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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=201703</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[Advances and challenges of MRI in breast]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.001</link>
<description><![CDATA[With the rapid increase of the incidence of breast cancer in China, the early diagnosis of breast cancer becomes more and more important. In recent years, MRI functional imaging technology develop rapidly, bringing about new ideas for the early diagnosis and predicting the prognosis of breast cancer. Dynamic contrast-enhanced MRI (DCE-MRI) could quantitatively analyze features of tumor tissue with injection of contrast agent. Diffusion-weighted imaging (DWI) could detect the characteristics of water molecules movement without contrast agent, reflecting the microstructure of the lesion. As a non-Gaussian, biexponential model, intravoxel incoherent motion (IVIM) model separates the diffusion of water molecules from microcirculation more accurately, which could reflect the information of blood flow perfusion. Diffusion kurtosis imaging (DKI) depicts the complexity of abnormal tissue more accurately by evaluating the degree of diffusion non-Gaussianity. More and more studies have shown that MRI technique may play an important role in the diagnosis of breast cancer and predicting the response of neoadjuvant chemotherapy by reflecting the microenvironment (such as blood perfusion, tissue composition and metabolic changes).]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[The study on the application value of DKI in the classification of invasive breast carcinoma and its correlation with prognostic factors]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.002</link>
<description><![CDATA[Objective: To evaluate the application value of diffusion kurtosis imaging (DKI) based MD, MK parameters in grading invasive breast carcinoma and compare their diagnostic potential. Materials and Methods: Collecting 53 patients with invasive breast carcinoma diagnosed by pathological examination in this study. One male patient and 52 female patients were included. All patients underwent breast magnetic resonance imaging, including traditional magnetic resonance imaging and diffusion kurtosis imaging. ADC, MK and MD were calculated by using post-processing software, Matlab 2011b. Compared with histological grade, the classification of invasive breast carcinoma and its correlation with prognostic factors were statistically analyzed. Results: ADC, MD and MK values have no significant difference in well, moderately and poorly differentiated invasive breast carcinoma (P＞0.05). Only ADC and MD were significantly different in ER expression (P＜0.05). ADC, MD and MK values showed no significant difference in PR, HER-2 and Ki-67 expression (P＞0.05, P=0.055 with MK in Ki-67). Conclusions: DKI has limited value in the evaluation on the classification of invasive breast carcinoma. However it provides useful information in the assessment of tumor proliferation activity.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[The feasibility of intravoxel incoherent motion to indicate immunohistochemical characteristics in breast cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.003</link>
<description><![CDATA[Objective: To explore the difference in apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters (D, D*, and f) of breast cancer regarding the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and antigen identified by monoclonal antibody Ki-67. Materials and Methods: Patients suspected to be suffering from breast cancer and had undergone preoperative breast MRI with intravoxel incoherent motion diffusion-weighted imaging in our institution between November 2015 and February 2016 were included in this study. All MR imaging examinations were performed on a 3.0 T MRI scanner (Philips, Ingenia). The ADC values were calculated from DW images at all b-values, assuming monoexponential signal shape. IVIM parameters (D, D*, and f) were obtained using multi-b-value DWI with a biexponential curve fitting. ADC and IVIM parameters (D, D*, and f) of patients with different ER, PR, HER-2, or Ki-67 expression were compared to explore the relationships between MRI and immunohistochemical findings of patients with breast cancer. Results: Fifty-five breast cancer lesions (51 patients) with positive pathologic results were included in our study. Of the 55 lesions, the amount of ER positive, PR positive, HER-2 