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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=202007</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[Predicting the histological classification of cervical squamous cell carcinoma based on multi-sequence MRI radiomics model]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.001</link>
<description><![CDATA[Objective: To investigate the value of radiomics model based on no-contrastenhanced multi-sequence MRI in predicting the histological classification of cervical squamous cell carcinoma. Materials and Methods: One hundred and three patients with cervical squamous cell carcinoma histological confirmed underwent conventional noncontrast-enhanced magnetic resonance imaging examination and were randomly divided into training dataset and test dataset according to 3︰1. The tumor region of interest was delineated in each sequence image, and the radiomics features of tumours based on T1WI, T2WI and FS-T2WI were extracted and filtered. The naive Bayesian algorithm was used to separately create the model by T1WI, T2WI, FS-T2WI and combined all features and to perform crossvalidation in training dataset. Each model was tested and evaluated in testing dataset. Results: The AUC value of each model predicting non-keratinized results in the training dataset was 0.718, 0.705, 0.756, and 0.863, and which were statistically significant (P＜0.001). In the testing dataset, combined model predicting non-keratinized results are the best. The AUC value was 0.860, P=0.003, the accuracy rate was 0.720, and the recall rate is 0.900. The pairwise comparison of the combined model with T1 model prediction in the delong test had a statistically significant difference in the predicting non-keratinized ROC curve (P＜0.05).Conclusions: The radiomics model based on MRI of multi-sequence can predict the nonkeratinized type of cervical squamous cell carcinoma, and the prediction model combined with multi-sequences predicted greater.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Clinical value of reduced field-of-view diffusion-weighted imaging in cervical cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.002</link>
<description><![CDATA[Objective: To compare the clinical efficacy of reduced field-of-view (r-FOV) diffusion-weighted imaging (DWI) in cervical cancer with full field-of-view (f-FOV) DWI. Materials and Methods: The data of 252 patients who underwent gynecological pelvic magnetic resonance examination from June 2015 to January 2017 were retrospectively analyzed. Fifty patients who were both positive for medical examination and magnetic resonance examination were included in the cervical cancer group. Resonance examination of 40 patients with no abnormal cervical cervix and negative cervical scraping were included in the normal cervical group. Patients underwent conventional MRI, r-FOV DWI, and f-FOV DWI scans before surgery. Two imaging diagnostic physicians used double-blind methods to display anatomical details and magnetic sensitivity of the two groups of DWI images of 50 cases of cervical cancer. The subjective evaluation of shadow, geometric deformation, and overall diagnostic confidence were performed. The signal noise ratio (SNR) and carrier to noise ratio (CNR) of the two DWI images of the cervical cancer group were measured and calculated for objective evaluation, and the ADC values of the cervical cancer group and the normal group were analyzed and compared on r-FOV DWI. Results: The subjective scores and objective measurements of the two field DWI images of the cervical cancer group by the two diagnostic doctors were in good agreement (both ICC values＞0.7). The two subjective scores of anatomical details, magnetically sensitive artifacts, geometric deformation, and overall diagnostic confidence of the two DWI images are: r-FOV DWI group 2.82±0.85, 2.88±0.75, 2.86±0.78, 2.82±0.83; f -FOV DWI group 2.04±0.70, 1.96±0.61, 2.06±0.62, 2.16±0.71. The subjective scores of r-FOV DWI images were higher than those of f-FOV DWI, and the P-values of each score were P＜0.05. The difference was statistically significant. There was no significant difference in the SNR and CNR between the two groups of DWI images. The ADC value of cervical cancer group measured by r-FOV DWI was lower than the normal group, and the difference between the two was significant. Conclusions: In cervical cancer DWI examination, r-FOV DWI can effectively reduce image distortion and artifacts to obtain higher image quality and better lesion display effect than conventional f-FOV DWI. The measurement of ADC value can be more effective Make a good distinction between cervical cancer and normal cervix.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Prediction of microsatellite instability in endometrial carcinoma by multiple quantitative parameters of magnetic sensitive sequence]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.003</link>
