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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=202105</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[Predictive value of susceptibility vessel sign for long-term neurologic outcomes in elder patients with malignant middle cerebral artery infarct]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.001</link>
<description><![CDATA[Objective: To investigate the predictive value of susceptibility vessel sign (SVS) on susceptibility weighted imaging (SWI) for long-term neurologic prognosis in elder patients with malignant middle cerebral artery infarct (mMCAI). Materials and Methods: Thirty-one mMCAI patients aged more than 60 years who had underwent decompressive hemicraniotomy (DHC) were respectively screened. We dichotomized them based on 12-month modified Rankin Scale (mRS) to those with favorable (mRS 0—3) and unfavorable (mRS 4—6), and the 2 groups were compared on differences in baseline, clinical and neuroimaging data, including the findings of SWI tests. Results: The univariate and multivariate logistics analysis for these 2 groups of patients identified an independent association of the positive SVS with the long-term neurologic outcomes in elder mMCAI patients (adjusted OR=18.655, 95% CI 1.129 to 308.173; P=0.041), and this sign also showed a good agreement rate with the recanalization of the cerebral arteries which were responsible for the stroke manifested on MRA (Kappa=0.842, P=0.020). However, SVS only presented a good specificity (0.905, 95% CI 0.699—0.988) for the neurologic outcomes in elder mMCAI patients without a favorable sensitivity (0.700, 95% CI 0.348—0.933). Conclusions: SVS can independently predict the long-term neurologic prognosis of elder patients with mMCAI, and particularly its negative results can accurately predict the poor outcomes of these patients.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Differential diagnosis of pituitary macroadenomas and sellar meningiomas by MRI basic signs combined with ADC value]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.002</link>
<description><![CDATA[Objective: To explore the value of MRI signs combined with ADC value in the differential diagnosis of pituitary macroadenomas and sellar meningiomas. Materials and Methods: Forty-two cases of pituitary macroadenomas and 40 cases of sellar meningiomas confirmed by pathology, were analyzed retrospectively. All cases were examined by traditional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) before operation.The apparent diffusion coefficient (ADC) value was measured in the solid part of the tumor and compared with the results of pathological diagnosis. t-test, Chi-square test were used in statistical methods, and the diagnostic efficacy of each parameter in differentiating the two groups of tumors was evaluated by the receiver working characteristic (ROC) curve. Results: Between pituitary macroadenomas and sellar meningiomas, significant enhancement (33%/95%, χ2＝33.581), waist sign (93%/7.5%, χ2＝50.831), wrapped around internal carotid artery (95%/57.5%, χ2＝16.390), enlarged sella turcica (93%/52.5%, χ2＝16.998), pituitary unrecognizable (95%/47.5%, χ2＝23.135) and pituitary stalk invisible (90%/62.5%, χ2＝7.761) were statistically significant (P＜0.05). The ADCmax (ADCmean and ADCmin) of pituitary macroadenoma and sellar meningioma was (1.126±0.266)×10-3 mm2/s and (0.855±0.176)×10-3 mm2/s [(1.052±0.271)×10-3 mm2/s and (0.817±0.177) ×10-3 mm2/s, (0.971±0.288) ×10-3 mm2/s and (0.777±0.182) ×10-3 mm2/s, P＜0.001]. Among ADC values, ADCmax demonstrated good performance with an AUC of 0.877 (95% CI, 0.791—0.962) and when the cut-off of ADCmax is 0.970×10-3 mm2/s, the sensitivity and specificity of distinguishing them are 81% and 92.5%. Conclusions: The basic signs of MRI combined with ADC value have high clinical value in the diagnosis of pituitary macroadenomas and sellar meningiomas, Which can improve the accuracy of preoperative diagnosis.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Correlation analysis of 3.0 T magnetic resonance spectroscopy combined with diffusion tensor imaging in children with medulloblastoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.003</link>
<description><![CDATA[Objective: To investigate the value of 1H-magnetic resonance spectroscopy (MRS) combined with diffusion tensor imaging (DTI) in the treatment of medulloblastoma (MB) in children. Materials and Methods: Twenty-one patients with MB confirmed by pathology were examined by 1H-MRS and DTI. The changes of metabolite information, ADC, FA and DTT were observed. The differences of N-acetylaspartic acid (NAA), creatine (Cr), choline (Cho), NAA/Cr, Cho/Cr, Cho/NAA, apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in tumor center, tumor periphery and normal tissues were analyzed. Results: In 21 cases of MB, the tumors occurred in the vermis (11/21), the fourth ventricle (7/21) and the right cerebellar hemisphere (3/21), male/female (13/8), the average age of onset was (28.20± 22.24) months in male, (37.37±21.86) months in female, (75.30±52.42) cm3 in male and (86.72±49.41) cm3 in female. MRS showed that the peak Cho wave increased, the peak of NAA decreased, the peak of NAA/Cr decreased, the peak of Cho/Cr increased; in DTI data, the ADC value of tumor center was low, the FA value was high, DTT showed that the fiber bundle was fine and disordered, and the local continuity of the fiber bundle in the tumor area was interrupted and pushed. Conclusions: 1H-MRS and DTI are consistent in MB display, and different principles give consistent results. At different cell and molecular levels, they can provide more accurate lesion range and help for operation.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of minimum apparent diffusion coefficient in evaluating the invasiveness of hepatocellular carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.004</link>
