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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=201105</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[Molecular magnetic resonance imaging techniques: a good tool with new brightness in interpretation of life sciences]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.001</link>
<description><![CDATA[Molecular magnetic resonance imaging (mMRI) is a major method of molecular imaging for the non-invasive visualization of biological processes at the cellular and molecular level. It has been widely  used in medical  researches, mainly focused on  facilitating the examination of cell migration, angiogenesis, apoptosis, and gene expression in in vivo. Although there are still some problems to be resolved, the unique technical advantages of mMRI will bring significant changes in clinical and basic researches.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Evaluation of CLT1-(Gd-DTPA) for MR molecular imaging in a mouse breast cancer model]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.002</link>
<description><![CDATA[A peptide targeted contrast agent, CLT1-(Gd-DTPA), was investigated for molecular imaging of fibrin-fribronectin complexes in tumor stroma with magnetic resonance imaging (MRI).  The contrast agent was evaluated in female nude mice bearing MDA-MB-231 human breast carcinoma xenografts on a Siemens 3T clinical scanner with a clinical agent Gd (DTPA-BMA) as a non-targeted control.  CLT1-(Gd-DTPA) specifically bound to tumor tissue and resulted in significant tumor contrast enhancement at a dose of 0.05 mmol/kg for at least 60 minutes after injection.  In contrast, a non-targeted contrast agent, Gd(DTPA-BMA), cleared rapidly from the body with little tumor enhancement after 30 minutes post-injection at a dose of 0.1 mmol/kg.  CLT1-(Gd-DTPA) had little non-specific binding in blood and normal tissues, including the liver and muscle, resulting in comparable non-specific enhancement in normal tissues to the control agent.  The study has shown that CLT1-(Gd-DTPA) can bind to the tumor tissue, resulting in significant tumor enhancement in a mouse breast cancer model.  The targeted contrast agent has a potential for MR molecular imaging of breast cancer.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[OxLDL-targeted iron oxide particles for magnetic resonance detection of carotid atherosclerotic lesions in vivo]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.003</link>
<description><![CDATA[Objective: The aim of this study was to determine the role of oxLDL targeted iron oxide particles in atherosclerotic lesions imaging in carotid atherosclerosis lesions of apoE-/- mice.  Materials and Methods: PEG coated USPIO was conjugated with anti-mouse-oxLDL antibodies to construct an anti-oxLDL-USPIO probe while IgG-USPIO and unconjugated USPIO was used as controls. All formulations were characterized by using TEM, DLS and ELISA. The model of perivascular collar in the left carotid in apoE-/- mice was used. The MRI was processed in pre-, 8 h and 24 h after tain vein injection of a 30 mg Fe/Kg dose of USPIO nanoparticles.  Results: MRI of atherosclerotic lesion, as manifested by signal loss, was observed after administration of targeted USPIO at 8 h and 24 h, the percent of signal reduced was -30.4±16% and -34.7±19% while the IgG-USPIO, pure USPIO and inhibition group have limited signal reduction, the difference was significant, P <0.05. Immunohistochemistry confirmed the presence of oxLDL/CD68 and iron particles. Conclusion: This study demonstrates that anti-oxLDL-USPIO can be used in imaging atherosclerotic lesions within 24 hours. It suggests a clinically translatable platform for the detection of oxLDL in atherosclerotic plaque in vivo and will play a role in therapeutic evaluation of atherosclerotic carotid plaque.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Magnetic resonance imaging of injected adipose derived stem cells (ADSCs) in rat myocardial infarction: the feasibility of cell tracking and left ventricular function measurement in vivo]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.004</link>
<description><![CDATA[Objective: To evaluate the feasibility of tracing the ultrasmall superparamagnetic iron oxide (USPIO) labled adipose derived stem cells (ADSCs) in vivo with clinical 1.5 T MR scanner. Methods and Materials: ADSCs were incubated with culture medium containing 40 μg/ml USPIO and 1.5 μg/ml poly-l-lysine (PLL) for 24 h. The distribution of iron particles in cells was determined by Prussian blue staining and transmission electron microscopy (TEM). MTS was used to assess the viability of USPIO labeled stem cells. The anterior descending coronary artery (LAD) of the rats in experimental group (n=10) were ligated to establish the acute myocardial infarction model. The labeled ADSCs were directlty injected into the myocardium. In vivo, MR imaging was performed with FIESTA Cine, FSPGR Cine, and 