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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=202202</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[The study of ischemic core volume combined with the relative perfusion ratio in evaluating vascular recanalization and prognosis in acute stroke]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.001</link>
<description><![CDATA[Objective: To investigate the value of ischemic core volume (ICV) combined with the relative perfusion ratio before endovascular thrombectomy (EVT) in evaluating vascular recanalization and outcome in acute stroke. Materials and Methods: A total of 200 acute ischemic stroke patients in our hospital were analyzed retrospectively. All patients underwent MRI examination before therapy within 24 h. Perfusion weighting ICV (pw-ICV) was defined as ICV multiply by relative cerebral blood flow (rCBF). Complete recanalization was assessed by mTICI grading (0-2a: incomplete recanalization; 2b-3: complete recanalization); the outcome was evaluated by using mRS score at 3 months (0-2 score: good outcome; 3-6 score: poor outcome). Statistical analysis was performed to evaluate the value of pw-ICV in predicting vascular recanalization and outcome. Results: Compared with incomplete revascularization group (n=68), the complete revascularization group had a smaller ICV before therapy was (27.31±19.18 vs. 54.45±29.87) and smaller pw-ICV (103.82±77.46 vs. 216.20±88.19), the difference was statistically significant (P＜0.05). Compared with the outcome group (n= 129), the good outcome group (n=71) had a lower NIHSS score (15.71±6.18 vs. 18.27±6.37), smaller ICV before therapy (28.42± 17.38 vs. 53.51±28.79) and smaller pw-ICV (113.27±79.61 vs. 221.07±87.37) and higher recanalization rate (89.15% vs. 23.94%), the difference was statistically significant (P＜0.05). Logistic multiple logistic regression analysis showed that pw-ICV (OR 0.930; 95% CI: 0.854-1.465; P=0.016) was an independent predictor of recanalization in acute stroke; pw-ICV (OR 0.971; 95% CI: 0.551-1.865; P= 0.025) and complete recanalization (OR 5.26; 95% CI: 1.572-13.179; P=0.037) were independent predictor of the outcome in acute stroke. Conclusions: pw-ICV plays an important role in recanalization and outcome of acute ischemic stroke before EVT therapy.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Preoperatively predict pathological grading of meningiomas using radiomics model based on transverse and sagittal enhanced T1WI images: a preliminary study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.002</link>
<description><![CDATA[Objective: To develop a radiomics model based on transverse and sagittal enhanced T1WI images for preoperatively predicting pathological grading of meningiomas, and test its performance. Materials and Methods: A total of 132 patients with pathologically confirmed meningiomas from January 2017 to December 2020 were enrolled according to the inclusion criteria. ITK-SNAP was used to draw regions of interest, and then features were extracted using pyradiomics. According to the ratio of 8∶2, 105 patients were used as the training set and 27 patients were selected as the test set. Feature reproducibility was evaluated using intra-class correlation coefficient, and the models were developed using support vector machine with RBF kernel after feature selection. Finally, the test set was used to assess the performance, and receiver operating characteristic (ROC) curves were plotted. Results: The combined models based on transverse and sagittal images outperformed other models using single sequence, and synthetic minority over sampling technique (SMOTE) could improve the performance to some degree. The combined model using SMOTE demonstrated the best performance, and the area under the curve, sensitivity, specificity and accuracy were 0.982, 0.900, 1.000 and 0.963 in the test set, respectively. Conclusions: The radiomics model based on transverse and sagittal enhanced T1WI images can help to preoperatively predict pathological grading of meningiomas.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of MR myocardial strain technique in the diagnosis and differential diagnosis of hypertrophic cardiomyopathy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.003</link>
<description><![CDATA[Objective: To apply cardiac magnetic resonance tissue tracking technology (CMR-TT) to quantitatively evaluate myocardial function in patients with hypertrophic cardiomyopathy (HCM) and myocardial function in patients with left ventricular hypertrophy caused by cardiac amyloidosis (CA), and to analyze the differences in myocardial strain changes. Materials and Methods: Select 30 patients with hypertrophic cardiomyopathy (HCM group), 15 patients with myocardial amyloidosis (CA group), and 30 normal people as normal controls (NC group), using CMR-TT technology and CVI42 post-processing software measure conventional strain parameters such as longitudinal strain (LS), circumferential strain (CS), radial strain (RS) of the whole myocardium and segments (basal, middle, apical) and relative apical sparing of strain (RAS), and quantitatively assess the overall and local movement of the myocardium. Results: The values of the strain parameters among the NC group, HCM group, and CA group decreased successively, and all three groups were statistically significant (P＜0.05); in the pairwise comparison, apical circumferential strain (ACS) was not statistically significant except for the NC group and the HCM group, the rest were statistically significant (P＜0.05); RASRS, RASCS, and RASLS were all statistically significant (P＜0.05). The area under the ROC curve of global radial strain (GRS), global circumferential strain (GCS), global longitudinal strain (GLS), basal radial strain (BRS), basal circumferential strain (BCS), basal longitudinal strain (BLS) in the HCM group and NC group were 0.77, 0.71, 0.77, 0.90, 0.73, 0.78, respectively (P＜0.05), and the area under the curve of BRS was significantly higher than other parameters. The area under the ROC curve of RASRS, RASCS and RASLS of HCM group and CA group were 0.83, 0.75, 0.71 respectively (P＜0.05), which has certain value for the differential diagnosis of HCM and CA. Conclusions: CMR-TT can be used to evaluate the overall and local functional movement of the heart. HCM myocardial strain is reduced, HCM basal segment strain is significantly reduced, and BRS has greater diagnostic value; CA patients<sup><sup>,</sup></sup> myocardial strain decreases more than HCM patients for obvious reasons, the relative apical retention mode provides a certain reference value for the differential diagnosis of the two, and the relative apical RS has the best diagnostic efficiency.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Quantitative comparative study of Dixon-MRI and BOLD-MRI on early renal injury in adult male with metabolic syndrome]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.004</link>