<description><![CDATA[Objective: To explore the value of the quantitative parameters of enhanced T2 star weighted angiography (ESWAN) sequence in predicting microsatellite instability (MSI) of endometrial carcinoma (EC). Materials and Methods: The data of 35 patients with EC were analyzed retrospectively, included 13 cases of MSI and 22 cases of microsatellite stability (MSS). All patients were examined with 1.5 T MR before operation, the scanning sequence included ESWAN. The amplitude, phase, R2* and T2* images were created by post processing. The amplitude value, phase value, R2* value and T2* value were measured by two observers. The intra-class correlation coefficients (ICC) was used to test the consistency of the measurement results of the two observers, the independent sample t test or Mann Whitney U test was used to compare the differences between the two groups of cases, the receiver operator characteristic (ROC) curve was used to evaluate the effectiveness of each parameter in predicting MSI. Results: The data measured by the two observers had good consistency (ICC value＞0.75). The R2* value of MSI group (15.303±2.274) Hz was significantly higher than that of MSS group (13.051±1.595) Hz, while the T2* value of MSI group (71.883±8.323) ms was significantly lower than that of MSS group (84.246±12.553) ms (P＜0.05). No statistical differences were observed in the amplitude and phase values between two groups (P＞0.05). The AUC, sensitivity, specificity of EC MSI predicted by R2* value and T2* value were 0.797, 84.6%, 63.6% and 0.787, 84.6%, 68.2%, respectively. Conclusions: The R2* value and T2* value of ESWAN can forecast the MSI state of EC, which has certain clinical application value.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of DTI and DTT in the depth of myometrial invasion of endometrial cancer stage Ⅰ]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.004</link>
<description><![CDATA[Objective: The study aimed to evaluate endometrial cancer (EC) stage Ⅰ diagnostic value by comparing the diffusion tensor imaging (DTI) parameters and diffusion tensor tractography (DTT) of endometrial cancer stage Ⅰa and Ⅰb, normal myometrium. Materials and Methods: Analyzed the conventional magnetic resonance imaging (MRI) and DTI examination of 40 cases pathologically confirmed endometrial cancer patients and 23 cases normal women. ADW 4.5 station to record the region of interest (ROI) average apparent diffusion coefficient (ADC) value, fractional anisotropy (FA) value, volume ratio anisotropy (VRA) value, and T2-weighted trace (T2-WT) value, and rebuilt DTT. Compared the differences DTI parameters among endometrial cancer stage Ⅰa and Ⅰb, normal myometrium. Results: Endometrial cancer Ⅰa and Ⅰb were 27 and 13 respectively. The ADC value of endometrial cancer stage Ⅰb was lower than stage Ⅰa (t=-3.141, P=0.003), FA valve and VRA valve were higher than stage Ⅰa (t=2.767, 2.947; P=0.009, 0.006), there was no statistically significant of VRA value (P＞0.05). Compared with the myometrium, the ADC value was lower (t=-12.141, P=0.000), VRA value and T2-WT value were higher (t=2.523, 8.582; P=0.014,0.000), there was no statistical difference of FA value between stage Ⅰ endometrial cancer and myometrium (P＞0.05). DTT showed that the myometrium fibers of the endometrial cancer were decreased, the arrangement was disordered and irregular and interrupted. Conclusions: DTI parameters and DTT can reflect the microscopic changes to endometrial cancer stage diagnosis, and can be used as an auxiliary diagnosis method in the depth of myometrial invasion.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of ESWAN in diagnosis and differential diagnosis of endometrial carcinoma and endometrial polyp]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.005</link>
<description><![CDATA[Objective: The quantitative parameters of endometrial carcinoma (EC) and endometrial polyp (EP) under enhanced T2* weighted angiography (ESWAN) sequence were analyzed to explore the value of ESWAN in the differential diagnosis of endometrial carcinoma (EC) and endometrial polyp (EP). Materials and Methods: Routine MRI and ESWAN were performed on twenty-five pathologically-diagnosed EC patients and twenty EP patients. ESWAN adopted 5 echoes, with TR of 16.5 ms and TE of 2.1, 5.1, 8.0, 10.9 and 13.8 ms, respectively. Intratumoral susceptibility signal intensity (ITSS) display in the two groups of lesion phase diagrams was scored by two observers, and the Mann-Whitney rank sum test was used to