2D MDE sequences both for rats in experimental group and those in control group (n=5). The left-ventricular end-diastolic volume (LVEDV), left-ventricular end-systolic volume (LVESV), and left-ventricular ejection fraction (LVEF) were calculated on Report Card Workstastion. Postmortal study was carried out to determine the distribution of USPIO particles in the myocadium with Prussian blue stain. Results: After incubating the stem cells with USPIO and PLL for 24h, the percentage of labeled ADSCs reached over 99%. Iron particles in the stem cells were conﬁrmed by TEM, which was mainly in lysosomes. MTS experiments revealed that USPIO (10, 20, 40, 80, 160 μg Fe/ml) exerted insignificant influence on the proliferation of ADSCs. The acute myocardial infarction animal model was successfully established by ligating LAD for all the 10 SD rats. The signal intensity of myocardium signiﬁcantly decreased both on FIESTA Cine and FSPGR Cine images after injection of USPIO labeled stem cells. In addition, the ventrical wall motion abnormalities were found on cine images of rats in experimental group. Delay enhancement was observed at the regions with motion abnormalities. The LVEDV, LVESV, and LVEF were 0.52 ± 0.05 ml, 0.20 ± 0.03 ml, and 61.0 ± 4.3% for rats in control group, and  0.44 ± 0.04 ml, 0.25 ± 0.05 ml, and 42.7 ± 13.4% for rats in experimental group, respectively. The LVEF and LVEDV were signiﬁcant different between two groups (P<0.05). The USPIO particles were found around infracted myocardium by Prussian blue staining. Conclusion:  In vivo, it is feasible to track the USPIO labled stem cells in the infarcted myocardium and to evaluate the motion function of left ventricular wall of SD rats by clinical 1.5 T MR imaging.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[The study of both MR diffusion-weighted imaging and expression of VEGF compared with pathology in dog model of liver fibrosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.005</link>
<description><![CDATA[Objective: To evaluate the change of diffusion-weighted MR imaging markers and expression of VEGF in dog model of liver fibrosis, and compared with histopathological features to investigate the diagnostic methods for liver fibrosis. Materials and Methods: 50% of the carbon tetrachloride (CCL4) oil solution were injected in peritoneal cavity in dogs, and were received the high fat diet. The dogs were underwent MR examination and liver biopsy every 4 weeks. The liver tissue were underwent pathology routine HE staining, Masson staining and immunohistochemistry VEGF staining, divided into groups by the results of pathological stage, the level of VEGF expression, the corresponding ADC values and eADC values were compared among different stages of liver ﬁbrosis, analyzing the correlations among them. Results: Grouping according to different stage of ﬁbrosis, S0 (n =12), S1 (n =9), S2 (n =9), S3 (n =10), S4 (n =10). ADC values decreasing and eADC values increasing as the stage of fibrosis progressed (P <0.05). There was a good relationship between ADC (eADC) and stage of fibrosis. The expression of VEGF increased with increasing degrees of liver fibrosis. Conclusions: An intraperitoneal injection of carbon tetrachloride in oil solution with the high fat diet in dogs can be established different stages of liver ﬁbrosis. The value of ADC (eADC) can quantitatly analysis deferent degree hepatic ﬁbrosis, they are more meaningful evaluation indicators to evaluate the hepatic ﬁbrosis. VEGF may play an important role in the process of liver ﬁbrosis in chronic liver disease.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Study of differentiation of benign and malignant lymph nodes based on ADC value of MRI diffusion weighted imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.006</link>
<description><![CDATA[Objective: To compare clinical value of three different semi-automatic methods in differential diagnosis of benign and malignant rabbit popliteal fossa nodes based on the apparent diffusion coefﬁcient (ADC) map of magnetic resonance (MR) diffusion weighted imaging. Materials and Methods: Twenty-one rabbits were randomly divided into inflammatory and metastatic groups. After popliteal fossa lymph node metastasis model was setted up, MR diffusion weighted imaging was performed. After the scan the lymph nodes were taken for the pathologic diagnosis. The mean ADC of each whole lymph node was compared in the inﬂammatory and metastatic groups. Three different methods were used for evaluation of lymph nodes based on the ADC map. Method 1: The ADC ratio of cortex vs. medulla (high/low) was calculated; Method 2: Curve of the mean ADC value vs. distance to the node's center, which was manually identiﬁed, was generated and slope of the curve was acquired. Method 3: Curve of the mean ADC value vs. distance to the node's morphological skeleton was generated and slope of the curve was acquired. Based on the pathological results, ROC was obtained and AUC was calculated in each procedure. Results: Forty-one  lymph nodes were included in the experiment, 22 were metastatic and 19 were inflammatory. The mean ADC value of whole nodes in the two groups was 1.54×10-3 mm2/s vs. 1.42×10-3 mm2/s (P =0.234). The area under the curve (AUC) in the three procedures and the mean of whole node were 0.839 (cortex vs. medulla), 0.775 (to the center), 0.654 (to the skeleton), and 0.583 respectively. And the Youden index were 0.639, 0.517, 0.304, and 0.266. Conclusions: Of the 3 methods, Method 1 showed the best AUC and it might be the best semi-automatic ADC methods for the identiﬁcation of lymph node malignancy.