<description><![CDATA[Objective: To compare the diagnostic value of Dixon-MRI and blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in the early renal injury of adult males with metabolic syndrome. Materials and Methods: Forty-two adult male volunteers (age 33.88±8.30) were enrolled prospectively. Renal Dixon-MRI and BOLD-MRI examinations were performed in all patients. The height, weight, waist circumference, hip circumference, and blood pressure were recorded. Serological indicators were determined and the glomerular filtration rate (eGFR) was calculated. According to the presence of metabolic syndrome (MetS), patients were divided into MetS group (n=24) and non-MetS group (n=18). The fat fraction (FF) and apparent relaxation rate (R2*) of renal cortex and medulla were measured, and the differences between groups were compared. The correlations between FF, R2*, eGFR, serum creatinine (Scr) and homeostasis model assessment 2-IR (HOMA2-IR) were further analyzed. Then compared the diagnostic efficacy of Dixon-MRI and BOLD-MRI in mild renal injury. Results: The fat fraction (FF) values of renal cortex in MetS group were significantly higher than that in non-MetS group, P＜0.001. The R2* values of the renal medulla in the MetS group (27.02±1.38 s-1) were significantly lower than that in the non-MetS group (31.29±1.17 s-1), P=0.008, but there were no statistically significant differences in FF values of renal medulla and R2* values of cortex between the two groups (P＞0.05). After adjusting for age, the FF values of renal cortex and the R2* values of medulla were still statistically significant between two groups (P＜0.001 and 0.035, respectively), while the FF values of renal cortex were negatively correlated with eGFR (r=-0.37, P=0.017), and positively correlated with Scr and HOMA2-IR (r=0.39, P= 0.012; r=0.34, P=0.026), while the R2* values of renal medulla were not correlated with eGFR and Scr (r=-0.25, P=0.119; r=0.27, P= 0.086). The area under the curve (AUC), sensitivity, and specificity of cortical FF in differentiating normal renal function from mild renal function injury were 82.7%, 85.7%, and 71.4%, respectively. The AUC, sensitivity, and specificity of medullary R2* in differentiating normal renal function from mild renal function injury were 74.2%, 50.0%, and 89.3%, respectively. Conclusions: Dixon-MRI and BOLD-MRI can noninvasively and quantitatively detect MetS-related potential or early renal injury, but Dixon-MRI has more potential to evaluate Mets-related potential or early renal injury than BOLD-MRI.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[A fMRI study of hippocampal functional connectivity changes in benign childhood epilepsy with centrotemporal spikes]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.005</link>
<description><![CDATA[Objective: To detect the changes of functional connection between subregions of the hippocampus and the whole brain in children benign epilepsy with centrotemporal spikes (BECTS) and analyze the potential neural mechanism and clinical value. Materials and Methods: The resting state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) whole brain data of forty-four BECTS patients and thirty-five age-and sex-matched healthy controls were prospectively collected. Functional connectivity analysis method based on seed points was used to analyze the functional connection between the anterior and posterior hippocampus and the whole brain respectively. Results: Compared with healthy controls, functional connectivity between the left anterior hippocampus and the right precuneus, the right inferior parietal lobule, and the left middle temporal gyrus was decreased in BECTS children (P＜0.001). The functional connectivity between the right anterior hippocampus and the left middle temporal gyrus temporal pole, right parahippocampal gyrus, and right middle frontal gyrus orbital was decreased (P＜0.001); The functional connectivity between the left posterior hippocampus and the left hippocampus and the right inferior parietal lobule was decreased (P＜0.001); The functional connectivity between the right posterior hippocampus and the right lingual gyrus and the right parahippocampal gyrus was increased (P＜0.001). Conclusions: The functional connectivity between the hippocampus and the whole brain in BECTS children was changed, which had a great significance on understanding the underlying neuropathological mechanism of BECTS.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[A study on the microstructure of hippocampus in Alzheimer<sup><sup>,</sup></sup>s disease and amnestic mild cognitive impairment based on NODDI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.006</link>
<description><![CDATA[Objective: Using neurite direction dispersion and density imaging (NODDI) to analyze the changes in the microstructure of the bilateral hippocampus in patients with Alzheimer<sup><sup>,</sup></sup>s disease (AD) and amnestic mild cognitive impairment (aMCI), to provide more information on the pathogenesis of AD and explore clinical value of NODDI technology for AD and aMCI. Materials and Methods: Fifteen patients with aMCI, 20 patients with AD and 20 normal controls (NC) was recruited for prospective NODDI scanning, using MRIcro software to measure the three groups of bilateral hippocampal neurite density index (NDI), neurite direction dispersion index (ODI), and volume fraction of isotropic water molecule (Viso). The differences of each parameter among the three groups using single-factor analysis of variance was compared, LSD was used to test the differences between groups. For the different parameters, Spearman correlation analysis was used to analyze the correlation between the parameters and the MMSE score and the MoCA score to obtain the correlation coefficient r. Results: Compared with the NC group, the bilateral hippocampal NDI value and ODI value of the aMCI group and the AD group were significantly lower than the NC group, the difference was statistically significant (P＜0.001); the Viso value was significantly higher than the NC group, and the difference was also statistically significant (P＜0.001). The aMCI group and the AD group were compared between the groups. The Viso value of the AD group was significantly higher than that of the aMCI group, and the difference was statistically significant (P＜0.001), while the difference between the NDI value and the ODI value was not statistically significant (P＞0.05). Correlation analysis shows that the left hippocampal NDI value (r=0.656, P＜0.001) have the strongest positive correlation with the MMSE score, and the left Viso value (r=-0.690, P＜0.001) has the strongest negative correlation with MMSE score; at the same time, the left hippocampal NDI value (r=0.632, P＜0.001) has the strongest positive correlation with MoCA score, and the left Viso value (r=-0.629, P＜0.001) has the strongest negative correlation with MoCA. Conclusions: The number, volume and arrangement complexity of bilateral hippocampal neurites in the aMCI stage and AD stage are significantly reduced, which provides more reference data for exploring the pathogenesis of AD. At the same time, during the progression of aMCI to AD, the bilateral hippocampal Viso value may become an important evaluation index, which has important value for the identification, follow-up and prognosis evaluation of aMCI and AD.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Changes of resting-state brain functional activities in breast cancer patients after neoadjuvant chemotherapy: a short-term longitudinal study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.007</link>
<description><![CDATA[Objective: To explore the short-term longitudinal changes of spontaneous and synchronous brain functional activity in newly diagnosed breast cancer patients after the first cycle of neoadjuvant chemotherapy (NAC). Materials and Methods: A total of thirty-six breast cancer patients with NAC were enrolled. Resting state functional magnetic resonance imaging (rs-fMRI) and neuropsychological tests were performed at the baseline before NAC (timepoint 0, TP0) and after the first cycle of NAC (time point 1, TP1). Amplitude of low-frequency fluctuations (ALFF) and seed-based functional connectivity (FC) analysis were conducted to assess intrinsic brain activity in all participants. Paired sample t test was used for longitudinal comparison, and the correlation between rs-fMRI parameters and neuropsychological test scores was analyzed. Results: Compared with TP0, the Self-Rating Anxiety Scale (SAS) scores of breast cancer patient at TP1 was significantly decreased (P＜0.05), and the scores of other neuropsychological tests were not significantly different between the two timepoints. The ALFF values of the right middle frontal gyrus, the right insula and the left dorsolateral superior frontal gyrus at TP1 were significantly decreased (voxel level P＜0.001, cluster level P＜0.05), and the FC between left dorsolateral frontal gyrus and the right middle frontal gyrus were significantly increased at TP1 (voxel level P＜0.005, cluster level P＜0.05). In addition, the ALFF value of the left dorsolateral frontal gyrus at TP0 was significantly positively correlated with the difference between TP0 and TP1 in the Self-Rating Depression Scale (SDS) score (ρ=0.429, P=0.016). The difference in FC z value between the left dorsolateral frontal gyrus and the right middle frontal gyrus between TP0 and TP1 was significantly positively correlated with the difference in trail making test A (TMT-A) time cost between TP0 and TP1 (ρ=0.443, P=0.012). Conclusions: NAC may affect spontaneous and synchronous brain function activity immediately in breast cancer patients, involving executive function and emotion-related brain regions.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Brain function study in T2DM comorbidity depression based on resting state degree centrality]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.008</link>