positive, and Ki-67 high-expression lesions were 45, 40, 14, and 36, respectively. Mean D values in the Ki-67 high-expression group were significantly lower than those in the Ki-67 low-expression group (0.80±0.16 vs 0.88±0.14, P=0.046), while no significant differences were showed in ADC, D*, and f value between the two groups. No statistical significance was reached regarding the difference in mean ADC value or IVIM parameters (D, D*, and f) between the groups with different ER, PR, or HER-2 expression. Conclusions: Statistical difference in D value of IVIM parameters was found between the two groups with different Ki-67 expression in breast carcinoma. This may indicate the potential to provide a surrogate measure of Ki-67 expression through noninvasive imaging tools.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparison of DWI IVIM model and mono-exponential model in evaluating the response of neoadjuvant chemotherapy for breast cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.004</link>
<description><![CDATA[Objective: To analyze the value of intravoxel incoherent motion (IVIM) model and DWI mono-exponential model in evaluating the response of neoadjuvant chemotherapy (NAC) for breast cancer by comparing the parameters of two models. Materials and Methods: Thirty patients confirmed breast cancer by needle biopsy who received NAC were enrolled in the study. The patients were divided into responders (n=19) and nonresponders (n=11) according to the pathological classification of Miller & Payne. ADC, Ds, Df, f and MR imaging data of patients before, after 2 and 4 cycles of NAC were analyzed retrospectively. Two independent samples t test were used to compare the parameters between the responder and nonresponders. The diagnostic efficacy of different parameters was analyzed by receiver operating characteristics (ROC) curves. The paired samples t test was used to compare the parameters after 2, 4 cycles of NAC to parameters before NAC respectively. Results: ADC and Ds before NAC were significantly higher in responders than those in the nonresponders; the sensitivity and specificity of ADC and Ds were about the same. ADC after 2 cycles of NAC was significantly higher than that before NAC Ds after 2 and 4 cycles of NAC was significantly lower than that before NAC. f after 4 cycles of NAC was significantly lower than that before NAC. Conclusions: ADC value and Ds value are helpful to predict the response to NAC before treatment, and ADC value and Ds value are equivalent in predicting the response of NAC. During the NAC course, ADC, Ds and f values play a certain role in predicting the response of NAC. Mono-exponential model is a better method to evaluate the response of NAC in breast cancer.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[The MRI diagnosis of mucinous breast carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.005</link>
<description><![CDATA[Objective: To analyze MRI features and diagnostic essentials of mucinous breast carcinoma (MBC). Materials and Methods: MRI characteristics of 15 MBC patients confirmed by postoperative pathology were analyzed retrospectively, including the lesions’ location, size, shape, and the signal intensity on T1WI, T2WI, T2WI-FS, and the enhancement features and time-signal intensity curve (TIC) types, and DWI, ADC value. The preoperative breast MRI BI-RADS reports were reviewed as well. Results: Fifteen patients (12 cases of simplex type, 3 cases of mixed type, 4 cases with lymph node metastasis) occurred in left breast in 8 cases (53.3%) and right breast in 7 cases (46.7%). One case (6.7%) located in the central front, another 14 cases (93.3%) located in the peripheral upper or inner area, which was located in the central in 10 cases (66.7%), and the back in 4 cases (26.6%). MRI showed a mass in all the patients, which diameters were 7—45 mm, of which 8 cases (53.3%) showed round, clear boundary or with light leaflets, 7 cases (46.7%) showed irregular shapes, local fuzzy or coarse edge, even combined with burr. On T1WI, all showed  iso-or slightly hypo-intensity. On T2WI and SPAIR, all showed hyper-or obvious hyper- intensity. Dynamic enhanced, 9 cases (60%) showed early rim enhancement, and then permeated into the mass, 6 cases (40%) showed heterogeneous enhancement. The TIC curves of 14 cases (93.3%) were gradually enhancing pattern, and just 1 case (6.7%) was plateau pattern. On DWI, there were obviously hyper-intensity in full or partial area, the average ADC value was (2.08±0.44)× 10-3 mm2/s  when b-value was 800 s/mm2, which was higher than normal breast tissue (1.45±0.56)×10-3 mm2/s . Conclusions: The MRI characteristics of MBC are helpful for the preoperative imaging diagnosis and the prognosis prediction.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Evaluation of brain injury in neonates by magnetization transfer imaging combined amide proton transfer imaging: a preliminary study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.006</link>
