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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=202206</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[Distribution characteristics and clinical value of U-fiber involvements in multiple sclerosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.001</link>
<description><![CDATA[Objective: To study the frequency and distribution characteristics of U-fiber involvements in relapsing-remitting multiple sclerosis (RRMS), and to investigate whether these findings are correlated with physical disability and neuropsychological impairments. Materials and Methods: This retrospective study included 49 cases of clinically diagnosed RRMS patients. Three-dimensional T2 fluid attenuation inversion recovery (3D T2-FLAIR) and T1-weighted magnetization-prepared rapid acquisition of gradient echo (T1 MPRAGE) sequences were obtained, as well as the clinical Extended Disability Status Scale (EDSS) and neuropsychological tests. Based on the ITK-SNAP software, the U-fiber lesions were manually delineated on the 3D T2-FLAIR image, and the prevalence of lesions was calculated in addition to the spatial distribution so as to make the U-fiber lesion probability map. The SPSS 26.0 software was used to evaluate the correlation between the number or volume of U-fiber lesions and clinical data, including EDSS and neuropsychological tests scores. Results: A total of 434 hyperintensities along the U-fiber were detected in 47 (95.9%) RRMS patients on 3D T2-FLAIR image. Two-hundred and nine lesions (48.2%) were seen in the frontal lobe, 85 (19.6%) in the parietal lobe, 55 (12.7%) in the temporal lobe, 61 (14.1%) in the occipital lobe, and 24 (5.5%) in the insula lobe. The number and volume of U- fiber lesions were positively correlated with the Hamilton Depression-17 (HAMD-17) Scale and Fatigue Severity Scale (FSS) scores , and negatively correlated with the Symbolic Digital Modal Test (SDMT) scores (all P＜0.05), and demonstrated no significant correlation with EDSS scores (P＞0.05). Conclusions: U-fiber involvement is common in RRMS patients and occurs frequently in the frontal lobe. U-fiber lesions are related to depression, fatigue and cognitive impairment in RRMS.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparison of echo-planar and turbo spin-echo diffusion-weighted imaging sequence in the diagnosis of middle ear cholesteatoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.002</link>
<description><![CDATA[Objective: To compare the diagnostic performance of echo planar diffusion weighted imaging (EP-DWI) and turbo spin-echo diffusion weighted imaging (TSE-DWI) for middle ear cholesteatoma. Materials and Methods: This study prospectively enrolled 63 patients with preliminary clinical suspicion of middle ear cholesteatoma; all patients underwent EP-DWI and TSE-DWI scans using a Philips Ingenia 3.0 T superconducting magnetic resonance scanner and a 32-channel head coil and subsequent surgical treatment. Using pathological results as the gold standard, the imaging diagnosis and postoperative pathology were compared, and area under the curve (AUC), sensitivity, specificity, positive predictive value, and negative predictive value of EP-DWI and TSE-DWI sequences in the diagnosis of suspected cholesteatoma were calculated. Results: Among the 63 patients with suspected middle ear cholesteatoma, 47 were pathologically diagnosed as cholesteatoma and 16 were non-cholesteatoma. The accuracy of TSW-DWI in the diagnosis of middle ear cholesteatoma was significantly higher than that of EP-DWI (TSE-DWI vs. EP-DWI: 0.895 vs. 0.644, P＜0.05). The sensitivity (91.49%) and specificity (87.50%) of TSE-DWI in diagnosing cholesteatoma were higher than those of the EP-DWI (sensitivity: 78.72%, specificity: 50.00%) sequence. Conclusions: Compared with EP-DWI, TSE-DWI can significantly improve diagnostic accuracy and reduce the misdiagnosis rate. TSE-DWI can improve the diagnostic confidence in middle ear cholesteatoma and has a high application value for clinical diagnosis.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Value of MRI multi-sequence model fusion radiomics in predicting the response to concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.003</link>
<description><![CDATA[Objective: To investigate the value of MRI multi-sequence model fusion (MSMF) radiomics model in predicting the efficacy of concurrent chemoradiotherapy (CCRT) in patients with locally advanced nasopharyngeal carcinoma (NPC). Materials and Methods: A total of 154 patients with locally advanced NPC were included in this study. All patients received CCRT treatment and MRI examination. RESIST 1.1 was used to evaluate the response after treatment, and the patients were divided into complete response group (83 cases) and incomplete response group (71 cases). The data were randomly divided into training and validation sets by a ratio of 3∶1, and the regions of interests of each sequence images were manually segmented. And 9766 radiomics features were respectively extracted from each of the three sequences using Matlab 2018a software, and the features were screened by t test and maximum correlation minimum redundancy algorithm. Support vector machines and logistic regression were used to build prediction models, and ROC curves were drawn. Delong test was used to compare the prediction performance. Results: In the validation set, the area under the curve (AUC) values of the clinical model, T1WI, T2WI, contrast enhanced T1WI models were 0.542, 0.633, 0.711, and 0.842 (P values were 0.661, 0.161, 0.026, and ＜0.001, respectively). In the multi-sequence fusion models, the AUC values of the MSMF model and the clinical-MSMF model were 0.896 and 0.867, respectively (P＜0.05 for both). The AUC of MSMF and clinical-MSMF radiomics models in predicting the response to CCRT in patients with locally advanced NPC was significantly higher than T2WI, T1WI and clinical models, and the differences were statistically significant (P＜0.05). Conclusions: The ability of MSMF radiomics model to predict the efficacy of CCRT is better than conventional single-sequence radiomics prediction models and clinical models. Therefore, this model is expected to be a method to predict the efficacy of CCRT and further promote the development of precision medicine.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Value of syMRI and DWI quantitative parameters measured using different regions of interest method in differentiating benign and malignant breast lesions]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.004</link>
<description><![CDATA[Objective: To investigate the value of synthetic magnetic resonance imaging (syMRI) and diffusion weighted imaging (DWI) quantitative parameters measured using different regions of interest (ROI) method in differentiating benign and malignant breast mass-like lesions. Materials and Methods: All patients underwent MRI scanning, including T2WI, dynamic contrast-enhanced MRI, DWI and syMRI. Two readers used the method of holistic drawing of lesions to outline ROI respectively, the ROI was drawn along the edge and recorded as "tumor". At the maximum slice of the lesion, the ROI was drawn along the edge and recorded as "max". In the solid area with the most obvious tumor enhancement, the ROI was drawn and recorded as "local". At the same time, apparent diffusion coefficient (ADC) values (ADCtumor, ADCmax and ADClocal) were measured in the ADC map according to the tumor enhancement position in the dynamic enhanced image. T1 relaxation time (T1tumor, T1max and T1local) were measured on T1 mapping images. T2 relaxation time (T2tumor, T2max and T2local) were measured on T2 mapping images. Proton density (PDtumor, PDmax and PDlocal) were measured on PD mapping images. The reader 1 repeated the above measurement after an interval of one month. The inter-class correlation coefficient (ICC) was calculated to evaluate the repeatability of the results measured by different physicians using different ROI delineation methods. Comparison of the differences of various parameters between benign and malignant breast lesions. The receiver operating characteristic (ROC) area under the curve (AUC) was used to evaluate the differential