<description><![CDATA[Objective: To explore the abnormal patterns of brain functional networks in type 2 diabetes comorbid depression (T2DD) by using Degree Centrality (DC) method of resting state functional magnetic resonance imaging. To further elucidate the neuroimaging mechanisms of T2DD. Materials and Methods: Fifty-six T2DD patients, 59 type 2 diabetes mellitus (T2DM) patients without depression and 57 healthy volunteers were prospectively enrolled. The whole brain DC values of the three groups were compared, and the correlation analysis between the DC values of the brain regions with significant differences and clinical variables and cognitive psychological scale was extracted.Results: Compared with control group and T2DM without depression group, T2DD group had lower cognitive score, depression score and anxiety score. Compared with the control group, the DC value of the right posterior cingulate gyrus decreased in T2DM without depression group, and the DC value of the right transverse temporal gyrus increased in T2DD group (GRF correction, voxel P＜0.001, cluster P＜0.05), no correlation was found between the DC values of these brain regions and the clinical data and the cognitive psychosocial scale scoring. Conclusions: T2DD patients are associated with more severe emotional abnormalities and cognitive impairment. In resting state, abnormal topology of the functional network of the right transverse temporal gyrus may be a potential neuroimaging biological marker of T2DD brain damage.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study on multi-voxel <sup>1</sup>H-MRS in brain of chronic mountain sickness]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.009</link>
<description><![CDATA[Objective: Using multi-voxel hydrogen proton magnetic resonance spectroscopy (1H-MRS) to explore the characteristics of brain metabolites in chronic mountain sickness (CMS) under long-term hypoxia, and compare the metabolites with correlations between blood parameters. Materials and Methods: Seventeen male patients who were diagnosed with CMS at Qinghai University Affiliated Hospital were collected as the experimental group, with age of (53.29±9.03) years, living altitude of (3989.12±937.45) meters and hemoglobin (HGB) of (224.35±11.81) g/mL. The control group consisted of eighteen healthy volunteers with the same age, gender and living altitude as the experimental group. The living altitude was (3674.94±634.27) meters, and the HGB was (156.67±9.46) g/mL. All cases were examined by routine head MRI and multi-voxel 1H-MRS 3D chemical shift imaging technology (CSI-SLASER) with 20-channel head coil of Siemens Prisma 3.0 T MR scanner. 1H-MRS images were obtained by Syngo. via post-processing software, bilateral frontal lobe and hippocampus were selected as ROIs. The ratios of N-acetylaspartate/creatine (NAA/Cr), choline/creatine (CHo/Cr), N-acetylaspartate/choline (NAA/CHo) and lactic acid/creatine (Lac/Cr) were measured. Then the correlation between the ratio of each metabolite in bilateral frontal lobe, hippocampus and blood biochemical indexes in CMS group was analyzed. Results: (1) There was no significant statistical difference in age and living altitude between the two groups (P＞0.05), but the HGB, red blood cell count (RBC) and hematocrit (HCT) in the two groups were significantly higher than those in the control group, while platet (PLT) was lower than those in control group, with significant differences (P＜0.01). (2) Compared with the control group, NAA/Cr and NAA/CHo in bilateral frontal lobe and bilateral hippocampus decreased, Lac/Cr increased in CMS group, which were statistically significant (P＜0.05). (3) Compared with the control group, the CHo/Cr of bilateral frontal lobe and bilateral hippocampus increased (P＞0.05), but there was no statistical significance between the two groups. (4) In CMS group, CHo/Cr in the right frontal lobe and left hippocampus was positively correlated with RBC, CHo/Cr in the left frontal lobe was positively correlated with HCT, Lac/Cr in the right frontal lobe and left hippocampus was positively correlated with HCT. Conclusions: Under the long-term hypoxia condition of CMS, local metabolites in brain tissues are changed, neurons are damaged and anaerobic metabolism increased, and the changes of these metabolites are correlated with blood indexes to a certain extent, which can provide imaging evidence and monitoring indicators for further prevention or intervention of brain damage in CMS patients.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study on thecerebrum metabolism in PI patients using magnetic resonance spectroscopy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.010</link>
<description><![CDATA[Objective: To study the cerebrum metabolism in patients with primary insomnia (PI). Materials and Methods: Proton magnetic resonance spectroscopy technology was used to detect concentrations of N-acetyl-aspartate, choline-containing compounds and creatine in the thalamus, hippocampus and putamen of 38 PI patients (PI group) and 39 healthy controls (HC group), and NAA/Cr and Cho/Cr were calculated. Polysomnography (PSG) was used to measure objective sleep parameters. Assess sleep quality by fill in the form of the Pittsburgh sleep quality index and insomnia severity index; Assess sentiment by fill in the form of State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI). Results: (1) Comparison of metabolite concentration: compared with the HC group, the concentration of Cr and Cho in the left thalamus of PI group increased (P=0.040, P=0.007), the concentration of Cho in the right thalamus increased (P=0.039), bilateral hippocampus and shell The metabolites in the nuclear area were not different from the control group (Pall＞0.05). (2) Correlation: The NAA value of the left thalamus in PI patients is negatively correlated with total sleep time and sleep efficiency (r=-0.384, P=0.017), and NAA/Cr value is negatively correlated with REM% (r=-0.387, P=0.016); right thalamus Cho/Cr value is positively correlated with SL% (r=0.380, P=0.019), There was no significant correlation between the thalamus NAA, Cr, Cho, NAA/Cr, Cho/Cr values and the scores of each scale. The Cho value of the left hippocampus of patients with insomnia is positively correlated with ArI (r=0.348, P=0.044); the Cho value of the right hippocampus (r=-0.334, P=0.047), Cr value (r=-0.445, P=0.007) and The BDI score was negatively correlated. The NAA value of the left putamen of PI was positively correlated with N3% (r=0.340, P=0.037); The Cr value of the left putamen is positively correlated with Trait Anxiety Inventory (TAI) (r=0.447, P=0.005); the NAA/Cr value of the left putamen is correlated with N1% (r=-0.344, P=0.047), TAI score (r=-0.521, P=0.001), State Anxiety Inventory (SAI) score (r=-0.400, P=0.013) is negatively correlated; Cho/Cr on the left putamen is negatively correlated with TAI score (r=-0.527, P=0.001) and SAI score (r=-0.434, P= 0.007). There was no obvious correlation between the parameters of the differences between the groups and the scores of the various scales and PSG parameters. Conclusion: The metabolism of Cho and Cr in the thalamus of PI patients is impaired. Objective sleep affects the metabolism of the thalamus. The patient<sup><sup>,</sup></sup>s mood disorder is related to the metabolism of the hippocampus and putamen.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Homology study of auditory region of superior temporal gyrus between human and macaque based on MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.011</link>