<description><![CDATA[objective: To evaluate the invasiveness of hepatocellular carcinoma (HCC) by using the minimum apparent diffusion coefficient (ADCmin). Materials and Methods: The 85 patients with HCC confirmed by pathology and examined by MRI diffusion weighted imaging (DWI) before operation from January 2015 to October 2020 were analyzed retrospectively. The clinical and pathological information were recorded and the tumor ADCmin was measured on ADC images. Statistical methods were used to evaluate the correlation between clinical information, ADCmin and microvascular invasion (MVI), histological differentiation and Ki-67 expression. The independent factors related to the invasiveness of HCC were screened by binary Logistic regression, and the diagnostic efficiency was evaluated by ROC curve. Results: The size of tumor was related to HCC MVI and the histological differentiation (P＜0.05). The difference of ADCmin between the two groups in MVI were statistically significant (0.87±0.15 vs. 1.14±0.24, P＜0.05). The AUC value of MVI judged by ADCmin was 0.866 (95% CI, 0.770—0.962). The difference of ADCmin between the two groups in histological differentiation were statistically significant (0.91±0.18 vs. 1.09±0.25, P＜0.05), and the AUC value of using ADCmin to predict the degree of HCC differentiation was 0.739 (95% CI, 0.608—0.870). There were significant difference in ADCmin between the two groups of Ki-67 (1.19±0.24 vs. 1.03±0.25, P＜0.05). The AUC value of Ki-67 predicted by ADCmin was 0.723 (95% CI, 0.576—0.871). Conclusion: This study showed that ADCmin had great clinical value in preoperative non-invasive evaluation of the invasiveness of HCC and can greatly improve the prognosis of patients.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of magnetic resonance imaging in the diagnosis of clear cell hepatocellular carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.005</link>
<description><![CDATA[Objective: The purpose of this study is to improve the accuracy of preoperative diagnosis by compare and analyze the clinical and magnetic resonance imaging features of clear cell hepatocellular carcinoma and common hepatocellular carcinoma. Materials and Methods: We analyzed clinical and magnetic resonance imaging features of 33 cases of clear cell hepatocellular carcinoma and 87 cases of common hepatocellular carcinoma confirmed by pathological results from August 2014 to May 2020. All patients underwent MR plain scan and multi-phase enhanced scan before operation. We obtained MR imaging features, age, gender, hepatitis type and AFP result of all patients from picture archiving and communication systems, and used SPSS 21.0 to perform statistical analysis on the results. Results: The infection rate of hepatitis C in clear cell hepatocellular carcinoma was 24.2% (8/33), and the infection rate of hepatitis C in common hepatocellular carcinoma was 4.6% (4/87). The incidence of intratumoral fat signal in clear cell hepatocellular carcinoma was 21.2% (7/33), and the incidence of intratumoral fat signal in common hepatocellular carcinoma was 2.3%(2/87). The incidence of intratumoral artery sign in clear cell hepatocellular carcinoma was 27.3% (9/33), and the incidence of intratumoral artery sign in common hepatocellular carcinoma was 49.4% (43/87). Conclusions: Compared with common hepatocellular carcinoma, clear cell hepatocellular carcinoma present higher infection rate of hepatitis C, higher incidence of intratumoral fatty signal and lower incidence of intratumoral artery sign. It could provide certain guiding value for the accurate diagnosis of clear cell hepatocellular carcinoma before surgery.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Evaluation of computer tomography and magnetic resonance imaging in the classification and viability of hepatic cystic echinococcosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.006</link>
<description><![CDATA[Objective: We aimed to explore the value of CT and apparent diffusion coefficient (ADC) in the classification and viability of hepatic cystic echinococcosis (HCE). Materials and Methods: A total of 181 HCE patients with 227 hydatids confirmed by surgery and pathology were admitted in hospital from January 2016 to December 2019. All patients experienced preoperative CT and MRI scans, and CT and ADC values of hydatid fluid were measured and analyzed. The differences and correlations among the types were compared through variance analysis and rank correlation test. Results: According to WHO classification, cyst fluid in 51 lesions of CE1 type, 47 lesions of CE2 type, 50 lesions of CE3 type, 52 lesions of CE4 type and 27 lesions of CE5 type were measured. The mean CT and ADC values of the 5 types of cystic lesions were: CE1 (4.79±1.70) HU and (3.25±0.31) ×10-3 mm2/s, CE2 (6.02±2.53) HU and (3.18± 0.15)×10-3 mm2/s, CE3 (22.96±4.82) HU and (2.57±0.25)×10-3 mm2/s, CE4 (35.30±17.80) HU and (2.40±0.12)×10-3 mm2/s, and CE5 (108.77±51.02) HU and (2.13±0.68) ×10-3 mm2/s, respectively. The CT values of CE3, CE4 and CE5 were significantly higher than those in CE1 and CE2 (P＜0.05). The ADC values of CE1, CE2, CE4 and CE5 were statistically different in pairwise comparison (P＜0.05). CT value and ADC value were obviously and negatively correlated (r=-0.835). Conclusions: CT value and ADC value were used as quantitative indicators to more accurately diagnose the activity of various lesions. CT and ADC values could be valuable imaging biomarkers for the viability of HCE, and it can provide some reference for the formulation of clinical operation plan.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of biparametric magnetic resonance imaging in the detection of prostate cancer: a contrastive study based on whole mount section after radical prostatectomy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.007</link>