<description><![CDATA[Objective: To evaluate neonatal brain injury at the internal environmental level with the application of amide proton transfer (APT) imaging and magnetization transfer (MT) imaging by measuring the APT and MTR values of the brain. Materials and Methods: A total of 38 neonatal patients who underwent MRI examination were enrolled in the study. Among them, there were 25 newborns with no abnormalities and 13 cases with brain injury who underwent conventional MRI (T1WI, T2WI, DWI) examination. After obtaining informed consent and permission of clinicians, routine MRI was followed by additional APT-MT scan. APT-MT imaging is single slice scanning, performed at the basal ganglia level in all neonates, and in the case group, with increased localization at the level of lesion, and with the contralateral relatively normal area as self-control. The APT/MTR values of bilateral frontal subcortical white matter, basal ganglia and occipital subcortical white matter were measured for all neonates, as well as the APT/MTR values of the lesion and contralateral areas. Several statistical methods were used for statistical analysis. Results: In the control group, bilateral frontal subcortical white matter, basal ganglia and occipital subcortical white matter had no significant difference in APT/MTR values (P＞0.05). Between the different parts of the brain, the differences among the APT/MTR of the frontal lobes, basal ganglia, and occipital lobes were significant, P＜0.05. In addition, the APT/MTR values of the above brain regions were found to have a positive correlation with gestational age. In the case group, there were significant differences in APT values between the lesion side and contralateral area, being significantly lower in lesion side than the contralateral side (P＜0.05). Conclusions: From changes in the pH level in the neonatal brain, APT-MT imaging can help to understand neonatal brain injury.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Dynamic contrast-enhanced MRI early predicts short-term control of nasopharyngeal carcinoma treated with neoadjuvant chemotherapy followed by intensity-modulated radiotherapy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.007</link>
<description><![CDATA[Objective: To investigate the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in assessing short-term control of chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC). Materials and Methods: MRI and clinical materials of local advanced NPC patients (n=87) who were scheduled for neoadjuvant chemotherapy (NAC) following by aggressive intensity-modulated radiation therapy (IMRT) were studied. DCE MRI was performed [before NAC and five fractions after IMRT (one week) treatment] and four kinetic parameters (Ktrans, Kep, Ve and Vp) based on extended Tofts model were measured. Comparisons were made between different clinical response groups during and after IMRT using independent-samples t test or Mann-Whitney U test. Results: Reductions of both Ktrans and Kep values early after one week IMRT were observed in patients who achieved well clinical response after NAC and IMRT treatment. Compared to residual disease (partial response, PR) patients after radical CRT, the pretreatment Ktrans value, percentage change and difference values of Ktrans and Kep parameters between pretreatment and after one week IMRT, and tumor regression ratio after one week IMRT were all significantly larger in complete response (CR) patients (P<0.05). According to receiver operating characteristic analyses, diagnosis efficacies of single Ktrans, △Ktrans, △Kep, Ktrans(Perc), and Kep(Perc) values ranged from 0.655—0.829, while combined tumor regression ratio with above kinetic parameters yielded the highest diagnosis efficacy, sensitivity, and equivalent specificity (0.832, 84.0%, 64.5%, respectively). Conclusions: DCE MRI has the potential to predict short-term control of local advanced toward chemoradiotherapy.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[A fMRI study on the amplitude of low-frequency fluctuation and functional connectivity in resting-state of sensorimotor network of primary hyperthyroidism individuals]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.008</link>