diagnosis performance of syMRI, DWI and their combination in benign and malignant lesions. Delong test was used to compare AUC. Results: Using different ROI delineation methods, the ADC value, T1 value, T2 value and PD value measured by the same physician twice and between different physicians were reproducible (ICC range 0.929-0.992). The ADC value, T2 value and PD value obtained by the three ROI delineation methods were all significantly different between benign and malignant breast lesions (all P＜0.001). Multivariate logistic regression analysis showed that ADClocal, T2tumor and PDlocal were independent variables in the diagnosis of breast cancer. The OR values were 0.001, 0.917 and 1.267, respectively (P=0.013, 0.039 and 0.043). ROC curve analysis showed that ADClocal+T2tumor+PDlocal had the highest AUC for differential diagnosis of benign and malignant breast lesions (0.953), with a sensitivity of 95.2%, a specificity of 84.2%, an accuracy of 91.0%, a positive predictive value of 93.0%, and a negative predictive value of 88.8%. There was no significant difference in diagnostic efficiency between ADClocal+T2tumor+ PDlocal and ADClocal (AUC=0.953, 0.942; P=0.143). Conclusions: For breast mass lesions, syMRI and DWI parameters are helpful to differentiating malignancy from benign lesions, the diagnostic performance of combined parameters model was comparable to that of the ADC value.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Preliminary study on the value of T2 mapping in predicting lymphovascular invasion of rectal cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.005</link>
<description><![CDATA[Objective: To investigate the value of T2 mapping quantitative parameters in predicting lymphovascular invasion (LVI) and non-LVI of rectal cancer. Materials and methods: A retrospective analysis of 34 cases with rectal cancer who underwent 3.0 T MRI scans in the First Affiliated Hospital of Dalian Medical University from October 2019 to November 2021 was divided into a LVI group (group A) of 13 cases and a non-LVI group (group B) of 21 cases. Scanning sequences include T1WI, T2WI, diffusion weighted imaging (DWI), and T2 mapping. Combined with the above sequence images, the lesions were located, and two observers placed three region of interest (ROIs) to measure the T2 value on the largest slice of the lesion displayed on the T2 mapping image. A Bland-Altman curve was used to test the agreement of the 2 observers<sup><sup>,</sup></sup> measurements. According to whether the data conformed to the normal distribution or not, independent samples t-test or Mann-Whitney U test was used to compare the difference of T2 value between rectal cancer group A and group B. Results: T2 mapping parameters measured by the two observers were in consistent, and most of the scattered points in the Bland-Altman graph were evenly distributed between the +1.96 and -1.96 standard lines. The T2 values of group A and group B were (77.15±6.95) ms and (87.06±7.55) ms, respectively. Group A was lower than group B, and the difference was statistically significant (P＜0.05); the area under the curve (AUC), threshold, sensitivity and specificity of T2 value in predicting LVI were 0.861, 83.19 ms, 84.62% and 76.19%, respectively. Conclusions: T2 mapping has high value in predicting LVI of rectal cancer.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Structural damage of the corpus callosum connecting interhemispheric homologous areas correlated with motor dysfunction after subcortical stroke]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.006</link>
<description><![CDATA[Objective: To investigate the relationship between the transcallosal tracts abnormality of interhemispheric homotopic regions and motor impairment in unilateral subcortical stroke. Materials and Methods: Diffusion tensor imaging data of 34 patients with unilateral subcortical stroke and 43 healthy subjects were collected. Using the high-resolution transcallosal tract template (TCATT), the fractional anisotropy (FA) of 32 transcallosal tracts connecting the interhemispheric homologous brain areas (including sensory motor area, prefrontal lobe, parietal lobe, temporal lobe and occipital lobe) in the stroke group and healthy control group were calculated and compared; furthermore, correlation analysis was conducted with the FA ratio (rFA) of corticospinal tract (CST) and the Fugl-Meyer assessment of upper extremity (FM-UE), respectively. Results: Compared with the healthy controls, FA values of all the 32 transcallosal tracts in the midsagittal plane decreased in the stroke group, of which 29 showed significant differences (except three transcallosal tracts connecting homotopic regions of gyrus rectus, medial orbital and paracentral lobule). FA values of the 29 transcallosal tracts in the midsagittal plane were positively correlated with rFA (CST) and FM-UE in the stroke group. There was also a significant positive correlation between rFA (CST) and FM-UE (r=0.596, P=0.0004). Conclusions: This study confirms that the damage of corpus callosum microstructure in subcortical stroke is closely related to the damage of ipsilesional CST. The secondary structural injury of the corpus callosum also have an important effect on the motor impairment following subcortical stroke.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[A clinical study of amygdala volume changes in medial temporal lobe epilepsy patients]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.007</link>
<description><![CDATA[Objective: The changes of hippocampus and amygdala volume in patients with medial temporal lobe epilepsy were studied by using T1 three dimensional magnetization prepared rapid acquisition gradient echo (3D-T1 MPRAGE) sequence and FreeSufer software to measure the volume of hippocampus and amygdala. Materials and Methods: A total of 102 patients with medial temporal lobe epilepsy (case group) and 15 healthy volunteers (control group) were collected to measure the volume of bilateral hippocampus and amygdala respectively, and the abnormality was judged by taking the mean value of the control group plus or minus 2 times the standard deviation as the normal limit. According to whether the hippocampal volume is normal or not, the patients with amygdala enlargement (AE) in the hippocampal sclerosis (HS) group and the normal hippocampal group were divided into L group and R group according to the epilepsy side. Paired t-test was used to compare bilateral amygdala volumes. One-way ANOVA was used to compare the ipsilateral amygdala of the normal hippocampus-L group, the normal hippocampal-R group and the normal control group; the ipsilateral amygdala of the HS-L group, the HS-R group and the normal control group was compared. Results: The study found that there was a statistically significant difference in the volume of bilateral amygdala between normal hippocampal-L group and normal hippocampal-R group (P＜0.05). There was a statistically significant difference in the volume of bilateral amygdala between HS-L group and HS-R group (P＜0.05). The volume of the right amygdala in the HS-L group was larger than that of the HS-R group and the same side of the control group (P＜0.05). The volume of the left amygdala in the HS-R group was greater than that in the HS-L group and the same side of the control group (P＜0.05). The volume of the left amygdala in the normal hippocampus-L group was larger than that in the normal hippocampus-R group and the ipsilateral side of the control group (P＜0.05). The volume of the right amygdala in the normal hippocampus-R group was larger than that in the normal hippocampus-L group and control group on the same side (P＜0.05). Conclusions: 3 D-T1 MPRAGE can accurately measure the volume of the amygdala. Meanwhile, patients with normal hippocampus in mesial temporal lobe epilepsy have amygdala enlargement on the same side of the epileptogenic foci, and HS patients have amygdala enlargement on the opposite side of the epileptic foci, indicating that the amygdala may be involved in the occurrence and development of mesial temporal lobe epilepsy.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Investigate the whole level alteration of dynamic functional connectivity of attention network in patients with major depressive disorder based on magnetic resonance imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.008</link>