compare the differences in the ITSS display in the two groups of lesion phase. The ESWAN parameters (magnitude value, R2* value and T2* value) were measured by the same two observers in both groups. Intra-class correlation coefficients (ICC) was used to test the consistency of the measurement results of the two observers, independent sample t-test was used to compare the ESWAN parameter values of the two groups of patients, and ROC curve was used to evaluate the diagnostic efficacy of the parameters with statistical difference. Results: The two observers measured data in each group with good consistency (ICC＞0.75). The ITSS scores of EC group and EP group were (1.60±1.29) were higher than that of EP group (0.85±0.99), respectively, and the difference between EC group and EP group was statistically significant (Z=-2.011, P=0.044). The magnitude value, R2* value and T2* value of EC were 817.77±269.65, (16.37±3.65) Hz, (70.56±20.99) ms, respectively. The magnitude value, R2* value and T2* value of EP were 885.43±254.36, (11.62±3.94) Hz, (121.91±54.13) ms, respectively. The R2* value of EC was higher than that of EP, and the T2* value was lower than that of EP, with statistically significant differences (P＜0.05). There was no significant difference in magnitude value between the two groups (P＞0.05). The AUC of R2* value and T2* value for EC diagnosis were 0.810 and 0.850, respectively, and the threshold were 14.969 and 71.233, respectively. Conclusions: R2* and T2* values are valuable for identifying EC and EP, and EC has more ITSS than EP on the phase map.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Application value of IVIM in predicting MGMT promoter methylation status in high-grade gliomas]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.006</link>
<description><![CDATA[Objective: Studies on intramoxin incoherent motion (IVIM) in predicting methylation of the high-grade glioma O6-methylguanine-DNA methyltransferase (MGMT) promoter application value of status. Materials and Methods: Thirty-four patients with high-grade glioma confirmed by pathology were collected, including 19 cases of WHO Ⅲ and 15 cases of Ⅳ. All patients underwent conventional craniocerebral MRI scans and IVIM scans before surgery. Tissue area, obtain true diffusion coefficient (D), perfusion related diffusion coefficient (D*), perfusion fraction (f), and divide the measured value of the tumor parenchyma by the normal brain on the opposite side In the substantial area, the corrected parameter values are obtained: relative D (relative D), relative D* (relative D*), and relative f (relative f). Two-sample independent t test is used to analyze the methylation group and non-methyl group of the MGMT promoter. The correction parameter differences between the groups were calculated, and receiver operating characteristic (ROC) curves were plotted to calculate the threshold, sensitivity, and specificity. Results: The rD and rf values of MGMT promoter methylation group in high-grade glioma was higher than that in non-methylation group, and rD* value were lower than those in non-methylation group. The differences were statistically significant (P＜0.05). The area under the ROC curve of rD, rD*, and rf values are: 0.856, 0.814, and 0.719; the thresholds are: 1.703, 1.058, and 1.756; the sensitivities are: 84.2%, 89.5%, and 63.2%; the specificities are: 73.3%, 60.0%, 93.3%. Conclusions: IVIM can non-invasively evaluate the methylation status of MGMT promoter in high-grade gliomas. Among them, rD* has high sensitivity, which can help guide patients' personalized diagnosis and treatment programs and assess prognosis.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[A research of the resting state network in patients with chronic neck and shoulder pain of cervical spondylosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.007</link>
<description><![CDATA[Objective: Based on resting-state functional magnetic resonance imaging, independent component analysis (ICA) was used to investigate the functional connectivity changes in the brain network of chronic neck and shoulder pain in cervical spondylosis. Materials and Methods: In our hospital 20 cases of patients with cervical myelopathy (CSM), 30 patients with cervical disc herniation patients (without spinal cord compression) (CDH) and 30 healthy controls (HC) with social recruitment were gathered. Then collected resting-state functional magnetic resonance data and used ICA to extract resting-state brain networks. In addition, analysis of comparison of intra-group network differences among the three groups, and correlation analysis of the different areas and clinical scales. Results: CSM group compared with HC group, the bilateral superior occipital