) and primary open-angle glaucoma (POAG). And 10 cases (20 eyes) of control subjects were recruited in this study. The mean defect (MD) of view was checked. All subjects underwent DTI examination. The fractional anisotropy (FA), average diffusion coefficient (ADC) of optic nerve and optic radiation were measured by MR post-processing software and were analyzed statistically. All these were analyzed by SPSS 22.0. Results: FA of optic nerve were lower than that of optic radiation in CACG, AACG and POAG (P＜0.05). There were no significant statistical difference in control group (P＞0.05). FA of optic nerves and optic radiation in group CACG, AACG and POCG were significantly lower than the controls (P＜0.05). The ADC values of optic nerve in group CACG, AACG and the right optic radiation in AACG were significantly higher than controls (P＜0.05). FA of right optic nerves in group AACG were significantly lower than group CACG and POAG (P= 0.015, 0.005), ADC of optic nerves in group AACG were higher than group POAG (P=0.011, 0.040), ADC of right optic radiation in group AACG were higher than group POAG (P=0.003). FA of right optic nerve in CACG and AACG were positively correlated with MD (r=0.844, P=0.002; r=0.648, P=0.043). Conclusions: The parameters of DTI reflected the microstructures of the optic pathway in different kinds of primary glaucoma, which wouldbe helpful in the diagnosis, curative effect evaluation of glaucoma.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Prediction of axillary lymph node metastasis in breast cancer based on radiomics nomogram of MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.024</link>
<description><![CDATA[Objective: To establish and verify a radiomics nomogram based on MRI for predicting small axillary lymph node (ALN) metastasis in breast cancer. Materials and Methods: A retrospective analysis of 238 patients with breast cancer confirmed by pathological from January 2018 to April 2021. ALN texture features were extracted based on dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and T2 fat suppression sequence, and stratified sampling was used to divide the group into training (n= 168) and testing (n=70) groups according to ratio of 7∶3, linear regression and the least absolute shrinkage and selection operator (LASSO) algorithm were used to select the feature. Based on the regression coefficients of the screened features. Multi-factor Logistic regression models combining independent factors from radiomic signature and MR imaging characteristics were developed and presented in the form of nomogram. Receiver operating characteristic (ROC) curve was used to evaluate the performance of the model. Hosmer-Lemeshow test was used and calibration curve was plotted to evaluate the goodness of fit of the model. Decision curve analysis (DCA) was used to evaluate the clinical application value of the model. Results: Univariate and multivariate analysis showed that Rad-score, short-to-long axis ratio and ADC value were independent factors in identifying lymph node metastases. Rad-score was the most important factor (OR=1.413, P＜0.001) with areas under the ROC curve (AUC) of 0.867 and 0.887 for the training and testing groups, respectively. The model showed good calibration and discrimination with AUC of 0.972 (95% CI: 0.950—0.994) in the training set and 0.938 (95% CI: 0.882—0.993) in the validation set. DCA findings indicated that the nomogram model was clinically useful. Conclusions: The MRI-based radiomics nomogram model could be used to preoperatively predict the ALN metastasis of breast cancer.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Value of preoperative MRI in the diagnosis of early endometrial carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.025</link>
<description><![CDATA[Objective: To investigate the diagnostic value of preoperative MRI in the depth of muscular invasion and cervical invasion of endometrial carcinoma. Meterials and Methods: One hundred and sixty two cases of endometrial carcinoma confirmed by operation and pathology were retrospectively included, aged 25 to 72 years old, median age 53-year-old. The depth of myometrial invasion and cervical involvement were evaluated by MR multisequence. And using pathological results as the gold standard, the sensitivity, specificity and accuracy of MRI diagnosis were calculated by diagnostic test formula. The Kappa test was used to evaluate the consistency between preoperative MRI results and surgical pathology results. Results: There were 162 cases of endometrial carcinoma confirmed by surgical pathology, including 137 cases of stage Ⅰ and 25 cases of stage Ⅱ. The sensitivity, specificity and accuracy of superficial myometrial infiltration were 94.7%, 93.3% and 94.4%, respectively. The sensitivity, specificity and accuracy of the diagnosis of deep myometrial invasion were 93.3%, 94.7% and 94.4%, respectively. The preoperative MRI evaluation of myometrial invasion was consistent with the operative pathological results (k=0.83). The sensitivity, specificity and accuracy of cervical invasion diagnosis were 48.0%, 94.2% and 87.0%, respectively. Preoperative MRI evaluation of cervical invasion had moderate consistency with surgical pathology results (k=0.46). Conclusions: Preoperative MRI plays an important role in the diagnosis of myometrium invasion and cervical invasion of early endometrial carcinoma, and has a certain guiding role in the development of personalized treatment plan.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Modulated flip angle techniques in refocused imaging with extended echo train for diagnosing lower extremity arteriosclerosis obliterans]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.026</link>