<description><![CDATA[Objective: To explore the application of biparametric magnetic resonance imaging (bpMRI) in the detection of prostate cancer (PCa) based on whole-mount histopathology. Materials and Methods: From May 2017 to September 2019, a retrospective analysis was used to identify the predictive factors affecting the detection of prostate cancer, based on a database correlating lesion-specific results from bpMRI co-registered with whole-mount pathology (WMP) prostatectomy specimens. Results: In 67 patients, 123 lesions were confirmed by whole-mount pathology. Tumor detection increases with tumor size and Gleason score. The detection rate of 1.0 cm foci was 92.1%, and that of Gleason score greater than 3+3 was 84.3%. Cancer focal size (P＜0.001) and Gleason score (P= 0.008) were independent predictors of tumor detection, respectively. There was no statistical difference in the detection rate between the transitional zone and peripheral zone. Conclusions: bpMRI is highly sensitive to the detection of prostate cancer, especially for foci larger than 1 cm in diameter or Gleason score ＞6.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Combining clinical characteristics and specific magnetic resonance imaging features to predict the risk of hysterectomy in gravid patients at high risk for placenta accreta spectrum disorders]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.008</link>
<description><![CDATA[Objective: To explore the value of clinical characteristics combined with MRI features for predicting the risk of intraoperative hysterectomy in gravid patients at high risk for placenta accreta spectrum (PAS). Materials and Methods: Retrospectively analyzed the MRI images and clinical data of 251 patients (including 64 patients who required hysterectomy and 187 patients did not) who underwent MRI during the third trimester from January 2010 to March 2020 with high risk for PAS disorders according to FIGO guidelines. Clinical characteristics included age, gestational age at delivery, number of cesarean deliveries, gravidity, prior other uterine surgeries and placenta previa. Two radiologists independently evaluated the following MRI features according to the consensus from Society of Abdominal Radiology and European Society of Urogenital Radiology: T2-dark intraplacental bands, placental bulge, loss of retroplacental T2-hypointense line, myometrial thinning, uterine serosa hypervascularity, focal exophytic mass and disruption of low-T2 bladder wall. Univariate analyses of clinical characteristics and MRI features were performed between patients with hysterectomy and those who without. Absence or uncertainty of MRI features was recorded as negative while presence as positive. Logistic regression was used to identify any clinical or MRI features in predicting hysterectomy. ROC analysis and calibration curve were performed to test the predictive power. Results: Significant differences were found in number of cesarean deliveries, placenta previa and all seven MRI features except for loss of retroplacental T2-hypointense line between patients with hysterectomy and those who without (P＜0.01). The number of cesarean deliveries (X1: OR=2.611, P=0.017), T2-dark intraplacental bands (X2: OR=4.379, P=0.001), placental bulge (X3: OR=4.804, P=0.000) and uterine serosa hypervascularity (X4: OR=6.691, P=0.000) were independent risk factors for intraoperative hysterectomy. The Logistic regression model combining the four independent risk factors to forecast intraoperative hysterectomy was Logistic (P)=-4.713+0.960X1+1.477X2+1.569X3+1.901X4. The AUC of the combined risk model reached 0.915, which was larger than that each of the four independent risk factors (P＜0.01). The diagnostic sensitivity and specificity of the model were 87.50% and 81.82%. The model illustrated good calibration. Conclusions: Combining clinical characteristics and specific MRI features is benefit to the assessment of the risk of intraoperative hysterectomy in gravid patients at high risk of PAS and improve their prognosis.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[A magnetic resonance imaging study of the influence of runner-related factors on the cross-sectional area of thigh muscles in male amateur marathon runners]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.009</link>
<description><![CDATA[Objective: To evaluate cross sectional area (CSA) of male amateur marathon runners in front, middle and back legs, and explore the correlation between them and age, body mass index (BMI), running age, speed exercise, and monthly exercise. Materials and Methods: To recruit standard male amateur marathon runners, 64 male 15 healthy volunteers, and often do not exercise will not exercise regularly male healthy volunteers set as group A, the other selected 15 with A height (less than 5 cm), age group (3 years), weight (3 kg) and BMI (1 points) that match the male amateur marathon runner set as group B. All subjects underwent bilateral axial mri scans of their thighs, and the cross-sectional areas of different muscle groups were delineated on T1WI images. Results: The anterior muscle CSA of group A (63.16±7.38) cm was lower than that of group B (72.05±8.34) cm, the difference was statistically significant (P＜0.01). The CSA of posterior group A and medial group was (31.16±4.78) cm and (46.06±7.06) cm, respectively, lower than that of group B (33.07±4.05) cm and (49.51±6.87) cm, with no statistical significance (P values were 0.248 and 0.186, respectively). Among the factors of male amateur marathon runners<sup><sup>,</sup></sup> age, BMI, running age, pace and monthly running amount, only BMI was positively correlated with CSA of all muscle groups, and the correlation was statistically significant. Conclusion: Long-term running exercises can increase the cross-sectional area of the anterior thigh muscles. Long-term endurance running training may counteract the effects of age on muscles. There was no significant correlation between running-related age, pace, and monthly running amount and thigh muscle cross-sectional area.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[The correlation between the expression of matrix metalloproteinase-1 and magnetic resonance T2-mapping in talus osteochondral injury]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.010</link>