gyrus functional connectivity was enhanced, and the left middle cingulate cortex, left postcentral gyrus, right precentral gyrus and left cerebellum 2 area functional connectivity were reduced. CDH group compared with HC group, the functional connectivity of the right superior frontal gyrus was enhanced, and the functional connectivity of the left middle cingulate cortex, right precentral gyrus, left postcentral gyrus was reduced. Correlation analysis results show, the functional connectivity values of the left postcentral gyrus in CDH was negatively correlated with the visual analogue scale scores (r=-0.535, P=0.002), the functional connectivity values of the left superior occipital gyrus in CSM was negatively correlated with the beck anxiety inventory scores (r=-0.448，P=0.048). Conclusions: There are abnormal functional connectivity in multiple resting-state brain networks in patients with chronic neck and shoulder pain, which are closely related to pain perception, emotional perception, and movement disorders.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Study on the application of DTI technology in the subtle structural changes of the brain in hypertensive patients with and without obstructive sleep apnea]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.008</link>
<description><![CDATA[Objective: Using diffusion tensor imaging (DTI) to investigate the subtle structural changes in the hypothalamus of patients with and without hypertension and sleep disorders. Materials and Methods: Twenty patients with hypertension and sleep disorder from the Second Affiliated Hospital of Xinjiang Medical University were selected as the case group. Twenty patients with hypertension without sleep disturbance were taken as the control group, using DTI technology score of two groups of patients with hypothalamic fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value. Statistical methods were used to retrospectively compare the differences of FA and ADC values between the two groups, and evaluate the correlation between the two groups of FA value, ADC values. Results: FA=0.31±0.11 in the case group, FA=0.50±0.12 in the control group, P=0.00. The FA value in the case group was significantly lower than that in the control group, and the difference was statistically significant (P＜0.05). ADC in the case group was 1.84±0.73, ADC in the control group was 1.45±0.41, P=0.045. ADC value in the case group was higher than that in the control group, with statistically significant difference (P＜0.05). At the same time, it was found that the analysis results of the correlation between the duration of hypertension and the score of sleep disorders showed that r=0.836, P＜0.001, indicating that there was a significant positive correlation between the duration of hypertension and the score of sleep disorders (P＜0.05). Conclusions: DTI technology can be found that there are subtle structural changes in the hypothalamus in patients with and without hypertension and sleep disorders.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Routine MRI study of craniopharyngioma with brain invasion]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.009</link>
<description><![CDATA[Objective: To explore the routine MRI characteristics of craniopharyngioma (CP) with brain invasion. Materials and Methods: The retrospective study recruited 138 patients with CP which was proven by post-operative pathology. The preoperative MRI was analyzed, focused on obstructive hydrocephalus and tumor size. These radiological indices and the pathological ratio of adamantinomatous type were compared between the adult (64 cases) and the juvenile patients (74 cases). The radiological and pathological indices, patient age and sex were also compared between tumors with and those without brain invasion. Finally, according to brain invasion which was pathologically diagnosed, both the adult and juvenile patients were divided into two sub-groups with the indices compared. Results: (1) Grouped by age: ① The tumor volume in the adult and juvenile group was 8619.5 (5358.0—12568.8) mm3 and 11469.0 (5367.4—26560.1) mm3, respectively. The difference was significant (P=0.008). ② The ratio of adamantinomatous CP was 56.3% (36/64) in the adult group, significantly lower than that of the juvenile group [83.8% (62/74); χ2=12.640, P＜0.01]. (2) Grouped by invasion: ① The ratio of hydrocephalus was 46% (22/48) in the invasive group and 18% (16/90) in the non-invasive group, significantly different (χ2=12.349, P＜0.01). ② The ratio of adamantinomatous CP was 90% (43/48) in the invasive group and 61% (55/90) in the noninvasive group, with a significant difference (χ2=12.329, P＜0.01). (3) In the adult group, the ratio of adamantinomatous