http://med-sci.cn/cgzcx/en/contents_list.asp?issue=202204 zh-cn An RSS feed for Chinese Journal of Magnetic Resonance Imaging http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.001 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.002 ^,s disease (AD) and 11 normal controls (NC) were selected. 18F-AV1451 tau protein imaging and DTI were examined by positron emission tomography-computed tomography scanner and magnetic resonance imaging scanner. GE ADW workstation was used to automatically register fraction anisotropy (FA), apparent diffusion coefficient (ADC) and positron emission tomography images. The regions of interest in posterior cingulate gyrus, parahippocampal gyrus and middle temporal gyrus were delineated at the same level. FA value, ADC value, maximum standard uptake value and standard uptake value ratio (SUVr) were measured. The changes and correlation of FA, ADC and SUVr between the two groups were analyzed by rank sum test and Person correlation analysis. Results: The positive predictive value, negative predictive value, sensitivity and specificity of 18F-AV1451 tau protein brain imaging in diagnosing aMCI patients were 70.0%, 57.1%, 53.8% and 72.7%, respectively. The numbers in AD group were 76.9%, 72.7%, 76.9% and 72.7%, respectively. There were significant differences in the SUVr values of left posterior cingulate gyrus and right parahippocampal gyrus between aMCI group and NC group (P=0.032,0.025). And there were significant differences between AD group and NC group in bilateral parahippocampal gyrus and left middle temporal gyrus (P=0.007, 0.007, 0.041). The SUVr values of the left posterior cingulate gyrus and the right parahippocampal gyrus in the AD group were significantly different from those in the aMCI group (P=0.032, 0.025). There was no significant difference in FA between aMCI group and NC group (P＞0.05). But there was significant difference in ADC values in bilateral posterior cingulate gyrus, right parahippocampal gyrus and right middle temporal gyrus (P=0.024, 0.012, 0.024, 0.024). There was no significant difference in FA and ADC between AD group and NC group (P＞0.05). There were significant differences in FA and ADC between aMCI group and AD group in bilateral posterior cingulate gyrus (P=0.047, 0.047, 0.047, 0.012). For 6 aMCI patients who underwent 18F-AV1451 tau protein brain imaging and DTI examination, Pearson correlation analysis showed that there was no significant correlation between FA, ADC value and SUVr value in each site (P＞0.05), but there was a negative correlation between ADC value and Minimental State Examination (MMSE) score in the right parahippocampal gyrus (r=-0.821, P=0.045). There was no significant correlation between FA, ADC and SUVr values of other parts and the scores of MMSE and Montrealcognitive assessment scale (P＞0.05). Conclusions: The detection of white matter injury in different parts of brain by DTI, especially the bilateral posterior cingulate gyrus, has certain significance in the early differentiation between aMCI and AD patients, and may be used as an index for the differential of aMCI and AD in the future. In addition, 18F-AV1451 tau protein brain imaging is more effective in differential diagnosis of aMCI, and the ADC value of the right parahippocampal gyrus is negatively correlated with the MMSE score, indicating that the clinical psychological scale score may reflect the microstructural changes in the brain tissue.]]> Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.003 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.004 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.005 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.006 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.007 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.008 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.009 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.010 ^,s disease (AD) and mild cognitive impairment (MCI), and stable mild cognitive impairment (sMCI) and progress mild cognitive impairment (pMCI) patients. Materials and Methods: We used ADNI dataset, which included 47 normal controls (NC), 66 sMCI, 24 pMCI, and 29 AD patients. The individual-specific functional connectivity was used as input to select features with least absolute shrinkage and selection operator (LASSO). And SVM was performed for AD/MCI/NC multiclassification and sMCI/pMCI classification. We extracted the most discriminative functional connectivities, the two-sample t-test (P＜0.05) was used to compare the differences in the strength of the most discriminative functional connectivities between groups. Results: Compared with the functional connectivity estimated by Pearson correlation (73.49%), the individual-specific functional connectivity estimated by multi-task learning-based sparse convex alternating structure optimization (MTL-sCASO) achieved 85.54% accuracy rate for AD/MCI/NC multiclassification. The individual-specific functional connectivity showed higher accuracy for identification sMCI and pMCI than the functional connectivity constructed by Pearson correlation (86.67% vs. 75.56%). The strength of the most discriminative connectivity were significantly different between groups. Conclusions: The individual-specific connectivities is beneficial to the classification of AD and MCI, and the strength of functional connectivity could be used as a neuroimaging biomarker for the diagnosis of AD and MCI.]]> Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.011 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.012 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.013 ^,s coefficient concordance regional homogeneity (KCC-ReHo) and coherence regional homogeneity (Cohe-ReHo). Results: Compared with the healthy control group, the increased connectivity of right thalamus and right inferior frontal gyrus was showed in MD patients. KCC-ReHo in MD patients were higher in the left inferior temporal gyrus, lower in the right superior frontal gyrus; Cohe-ReHo in MD patients was higher in the right cerebellum and the left inferior temporal gyrus, lower in the right parietal superior gyrus, right superior frontal gyrus, and left precuneus (corrected by Alphasim, P＜0.05 after correction). Conclusions: This study identified specific alterations of FC and ReHo values in patients with MD, which may relate to the pathogenesis of Meniere^,s disease.]]> Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.014 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.015 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.016 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.017 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.018 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.019 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.020 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.021 ^, general clinical data and mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK) value, the correlation between DKI parameters of different brain regions and neuropsychological assessments scores were analyzed. Results: There were no statistically significant differences in neuropsychological scores and MK, AK, RK value between the chemotherapy group and the control group before chemotherapy. There were statistically significant differences in Montreal Cognitive Assessment Scale (MoCA), Clock Drawing Test, Auditory Verbal Learning Delay 5 min Test (AVLT2) scores and MK, RK value before and after chemotherapy (P＜0.05). MK value in the genu of corpus callosum, the right posterior cingulate gyrus and the right superior frontal gyrus decreased significantly; RK value in the posterior cingulate gyrus, the right middle frontal gyrus decreased significantly after chemotherapy by false discovery rate (P＜0.05). Correlation analysis shows that MK value of the right posterior cingulate gyrus was positively correlated with AVLT2 results (r=0.548, P=0.007); RK value of the posterior cingulate gyrus was positively correlated with MoCA results (r=0.654, P=0.001) after chemotherapy. Conclusions: In the short term, there are dominant region associated with cognitive impairment in breast cancer survivors with chemotherapy. The MK, RK value can be sensitive to changes of brain microstructure, and provide valuable reference for early evaluation of chemotherapy-related cognitive impairment.]]> Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.022 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.023 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.024 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.025 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.026 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.032 ^,s disease (PD) is the second largest neurodegenerative disease after Alzheimer^,s disease. It is considered a "classic" basal ganglia disease, so most research on PD has focused on the basal ganglia, while the cerebellum is often overlooked. In recent years, more and more anatomical, pathophysiological and clinical evidences have shown that the cerebellum plays a very important role in the occurrence and development of PD. With the rapid development of MRI technology, more and more scholars have found that there are obvious changes in the cerebellar structure and functional MRI of PD patients, and these changes are related to movement, cognition, sleep function, etc. This paper summarizes the changes of cerebellar structure and functional MRI in PD patients. The results show that there are obvious gray matter atrophy, white matter microstructure changes, abnormalities in spontaneous neuronal activity and changes in perfusion patterns, etc. in the cerebellum of PD patients. However, so far, studies on the structural and functional MRI changes of the cerebellum in PD patients have shown great heterogeneity, and there is no PD-specific atrophy pattern or related specific imaging indicators. In the future, it is expected to search for sensitive neuroimaging biomarkers for early diagnosis of PD from the perspective of the cerebellum.]]> Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.033 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.034 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.035 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.036 Wed,20 Apr 2022 00:00:00 GMT http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.04.037 Wed,20 Apr 2022 00:00:00 GMT