<description><![CDATA[Objective: To investigate the relationship between the expression of matrix metalloproteinase-1 (MMP-1) and magnetic resonance (MR) T2 value and its mechanism in talus osteochondral injury (OLT). Materials and Methods: Thirty cases of ankle OLT patients under minimally invasive therapy and 30 healthy volunteers were collected. 3.0 T routine MR and T2-mapping scans were performed and T2 values were measured. The HE staining of the talus cartilage during the operation were used and the Western Blot method were used to measure the expression of MMP-1. The correlation between the T2 value of MR and the content of MMP-1 was statistically analyzed. Results: OLT was most common in the medial central of the talus (MRI 6 zoning method). The T2 value increased with the severity of the cartilage degeneration under Mankin grade, and the difference was statistically significant (P＜0.05). The expression of MMP-1 was significantly different between high-grade and low-grade (P＜0.05). The cartilage T2 value and MMP-1 expression showed a linear trend. Pearson correlation analysis showed a linear positive correlation between the two (r=0.821, P＜0.0001). Conclusions: OLT is most common in the medial central side of the talus. The T2 value of MRI increased with the degrade of cartilage injury. The T2 value of OLT showed a positive correlation with the determination of MMP-1. T2-mapping functional imaging could provide a quantitative imaging basis for clinical treatment of OLT by predict the expression of MMP-1 protein in different grades of cartilage injury in vivo and noninvasion.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Texture analysis based on MR T2WI single sequence for differentiating rheumatoid arthritis from gouty arthritis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.011</link>
<description><![CDATA[Objective: To evaluate the feasibility of texture analysis based on MR T2WI for differentiating rheumatoid arthritis (RA) from gouty arthritis (GA). Materials and Methods: The MRI imaging data of 81 joints with RA and 61 joints with GA were retrospectively analyzed. Texture features were extracted from T2WI fat saturated sequence image, and the texture features with good consistency (ICC＞0.75) were selected for statistical analysis. Results: There were significant differences in 10, 9, 6 and 5 texture features in the first order statistics, GLCM, GLRLM, and GLSZM (P＜0.05), corresponding AUC value were 0.898, 0.826, 0.831 and 0.830, respectively. The AUC value of all texture feature sets combined analysis was 0.902. The minimum in the first order statistics showed the maximum AUC value (0.836) of all individual texture features. Conclusions: Texture analysis based on MR TaWI fat saturated single sequence image could effectively identify RA from GA.Texture analysis of different texture feature sets displayed certain value for differentiating RA from GA, and the texture features in the first order statistics set showed the best identification efficiency.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Synthetic MRI of the hippocampal application value of normal adults]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.012</link>
<description><![CDATA[Objective: To explore the application value of synthetic magnetic resonance technology (SyMRI) in the quantitative measurement of the hippocampus in normal adults. Materials and Methods: A total of 139 healthy adults aged 20 to 72 were collected, including 61 males and 78 females. According to age, they were divided into three groups (20—35 years old) 36 cases, (36—55 years old) 72 cases, (56—72 years old) 31 cases. All subjects were examined with GE SIGNA Pioneer 3.0 T MRI. The scanning sequence included 3D-TWI damage gradient echo sequence (3D T1WI-SPGR) and SyMRI sequence. The whole brain was automatically registered and extracted by SyMRI post-processing software. The hippocampal T1, T2 and proton density (PD) values of both sides were tested by paired t-test. The hippocampal T1, T2 and PD values of different gender groups were tested by two independent samples Mann-Whitney U test, the analysis of variance was used among different age groups, and the pairwise comparison among different age groups was performed by LSD method. Results: The mean values of T1, T2 and PD in 139 healthy adults were (1258.43±110.59) ms,(105.88±16.05) ms, (74.71±1.52) pu, respectively. The range of T1 value, T2 value, and PD value were (1070.16—1725.59) ms,(86.43—190.71) ms, (70.72—80.21) pu. There were significant differences in T1 and PD values of hippocampus in different sides (P＜0.05), and the values of T1 and PD on the left side were higher than those on the right side. There was no significant difference in T2 values between different sides of hippocampus and T1, T2 and PD values between sexes (P＞0.05). There were significant differences in T1, T2 and PD values among different age groups (P＜0.05). There were significant differences between 20 to 35 years old group, 36 to 55 years old group and 56 to 72 years old group (P＜0.05). There was no significant difference between 20 to 35 years old group and 36 to 55 years old group (P＞0.05). Conclusions: SyMRI can provide quantitative reference values of hippocampus in normal adults of different ages and genders, and provide an important basis for early diagnosis of hippocampal related diseases.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Combination of 3D-pCASL and diffusion kurtosis imaging in the diagnosis of subcortical arteriosclerotic encephalopathy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.013</link>