<description><![CDATA[Objective: To investigate the diagnostic value of magnetic resonance modulated flip angle techniques in refocused imaging with extended echo train (MATRIX) for lower extremity arteriosclerosis obliterans (ASO), to provide a new imaging method for the visualization and accurate diagnosis of lower extremity ASO. Materials and Methods: Twenty-two cases of lower extremity ASO were continuously included. Bilateral lower extremities of all the patients underwent digital subtraction angiography (DSA) and MRI (T1-MATRIX and T2-MATRIX sequences). Measure muscle signal-to-noise ratio (SNR) and thrombus-vessel contrast signal-to-noise ratio (CNR) of T1-MARIX and T2-MARIX. The differences and inter-observer consistency in image quality and diagnostic confidence were analyzed. DSA was used as the reference to calculate the diagnostic accuracy of MATRIX sequences for the detection of thrombus. Results: In 22 patients with lower extremity ASO (211 vessels), occlusion caused by thrombosis and plaque was found in 68 vessels. Using DSA diagnosis as the reference criteria, the sensitivity, specificity, accuracy of detection, positive predictive value, and negative predictive value of lower extremity ASO in MATRIX at the level of vascular segments were 90.63%, 93.20%. 92.56%, 85.29% and 95.80%, respectively. The interobserver agreements in image quality and diagnostic confidence of the MATRIX sequences were excellent (ICC≥0.75, P＜0.05). Conclusions: MATRIX can realize contrast-free examination and imaging of lower extremity ASO, and can carry out definite diagnosis. It has high image quality and diagnostic efficiency, and can be applied to clinical practice.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research advances in MRI diffusion imaging on grading and typing of meningiomas]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.032</link>
<description><![CDATA[Meningioma originated from arachnoid cap cells and is the most common non-neuroepithelial tumor in the brain. In 2016, the WHO Classification of Tumors of the Central Nervous System divided meningiomas into 15 subtypes of grade Ⅰ, Ⅱ and Ⅲ. In 2021, the WHO Classification of Tumors of the Central Nervous System replaced previous grades Ⅰ, Ⅱ and Ⅲ with grades 1, 2 and 3, emphasizing that the criteria for defining atypical or anaplastic (grades 2 and 3) meningiomas should apply to any potential subtype and that some molecular markers are also associated with the grading and typing of meningiomas. Different grades of meningiomas have different treatment and prognosis, MRI diffusion imaging, such as diffusion weighted imaging, intravoxel incoherent motion weighted imaging, diffusion tensor imaging and diffusion kurtosis imaging, can be used to grade meningiomas and distinguish subtypes. The radiomics method combined with MRI diffusion imaging has showed good performance also, which is beneficial for patients and clinicians to select treatment methods and evaluate prognosis. Based on previous studies at home and abroad, this paper will summarize the research advances in MRI diffusion imaging on grading and typing of meningiomas.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of magnetic resonance imaging in the diagnosis and brain stimulation treatment of Parkinson<sup><sup>,</sup></sup>s disease tremor]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.033</link>
<description><![CDATA[Parkinson<sup><sup>,</sup></sup>s disease (PD) is characterized by the dopamine degeneration in substantia nigra and striatum. Its clinical manifestations include motor symptoms tremor, bradykinesia and rigidity, also have additional non-motor symptoms such as depression anxiety, cognitive impairment. Tremor, as one of most common symptoms, the underlying mechanism is still unclear, about three out of four PD patients develop tremor during the course of their disease and tremor-dominant patients generally follow a more benign disease course than non-tremor patients. There is growing evidence that brain stimulation such as deep brain stimulation and transcranial magnetic stimulation has been a treatment option for PD. Recently, magnetic resonance imaging is widely used in the diagnosis and treatment of PD which can provide important information for early diagnosis and treatment effect evaluation from the aspects of structure and function. This paper reviews the application of MRI in the diagnosis of tremor-dominant PD patients and the value of MRI in evaluating the efficacy of brain stimulation therapy.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of white matter microstructure analysis methods based on diffusion tensor imaging in visual pathway injury]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.034</link>
<description><![CDATA[The visual pathway includes optic nerve, optic chiasma, optic tract, optic radiation and visual cortex. Conventional MRI can<sup><sup>,</sup></sup>t detect the change of microstructure, and the ophthalmology examination also has certain subjectivity and limitations that can<sup><sup>,</sup></sup>t detect the changes of posterior visual pathway. As an emerging technology, diffusion tensor imaging (DTI) can provide microstructure information and visually display white matter fiber bundles in vivo through various post-processing analysis methods combined with different parameters. It plays an important role in non-invasive exploration of neuropathological mechanisms of diseases and prognosis assessment. Recently, with the innovation of post-processing analysis methods, DTI is more and more widely used in visual pathway injury. This review introduces analysis methods of white matter fiber bundle microstructure based on DTI and its application in visual pathway injury.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[MRI quantitative susceptibility mapping: research advances in central nervous system]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.035</link>