<description><![CDATA[Objective: To explore the homology of structural connectivity patterns between the two species and to provide a theoretical basis for cross-species comparisons and alternative experiments, the similarities and differences in the structural connections responsible for auditory information processing in the superior temporal gyrus of humans and macaques were observed using magnetic resonance imaging. Materials and Methods: A publicly available brain imaging dataset with 22 human subjects and 9 macaque subjects was selected as the study subjects. For the pre-processed human data, 6 regions of interest with 18 target regions were extracted, and for the macaque data, the STGr and 18 target regions was extracted. Connection strengths were calculated and connection fingerprints were constructed. Similarities and differences in connection patterns were analysed using Manhattan distance and cosine similarity, and the results were finally examined using a permutation test. Results: The result shows that the highest similarity values (cosine=0.966) were found in the connectivity fingerprints of the human superior temporal gyrus (area 38 m) and the macaque anterior superior temporal gyrus, and the structural connectivity patterns in the right side of the human superior temporal gyrus (area 38 m) were more similar to those in the macaque anterior superior temporal gyrus. Both regions had strong connections to the perinasal cortex associated with situational memory, the ventral striatum associated with reward, emotion and movement, and the hippocampus associated with memory and learning, and weaker connections to the parietal insula associated with cognition and movement. Conclusions: Therefore, the human area 38m has a similar structural connectivity profile to the rostral superior temporal gyrus of macaque. In other words, macaque and human audition processing areas might have a similar precursor. This discovery provides theoretical support for constructing the cross-species comparison framework between human and macaques.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of magnetic nanoparticles in vitro MRI of mouse macrophages]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.012</link>
<description><![CDATA[Objective: To investigate the optimal concentration of mouse macrophage cell line RAW264.7 labeled with ultra-micro superparamagnetic iron oxide nanoparticles (USPIO) and to compare the sensitivity differences of different scanning sequences in the evaluation of cell phagocytosis in MRI imaging. Materials and Methods: The final concentrations of USPIO (0, 25, 50, 75, 100, 125 μg/mL) were co-cultured with mouse macrophages for 24 h and then the cell viability was calculated using the cell counting reagent (CCK-8) as well as the half inhibitory concentration (IC50) of USPIO on the cells. The morphological changes of the cells were observed under a light microscope. Prussian blue staining was used to confirm the phagocytic effect of cells on USPIO. 3.0 T MRI scan of the cell-agarose gel model was performed to record the relaxation time and relaxation rate of T1WI and T2WI sequences and calculate the reduction rate of relaxation time. Results: When the concentration of USPIO was 25 μg/mL, there was no effect on the cell viability and the difference was not statistically significant (P＞0.05). When the concentration of USPIO was ≥50 μg/mL, the cell viability was significantly decreased with the increase of USPIO concentration (all P＜0.05). The IC50 for the median inhibitory concentration of USPIO on cells was (186.5±7.2) μg/mL. When the concentration of USPIO was 50 μg/mL, the cell morphology began to shrink and the light transmittance decreased. When the concentration of USPIO was 25 μg/mL, the Prussian blue staining was significantly positive. MRI imaging showed significant signal changes in the cells at a concentration of USPIO of 25 μg/mL compared to the control group; With the increase of USPIO concentration, the relaxation times of T1 and T2 were significantly shortened (all P＜0.01), and the corresponding relaxation rates R1 and R2 were gradually increased. Under the same concentration of USPIO, the reduction rates of T2 relaxation time in each group were significantly higher than that of T1 relaxation time (all P＜0.001). Conclusions: USPIO at a concentration of 25 μg/mL has no obvious toxic effect on cells, and it is efficient in labeling, with obvious signal changes on MRI and good imaging effect. It is the optimal concentration for labeling macrophages. MRI can be used for imaging in vitro after cell labeling, and the signal changes of T2WI sequence after detecting the phagocytosis of USPIO by cells are superior to that of T1WI sequence.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Design and verification of flexible and elastic coil for the head of wearable MRI device]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.013</link>
<description><![CDATA[Objective: To reduce the influence of the matching degree between the scanning site and the coil size on signal-to-noise ratio (SNR) in high field magnetic resonance imaging due to the difference of patients<sup><sup>,</sup></sup> body geometry. Materials and Methods: To achieve better matching of scanning position and coil, one adult head was selected as the research object, and the flexible coil for the head was made by filling the surface of the coil with common-side regular hexagon. To verify the performance of the self-made coil and the commercial coil, comparative experiments were carried out with water film and true human head respectively. Results: The water film experiment proved that with the increase of imaging depth, the SNR of the self-made coil showed a decline trend. The maximum SNR was of the surface layer which was 3 times that of the deep layer; compared with the commercial 8-channel head coil, from the tissue surface to the deep layer (46 mm) of the water film, the SNR of the self-made coil increased by 0-2 times. Compared with the SNR at the 46 mm depth, the SNR at a deeper point was reduced by about 15%. Scanning the coronal surface structure of the human head showed that the SNR value of the coronal surface structure of the human head had the largest SNR value at the surface position and the smallest SNR value at the center. From the surface layer to the deep layer, the SNR of the image gradually decreased. At the same time, due to incomplete coil laying, the imaging results would be worsened to a certain extent. The tests showed that the self-made coil was feasible and stable. Conclusions: It fully proves that the combination of flexible material and elastic material can adapt to the geometric deformation caused by the adult<sup><sup>,</sup></sup>s head change, so as to obtain the maximum filling coefficient inside the coil. At the same time, the imaging quality worsening caused by the incomplete laying of the coil also exists, which cannot be compensated by a high filling coefficient, so in the clinical application it cannot be ignored.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Intravoxel incoherent motion diffusion-weighted imaging for assessment of the differential diagnosis and Gleason grade in prostate cancer: a Meta-analysis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.014</link>