<description><![CDATA[Objective: To explore the diagnostic value of diffusion kurtosis imaging (DKI) and 3D pseudo continuous arterial spin labeling (3D-pCASL) technologies in subcortical arteriosclerotic encephalopathy (SAE). Materials and Methods: Regular MRI, 3D-pCASL and DKI scans were performed on 35 clinically diagnosed SAE patients and 33 control groups. The fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr), anisotropy fraction of kurtosis (FAk), mean kurtosis (MK), axial kurtosis (Ka) and radial kurtosis (Kr) were measured in three groups including the lesion areas of white matter (WM) in SAE group (frontal and occipital WM around the horns of bilateral ventricle), normal WM area of SAE group (normal WM adjacent to the lesion area, the genu/splenium of the corpus callosum, and temporal WM) and the control group. The CBF value was measured in SAE group (lesion areas, genu/splenium of the corpus callosum, and temporal WM) and the control group. These data acquired were statistically analyzed and the correlations between DKI/ASL derived parameters value and Mini-mental State Examination (MMSE) score of SAE patients were studied. The receiver operating characteristic (ROC) was used to analysis the diagnostic value in SAE by these two technologies. Results: Compared with the control group, the SAE group had a significant decline in the values of CBF, FA and kurtosis parameters in all WM lesion areas, and the values of diffusion parameters increased considerably (P＜0.05). The significant changes, similar to WM lesions of SAE, were shown in some values of DKI parameters of the normal control group. Additionally, for SAE patients, MMSE showed positive correlation with CBF in parietal/temporal WM (r=0.496/0.392, P=0.003/0.020), and positively correlated with FA and Kr values of frontal WM around the horns of bilateral ventricle (r=0.488/0.437, P=0.003/0.009). Finally, FA in GCC, CBF in SCC, and the combined FA/MD/Dr/CBF in temporal WM showed high accuracy (AUCs 0.957/0.946/0.986) in distinguishing SAE patients from controls. Conclusions: For SAE patients, the DKI and 3D-pCASL can sensitively detect the potential changes of brain microstructure with normal performance in regular MRI examinations, and these two techniques can detect the progression of cognitive dysfunction for SAE. Thus, DKI and 3D-ASL imaging were proven to effectively improve the diagnosis of SAE.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Value of MRI and cerebrospinal fluid examination in evaluating the curative effect of anti-tuberculosis treatment on patients with intracranial tuberculosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.014</link>
<description><![CDATA[Objective: To investigate the value of MRI and cerebrospinal fluid examination in evaluating the curative effect of anti-tuberculosis treatment on patients with intracranial tuberculosis. Materials and Methods: A total of 400 patients with intracranial tuberculosis who received MRI in the radiology department of the hospital from May 2012 to May 2017 were enrolled in the study. According to the type of intracranial tuberculosis, they were divided into simple brain parenchymal tuberculosis, tuberculous meningitis and mixed intracranial tuberculosis. The MRI characteristics of different types of intracranial tuberculosis and the dynamic MRI changes during anti-tuberculosis treatment were analyzed. Patients<sup><sup>,</sup></sup> cerebrospinal fluid samples were collected for biochemical and cytological examinations. Changes in cerebrospinal fluid indicators during anti-tuberculosis treatment were analyzed, and the value of MRI and cerebrospinal fluid examination in evaluating the curative effect of anti-tuberculosis treatment was summarized. Results: In 400 cases with intracranial tuberculosis, there were 179 cases (44.75%) with simple brain parenchymal tuberculosis, 71 cases (17.75%) with tuberculous meningitis and 150 cases (37.50%) with mixed intracranial tuberculosis. A total of 425 lesions were detected in patients with simple brain parenchymal tuberculosis, including 196 of miliary type, 167 of nodular type, and 62 tuberculomas. MRI findings were as follows: even signals, slightly longer or equal T1 signals, long or slightly longer T2 signals; uneven signals, long or equal T1 signals and long T2 signals in the center, slightly longer or equal T1 and T2 signals at the edge. Enhanced scan showed homogenous enhancement, circular enhancement and solid enhancement. The disappearance rate of miliary lesions was higher than that of nodular ones and tuberculoma at 1 month, 3 months and 6 months after treatment. MRI of patients with tuberculous meningitis showed gyrus-like high signal on T2WI, equal or low signal on T1WI. After enhanced scan, the meninges showed radial enhancement, dominated by enhancement in the suprasellar cistern meninge, ambient cistern meninge, and quadruplet cisternal meninge. After treatment, meninge enhancement and thickening were relieved, and meningeal lesions were improved. The MRI findings of patients with mixed intracranial tuberculosis had both the MRI signs of simple brain parenchymal tuberculosis and tuberculous meningitis. After treatment, the meningeal lesions were improved, and some had enlarged or increased meningeal nodules. One month, 3 months and 6 months after treatment, the levels of protein, white blood cells, neutrophils and lymphocytes in patients with intracranial tuberculosis decreased, while the levels of chloride and glucose increased (P＜0.05). Conclusions: Different types of intracranial tuberculosis have obvious MRI features. Having a clear understanding of dynamic MRI and cerebrospinal fluid changes during anti-tuberculosis treatment is helpful for the evaluation and prediction of clinical anti-tuberculosis treatment effect.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Study on the correlation between MRI diffusion-weighted imaging apparent diffusion coefficient and Ki-67 index of triple negative and non-triple negative breast cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.015</link>