<description><![CDATA[Objective: To explore the abnormalities of dynamic connectivity of attention network in patients with major depressive disorder (MDD) by using resting state-functional magnetic resonance imaging (rs-fMRI). Materials and Methods: Totally, 73 MDD subjects and 71 healthy controls (HC) were included in this study. The rs-fMRI data were acquired for each subject, and the functional network of attention was established based on previous meta-analysis. Then, the attention network was temporally segmented according to a series of sliding windows, and the temporal variability of attention network connectivity was calculated and then compared between the MDD and HC groups. Results: Compared with the HC group, significantly increased temporal variability of attention network across all the nodes of the whole network (P=0.019) was observed in the MDD group, while no significant difference of temporal variability was observed in any individual node between the two groups. No significant correlation between the mean temporal variability of attention network and the scores of the depression and anxiety was found. Conclusions: The results may indicate that the abnormally increased dynamic connectivity of attention network in patients with MDD are at the whole network level, instead of a localized change driven by regional abnormalities.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Dynamic changes of regional homogeneity in patients with Parkinson<sup><sup>,</sup></sup>s disease based on resting-state functional magnetic resonance imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.009</link>
<description><![CDATA[Objective: To examine abnormal dynamic characteristics of regional homogeneity in Parkinson<sup><sup>,</sup></sup>s disease (PD) patients by resting-state functional magenetic resonance imaging (rs-fMRI) and to investigate whether the altered dynamic regional characteristics were associated with the clinical behavior scores in PD patients. Materials and Methods: The rs-fMRI data of 32 PD patients (PD group) who have enrolled in the Subei People<sup><sup>,</sup></sup>s Hospital from August 2018 to August 2021 and 33 age-and sex-matched healthy controls (HC group) were prospectively collected. Temporal dynamic analysis (TDA) toolbox based on MATLAB were used for data processing. The differences of dynamic regional homogeneity (dReHo) between PD and HC groups were detected by two sample t-test. The cognitive function of the patients was evaluated with the Mini-Mental State Examination (MMSE) scores and Montreal Cognitive Assessment scores. The third part of Unified Parkinson<sup><sup>,</sup></sup>s disease Rating Scale (UPDRS) was used to assess the patients<sup><sup>,</sup></sup> motor function. Pearson correlation was used to analyze the correlation between dReHo in regions showing significant intergroup differences and clinical scores. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of altered dReHo indexes to identify PD patients. Results: Compared with HC group, PD group showed decreased dReHo in left caudate,right putamen and bilateral lingual (P＜0.05). The dReHo variability in left caudate (r=0.374, P=0.04) and right putamen (r=0.379, P=0.03) was positively correlated with the MMSE scores of the PD patients. The dReHo variability in the left caudate (r=-0.446, P=0.01), right putamen (r=-0.369, P=0.04) and left lingual (r= -0.419, P=0.02) was negatively correlated with the UPDRS-Ⅲ scores of the PD patients. Furthermore, ROC curve analysis demonstrated a higher diagnostic performance of altered dynamic regional characteristics to identify PD patients. Conclusions: PD patients have abnormal brain activity at resting state, which affects the movement and cognitive function. The dynamic regional homogeneity variability in related brain regions could distinguish Parkinson<sup><sup>,</sup></sup>s patients from healthy controls at the individual level.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.010</link>
<description><![CDATA[Objective: To investigate whether interictal voxel-mirrored homotopic connectivity (VMHC) was impaired in migraine without aura (MwoA) patients, and how did VMHC change after acupuncture treatment. Materials and Methods: Fifty-four MwoA patients and matched forty-four healthy controls were recruited into this study. Patients underwent a four-week acupuncture treatment, whereas controls didn<sup><sup>,</sup></sup>t have any therapy. Functional magnetic resonance imaging data and clinical information were acquired at baseline and after treatment. The VMHC analysis method was used to compare the difference between two groups at baseline and in MwoA patients before and after treatment. Furthermore, correlation analysis was conducted to explore the relationship between VMHC changes of brain regions modulated by acupuncture treatment and improvement in clinical scores. Results: Compared with healthy controls, MwoA patients revealed significantly decreased VMHC in the bilateral cerebellum_Ⅷ, cuneus and postcentral gyrus (voxel level P＜0.001,cluster level P＜0.05). After acupuncture treatment, the clinical indicators of migraine patients were significantly improved, and resting-state functional magnetic resonance imaging showed that weakened VMHC of the bilateral cuneus remarkably enhanced (voxel level P＜0.001, cluster level P＜0.05). The change of VMHC in the bilateral cuneus was positively correlated with change of self-rating anxiety scale scores (r=0.291, P＜0.05). Conclusions: Impaired VMHC in the bilateral cerebellum, visual cortex and primary somatosensory cortex may be involved in the central mechanism of MwoA during interictal period. Acupuncture treatment had significant clinical efficacy for migraine, and could enhance weaken VMHC in the bilateral cuneus.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Abnormal spontaneous brain activities in breast cancer patients after EC-T chemotherapy: A resting-state functional magnetic resonance imaging study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.011</link>
<description><![CDATA[Objective: Using resting-state functional magnetic imaging (rs-fMRI) and amplitude of low frequency fluctuation (ALFF) algorithm to investigate the abnormal spontaneous brain activities and related cognitive dysfunction in breast cancer patients after chemotherapy. Materials and Methods: We selected twenty-nine patients with invasive ductal carcinoma of the breast (patients group) confirmed by pathology. All patients were female and all received standard EC-T (E: Epirubicin; C: Cyclophosphamide; T: Paclitaxel) sequential chemotherapy. Thirty age- and education level matched female healthy volunteers (controls group) were selected during the same period. All subjects first underwent Montreal Cognitive Assessment (MoCA) and Auditory Verbal Learning Test-Huashan version (AVLT-H), 3D brain volume imaging and rs-fMRI scans. Finally, the DPARSF software package was used for processing and statistical analysis. The SPSS 19.0 software package was used for statistical analysis of clinical data and scales. Results: The MoCA scores of the patients group were lower than controls group (P=0.002). There was no significant difference in the scores of each sub-item of AVLT-H between-group (P＞0.05). The ALFF values of left dorsolateral superior frontal gyrus (Frontal_Sup_L) in the Patients group were higher than controls group (P＜0.001), whereas the ALFF values of cerebellar vermis_6 (Vermis_6) and left lateral cingulate gyrus (Cingulum_Ant_L) were lower than the controls group (P＜0.001). Pearson correlation analysis showed that the ALFF values of the left lateral cingulate gyrus were significantly positive correlated with the MoCA score (r=0.789, P＜0.001). Conclusions: Patients with breast invasive ductal carcinoma after EC-T chemotherapy have global cognitive dysfunction. Spontaneous neural activity abnormalities in key brain regions are closely related to the overall cognitive impairment. Spontaneous brain activity abnormalities in these regions are expected to become imaging markers for monitoring and treatment of breast cancer patients<sup><sup>,</sup></sup> cognitive dysfunction after EC-T chemotherapy.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Study on time variability of brain activity in patients with irritable bowel syndrome with diarrhea based on dynamic amplitude of low-frequency fluctuation]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.012</link>