type was 78% (18/23) and 44% (18/41) in the invasive and noninvasive sub-group, respectively, showing a significant difference (χ2=7.068, P=0.008). (4)In the juvenile group: ① The ratio of adamantinomatous tumor was 100% (25/25) and 76% (37/49) in the invasive and non-invasive subgroup, respectively, significantly different (χ2=5.616, P=0.018). ② The ratio of hydrocephalus was 60% (15/25) in the invasive sub-group and 20% (10/49) in the non-invasive sub-group. The difference was significant (χ2=11.600, P=0.001). Conclusions: The tumor volume and pathological types are different in CP patient with different age. CP with brain invasion shows a preference of adamantinomatous type,obstructive hydrocephalus, and younger age.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[A comparative study of 3.0 tesla cardiac magnetic resonance imaging on cardiac structure and function of healthy normal people in plateau and plain areas]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.010</link>
<description><![CDATA[Objective: To compare the differences in cardiac structure and function between healthy and normal people in the plateau and plain areas by cardiac magnetic resonance imaging (CMRI). Materials and Methods: One hundred normal healthy people underwent CMRI (n=50 each from plateau and plains areas). Cardiac structural parameters, such as anterior wall thickness of interventricular septum (AWOIVS), left atrial diameter (LAD), left ventricular end diastolic diameter (LVEDD), aortic diameter (AOD), main pulmonary artery diameter (MPAD), right atrial transverse diameter (RATD), right atrium long diameter (RALD), right ventricular transaction diameter (RVTD) and right ventricular long diameter (RVLD), and left ventricular functional parameters were measured. Independent-sample t-test was used to compare and analyse the differences in parameters between the two groups. Results: In the cardiac structure, the AWOIVS and MPAD in the plateau group were significantly larger than those in the plain group (P＜0.05), and the LVEDD in the plateau group was significantly smaller than the plain group. (P＜0.05). In the left heart function, the LVEDV in the plateau group was significantly smaller than that in the plain group (P＜0.05). The LVEF in the plateau group was larger than that in the plain group, and the difference was not statistically significant (P＞0.05). Conclusions: Compared with healthy people in plain area, healthy normal people in plateau area have some changes in heart structure and function, with increased thickness of anterior ventricular septum, wider inner diameter of main pulmonary artery, and reduced left ventricular volume. Healthy normal people in plateau area have strong heart reserve capacity and oxygen uptake capacity.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of ADC value in T staging and histologic differentiation grade of esophageal cancer]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.011</link>
<description><![CDATA[Objective: To analyze the correlation with T stage, histologic differentiation grade of esophageal cancer. Materials and Methods: A total of 45 pathologically confirmed patients with esophageal cancer were included. Mean tumor apparent diffusion coefficient (ADC) for different histologic differentiation grades, T-stages were measured and compared. Results: The average ADC value of esophageal cancer was negatively correlated with the T staging, and the ADC value decreased with the increase of T staging. The results of Spearson correlation analysis showed that average ADC value was negatively correlated with T stage (r=-0.645, P＜0.01). The average ADC value of the low-differentiation group was lower than that of the medium-high differentiation group (1.8514±0.40295)×10-3 mm2/s, 1.7125±0.37767)×10-3 mm2/s). There were no significant differences in ADC value no matter what kind of histological grade. Conclusions: DWI was useful for evaluating T stage of esophageal cancer,and can reflect the clinical T stage of esophageal cancer, providing help for clinical treatment.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparison between IVIM parameters and ADC value in rectal cancer for estimate histological grade]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.012</link>