<description><![CDATA[Objective: To explore the the utility of the minimum apparent diffusion coeffcient (ADC), average ADC, maximum ADC, and ADC difference value and to find optimum ADC parameters for differentiation between triple negative and non-triple negative breast cancer in diffusion-weighted imaging (DWI),and further investigated the relationship between ADC values and the Ki-67 proliferation index. Materials and Methods: One hundred and forty-eight patients, who underwent breast MRI and collectively had 148 pathologically proven invasive carcinomas, were retrospectively enrolled. The apparent diffusion coefficient (ADC) value of the breast cancer lesions with each molecular subtype were identified and assessed jointly. all patients were female, aged 25—80 (51.4±10.5) years, 28 case TNBC and 120 case nTNBC patients. Receiver operating characteristic curves were drawn to evaluate the differentiating accuracy of ADC values. The Ki-67 proliferation index of the solid tumor components was also measured to explore its relationship with ADC values. Results: Statistical analysis of ADC values showed that ADCmean [(0.769±0.117) vs. (0.897±0.088) ×10−3 mm2/s] and ADCmin [(0.633±0.091) vs. (0.712±0.121)×10−3 mm2/s] were significantly lower in TNBC than nTNBC (all P＜0.05). The ADCDR of TNBC was significantly higher than that of nTNBC [(0.692±0.082) vs. (0.468±0.133)×10−3 mm2/s], P＜0.05). ADCmax value was not statistically significant (P＞0.05) in the two groups. ADCDR best distinguished the two groups, with an area under the curve value of 0.925. Using 0.635×10-3 mm2/s as the optimal threshold, the sensitivity, specificity of the two groups were 78.6%, 93.3%, respectively. ADCmean (r=-0.321) and ADCmin (r=-0.316) showed significant negative correlations with the Ki-67 proliferation index, ADCmax (r=0.249) and ADCmin (r=0.447) showed significant positive correlations with the Ki-67 proliferation index (all P＜0.01). Conclusions: Quantitative analysis of ADC value can identify TNBC and nTNBC. ADCDR value may be the best single parameter for DWI to identify the two groups, and there is a certain correlation between ADC value and Ki-67 proliferation index.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Assessment of angiogenesis and differentiation grade of extrahepatic cholangiocarcinoma by diffusion weighted imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.016</link>
<description><![CDATA[Objective: To explore the value of apparent diffusion coefficient (ADC) value in evaluating angiogenesis and differentiation grade of extrahepatic cholangiocarcinoma (EHCC). Materials and Methods: A retrospective analysis of 88 cases of EHCC confirmed by surgery and pathology in our hospital from August 2011 to December 2017 was performed.Preoperative MR-DWI examination was performed and ADC value was measured.The correlation between ADC value and microvessel density (MVD) was calculated. According to the expression of vascular endothelial growth factor (VEGF), all cases were divided into negative group and positive group. Then, according to the differentiation grade,it was divided into well, medium and poorly differentiated groups. Next, ADC value was compared between groups, and receiver operating characteristic (ROC) curve was used to evaluate the ADC value to judge the performance of VEGF expression and differentiation grade. Results: There was a negative correlation between ADC value and MVD (rs=-0.726, P＜0.05). The ADC value of the VEGF expression positive group was significantly smaller than that of the negative group (U=406. 50, P＜0.05). The ADC value＜1.291×10-3 mm2/s can predict the VEGF positive expression with the AUC value of 0.790, the sensitivity of 71. 43% and the specificity of 78.26%. As the differentiation grade decreased, the ADC value of EHCC gradually declined (χ2=72.51, P＜0.05), and pairwise comparison between groups showed statistically significant difference (P＜0.05). The ADC value＞1.319×10-3 mm2/s can predict the well differentiated group with the AUC value of 0.986, the sensitivity of 96.77% and the specificity of 89.47%. The ADC value＜1.184× 10-3 mm2/s can predict the poorly differentiated group with the AUC value of 0.998, the sensitivity of 100% and the specificity of 97.10%. Conclusions: The ADC value of EHCC is related to MVD and it can predict the VEGF expression and differentiation grade.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[MRI texture analysis and identification of clear cell renal cell carcinoma and renal oncocytoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.017</link>
<description><![CDATA[Objective: To explore the identification value of magnetic resonance imaging (MRI) texture analysis in clear-cell renal cell carcinoma (ccRCC) and renal oncocytoma (RO). Materials and Methods: The data of 42 ccRCC patients (ccRCC group) and 15 RO patients (RO group) who were admitted to the hospital from May 2012 to November 2019 were retrospectively analyzed. After patients underwent routine MRI scan and enhanced scan, texture scan analysis was conducted. The selection frequency of three-dimensional texture features was identified by ccRCC and RO. The diagnostic efficiency of ccRCC and RO was identified by MRI texture analysis. COM texture parameters were compared between ccRCC and RO patients. The identification value of COM texture parameters in ccRCC and RO patients was analyzed. Results: The texture features screened by ccRCC and RO identification were mostly from the co-occurrence matrix (COM). In the identification of ccRCC and RO, interlayer texture features screened by renal parenchymal enhancement T1 weighted imaging (T1WI) sequence were the most. By nonlinear discriminant analysis, the diagnostic efficiency of MRI texture analysis for identifying ccRCC and RO in terms of enhancement texture features during renal parenchymal stage was the best, its diagnostic sensitivity, specificity and accuracy were 92.86%, 73.33% and 87.72%, respectively. T1WI enhancement COM texture parameters such as entropy, homogeneity and correlation in ccRCC group were significantly lower than those in RO patients (P＜0.05), while there had no significant difference in the contrast and energy (P＞0.05). The receiver operating characteristic (ROC) curve analysis showed that the area under curve (AUC) values of COM texture parameters such as entropy, homogeneity and correlation for identifying ccRCC and RO patients were 0.883, 0.752 and 0.806, respectively. The value of entropy for identifying ccRCC and RO was the best, its sensitivity and specificity were 88.5% and 83.6%, respectively. Conclusions: MRI texture analysis, especially COM, can effectively identify ccRCC and RO.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Imaging findings of undifferentiated pleomorphic sarcoma of long bone (20 cases report)]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.018</link>