<description><![CDATA[Objective: To investigate the changes in local brain function activity in the resting state of irritable bowel syndrome with diarrhea (IBS-D) patients. Materials and Methods: Twenty-four patients with diarrhea-predominant IBS-D and 20 healthy controls underwent resting-state functional magnetic resonance imaging, the dynamic amplitude of low-frequency fluctuation (dALFF) value was calculated by using the amplitude of low-frequency fluctuation method combined with sliding window approach. Finally, the correlation
analysis was performed to detect the relationship between the changes in dALFF value and some clinical data in IBS-D patients. Results: The group comparison results in dALFF variability showed that patients with IBS-D exhibited increased dALFF variability in the left cerebellum(t=3.95) and right putamen (t=3.13, corrected by Alphasim, P＜0.01 after correction). The abnormal dALFF variability of the putamen was positively correlated with the abdominal pain in patients with IBS-D (r=0.398, P=0.054). Conclusions: The findings indicated that the patients with IBS-D exhibited abnormal temporal variability of spontaneous neural activity in the cerebellum and putamen. Moreover, the right putamen might be related to the occurrence and development of abdominal pain in IBS-D patients.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[fMRI research on regional homogeneity and functional connectivity changes of brain regions in patients with end-stage renal disease]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.013</link>
<description><![CDATA[Objective: To investigate the alterations of neuronal functional activity in patients with end-stage renal disease (ESRD) by using regional homogeneity (ReHo) and functional connectivity (FC) algorithm based on resting-state functional magnetic resonance imaging (rs-fMRI), and to analyze the association between spontaneous brain activity changes and blood biochemical index. Materials and Methods: Thirty-six patients with ESRD and 32 healthy controls were scanned with rs-fMRI to calculate the ReHo value of the whole brain. Brain areas with altered ReHo values were selected as regions of interest for FC analysis. Two independent sample t tests was used for comparison between groups, and Pearson<sup><sup>,</sup></sup>s correlation analysis was used between altered ReHo values and blood biochemical index. Results: Compared with the healthy controls, ESRD patients showed the ReHo values in left temporal pole, right orbital inferior frontal gyrus and bilateral rectus gyrus were significantly increased (P＜0.001, AlphaSim corrected), meanwhile, the ReHo values in bilateral calcarine sulcus, left inferior frontal gyrus, right superior temporal gyrus and supramarginal gyrus were significantly decreased (P＜0.001, AlphaSim corrected). ESRD patients showed decreased FC between right calcarine sulcus and left inferior frontal gyrus and right supramarginal gyrus (P＜0.05, NBS corrected). We also found decreased FC between right supramarginal gyrus and right superior temporal gyrus (P＜0.01, NBS corrected). Correlation analyses showed that ReHo values in right calcarine sulcus were positively correlated with haemoglobin levels (r=0.347, P=0.048) and haematocrit (r=0.357, P=0.041). Conclusion: ESRD patients had dyssynchrony of local functional activities in several brain regions, mainly involving the default mode network, which may contribute to further understanding of the neuropathological mechanism of brain injury in ESRD patients.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Resting-state functional magnetic resonance imaging in patients with nocturnal enuresis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.014</link>
<description><![CDATA[Objective: To explore the mechanism of spontaneous brain activity in children with nocturnal enuresis (NE) by resting-state functional magnetic resonance imaging (rs-fMRI). Materials and Methods: NE (n=37) and healthy controls (n=37) matched by gender, age, and education were recruited. All subjects underwent brain rs-fMRI scanning. The resting-state data calculated the regional homogeneity (ReHo) and degree centrality (DC) of children with NE and the healthy control group. A two-sample t-test compared the differences between the two groups. The DC value and ReHo value of brain areas with differences between the two groups were extracted for correlation analysis with clinical indicators and the score of Children<sup><sup>,</sup></sup>s Sleep Habits Questionnaire (CSHQ). Results: The results of the t-test showed that compared with the healthy control group, the DC value of the NE group decreased in the anterior cingulate gyrus and parahippocampal gyrus of the limbic lobe; Compared with healthy controls, the ReHo value of NE group in the anterior cingulate gyrus decreased. Correlation analysis showed that the DC value of the parahippocampal gyrus was positively correlated with the score of abnormal sleep (P=0.045, r=0.256); Correlation analysis showed that the DC value of the parahippocampal gyrus was positively correlated with the score of CSHQ (P=0.010, r=0.062). Conclusions: The study shows that the decrease of local brain function activity in children with NE at rest may be closely related to the pathology of enuresis.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Clinical application of high resolution myocardial T2-weighted dark blood sequence based on artificial intelligence assisted compressed sensing technique in myocardial edema]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.015</link>
<description><![CDATA[Objective: To explore the feasibility of high spatial resolution T2-weighted dark blood imaging sequence using artificial intelligence assisted compressed sensing (ACS HR-T2W-DB) technique in evaluating myocardial edema in cardiovascular magnetic resonance (CMR) imaging, compared with conventional T2W-DB sequence. Materials and Methods: A total of 38 patients who underwent cardiac magnetic resonance examination in our hospital from August to December 2021 were prospectively enrolled. All patients underwent short axial conventional T2W-DB and ACS HR-T2W-DB sequences. Subjective score and objective quantitative parameters were used to evaluate the image quality of conventional T2W-DB and ACS HR-T2W-DB sequences, respectively. Likert score scale was used to evaluate the overall image quality, blood pool inhibition effect, right ventricular free wall, left ventricular free wall and interventricular septum visibility. Objective quantitative parameters included peak signal-to-noise ratio (pSNR) and myocardial blood pool contrast-noise ratio (myocardial-CNR), and 14 patients with regional myocardial edema were evaluated by CNR (edema-CNR). Results: Compared with conventional T2W-DB sequence, the spatial resolution of ACS HR-T2W-DB sequence was doubled (conventional 256×163 vs. ACS 336×269). Compared to ACS HR-T2W-DB sequences, the image quality scores of right ventricular wall and left ventricular free wall in ACS HR-T2W-DB sequence were significantly higher than those in conventional T2W-DB sequence, and the difference was statistically significant (P＜0.05), but there was no significant difference in overall image quality, blood pool suppression effect and interventricular septum visibility (P＞0.05). In the objective quantitative parameters of image quality, pSNR and edema-CNR based on ACS HR-T2W-DB sequence were significantly higher than those of conventional T2W-DB sequence, and the difference was statistically significant (P＜0.05), but there was no significant difference in myocardial-CNR (P＞0.05). Conclusions: Compared with conventional T2W-DB sequence, ACS HR-T2W-DB sequence provides higher spatial resolution, higher image quality, edema-CNR and better left ventricular free wall visibility without longer scanning time, which is promising to become a routine sequence for patients with suspected myocardial edema.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Quantification of the impact of Gadolinium agent on amide-proton-transfer weighted MRI: An ex vivo and in vivo study]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.016</link>