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Improved visibility of the subthalamic nucleus in PD patients using susceptibility-weighted imaging: a preliminary study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.007</link>
<description><![CDATA[Objective: To evaluate the visibility of the subthalamic nucleus (STN) using susceptibility-weighted imaging (SWI) for  Parkinson's disease (PD). Materials and Methods: Twenty PD patients were collected and examined with MRI to visualize the STN. Scanning protocols included SWI, T2-weighted fast spin-echo images (FSE) in axial and coronal plane and high-resolution T1WI images in axial plane. According to the signal contrast and border sharpness between STN and structures, the images were classified to four grades (grade 0, 1, 2, 3) by experienced radiologist. The visibility of STN was evaluated in the three protocols. Results: In SWI images, the STNs of 18 cases (90%) were classiﬁed to grade 2-3 which clearly visualized as hypointense, biconvex lens-shaped structure. In T2WI images, the STNs of 4 cases (20%) couldn't be identiﬁed as grade 0. Thirteen cases (65%) showed hypointense but poor contrast as grade 1, only 3 cases (15%) were clearly visualized as grade 2-3. In T1WI images, the STNs of 18 cases (90%) couldn't  be identiﬁed as grade 0. Only 2 cases (10%) showed but poor contrast as grade 1. Signiﬁcant difference was found among three protocols. Significant differences were found between T1WI and T2WI, T2WI and SWI. Conclusion: Compared to T1WI and T2WI, SWI improves the visibility of the STN. It may be a promising technique to accurately localizes the STN for precise surgical targeting.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[The initial study of interpolated finite impulse response sequence in portal system changes after hepatic cirrhosis on 1.5 T MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.008</link>
<description><![CDATA[Objective: To study the feasibility and clinical significance of IFIR sequence in portal system changes after hepatic cirrhosis on 1.5 T MR. Materials and Methods: Forty patients with hepatic cirrhosis and 20 normal volunteers (control group) were scanned on GE signa 1.5 T HD echospeed MRI with 3 types of presaturation band. MIP reconstruction was done on ADW 4.4 workstation to evaluate the branches and trunk of portal vein; measure the diameters of portal vein (PV), splenic vein (SV), superior mesenteric vein (SMV) and splenic volume, and those data were compared with control group. The data were also compared with different graded patients (A, B, C grade) with the grading of Child-Pugh; and the collateral circulation (CC) to assess the relationship with the splenic volume were observed. Results: In the 40 cases of hepatic cirrhosis patients, 6 cases were out of group (3 cases in splenectomy, 3 in portal system thrombosis). Among 34 patients, 25 cases (74%, 25/34) belong to high grade (3-4 grade) and 9 cases (26%, 9/34) were low grade (1~2 grade). The diameters of PV, SV, SMV and splenic volume in patients group were significantly larger than those in controls (P<0.05). The PV diameter showed a descent tendency (P<0.05) with the damage of liver function, while the diameter of SV, SMV and splenic volume showed an increased tendency (P<0.05). Among 34 patients, 22 cases (65%) were present of collateral circulation, and the splenic volume among those was larger than that of patients in no-CC groups (P<0.05). Conclusion: It is feasible to show the branches and main trunk of portal vein and assess the hemodynamics of portal vein system using IFIR sequence without contrast media on 1.5 T MRI.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[MR diffusion weighted imaging for pancreatic carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.009</link>