<description><![CDATA[Objective: To investigate the imaging features of undifferentiated pleomorphic sarcoma of long bone (BUPS). Materials and Methods: Collect clinical and imaging data of 20 cases (BUPS) confirmed by surgery and pathology in our hospital, imaging features were retrospectively analyzed. Results: Fifteen cases occurred in the Epiphysis (5 cases occurred in the neck of femur, 10 cases occurred in the other epiphysis), 5 cases occurred in the diaphysis. Cystic bone destruction was observed in all 5 cases of femoral neck, and high density shadow was seen in 1 case. The 5 cases of diaphysis presented worm etched bone destruction, which grew along the longitudinal axis of the bone, and the longitudinal diameter was much larger than the transverse diameter (all the 5 cases had greater longitudinal diameter than the transverse diameter). Large massive bone destruction occurred at the distal femur and the proximal tibia, or the area of bone destruction was mainly mixed up with thick bone crest of different thickness, and Codman, were observed in 2 cases. Magnetic resonance T1WI is a hybrid signal dominated by isosignals. T2WI showed mixed signals mainly with high signals, high signals were mostly seen at the edge of lesions. High signal cystic changes were observed at the lesion margins in 7 of 11 cases on FS-T2WI. Nine cases have large soft masses, soft tissue masses is larger than the area of bone destruction. Conclusions: The imaging features of BUPS in different parts are different. The femoral neck was mostly characterized by cystic bone destruction with clear boundaries. Most of the diaphysis presented as worm erosion bone destruction along the longitudinal axis of the bone. The metaphysis of distal femur and proximal tibia showed large lamellar bone destruction, interspersed with bone crest of different thickness. Magnetic resonance T1WI is dominated by isosignals. T2WI was mainly manifested by high signal, and high signal at the edge of lesion on FS-T2WI was suggestive.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[The interpretation of 2020 SCMR position paper on clinical indications for cardiovascular magnetic resonance]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.019</link>
<description><![CDATA[Based on the latest research evidence and expert consensus, Society for Cardiovascular Magnetic Resonance (SCMR) published the Position Paper (2020) on clinical indications for cardiovascular magnetic resonance, including congenital heart disease, cardiomyopathy, myocarditis, acquired vascular disease, coronary artery disease, pericardial disease, cardiac masses, and valvular heart disease. Meanwhile, the usefulness of CMR in specific diseases was graded. We aim to interpret this position paper and provide relevant reference for clinical practice.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[A case of prostate non-Hodgkin lymphoma MRI misdiagnosed as metastatic tumor]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.022</link>
<description><![CDATA[prostate; non-Hodgkin<sup><sup>,</sup></sup>s lymphoma; magnetic resonance imaging]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of DTI and fMRI in the network connection of the pedunculopontine nucleus in Parkinson disease]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.023</link>
<description><![CDATA[Falls and gait disorders are the main causes of disability in Parkinson<sup><sup>,</sup></sup>s disease, and its response to drug therapy and subthalamic stimulation is usually poor, which seriously affect the quality of life. As a part of mesencephalic locomotor region and reticular activating system, the pedunculopontine nucleus is closely connected with the basal ganglia, thalamus, cerebellum and other brain regions, and participates in posture and gait control. Diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) can reflect the structure of white matter fiber tracts and the function of brain regions, who well assess the role of the pedunculopontine nucleus in postural instability/gait difficulty. This article will review the application of DTI and fMRI in the network connection of the pedunculopontine nucleus in Parkinson<sup><sup>,</sup></sup>s patients.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of functional magnetic resonance imaging in minimal hepatic encephalopathy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.024</link>
<description><![CDATA[Hepatic encephalopathy (HE) is one of the common and serious complications of decompensated cirrhosis, which causes serious damage to the central nervous system. Minimal hepatic encephalopathy (MHE) is a subtype of HE. Early diagnosis and intervention have important clinical significance in preventing MHE from developing into overt hepatic encephalopathy (OHE) and its prognosis. With the continuous development of functional magnetic resonance imaging (fMRI), fMRI can not only clearly show the changes of brain morphological structure, but also make the researchers fully understand the changes of brain function and metabolism, and play an important role in the early diagnosis of mild hepatic encephalopathy. In this paper, the application progress of fMRI in MHE is reviewed.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress on isocitrate dehydrogenase genotype and imaging of glioma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.025</link>
<description><![CDATA[Isocitrate dehydrogenase (IDH) is not only one of the important contents of glioma gene diagnosis, but also one of the key factors affecting the treatment and prognosis of glioma patients. A variety of imaging features and radiomic features of MRI imaging, multimodal imaging and radiomics are associated with the phenotype of IDH gene. This article reviews the progress in the study of IDH genotypes and imaging of gliomas.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Current progress of machine learning combined with functional magnetic resonance imaging in depression<sup><sup>,</sup></sup>s diagnosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.026</link>