<description><![CDATA[Objective: To investigate the impact of Gadolinium agent (Gd) in clinical dosage on the amide proton transfer (APT) effect by a designed ex vivo phantom study and in vivo human study. Materials and Methods: A phantom was made by mixing a gradient of 24 dosages of Gd-based contrast agent with 10 mL pure egg white in each tube, with reference to the clinical dosage. To verify the reproducibility of the results, the phantom was scanned three times and the scan results were analyzed for consistency. Nineteen patients with brain tumor had undergone routine clinical brain MR scan, in which APT weighted imaging was added before and after the administration of Gd. On an in-house MATLAB platform, APT values were calculated and measured for each tube of the phantom, and different regions of interest (ROIs) of the brain, including peripheral edema, tumor area, white matter (WM) and gray matter (GM). Similarity between the pre-contrast and post-contrast APT map was quantified using cosine similarity. Paired student t-test was used to evaluate the difference in the APT values between the same ROI of pre-contrast and post-contrast APT maps. Results: The results of ex vivo experiment showed that the three scans had a high consistency (ICC=0.998), and along with the increase of the MRI contrast agent concentration, the average APT value of each tube in the phantom showed a downward trend. When the added Gd content was less than 1 μL, the average value of APT remained relatively stable and fluctuated around 12% (from 11.61% to 13.42%). However, when the Gd content exceeded 1 μL, the APT value of the egg white was considerably reduced. Until the content reached about 20 μL, the decline rate of APT value gradually stabilized at about 2% (from 1.88% to 2.13%). The results of in vivo experiment showed that for the whole brain tissue, gray matter and weakly enhanced tumor lesions, the APT values not significantly changed between before and after contrast agent enhancement(P=0.18, 0.21, 0.53). For white matter and enhanced tumor lesions, the APT values were significantly increased between before and after contrast enhancement (P＜0.05). Conclusions: Both in vitro phantom study and in vivo study demonstrated the various impact of Gd-based contrast agent on APT effect, especially for highly enhanced brain tumor, suggesting that it should be avoided to perform APT weighted imaging after contrast enhanced imaging in clinical setting.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Resting-state fMRI study of vulnerable brain regions in patients with primary insomnia: A Meta-analysis based on activation likelihood estimation]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.017</link>
<description><![CDATA[Objective: To examine the use of resting state functional magnetic resonance imaging (rs-fMRI) technology in the study of the more consistent impaired brain regions in patients with primary insomnia (PI), in order to uncover the potential neural mechanism of PI brain injury. Materials and Methods: Before April 7 2022, the literature on changes in brain function in patients with PI was searched using regional honogeneity (ReHo) and amplitude of low-frequency fluctuation/fraction amplitude of low-frequency fluctuation/dynamic amplitude of low-frequency fluctuation (ALFF/fALFF/dALFF) analytic methods. The activation likelihood estimation (ALE) method was utilized to integrate and assess brain regions with aberrant spontaneous neural activity in patients with PI compared to healthy controls (HCs), based on tight exclusion criteria. Results: A total of 19 literatures and 20 studies (706 instances of PI and 681 cases of HCs) were included in the results. Combining ReHo and ALFF/fALFF/dALFF data element analysis, the results revealed that the activity of the left fusiform gyrus and parahippocampal gyrus in PI patients was higher than in HCs (voxels were 3640 and 928 mm3, respectively, P＜0.05), and no brain region had lower activity. The results of ALFF data element analysis alone revealed that the activity of the left fusiform gyrus in PI patients was higher than in HCs (voxel was 1360 mm3, P＜0.05), and no brain region had lower activity. The results of ReHo data element analysis alone revealed areas of the brain where PI patients do not exhibit any increased or decreased brain regions relative to HCs. Conclusions: In this paper, an ALE meta-analysis discovered that the more consistent susceptible brain regions in PI patients were the left fusiform gyrus and parahippocampal gyrus, which is helpful in understanding PI brain injury from a neuropathological standpoint.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[MRI features of intracranial atypical teratoid/rhabdoid tumor and its correlation with the labeling index of Ki-67]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.018</link>
<description><![CDATA[Objective: To investigate the MRI features of intracranial atypical teratoid/rhabdoid tumors (AT/RT) and the correlation between MRI features and the labeling index of Ki-67. Materials and Methods: MRI features of 11 patients with intracranial AT/RT confirmed by the postoperative histopathology from November 2013 to May 2021 were retrospectively analyzed, and the correlation between MRI and the labeling index of Ki-67 was further studied. Results: Nine cases occurred in the posterior cranial fossa; the maximum diameter was (37.08±2.57) mm; cystic degeneration occurred in 8 cases, hemorrhage in 6 cases, and mild edema around the focus in 3 cases. In diffusion weighted imaging (DWI) (b=1000 s/mm2), 7 cases showed high signal and 4 cases showed slightly high signal. MR enhanced scan was not performed in 1 case, 7 cases showed obvious inhomogeneous enhancement and 3 cases showed mild inhomogeneous enhancement. The range of Ki-67 was 30%–80%; there were 6 cases with high expression (Ki-67＞40%) and 5 cases with low expression (Ki-67≤40%). There was no significant difference between the two groups in the location and size of lesions, intratumoral hemorrhage, intratumoral cystic degeneration, peritumoral edema and enhancement degree. However, there was significant difference in apparent diffusion coefficient (ADC) value between the two groups (P＜0.05). Spearman correlation analysis showed that ADC value was negatively correlated with the labeling index of Ki-67 (r=-0.866, P＜0.01). Conclusions: Intracranial AT/RT always has cystic degeneration, hemorrhage, and most of them have inhomogeneous signal intensity on MRI and obvious inhomogeneous enhancement on enhanced scan; ADC value was negatively correlated with the labeling index of Ki-67.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Diffusion tensor imaging of the lumbosacral enlargement helps to estimate the neurologic recovery after decompression surgery in patients with cervical spondylotic myelpoathy]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.019</link>
<description><![CDATA[Objective: To evaluate changes in injury severity and assess postoperative neurologic recovery by conducting diffusion tensor imaging (DTI) of the lumbosacral enlargement and measuring modified Japanese Orthopedic Association (mJOA) score in patients with cervical spondylotic myelopathy (CSM). Materials and Methods: Lumbosacral DTI was performed in 9 CSM patients before surgery and at approximately 1 year after surgery. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured as two primary metrics of DTI. The correlation between both metrics and mJOA score was further examined. Results: The postoperative ADC value of the lumbosacral enlargement was significantly decreased (t=-3.024, P=0.004), but FA value was significantly increased (t=3.741, P=0.001) from preoperative levels in CSM patients after surgery. There was significant correlation between FA and mJOA score at both preoperative (r=0.832, P＜0.05) and postoperative conditions (r=0.710, P＜0.05). There was no significant correlation between ADC and mJOA score at both preoperative (r=0.281, P=0.465) and postoperative conditions (r=0.195, P= 0.616). Conclusions: The DTI parameter FA value of spinal lumbosacral enlargement in CSM patients is related to neurological function before and after surgery, which can provide a new way for clinical evaluation of functional recovery after cervical spinal cord injury.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of MRI ultrashort echo time and gradient echo sequence in the lungs of preterm infants]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.020</link>