<description><![CDATA[Objective: To compare the value between intravoxel incoherent motion (IVIM) parameters and ADC value in assessing the histological differentiation grade of rectal adenocarcinoma. Materials and Methods: Ninety-three patients of rectal adenocarcinoma were enrolled and were analyzed MR images retrospectively. The parameters from IVIM (D, D*, f) and ADC value were measured. All parameters between different differentiation grade of rectal adenocarcinoma were compared. ROC analysis was used to assess the diagnostic performance in distinguishing well/moderately and poorly differentiated. Spearman correlation analyses were used among the IVIM parameters and histological differentiation grade. Results: There were significant differences in terms of ADC, D and f value between different differentiation grade of rectal adenocarcinoma (P=0.032, 0.000, 0.025 respectively). D value achieved the highest AUC in distinguishing well/moderately and poorly differentiated, when a cutoff value was 2.465×10-3 mm2/s, the sensitivity and specificity were 66.7% and 79.6%. The D value exhibited a moderate relationship with differentiation grade of rectal adenocarcinoma with |r| value of 0.441. The ADC and f value exhibited a poor relationship with differentiation grade, which |r| value were 0.249 and 0.246 respectively (all P＜0.05). Conclusions: Both parameters from IVIM and ADC value could be helpful in differentiating histological differentiation grade of rectal adenocarcinoma. D value achieved the better diagnostic performance.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[The correlation between multiparametric MR imaging characteristics of breast cancer and axillary lymph node metastasis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.013</link>
<description><![CDATA[Objective: To explore the MR imaging features of breast tumor in correlation with axillary lymph node metastasis in breast cancer patients. Materials and Methods: Two hundred and sixteen patients with breast cancer were confirmed by surgery and pathology were retrospectively reviewed at our institution between January 2016 to December 2016. According to the postoperative pathological results, the patients were divided into axillary lymph node metastasis [ALNM (+)] and non-metastasis lymph node group [ALNM (-)]. The MRI features of the primary breast cancer lesions were recorded by two experts. The MR image characters including: the corpus mamma patterns, background parenchymal enhancement, tumor size, tumor location, multifocality, signal characteristics of T2WI, ADC value, enhancement pattern, time-intensity curve (TIC) curve type and the axillary lymph node status. The continuous variables was studied using Mann Whitney U test, and The categorical variables was studied using χ2 tests and Fisher exact test. Results: The sensitivity, specificity and accuracy of MRI for metastatic axillary lymph nodes was 63.64%, 94.41%, 86.57%, respectively. Statistical differences were found between ALNM (+) group and ALNM (-) group in tumor location, tumor size, ADC value, multifocality. There were no statistical differences between ALNM (+) group and ALNM (-) group in age, the corpus mamma patterns, background parenchymal enhancement, signal characteristics of T2WI, enhancement pattern, TIC curve type. Drawing the ROC curve according to the tumor size and ADC values, the AUC was 0.686 (P=0.000, 95% CI=0.609—0.762), 0.771 (P=0.000, 95% CI=0.704—0.838). When the threshold of tumor size was set at 1.95 cm, the diagnostic sensitivity and specificity were 70.9% and 55.9%, respectively. when the threshold of ADC was set at 1.125×10-3 mm2/s, the diagnostic sensitivity and specificity were 80% and 60.9%, respectively. Conclusions: Preoperative MRI can effectively evaluate axillary lymph node metastasis of breast cancer. Breast tumor location, size, multifocality and ADC value have a good correlation with axillary metastasis lymph nodes.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of mono-exponential, bi-exponential and stretched exponential DWI models in identifying prostate cancer and stromal prostate hyperplasia]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.014</link>
<description><![CDATA[Objective: To compare the value of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging (DWI) models in identification of prostate cancer and prostate hyperplasia. Materials and Methods: Retrospective analysis of puncture biopsy confirmed prostate cancer (PCa) 28 cases, stromal prostate hyperplasia (SH) 22 cases of clinical data. All patients underwent T2WI, T1WI, DWI, multi-b DWI scan. According to the results of puncture pathology to determine the location of cancer or hyperplasia, with DWI and multi-b value DWI images to match. ADC, D, D*, f and DDC, α values were measured in PCa group and SH group. Differences were compared using independent t test, receiver operating characteristic (ROC) to differentiate the diagnostic efficacy, Correlation analysis using Sperman or Pearson. Results: (1) ADC, D, DDC, α were lower in the PCa group (0.72±0.14×10-3 mm2/s, 0.57±0.11×10-3 mm2/s, 0.71±0.14×10-3 mm2/s, 0.63±0.03) than in the SH group (1.14±0.13×10-3 