<description><![CDATA[Depression is one of psychiatric disorders with serious negative health outcomes, and it is of high incidence and easily recurrence. As for its diagnosis, it relies on Diagnostic and Statistical Manual of Mental Disorders,fifth edition (DSM-5) and International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). While combining fMRI with machine learning is potential to search for specific markers which provide objective imaging evidence for its diagnosis. Therefore, this review introduces current progress about task-state functional magnetic resonance imaging (task-state fMRI), rest-state functional magnetic resonance imaging (rest-state fMRI), arterial spin labeling (ASL) and diffusion tensor imaging (DTI) respectively combined with machine learning in depression<sup><sup>,</sup></sup>s diagnosis.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress on the specificity and brain network of acupuncture at Zhigou acupoint based on brain fMRI technology]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.027</link>
<description><![CDATA[The clinical effect of Zhigou point is remarkable and widely used, but the mechanism of acupuncture action is not completely clear, and functional magnetic resonance imaging (fMRI) technology has become an important means to study the mechanism of acupuncture action of brain nerve. After searching and sorting out the literatures related to acupuncture at Zhigou point by using brain fMRI technology, it is known that the specific activation of the brain area by acupuncture at Zhigou point is highly consistent with the structural changes of the brain area related to the diseases of the gastrointestinal tract, and its function is closely related to the regulation of the brain and intestine axis. There was no significant difference between acupuncture point and sham point in the brain activation area, but there was also a relative tendency to some dominant brain areas. Compared with the pure resting state before acupuncture, multiple brain regions have time-varying effects after acupuncture at Zhigou. After acupuncture, the temporary dynamic equilibrium network in the brain of the subjects was broken, and a functional connection network changing with time series was formed between the inferior frontal gyrus and part of the gyri. The purpose of this paper is to provide better guidance and service for clinical treatment by elaborating the changes of specific brain activation areas and brain network connections of acupuncture at Zhigou points.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Progress in quantitative assessment of liver fibrosis and cirrhosis by MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.028</link>
<description><![CDATA[Liver fibrosis is a reversible wound repair response. Early detection and staging of liver fibrosis can reduce its risk. As the end stage of liver fibrosis, cirrhosis will cause a series of serious complications if not timely and effective intervention. For the assessment of liver fibrosis and cirrhosis, MRI examination can reflect the changes of liver more directly and comprehensively than pathological and blood biochemical indexes. This article mainly reviews the technical principles of diffusion-weighted imaging (DWI), gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced imaging, magnetic resonance elastography (MRE) and the research progress in the evaluation of liver fibrosis and cirrhosis.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[The quantification methods of the confounding effects in chemical exchange saturation transfer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.029</link>
<description><![CDATA[Chemical exchange saturation transfer (CEST) is a new molecular imaging technique, which can be used to obtain metabolite concentration information indirectly for clinical diagnosis and prognosis evaluation. However, the CEST signal obtained is not simply from chemical exchange, but contains mixed effects such as direct water saturation (DS), traditional magnetization transfer (MT), nuclear overhauser enhancement (NOE) and so on. How to remove or utilize these effects to improve the quantization accuracy and imaging quality is crucial to clinical transformation.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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<title><![CDATA[Tumor microenvironment responsive <sup>19</sup>F-MR molecular imaging nanoprobe]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2021.05.030</link>
<description><![CDATA[Tumor microenvironment (TME) is closely related to the occurrence and metastasis of tumors and the structure and function of the tumor tissues. In vivo research on the interaction mechanism between tumor cells and TME is an urgent need for basical and clinical research on the occurrence and development of cancer, the development of new technology for accurate tumor diagnosis, and the development of new strategy for effective tumor inhibition. Molecular imaging focuses on molecular changes in biological processes, and early intervention and improvement of prognosis are of great significance for the study of molecular changes and environmental changes in early TME. With the continuous development of nanotechnology, a variety of 19F-MR nanomolecular imaging probes have been developed in response to TME. Such probes can change their molecular conformations under certain stimuli in complex TME, exposing the 19F nuclear mass and significantly enhancing the 19F-MR signal. By utilizing the environmental response characteristic of probe and combining with 19F-MR imaging, abnormal malignant biological behaviors in TME can be visualized at the early molecular level, providing favorable support for the realization of early diagnosis of tumor and guidance of precise treatment of tumor. This review based on basic and clinical studies, reviews the developed TME responsive nanomolecular imaging probes, so as to provide research ideas and theoretical basis for the design, preparation and clinical transformation of the new 19F-MR nanomolecular imaging probes.]]></description>
<pubDate>Thu,20 May 2021 00:00:00  GMT</pubDate>
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