<description><![CDATA[Objective: To explore the feasibility of three-dimensions ultra short echo time (3D UTE) sequence and three-dimensions gradient echo (3D GRE) sequence for magnetic resonance imaging of preterm infants<sup><sup>,</sup></sup> lungs, and to optimize magnetic resonance sequence scanning parameters. Materials and Methods: Prospectively enrolled 95 preterm infants, 50 male infants and 45 female infants who underwent pulmonary MR examinations in our hospital from March to July 2021, aged from 1 day to 1 year and 10 months, and the median age was 5 months. All volunteers performed lung magnetic resonance examinations on the United Imaging 3.0 T pediatric specific magnetic resonance equipment (UIH uMR Alpha). The scanning sequence included 3D UTE and 3D GRE sequences. Each sequence uses different scanning parameters for sequence debugging. According to different scanning parameters, all subjects were randomly divided into five groups in 3D UTE sequence: Group 1 (18 cases), Group 2 (17 cases), Group 3 (19 cases), Group 4 (21 cases) and Group 5 (20 cases). 3D GRE sequence were randomly divided into four groups: Group Ⅰ (24 cases), Group Ⅱ (22 cases), Group Ⅲ (23 cases) and Group Ⅳ (26 cases). Two radiologists evaluated the image quality at different scanning parameters using objective evaluation methods. The objective evaluation indicators include signal noise ratio (SNR) and contrast noise ratio (CNR). Scanning time among different groups were further compared. Results: There were statistically significant differences (P＜0.05) in SNR and CNR of lung images at different scanning parameters for the 3D UTE and 3D GRE sequences. In the 3D UTE sequence, the SNR and CNR of Group 1, 2, and 3 were significantly different from those of Group 4 and 5, respectively (P＜0.05), while there was no significant difference in image quality between Group 4 and 5 (P＜0.05). Meanwhile, the scanning time was reduced by 77.95%, 75.55% and 6.67% in Group 4 compared with Group 1, 2, and 3, and 76.06% and 73.45% in Group 5 compared with Groups 1 and 2, respectively. In the 3D GRE sequence, the SNR and CNR of Group Ⅰ and Ⅱ were statistically significant (P＜0.05) compared with those in the Group Ⅲ and Ⅳ, respectively, while no statistically significant differences were seen in the image quality between the Group Ⅲ and Ⅳ (P＞0.05). Meanwhile, the scan time was reduced by 70.80%and 24.24% in Group Ⅲ compared with Group Ⅰ and Ⅱ, respectively, and 40.71% in Group Ⅳ compared with Group Ⅰ, while the image quality was significantly improved. Conclusions: 3D UTE and 3D GRE sequences are feasible for MRI of the of preterm infants<sup><sup>,</sup></sup> lungs. The recommended scanning parameters for 3D UTE sequences are the Group 4 and 5, and the recommended scanning parameters for 3D GRE are the Group Ⅲ and Ⅳ.While ensuring high image quality, it greatly shortens the clinical scan time, and improves the success rate of examinations.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[A comparison of the Kaiser score and apparent diffusion coefficient mapping in the assessment of breast lesions]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.021</link>
<description><![CDATA[Objective: To compare the diagnostic performance of Kaiser score with apparent diffusion coefficient (ADC) to distinguish benign from breast malignant lesions and to assess the potential of those approaches to avoid unnecessary biopsies. Materials and Methods: This retrospective study enrolled 127 patients with 134 lesions (7 patients had 2 lesions) undergoing breast MRI from January 2019 to September 2021. KS+ score was calculated by combining ADC and Kaiser score. With pathological results as the gold standard, the area under the receiver operating characteristics curve (AUC) was calculated and compared between Kaiser score, ADC and KS+ score through Delong Test. Sensitivity and specificity were calculated and compared between them through McNemar Test. Results: The AUC of Kaiser score (0.917) was significantly different from that of ADC (0.812) (P=0.0404), and the largest difference was found in non-mass lesions. There were statistically significant differences in specificity between Kaiser score (0.809) and ADC (0.426) (P=0.0215), but no difference in sensitivity between Kaiser score (0.954) and ADC (0.977) (P=0.6875). There were no differences between the AUC (0.917)、sensitivity (0.954) and specificity (0.809) of the Kaiser score and the AUC (0.914)、sensitivity (0.943) and specificity (0.830) of the KS+ score (P＞0.05). Conclusions: Kaiser score is superior to ADC in distinguishing benign from malignant breast lesions, especially in non-mass enhancement lesions. Kaiser score also performs better in avoiding unnecessary biopsies compared with ADC. The combination of the Kaiser score and ADC does not contribute to the diagnosis of breast cancer.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application of magnetic resonance diffusion-weighted imaging in prognostic evaluation of microwave ablation of hepatocellular carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.022</link>
<description><![CDATA[Objective: To investigate the application value of magnetic resonance diffusion-weighted imaging (MR-DWI) in the prognostic assessment of patients with hepatocellular carcinoma (HCC) that underwent microwave ablation (MVA). Materials and Methods: Sixty two consecutive patients with HCC treated by MVA in the Department of Interventional Ultrasound, PLA General Hospital from October 2016 to August 2017 [35 males, 25 females, age (57.8±3.56) years old] were retrospectively enrolled in our study. All patients underwent MR-DWI examination within 1 week before and after MVA, and regular follow-up. To analyze the value of DWI in the prognostic evaluation of MVA for HCC. Results: A total of 73 lesions in 62 patients with primary liver cancer were completely ablated. During follow-up, 23 cases had early recurrence and metastasis (13 cases of local recurrence, 8 cases of intrahepatic metastasis, and 2 cases of extrahepatic metastasis). The area under the ROC curve of the apparent diffusion coefficient (ADC) and exponential apparent diffusion coefficient (eADC) for evaluating early recurrence and metastasis after microwave elimination are 0.901 and 0.875 respectively, and the best diagnostic cut-off value is 1.27×10-3 mm2/s (sensitivity: 93.1%, specificity: 90.6%), 0.364 (sensitivity: 87.9%, specificity: 89.5%); according to the follow-up results, the enrolled patients were divided into early recurrence group and no-early recurrence group. The ADC value of patients in no-early recurrence group [(1.43±1.52)×10-3 mm2/s] was significantly higher than that of the early recurrence and metastasis group [(1.15±0.94)×10-3 mm2/s] (P＜0.05); eADC value in no-recurrence group (0.42±0.04) was significantly higher than that of early recurrence group (0.32±0.04), and the difference was statistically significant (P＜0.05). Multivariate analysis showed that ADC value and eADC value and safety margin after ablation were independent predictors of recurrence-free survival (RFS) after MVA of liver cancer. Conclusions: The preoperative ADC value and eADC value have certain clinical value in predicting the early recurrence and metastasis of liver cancer after MVA.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The differential diagnosis value of quantitative parameters of hepatobiliary phase from Gd-EOB-DTPA enhanced MRI in differentiating benign biliary strictures from malignant strictures]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.023</link>