<description><![CDATA[Objective: To explore the value of parameters of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI), including apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f) in the differential diagnosis and Gleason grade of prostate cancer (PCa). Materials and Methods: A literature search on Embase, Medline, PubMed and Cochrane Library was performed to identify all the relevant studies characterizing differential diagnosis and Gleason grade of PCa by IVIM DWI published until August 2021. Stata 15.0 software was used for statistics analysis, for continuous variables, weighted mean difference (WMD) with corresponding 95% confidence interval (95% CI) was used as the statistical effect size, and forest maps were drawn. In addition, subgroup analysis was conducted to assess for heterogeneity, and risk of bias was assessed by Begg<sup><sup>,</sup></sup>s test. Results: A total of 13 articles were included, involving 504 patients and 821 ROIs. The pooled results of IVIM parameters for differentiating between PCa and healthy peripheral zone (PZ) showed that ADC, D and f values were significantly lower in regions of PCa compared to those of regions of PZ {WMD=-0.82 [95% CI (-1.01--0.64)], Z=8.69, P＜0.0001; WMD=-0.54 [95% CI (-0.78--0.29)], Z=4.34, P＜0.0001; WMD=-6.91 [95% CI (-12.12--1.70)], Z=2.60, P＜0.0001}. In addition, D was significantly lower than ADC in the regions of PCa {WMD=-0.20 [95% CI (-0.38--0.03)], Z=2.26, P=0.02}. Compared with the low-grade (LG) PCa group, the pooled results showed that ADC value and D value in intermediate/high-grade (HG) PCa were significantly decreased {WMD=-0.24 [95% CI (-0.30--0.19)], Z=8.06, P＜0.001; WMD=-0.25 [95% CI (-0.33--0.17)], Z=5.99, P＜0.001}. Conclusions: IVIM parameters are suitable for the differential diagnosis of PCa, and the D value may be more valuable than the ADC value in the characterization of PCa lesions. In addition, ADC value and D value can further distinguish LG and HG prostate cancer.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Diagnosis of cerebral venous thrombosis in children: Comparative study of 3D Brainview T1W black blood sequence and 3D CE-MRV sequence]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.015</link>
<description><![CDATA[Objective: To retrospectively evaluate the performance of 3D Brainview T1W black blood sequence for diagnosis of cerebral venous thrombosis (CVT) in children. Materials and Methods: This retrospective study included 25 children who had clinical symptoms suggesting CVT or with known CVT with MRIs performed with 3D Brainview T1W and 3D contrast-enhanced (CE) magnetic resonance venography (MRV) sequences on a 3.0 T scanner, and 10 of them also were performed with routine MRI and 3D phase-contrast (PC) MRV. Two neuroradiologists blindly reviewed 3D Brainview T1W and 3D CE-MRV images to obtain a diagnositic outcome for the presence or absence of CVT for each sequence, respectively. Final diagnostic reference standard was based on clinical diagnosis. The inter-observer agreement for the diagnosis of CVT was evaluated by using Kappa analysis for 3D Brainview T1W. Sensitivity/Specificity was used to assess the diagnostic performance of 3D Brainview T1W and 3D CE-MRV against the final diagnostic reference standard. Results: The inter-observer agreement in the diagnosis of CVT was high for 3D Brainview T1W sequence (κ=0.95). The sensitivity/specificity for 3D Brainview T1W and 3D CE-MRV were 97.1%/99.6% and 91.4%/99.2%, respectively. There was no significant difference between 3D Brainview T1W and 3D CE-MRV in the diagnosis of CVT. However, 3D Brainview T1W provided more details of thrombi and diagnostic information. Conclusions: 3D Brainview T1W showed the excellent performance in the diagnosis of CVT in children.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Characteristics of blood oxygen level-dependent fMRI time-signal intensity curve in amyotrophic lateral sclerosis and nerve damage]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.016</link>
<description><![CDATA[Objective: To analyze the type of time-signal intensity curve (TIC) of blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) fed back by motor center and sensory center in patients with amyotrophic lateral sclerosis (ALS), and the correlation of TIC fed back by the motor and sensory centers. Materials and Methods: Eighteen clinically diagnosed ALS patients (ALS group) and 18 age and gender-matched healthy volunteers (control group) were selected. All subjects signed the informed consent and were right-footed. The right toe was asked to stretch dorsally and regularly, the dorsal skin of the lower part of the right lower leg was stimulated regularly using a blunt-headed bamboo stick, and brain BOLD scanning was performed to detect the feedback of motor and sensory centers. The distribution of TIC types in the highest motor and sensory feedback areas of the two groups were statistically compared. According to the TIC slope grade score, the correlation of TIC type in the highest motor and sensory feedback areas in the ALS group was analyzed by Spearman correlation analysis. Results: In the highest motor feedback area of the brain, descending TIC: the ALS group＞the control group (P＜0.001), horizontal TIC: the ALS group＜the control group (P＜0.001), ascending TIC: the ALS group=the control group (P=1.00). In the highest sensory feedback area of the brain, descending TIC: the ALS group＜the control group (P=0.221), horizontal TIC: the ALS group＜the control group (P＜0.001), ascending TIC: the ALS group＞the control group (P＜0.001). In the ALS group, the descending TIC in the highest motor feedback area was correlated with the ascending TIC in the highest sensory feedback area (P＜0.05). Conclusions: In BOLD-fMRI in ALS, descending TIC is more common in motor feedback, while ascending TIC is more common in sensory feedback. Their TIC slopes have a strong negative correlation.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparison of value of three MRI perfusion techniques in the preoperative assessment of brain glioma grading]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.017</link>
<description><![CDATA[Objective: To analyze the value of three kinds of magnetic resonance imaging (MRI) perfusion techniques of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) and three-dimensional arterial spin labeling (3D-ASL) in the preoperative assessment of brain glioma (BG) grading. Materials and Methods: The clinical data of patients with BG in the hospital were retrospectively analyzed, including 48 cases with preoperative DCE-MRI examination and 34 cases with preoperative DSC-PWI and 3D-ASL examinations. The diagnostic value of DCE-MRI parameters [volume transport constant (Ktrans), rate constant (Kep), extravascular extracellular space fraction (Ve), plasma volume fraction (Vp)], DSC-PWI parameter [relative cerebral blood flow (rCBF)] and 3D-ASL parameter (rCBF) on BG pathological grading was analyzed. The differences in rCBF of DSC-PWI parameter and rCBF of 3D-ASL parameter were compared. Results: There were no significant differences in Kep and Vp among different BG pathological grades (P＞0.05). Ktrans and Ve of BG pathological grade Ⅱ were significantly lower than those of grades Ⅲ and Ⅳ (P＜0.05), but there were no statistically significant differences in Ktrans and Ve between grade Ⅲ and grade Ⅳ (P＞0.05). In DSC-PWI and 3D-ASL, there were significant differences in rCBF values between patients with different BG pathological grades and the contralateral hemisphere, gray matter, and white matter (P＜0.05), and the rCBF values of grade Ⅱ were lower than those of grade Ⅲ and Ⅳ (P＜0.05), and the values of grade Ⅲ were lower than those of grade Ⅳ (P＜0.05). ROC curve analysis showed that rCBF values measured by Ktrans, Ve, DSC-PWI and 3D-ASL had high diagnostic value on BG pathology grade Ⅳ (P＜0.05). There was no significant difference in rCBF measured by DSC-PWI and 3D-ASL (P＞0.05). Conclusions: The effect of DCE-MRI in judging BG grading is not as good as DSC-PWI and 3D-ASL. DSC-PWI measures more parameters than 3D-ASL, but its safety and non-invasiveness are not as good as 3D-ASL. The three perfusion techniques have their own advantages and disadvantages, thus it is necessary to select the appropriate perfusion technique according to the actual situation in clincial practice.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Predictive value of MRI for cardiac function improvement after intervention in acute myocardial infarction patients]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.018</link>