<description><![CDATA[Objective: To investigate the values of magnetic resonance diffusion-weighted imaging (DWI) in the diagnosis of pancreatic carcinoma. Materials and Methods: This study included 23 cases with pancreatic carcinoma, 26 cases with acute pancreatitis and 25 normal subjects. All patients were examined with traditional and DWI MR sequences. The signal intensity ratio (SIR) of tumor tissues, the tissues adjacent to the tumor on T1WI, T2WI and DWI were analyzed. The ADC values of the pancreatic carcinoma tissues, the pancreatic tissues adjacent to the tumor, the acute pancreatitis tissues and the normal pancreas tissues of control subjects were measured respectively and analyzed. Results: The SIR on DWI was higher than that of on T1WI and T2WI. The ADC values of tumor were significant lower than that of pancreatic tissues adjacent to the tumor, the acute pancreatitis tissues and normal pancreatic tissues, there was signiﬁcant difference in ADC value (P<0.05). Conclusion: DWI can show the tumor tissues clearly and provide useful information for the diagnosis and differential diagnosis of pancreatic carcinoma.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Proton magnetic resonance spectroscopy of the breast]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.010</link>
<description><![CDATA[Contrast-enhanced MRI has gained acceptance as an important breast imaging modality. However, it does not always provide a definitive pathology. Initial studies where in vivo proton MR spectroscopy has been added as an adjunct to dynamic contrast-enhanced MR imaging of the breast have shown promising results and a growing number of research groups are incorporating the technique into their breast MR protocols. The aim of this article is to illustrate the expected examination results and outline some of the pitfalls associated with undertaking a breast MRS examination.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Problems in manuscripts of clinical studies of functional magnetic resonance imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.011</link>
<description><![CDATA[This article summarized some problems which were found when I review manuscripts of clinical functional magnetic resonance imaging (fMRI) studies. These problems were listed in the following order: Introduction, Material and Methods, Results, Discussion, and English Abstract. I hope these personal views would be helpful to fMRI researchers.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of superparamagnetic iron oxide nanoparticles as contrast agents in brain magnetic resonance imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.012</link>
<description><![CDATA[Superparamagnetic iron oxide nanoparticles have a variety of biomedical applications because of their magnetic property and biocompatibility. The basic principles and parameters of the magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) are presented. Recent advances of iron oxide nanoparticles with various properties acting as MRI contrast agents are described. The iron oxide nanoparticles modified or conjugated with monoclonal antibodies, proteins, peptides, nucleotides, and other particular polymers, are taken up specifically, and can be used as contrast agents in MRI to enhance detection of neurodegenerative diseases, to monitor targeted drug delivery and therapeutic processes, and to image targeted biomolecules or cells; Iron oxide nanoparticles coated with dextran or polyethylene glycol (PEG) have long blood half-life, and are used as fMRI contrast agents to measure haemodynamic changes after enhanced neural activity. Further studies are needed on the control of particle sizes and the physicochemical properties of the modifications, increase of crystallinity and consequently saturation magnetization, conjugation with different targeting substances, the development of hybrid nanoparticles with optical and magnetic properties, and comprehension of  the interactions between the nanoparticles and biomolecules, cells and tissues.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[Advances of magnetic resonance perfusion imaging in hypertensive cerebrovascular diseases]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.013</link>
<description><![CDATA[MR perfusion-weighted imaging (PWI) can non-invasively evaluate the status of brain blood perfusion. By its two methods, dynamic susceptibility magnetic resonance imaging (DSC-PWI) and arterial spin labeling (ASL), it can evaluate brain ischemia, hemorrhage, and hemodynamic change caused by hypertension, which is helpful for a further understanding of the pathophysiological mechanism in hypertensive encephalopathy.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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<title><![CDATA[MR Imaging Techniques and Anatomy of the Shoulder]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2011.05.014</link>
<description><![CDATA[MR imaging is an effective method to evaluate shoulder disorders, with more attention received in recent year. It is essential to understand the specific  MR imaging techniques and normal sectional anatomy of shoulder for better diagnosis. This article is to discuss the common MR imaging techniques and normal sectional anatomy of major slices so as to understanding the normal imaging features of shoulder.]]></description>
<pubDate>Fri,20 May 2011 00:00:00  GMT</pubDate>
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