<description><![CDATA[Quantitative susceptibility mapping (QSM) is an extension of the susceptibility weighted imaging (SWI) technology, which can quantify the iron in tissues. It has advantages in displaying microvascular, monitoring blood oxygen saturation and differentiating microbleed and calcifications. It is conducive to early detection of diseases and early to provide reference for clinical decision-making. At present, QSM technology has been widely applied in clinical diseases and scientific research. This paper mainly reviews the research progress of QSM in central nervous system at home and abroad.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study progress of magnetic resonance imaging in age-related macular degeneration]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.036</link>
<description><![CDATA[Age-related macular degeneration (AMD) usually occurs in middle-aged and elderly people aged 50 or above, developing progressively, which can lead to monocular or binocular partial or even complete vision loss. It is the primary cause of vision loss in the elderly. In recent years, researchers can non-invasively examine the effects of eye disease on the visual pathway even the whole central nervous system by using magnetic resonance imaging (MRI) technique. This paper mainly reviews the research progress of MRI in AMD in recent years from the aspects of structural magnetic resonance imaging, blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) and diffusion-weighted magnetic resonance imaging (dMRI).]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of proton magnetic resonance spectroscopy in primary insomnia]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.037</link>
<description><![CDATA[Primary insomnia (PI) is one of the most common sleep disorders. Although we have made some progress in the study of the nature, etiology and pathophysiology of insomnia, there is still no universally accepted pathophysiological model. Today, the most widely accepted hypothesis is that PI is a manifestation of an over-arousal state.Proton magnetic resonance spectroscopy (1H-MRS) provides a non-invasive method to measure the levels of various neurotransmitter and metabolites in the brain, emerging the multi-voxel magnetic resonance spectroscopy can even measure the concentration of neurotransmitters and metabolites in specific brain areas, for the primary insomnia of pathophysiology, pathogenesis, diagnosis and treatment of research provides a fresh view. This paper systematically summarized the domestic and foreign research results and development process of different neurotransmitters and metabolites in various brain regions of primary insomnia by means of magnetic resonance spectroscopy, providing a new perspective for further exploration of the pathophysiological mechanism, diagnosis and treatment of primary insomnia.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The basic principle of intravoxel incoherent motion imaging and its application progress in Sjogren<sup><sup>,</sup></sup>s syndrome]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.038</link>
<description><![CDATA[Sjogren<sup><sup>,</sup></sup>s syndrome (SS) is a systemic autoimmune disease, and imaging examinations of the salivary glands play an important role in its diagnosis. Intravoxel incoherent motion (IVIM) imaging is a kind of multi-b diffusion weighted imaging, which can reflect and quantify the diffusion of pure water molecules and perfusion-related diffusion in the tissue at the molecular level, and then reflect the pathological and functional status. The author reviewed the basic principle and current application progress of IVIM technology in SS.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The advances of MRI in the clinical pathway of acute pancreatitis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.039</link>
<description><![CDATA[Acute pancreatitis is a common clinical acute abdomen with local and systematic complications. According to clinical manifestations and prognosis, the revised Atlanta classification defines three degrees of severity: mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis. In recent years, incidence rate of acute pancreatitis increases gradually and mortality is relatively high in severe acute pancreatitis. Computed tomography, ultrasound and magnetic resonance imaging (MRI) are common radiological technologies in acute pancreatitis clinically. Owing to multiple imaging parameters, MRI has excellent soft tissue contrast resolution and good evaluation capability of biliary and pancreatic duct. Despite the application in morphology, advanced MR techniques such as diffusion-weighted imaging and radiomics, help uncover underlying changes of pancreas and imaging biomarkers for classification and prognosis. Numerous studies use MRI to explore various factors related to the severity and prognosis of acute pancreatitis. The purpose of this article is to review the application advances of MRI in acute pancreatitis in recent years.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Principle and clinical application of high resolution magnetic resonance diffusion imaging with multiplexed sensitivity encoding]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.01.040</link>
<description><![CDATA[By combining conventional diffusion-weighted imaging (DWI) and multiple sensitivity encoding (MUSE) to correct random motion-induced phase variations, multiplexed sensitivity-encoding diffusion-weighted imaging (MUSE-DWI) can minimize image distortion, milder susceptibility artifacts and improve imaging quality in echo-planar imaging. Compared with traditional diffusion-weighted imaging, MUSE-DWI has improved matrix inversion conditions, better signal-to-noise ratio and higher spatial resolution. So far, the multiplexed sensitivity-encoding algorithm has improved imaging quality by integrates multiple magnetic resonance imaging (MRI) techniques and has been widely used in multiple organs. In this paper, we introduced some aspects including MUSE imaging technology, the basic principle of MUSE, multi-technology combined MUSE, clinical application of MUSE-DWI briefly.]]></description>
<pubDate>Thu,20 Jan 2022 00:00:00  GMT</pubDate>
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