<description><![CDATA[Objective: To investigate the prognostic value of cardiac magnetic resonance multiparameter in patients with acute ST segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PCI). Materials and Methods: STEMI patients who underwent emergency PCI in the Affiliated Hospital of Xuzhou Medical University from Sep 2019 to Mar 2021 were retrospective analyzed, and CMR examination was performed within 1 week after surgery, 52 patients with left ventricular ejection fraction (LVEF)＜50% were selected. The 52 patients underwent CMR examination again 3-4 months after PCI, and were divided into LVEF＜50% group and LVEF≥50% group according to follow-up LVEF. Clinical data and all CMR parameters (LVEF, myocardial infarction size, transmurality, microcirculation obstruction) were compared between the two groups, and Logistic regression model was used to analyze the predictive value of CMR parameters on cardiac function recovery after PCI in acute STEM patients. Results: In this study, 50% of the patients with cardiac dysfunction after STEMI emergency PCI recovered short-term cardiac function. In LVEF＜50% group, the level of hypersensitive troponin T level and creatine kinase within 48 hours after PCI, infarct size, transmurality and microvascular obstruction (MVO) in the baseline CMR were all higher than those in LVEF≥50% group. P values were all＜0.05. Logistic regression analysis showed that age≥60 (P=0.017, OR=7.053, 95% CI: 1.413-35.211) and transmural myocardial infarction (P=0.040, OR=5.913, 95% CI: 1.065-32.835) were independent factors for predicting poor cardiac function recovery. Conclusions: The elderly and acute transmural myocardial infarction are independent predictors of poor short-term cardiac function recovery in STEMI patients with cardiac dysfunction after PCI.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study on parotid gland morphologic changes in diabetic patients based on diameter measurement by MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.019</link>
<description><![CDATA[Objective: The correlation between parotid diameter and parotid volume was preliminarily studied by MRI in order to evaluate the morphological changes of parotid gland with parotid diameter instead of volume. Materials and Methods: The correlation diameter and volume of bilateral parotid gland were measured by 90 healthy subjects, and the correlation was analyzed. The correlation between diameter and volume is analyzed by multivariate linear regression, and the regression equation is obtained. The correlation diameter of parotid gland was measured in 10 patients with type 2 diabetes and the volume was obtained by substituting the value into the regression equation. Results: The anteroposterior and vertical diameters was positively correlated with the volume of the parotid gland of healthy subjects (anteroposterior diameter correlation coefficient r=0.728, vertical diameter correlation coefficient r=0.720), the regression equation was V=9.506+4.144X+2.190Y (X=anteroposterior diameter, Y=vertical diameter). There was no significant difference between the measured volume and the calculated volume of parotid gland by regression equation. Conclusions: The anteroposterior diameter, the upper and lower diameter were obvious correlated with the volume of parotid gland, and parotid gland can be easily calculated using the regression equation. Our study provided a simple and easy method for estimate the parotid gland volume.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Progress of neuroimaging study on dietary improvement of cognitive impairment]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.025</link>
<description><![CDATA[Mild cognitive impairment (MCI) is considered to be a precursor to Alzheimer<sup><sup>,</sup></sup>s disease (AD), so early diagnosis and treatment of patients with MCI is important to prevent and delay the progression to various types of dementia. At present, there is no clear drug treatment can significantly delay or change the course of AD development. Diet as a major part of lifestyle, a large number of studies have confirmed that certain nutrients, dietary patterns are associated with cognitive function and brain morphology or function, and can reduce the risk of AD and the transition from MCI to AD. With the development of imaging technology, the relationship between dietary factors and imageology in patients with cognitive impairment and the changes of neuroimageology after dietary improvement have gradually become a research hotspot both at home and abroad. This article reviewed the recent advances in neuroimaging of dietary intervention in cognitive impairment in order to explore the neuroimaging mechanism of dietary intervention and its clinical application.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Advances in magnetic resonance imaging studies in patients with cognitive impairment in type 2 diabetes mellitus]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.026</link>
<description><![CDATA[Type 2 diabetes mellitus causes structural and functional abnormalities in the brain and increases the risk of cognitive impairment. However, we are still unclear about the pathogenesis of cognitive impairment in type 2 diabetes mellitus. However advances in magnetic resonance imaging studies have further identified the neurological factors associated with type 2 diabetes mellitus leading to cognitive impairment. We systematically reviewed the literature on neuroimaging alterations in patients with type 2 diabetes mellitus that include changes in structure, brain function, and metabolites. Studies have shown that changes in the type 2 diabetes mellitus brain include atrophy of brain structures, high white matter signal, altered functional connectivity, cerebral microangiopathy, cerebral blood flow, and altered metabolites. Magnetic resonance imaging promises to further elucidate the basis of cognitive decline in type 2 diabetes mellitus and enable better diagnosis and treatment of the disease, offering potential translational opportunities for clinical intervention.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress on neuroimaging biomarkers of chemotherapy-related cognitive impairment in breast cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.027</link>
<description><![CDATA[Neuroimaging technology, especially magnetic resonance imaging (MRI), is widely used in evaluating the alterations of brain anatomy and function, and has gradually become a powerful tool for clinical study of chemotherapy-related cognitive impairment (CRCI) in breast cancer, and provides a possible neuroimaging diagnostic marker for its early diagnosis. The article reviewed the application of neuroimaging in the study of neuroimaging biomarkers of CRCI in breast cancer, in order to provide imaging evidence for revealing its pathophysiological mechanism and early diagnosis.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Advances in research on brain networks in psychogenic erectile dysfunction]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.028</link>