<description><![CDATA[Objective: To investigate the differential diagnosis value for differentiating benign and malignant biliary strictures using quantitative parameters of hepatobiliary phase (HBP) from gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) enhanced MRI. Materials and methods: The Gd-EOB-DTPA enhanced MRI images of 143 cases with biliary strictures were retrospectively analyzed, including 71 cases with benign strictures and 72 cases with malignant strictures. The relevant parameters of HBP enhancement ratio were calculated, including liver parenchyma enhancement ratio (LER), kidney medulla enhancement ratio (KER), corrected parameter of liver parenchyma enhancement ratio (LERc) and corrected parameter of kidney medulla enhancement ratio (KERc). Functional liver imaging score (FLIS) were calculated on HBP images from Gd-EOB-DTPA enhanced MRI. We compared the differences of relevant parameters of enhancement ratio, FLIS and related laboratory indexes between benign and malignant biliary strictures. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy in differentiating benign biliary strictures from malignant strictures using HBP quantitative parameters. Results: LER of benign and malignant strictures was 73.4% (51.3%) and 36.2% (32.0%), respectively. LERc of benign and malignant strictures was (39.3±25.4)%and (12.0±15.3)%, respectively. The FLIS of benign and malignant biliary strictures was 5.0 (4.0) score and 2.0 (1.0) score, respectively. The differences were all statistically significant for above parameters (P＜0.001). The area under the curve (AUC) of LER was 0.769 in differentiating benign from malignant biliary strictures, and the AUC of LERc was 0.818. The AUC of FLIS in differentiating benign from malignant biliary strictures was 0.810. The AUC of combining LER and FLIS was 0.836. The AUC of combining LERc and FLIS was 0.851. Conclusions: The parameters of hepatic enhancement ratio from HBP Gd-EOB-DTPA enhanced MRI and FLIS were both valuable in differentiating benign from malignant biliary strictures, with even better diagnostic efficiency on their combination.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Clinical study of the effect of P53 on the degree of osteoarthritis space stenosis based on magnetic resonance imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.024</link>
<description><![CDATA[Objective: To identify and analyze the differentially expressed genes in osteoarthritis (OA) using bioinformatics techniques, and clinical data were used to study the effect of P53 on the degree of OA gap stenosis based on MRI. Materials and Methods: Microarray data (GSE55235) were downloaded and GEO2R was used to identify differentially expressed genes (DEGs) between OA patients and normal synovial samples. The enrichment analysis for the differentially expressed genes was performed by using the gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Protein-protein interaction network (PPI) analysis was further constructed to identify important modules and identify core genes. Fifty patients with OA space stenosis were selected, and their bone and joint conditions were detected by MRI, and their clinical data were analyzed by Pearson Chi-square test, Spearman correlation analysis and multivariate Logistic regression. Results: The difference of synovial tissue between control group and OA group was analyzed. Analysis of GSE55235 identified 91 differentially expressed genes. DEGs enrichment analysis comprehensively summarized some main pathophysiological mechanisms of OA: cell response to hydrogen peroxide, P53 signaling pathway. Four hub genes were identified: MMP1, CXCL8, VEGFA and JUN. Compared with the normal group, MMP1 was highly expressed in the OA group, while CXCL8, VEGFA and JUN were down-regulated in the OA group. Pearson Chi-square test, Spearman correlation analysis and multiple Logistic regression results showed that P53 was significantly correlated with the degree of OA space stenosis (OR=0.112, 95% CI: 0.025-0.495, P=0.004), while gender, age, MMP1, VEGFA and CXCL8 were not significantly correlated with the degree of OA space stenosis (P values were all greater than 0.05). Conclusions: In conclusion, based on MRI results, it is concluded that cell reaction to hydrogen peroxide and P53 signaling pathway can provide new research targets for the diagnosis and treatment of OA. The low expression of P53 in OA patients may be a potential therapeutic target. MRI is also beneficial to early diagnosis and treatment of OA patients and reduce the incidence of OA.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of MRI radiomics in mild cognitive impairment]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.027</link>
<description><![CDATA[Mild cognitive impairment (MCI) is the early manifestation of Alzheimer<sup><sup>,</sup></sup>s disease (AD). At present, there is no effective radical cure for AD. Therefore, early diagnosis and intervention of MCI are of great significance to prevent or delay the development of AD. MRI radiomics can extract and analyze the features of MCI patients<sup><sup>,</sup></sup> images in a non-invasive way, which can provide more potential imaging biomarker information, and then guide clinical accurate diagnosis and treatment, which has a broad development prospect. This paper reviews the concept of radiomics and the research progress of MRI radiomics in the diagnosis, classification and conversion prediction of MCI.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress of multimodal MRI and radiomics in evaluation of Parkinson<sup><sup>,</sup></sup>s disease with depression]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.028</link>
<description><![CDATA[Depression is a common type of non-motor symptoms in Parkinson<sup><sup>,</sup></sup>s disease (PD). PD with depression (DPD) can aggravate motor and cognitive dysfunction, and lead to poor prognosis. Therefore, for the early diagnosis and timely intervention of DPD, there is a great significance to improve the condition and alleviate the deterioration of other symptoms. Unfortunately, the symptoms of DPD are easy to overlap with other symptoms of PD, which is difficult to find in the process of clinical diagnosis and treatment. These imaging techniques such as voxel-based morphometry (VBM), resting-state functional magnetic resonance imaging (rs-fMRI), diffusion tensor imaging (DTI), diffusion spectrum imaging (DSI), and high angular resolution diffusion imaging (HARDI) can objectively show not only changes in the structure but also functional of the central nervous system. In addition, the imaging characteristics of lesions can be extracted by radiomics to improve the accuracy of diagnosis and differential diagnosis. Therefore, this paper reviews the research progress of multimodal MRI and radiomics in DPD in recent years.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress in the application of chemical exchange saturation transfer imaging in glioma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.029</link>
<description><![CDATA[Glioma is the most common primary central nervous system tumor with strong invasiveness and poor prognosis. Its growth is accompanied by changes in the contents of protein, glutamic acid, amine and other substances. Chemical exchange saturation transfer (CEST) imaging is a novel and noninvasive MRI mechanism, relying on the exchange between the mobile protons in amide (-NH), amine (-NH2) and hydroxyl (-OH) and bulk water. It can reflect the changes of the mobile protons content in the protein or peptide and pH value in the tissue at the molecular level. It can detect and quantify changes within gliomas at the molecular level. In this article, the principle, the applications in the diagnosis and classification, grading, molecular typing prediction and response evaluation of gliomas and the shortcoming of CEST were reviewed.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[MRI research progress of vasogenic edema after traumatic brain injury]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.030</link>