<description><![CDATA[Objective: To investigate the changes of ALFF (amplitude of low-frequency fluctuation) and FC (functional connectivity) in hyperthyroid patients with RS-fMRI (resting-state functional magnetic resonance imaging), and the relationships of the characteristics with emotional disorders, spontaneous brain resting activities, biochemical and biological characteristics. Materials and Methods: Twelve patients diagnosed with primary hyperthyroidism were collected in this study. Another 12 age-and-sex-matched healthy individuals served as control. Gathering fMRI scaned of all the subjects at their resting -state, using REST and DPARSF software to obtain each amplitude of low-frequency fluctuation (ALFF), then we used two sample t-test to discover the brain areas with significant differentiation of ALFF values. The brain areas were defined as regions of interest (ROI). ROI based functional connectivities (FC) were analyzed to explore some possible abnormalities. Results: Compared with controls, the ALFF of hyperthyroidism individuals was reduced in the bilateral caudate, and bilateral thalamus (P＜0.001). In these brain regions, we find no correlation between ALFF and T3, T4 (P＞0.05). In contrast with controls, hyperthyroid patients showed stronger FC between the left thalamus and both the bilateral precentral gyrus and bilateral postcentral gyrus (P＜0.001), as well as between the right thalamus and both the right precentral gyrus and right postcentral gyrus (P＜0.001). Conclusions: The present study shows that, functional demands between bilateral thalamus and sensorimotor network are higher in patients compared to controls. It is likely attributed to motor function deficit associated with metabolic impairment in these patients.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of MRI in the nonimmune hydrops fetalis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.009</link>
<description><![CDATA[Objective: To investigate the clinical value of prenatal MRI in the diagnosis of nonimmune hydrops fetalis. Materials and Methods: The retrospective analysis of 8 cases of fetal nonimmune hydrops MRI images from May, 2015 to October, 2016. Results: Eight cases were diagnosed of typical nonimmune hydrops fetalis after the autopsy or diagnosed after birth. The causes of the disease included: fetal lung congenital cystic adenomatoid malformation (CCAM) 25% (2/8), congenital chylothorax (25%, 2/8), meconium peritonitis (25%, 2/8), cardiovascular abnormalities (12.5%, 1/8) and of intrauterine hypoxia (12.5%, 1/8). Four cases have shown favorable prognosis after treatment or surgery, while 4 cases died after the birth (including induced labour). Conclusions: The causes of nonimmunologic hydrops fetalis are complex. Evaluation on MRI diagnosis can effectively indicate the causes and degree of fetal hydrops, which is an important test means for prenatal evaluation on nonimmune hydrops fetalis.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Value of magnetic resonance imaging combined with diffusion-weighted MR tumor volumetry in the  diagnosis of TN staging for rectal cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.010</link>
<description><![CDATA[Objective: To investigate the value of magnetic resonance imaging (MRI) in the diagnosis of preoperative TN staging for rectal cancer and the correlation between diffusion-weighted MR tumor volumetry and TN staging. Materials and Methods: Between September 2014 and February 2016, 74 patients with histologically proven rectal cancer by the colonoscopic biopsy in our hospital was performed by pelvic 3.0 T MRI. We analyzed the preoperative MRI TN staging of rectal cancer diagnosis accuracy. Concordance between MRI TN staging of tumor and pathologic reporting was assessed by means of the Kappa statistic. The correlation between diffusion-weighted MR tumor volumetry and TN staging was analyzed by one-way analysis of variance. Results: The accurate rate for T-staging of rectal cancer using MRI was 87.8% (66/74). There was a good correlation between pathologic and MRI tumor staging (Kappa=0.78, P=0.000). The accurate rate for N-staging of rectal cancer using MRI was 66.2% (49/74). There was a poor correlation between pathologic and MRI tumor staging (Kappa=0.33, P=0.000). The tumor volume of rectal cancer at DWI in ≤T2, T3and T4 staging