<description><![CDATA[Erectile dysfunction (ED) is a common male sexual dysfunction disease, manifested by the persistent inability to achieve and maintain erection satisfactorily for sexual performance. Psychogenic erectile dysfunction (pED) is the most common type of ED, previously believed to be mainly caused by psychological factors. With the development of imaging technology, it has been widely confirmed that there were structural and functional network abnormalities in specific brain regions in patients with pED. The results of our review suggested that there were widely abnormal topological connection patterns of default mode network, cognitive control network, emotion/frontal-limbic system and salience network in the structural networks and functional networks of patients with pED, which might be a potential biomarker of pED. This finding will provide a new idea for the central neurophysiological mechanisms research of pED.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress in brain functional changes in PTSD patients]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.029</link>
<description><![CDATA[Post-traumatic stress disorder (PTSD) is a disorder sequelae of changes in their mental state after encountering or fighting major stress. Early explored by military psychiatrists and psychoanalysts, PTSD was a public health issue that attracted widespread social concern. In recent years, a series of public health emergencies around the world, such as the popular SARS in 2013 and novel coronavirus (COVID-19) began in the end of 2019, the outbreak of these events led to a series of psychological problems in some patients and medical workers, and even PTSD, makes PTSD a disease research hotspot, understand brain function changes in PTSD patients to prevent people<sup><sup>,</sup></sup>s mental illness and actively treat patients are of great help. So this paper provides a review of the recent research progress on functional magnetic resonance imaging (fMRI) on changes in brain function in PTSD patients to enhance public mental health recovery in response to the persistence of a series of public health emergencies.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[New progress in imaging evaluation of intracranial atherosclerosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.030</link>
<description><![CDATA[Intracranial atherosclerosis is one of the main causes of ischemic stroke. Early diagnosis is of great significance to the later treatment and prognosis of patients. The traditional imaging evaluation methods are not enough to accurately evaluate this kind of disease. High resolution MR vessel wall imaging and the imaging omics of plaque have developed rapidly, showing its unique advantages. New methods such as intravascular imaging and computational fluid dynamics also play an important role in intracranial atherosclerosis, and the combined application of different evaluation methods will improve the accuracy of clinical diagnosis. The imaging evaluation methods of intracranial atherosclerosis were reviewed in this paper to clarify the main roles of different methods.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Principle of amide proton transfer imaging and its research progress in glioma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.031</link>
<description><![CDATA[Glioma is the most common primary tumor of the central nervous system, high mortality and postoperative recurrence rate. At present, conventional magnetic resonance imaging technology can not meet the needs of clinical diagnosis and treatment decision-making. Amide proton transfer (APT) imaging can reflect the protein content and pH changes in cells at the molecular level by detecting the exchange rate of amide protons in free proteins and polypeptide chains in vivo with hydrogen protons in water, which can make up for the shortcomings of conventional magnetic resonance imaging technology. In recent years, APT imaging technology has been gradually applied in central nervous system diseases, especially in the early diagnosis, preoperative grading and curative effect evaluation of glioma. This paper mainly expounds the basic principle of APT imaging technology and its research progress in glioma.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of intelligent image prediction of MGMT methylation status in high-grade glioma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.032</link>
<description><![CDATA[Glioma is the most common primary malignant tumors in the brain. which is highly heterogeneous. Even if the classification is the same, sometimes the prognosis is significantly different. Genotyping can better explain the biological behavior of the tumor. Amongthem, O6-methylguanine-DNA methyltransferase (MGMT) is closely related to the prognosis and treatment decisions of high-grade gliomas. It is an important DNA repair enzyme, which is not only associated with the development of glioma, but also with the sensitivity of alkylating agent chemotherapy and radiotherapy response. The methylation of the MGMT promoter will silence the transcriptional expression of MGMT, and is an important mechanism for the decrease of MGMT expression. In recent years, with the rapid advancement of science and technology, radiology has gradually developed towards the direction of artificial intelligence. The predictive performance of intelligent imaging on the methylation status of the MGMT promoter in high-grade gliomas was reviewed in this article.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of MRI technology in the diagnosis of parotid tumor]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.033</link>
<description><![CDATA[Parotid tumors are relatively rare histologically heterogeneous tumors. Because of their complex pathological types and non-specific clinical presentation, preoperative differentiation of tumor benignity and malignancy and different subtypes is very important for treatment strategy planning. In recent years, MRI technology has developed rapidly. The application of various technologies makes magnetic resonance examination of great significance in distinguishing benign and malignant parotid tumors and evaluating prognosis. The authors mainly focus on diffusion-weighted imaging (DWI), amide proton transfer (APT) imaging, arterial spin labeling (ASL) perfusion-weighted imaging and radiomics for evaluating parotid gland tumors. The research progress of parotid tumors is reviewed, which provides an basis and reference for the differential diagnosis of benign and malignant parotid tumors and their classification, planning treatment plans and evaluating tumor prognosis.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The application of cardiovascular magnetic resonance in prognosis evaluation and risk stratification in hypertrophic cardiomyopathy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.034</link>
<description><![CDATA[Hypertrophic cardiomyopathy (HCM) is the most common monogenic idiopathic cardiomyopathy, which also the predominate cause of sudden death in young adults. Characterized by multi-parameter and multi-modal image, cardiovascular magnetic resonance (CMR) could evaluate the degree of cardiac involvement from multiple aspects in HCM patients, thus provide more valuable information for risk stratification and prognosis assessment. This article reviews the application of CMR in risk stratification and prognosis assessment of HCM patients, especially in histological imaging.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application progress of intravoxel incoherent motion diffusion weighted imaging in lungs]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.035</link>