<description><![CDATA[Traumatic brain injury (TBI) is a common life-threatening disease, while cerebral edema is the main factor affecting the mortality and subsequent functional recovery of TBI. Different types of edema usually require different clinical treatments, and vasogenic edema is the main form. Conventional magnetic resonance sequences are limited in their ability to identify the type and extent of edema. With the increasing innovation of MRI functional sequences, various functional magnetic resonance imaging (fMRI) studies have their own unique characteristics in the study of vasogenic brain edema after TBI. Relevant studies have applied fMRI sequences such as diffusion weighted imaging, diffusion tensor imaging, free water diffusion tensor imaging and diffusion kurtosis imaging, and achieved satisfactory results. Other fMRIs, such as magnetization transfer and susceptibility imaging, have also shown their due role in this field. This article concludes and summarizes the MRI research progress of vasogenic brain edema after TBI, in order to provide an updated and more comprehensive theoretical basis and examination methods for the prevention, treatment and prognosis of vasogenic brain edema after TBI.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application and prospect of preoperativeMRI in predicting the prognosis of breast cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.031</link>
<description><![CDATA[Breast cancer is the most common cancer in women and the top 5 in terms of mortality, and its prognostic factors are complex. In recent years, MRI has actively explored imaging markers related to breast cancer prognosis, including morphology, hemodynamics, functional imaging, radiomics and many other parameters. The study confirmed that tumor size and edge, non-mass-like enhancement, rim enhancement, peritumoral edema, and background enhancement are morphological parameters related to prognosis; hemodynamic time-intensity curves (TIC) and quantitative and semi-quantitative parameters are associated with prognosis to varying degrees; although there are still some controversies, diffusion-weighted imaging (DWI) and its derived techniques have shown great potential in prognosis prediction; MRI-based radiomics has further revealed more high-dimensional parameters related to prognosis, and computer-guided artificial intelligence is emerging. This article reviews the research progress of preoperative MRI in predicting the prognosis of breast cancer, and provides a reference for the next related research in this field.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application progress of hepatobiliary specific contrast agent MRI in diffuse disease of the liver]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.032</link>
<description><![CDATA[MRI plays an important role in the detection and diagnosis of liver disease. As a new type of cell-specific contrast agent, hepatobiliary-specific contrast agent can be specifically taken up by normal hepatocytes, while the uptake of impaired hepatocytes is reduced. This characteristic not only makes it possible to obtain information of the overall liver function, but also has unique advantages in the assessment of segmental liver function. This article first introduces the principle of hepatobiliary specific contrast agent MRI, and the application progress in liver diffuse disease such as fatty liver, liver fibrosis, hepatitis, cirrhosis, liver ischemia is reviewed. The combination of hepatobiliary specific contrast agent and artificial intelligence methods in liver function assessment have also been reviewed.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[The application progress of artificial intelligence in gastric cancer imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.033</link>
<description><![CDATA[Gastric cancer (GC) is one of the most common cancers and one of the leading causes of cancer-related death in China. The non-invasive accurate diagnosis is fundamental to optimal therapeutic decision-making. Artificial intelligence (AI) techniques, particularly radiomics and deep learning, have brought new research hotspots in interdisciplinary of imaging and gastric cancer diagnosis and treatment. AI has been used widely in GC research, because of its ability to convert medical images into minable data and to detect invisible textures. In this article, we systematically reviewed the methodological processes and current clinical applications involved in AI. Challenges and opportunities in AI-based GC research are highlighted.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Development of artificial intelligence in diagnosis and treatment of spinal diseases]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.034</link>
<description><![CDATA[Artificial intelligence mainly refers to machine learning, and deep learning is a specific type of mechine learning. The technologies in the field of artificial intelligence, especially the deep learning methods, have been widely used in medical image and big data processing, including image reconstruction, image processing, image analysis and model construction. By using the related methods of artificial intelligence, we can achieve the aim of location and segmentation of spinal structure, and the comprehensive analysis of spinal diseases, such as the diagnosis and differential diagnosis, clinical decision support and prognosis prediction, which provides the basis for the selection of the most reasonable treatment of spinal diseases.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application progress of whole body-magnetic resonance imaging in common tumors and screening progress in high-risk groups]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.035</link>
<description><![CDATA[With the continuous development of society, the incidence of cancer is increasing year by year. Improving the early detection rate of lesions is helpful for clinicians to formulate effective diagnosis and treatment plans, which is of great significance to improve the survival rate and quality of life of cancer patients. Whole body-magnetic resonance imaging (WB-MRI) has great advantages in early detection of tumor lesions and screening of tumor high-risk population. WB-MRI has no ionizing radiation and high resolution of soft tissue, and it can make up for the disadvantages of high radiation dose and low soft tissue resolution in positron emission tomography/computed tomography (PET/CT), and has been verified in practical application. It can be used in early tumor lesion detection, imaging diagnosis, tumor clinical staging and therapeutic effect evaluation. At the same time, the bone destruction of metastatic bone tumor and the bone marrow infiltration of hematological tumor can be detected out. Through reviewing a large number of literatures, the author found that WB-MRI has the advantages of high accuracy and sensitivity in the detection of hematologic tumors and bone metastases as well as the screening of tumor high-risk groups. To sum up, this paper reviews the clinical application progress of WB-MRI in the detection of respiratory system tumors, digestive system tumors, hematologic tumors and bone metastases as well as the screening of tumor high-risk population.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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<title><![CDATA[Application progress of imaging technology in high-pressure injection injury]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2022.06.036</link>
<description><![CDATA[High-pressure injection injury is a serious compound injury. The early clinical manifestations include small wounds and mild symptoms. However, the disease progresses relatively rapidly. Delay of debridement can even lead to amputation. The use of imaging technology can evaluate injection of foreign materials and the changes in tissue structure caused by high-pressure injection injury, including diffusion of foreign materials, invasion of soft tissue, infection and blood supply. To further explore the relationship between imaging features and tissue damages caused by high-pressure injection injury. This article reviews the application progress of X-ray, CT, MRI and ultrasonography in the diagnosis and treatment of high-pressure injection injury.]]></description>
<pubDate>Mon,20 Jun 2022 00:00:00  GMT</pubDate>
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