rectal cancer was (4145.13±718.00) mm3, (14939.73±3591.38) mm3 and (22714.76±4251.71) mm3. The tumor volume of rectal cancer at DWI in N0, N1 and N2 staging was (14367.15±6425.83) mm3, (17967.69±5259.88) mm3 and (19464.00±3588.77) mm3. The greater of the tumor volume, the higher of the T-staging of rectal cancer, and the discrepancies were statistically different (F=75.189, P=0.000). The discrepancies between tumor volume and N-stagings of rectal cancer were statistically different (F=3.545, P=0.034). Conclusions: MRI has a good concordance with pathologic T-staging of rectal cancer, and has a certain clinical value in the N-staging. DWI tumor volumetry contributes a lot to diagnosis of TN-staging of rectal cancer.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[MRI diagnosis of the cruciate ligament cysts]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.011</link>
<description><![CDATA[Objective: To explore the MRI features and diagnostic value of the cruciate ligaments cysts. Materials and Methods: Clinical data and imaging features of 12 cases surgically confirmed of the cruciate ligaments cysts of knee joint were reviewed retrospectively, and the imaging features of MRI were summarized. Results: All of the 12 patients were unilateral knee joint, 1 patient presented both the anterior and posterior cruciate ligaments cysts,11 patients were solitary cysts. Five cysts were found in the anterior cruciate ligaments and 8 in the posterior cruciate ligaments. MRI of cysts showed long T1 long T2 signal round, oval, banded or fusiform shape. It was high signal on the PD-FS sequence. Conclusion: MRI can clearly display the size, shape, location, number and surrounding structures of the cruciate ligaments cysts, MRI could be useful in the diagnosis, it has important guidance value for clinical work.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Experimental study on DWI in identifying ischemic renal impairment and dysfunction in rats]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.012</link>
<description><![CDATA[Objective: To investigate diffusion weighted imaging (DWI) in evaluating renal impairment and dysfunction in rats due to unilateral renal arterial stenosis (RAS), contrast to 99Tcm-DTPA SPECT Renograhy and pathology. Materials and Methods: The model of the unilateral left RAS was created in twenty-four rats according to the approved protocol. The renal impairment and dysfunction were subsequently measured by 99Tcm-DTPA SPECT based on the glomerular filtration rate (GFR), DWI based on the apparent diffusion coefficient (ADC) value after two, three and four weeks. The b value of DWI was scanned under the 0 s/mm2, 800 s/mm2, 1200 s/mm2 and 1500 s/mm2 respectively. As well the average values of ADC of the renal medulla and cortex parenchyma were calculated respectively and compared. The relationship between GFR and the imaging based on 99Tcm-DTPA SPECT were detected. The Spearman's correlation test and the paired-samples t test were adopted in statistics. Results: The values of ADC of renal parenchyma (ROI including medulla and cortex) had a significant positive correlation with GFR (P=0.001, r=0.584). The values of ADC of the cortical and medulla were significant different between the two kidneys (cortex: t=4.626, P=0.001; medulla: t=2.699, P=0.019). Conclusions: The DWI based on ADC is significant to evaluate the renal impairment and dysfunction, which is helpful to detect the late period of renal ischemic injury and reduce the renal injury caused by contrast agent.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[An update of functional neuroimaging of REM sleep behavior disorder in Parkinson<sup><sup>,</sup></sup>s disease]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.03.016</link>
<description><![CDATA[Parkinson's disease (PD) is a common neurodegenerative disease. The main clinical manifestation of PD are motor symptoms, but it is also related to non-motor symptoms. Studies found that RBD affects 30%—60% of patients with PD,  it also easy to injure co-sleepers and increased cognitive impairment risk. However, the mechanism of PD and RBD (PDR) is unclear. With the advance of imaging technology, more and more studies seek to set up neuroimaging markers to explore brain alterations in patients with PDR. These studies will be helpful to the early diagnosis, monitoring disease progression and pathomechanism of PDR.]]></description>
<pubDate>Mon,20 Mar 2017 00:00:00  GMT</pubDate>
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