<description><![CDATA[The diffusion weighted imaging (DWI) can reflect the degree of diffusion of water molecules in tissues without contrast enhancement. However, DWI is a mono-exponential model, which cannot separate the pseudo-diffusion from pure molecular diffusion. Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) utilizes a double-exponential model to obtain parameters of pure water molecule diffusion and microcirculatory perfusion-related diffusion, more comprehensively and accurately reflects the complexity of the microstructure of the tumor tissue. In recent years, the application of IVIM-DWI in lung has been gradually increasing and become the focus of lung functional magnetic resonance imaging research. In this paper, we mainly reviewed the technical parameters of IVIM-DWI in lung and related research progress in the diagnosis and treatment of the lung cancer.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research status and potential of multi-parameter breast MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.036</link>
<description><![CDATA[Magnetic resonance imaging (MRI) is an indispensable tool in breast imaging, especially functional breast imaging plays an important role in the identification of benign and malignant breast masses. Dynamic contrast enhancement MRI can provide breast tumor tissue perfusion and other related functional information, which improves the sensitivity of breast cancer diagnosis. Diffusion weighted imaging can reflect the movement of water molecules. Studies have shown that diffusion function maps such as apparent diffusion coefficient, intravoxel incoherent motion, and diffusion kurtosis imaging can effectively improve the diagnostic specificity. There are also new MRI technical parameters sodium imaging, phosphorus spectroscopic imaging, chemical exchange saturation transfer imaging, blood oxygen level-dependent MRI and positron emission tomography/MRI provides information on the content of specific elements. Existing data indicate that multi-parameter imaging using different functional MRI can provide detailed information about cancer development and progression and provide added value for the specific diagnosis of breast cancer. This article will review the diagnostic value of current and emerging functional parameters of breast MRI technology.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress and prospect of DCE-MRI in breast lesions with rim enhancement]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.037</link>
<description><![CDATA[Breast disease is common in women, and the dynamic contrast enhanced magnetic resonance imaging plays an important role in clinical diagnosis. In breast MRI examination, rim enhancement as a common enhancement mode, can be seen in a wide range of benign and malignant breast lesions, and is easy to be misdiagnosed clinically. At present, there are few studies on the rim-enhancing lesions on breast MRI. In this paper, the MRI manifestations and pathological features, hemodynamic characteristics and functional imaging of breast rim enhanced lesions were reviewed. Meanwhile, the feasibility of magnetic resonance spectroscopy, diffusion kurtosis imaging and radiomics for diagnostic application were prospected and analyzed in this paper.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Advances in imaging studies of nipple-areola complex involvement]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.038</link>
<description><![CDATA[Nipple-sparing mastectomy (NSM) has become the first choice for the treatment of breast cancer patients or for prophylactic resection of women at high risk of cancer due to its high oncological safety and aesthetic effec. It<sup><sup>,</sup></sup>s the main problem to be solved urgently to preoperative evaluate the involvement of the nipple-areola complex (NAC) and to select the proper patients for NSM. The research progress and advantages and disadvantages of using imaging methods to predict the preoperative involvement of NAC in recent years were reviewed in this paper, which provided important information for surgeons to choose subsequent surgical methods.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress in predicting microvascular invasion of hepatocellular carcinoma by preoperative MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.039</link>
<description><![CDATA[Microvascular invasion (MVI) is one of the important factors affecting postoperative recurrence and metastasis of hepatocellular carcinoma, and is closely related to the prognosis and treatment of patients. However, MVI can only be diagnosed by pathology. Accurate prediction of MVI by MRI is of great significance and prospect for selecting treatment measures and improving the prognosis of patients. Many MRI-based imaging features have been proposed for the prediction of MVI, including tumor size, number, incomplete capsule, uneven margins, peritumoral enhancement in arterial phase, and peritumoral hypointensity in hepatobiliary phase. As an emerging field, radiomics may be an accurate and effective tool for predicting MVI in patients with hepatocellular carcinoma, and it has also been used by researchers to explore the link with MVI in recent years. This article reviewed the research on preoperative MRI examination and MRI-based radiomics model for predicting MVI in hepatocellular carcinoma.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of preoperative prediction of microvascular invasion of hepatocellular carcinoma based on magnetic resonance imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.040</link>
<description><![CDATA[Hepatocellular carcinoma (HCC) is a common malignant tumor in the world, the primary treatment of HCC is surgical resection, but recurrence after surgical treatment is common, a large part of the reason is related to microvascular invasion. Therefore, looking for a non-invasive method to predict microvascular invasion before operation is of great significance for guiding surgical treatment, improving the prognosis and improving the survival rate of patients. Multi-sequence, multimodal magnetic resonance imaging (MRI) and MRI-based radiomics and deep learning technology are developing rapidly, which makes preoperative non-invasive prediction of microvascular invasion in hepatocellular carcinoma possible and highly promising. This paper mainly reviewed in this respect.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Progress in the application of ultrashort magnetic resonance echo time sequences]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.041</link>
<description><![CDATA[Magnetic resonance imaging has good soft tissue resolution and no ionizing radiation, so it is widely used in many parts of the human body, but there are some substances with ultra-short T2 value in human body. such as bone cortex, tendons, ligaments, lung tissue and so on, this kind of tissue cannot be imaged by conventional magnetic resonance imaging sequence. With the development of magnetic resonance imaging technology, the application of Magnetic Resonance Imaging Ultrashort echo time (Magnetic Resonance Imaging Ultrashort echo time. MRI-UTE) sequence makes short T2 tissue imaging possible. The research progress in the application of ultrashort echo time series in recent years was reviewed in this paper.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Current state-of-the-art of MRI zero echo time technique]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.02.042</link>
<description><![CDATA[Zero echo time (ZTE) technology is a 3D volumetric imaging sequence, with unique gradient system switching sequence and radial K-space sampling, spatial encoding can be carried out immediately after radiofrequency excitation, which achieves higher data acquisition efficiency. Clinical studies mainly focus on cerebrovascular imaging, depiction of pulmonary parenchymal structure and lesion details, measurement and evaluation of bone and joint structures. In this paper, the main clinical application progress of ZTE in the above aspects was systematically analyzed and reviewed.]]></description>
<pubDate>Sun,20 Feb 2022 00:00:00  GMT</pubDate>
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