mm2/s, 0.94±0.12×10-3 mm2/s, 1.30±0.17×10-3 mm2/s, 0.76±0.05) the difference was statistically significant. D* was higher in the PCa group (17.96±13.39×10-3 mm2/s) than in the SH group (10.28±4.96×10-3 mm2/s), the difference was statistically significant. f was slightly higher in the PCa group (0.30±0.08) than in the SH group (0.29±0.05) , the difference was no statistically significant. (2) DDC, D, ADC, α all have higher diagnostic performance, the area under the curve (AUC) values were 0.9961, 0.9957, 0.9903, 0.9573 respectively; the diagnostic threshold were 0.97×10-3, 0.70×10-3, 0.86×10-3, 0.69. (3) ADC, D, DDC have good correlation both in PCa and SH groups. The PCa group had the strongest correlation with ADC and DDC, the coefficient r=0.852; the correlation between ADC and D was the strongest in SH group, the correlation coefficient r=0.751. Conclusions: DDC, α calculated from stretched exponential model, D calculated from bi-exponential model and ADC calculated from mono-exponential model in the identifying prostate cancer and stromal prostate hyperplasia all have high performance. MRI has obvious advantages in the diagnosis and differential diagnosis of PCa, and different DWI models become its beneficial supplements, the bi-exponential model can provide perfusion information, the stretched exponential model can provide diffusion heterogeneity information. However, the diagnostic performance of the biexponential model and the stretched exponential model is not higher than the traditional monoexponential model, so DWI is still recommended in clinical practice.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[The advantage of advanced diffusion-weighted imaging compared with single index DWI in differentiating transitional zone prostate cancer and benign prostatic hyperplasia]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.015</link>
<description><![CDATA[Objective: To investigate the advantage of advanced diffusion-weighted imaging in the differential diagnosis of transitional zone prostate cancer (TZ-PCa) and benign prostatic hyperplasia (BPH) compared with single index diffusion-weighted imaging (DWI). Materials and Methods: Forty-eight patients with TZ-PCa and 56 patients with BPH confirmed by pathology were collected. All patients were scanned with conventional sequence, single index DWI and advanced diffusion weighted imaging sequence. advanced diffusion weighted imaging included introvoxel incoherent movement DWI (IVIM-DWI), stretched exponential DWI model (SEM) and diffusion kurtosis imaging (DKI). Measure the diffusion coefficients (ADC, ADCslow, DDC) from single index DWI, IVIM-DWI and SEM and average kurtosis (MK) from DKI, independent sample t-test was used to compare the differences of these parameters between the two groups. The ROC curve was used to evaluate the effectiveness of the parameters in the differential diagnosis of TZ-PCa and BPH, and the AUC between the parameters was compared by Z-test. Results: there were significant differences in ADC, ADCslow, DDC and MK between TZ-Ca and BPH (P＜0.001). The diagnostic efficiency of MK, DDC, ADCslow, ADCslow+DDC+MK and ADC value were all higher (AUC＞0.9), the diagnostic efficiency of MK, DDC and ADCslow+DDC+MK was better than ADC value (P＜0.05), the diagnostic efficiency of ADCslow+DDC+MK was the highest (AUC=1), and the combined parameters had better sensitivity and specificity than single parameters. Conclusions: advanced diffusion-weighted imaging is superior to the single index DWI in the differential diagnosis of TZ-PCa and BPH. ADCslow+DDC+MK can further improve the sensitivity and specificity of the diagnosis.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[USPIO-DSC MRI study on acupuncture improving cerebral blood flow of pMCAO rats by regulating levels of inflammatory cytokines]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.016</link>
<description><![CDATA[Objective: To evaluate the effectiveness of acupuncture on improving CBF and CBV within infarcted areas during acute-stage by regulating serum levels of inflammatory cytokines in permanent middle cerebral artery occlusion (pMCAO) model rats with ultrasmall superparamagnetic particles of iron oxides (USPIO) dynamic susceptibility contrast (DSC) MRI. Materials and Methods: Twenty-four SD rats models were established, including sham-operation group (group A, n=6), pMCAO group without acupuncture (group B, n=10), pMCAO group with electroacupuncture (group C, n=8). Each group was further divided into 2 subgroups according to 24 h and 48 h after modeling. Rats in the group C were treated with electroacupuncture on Baihui, Shuigou and right Zusanli acupoints. Every rat in each group was scanned with USPIO-DSC on a 1.5 T MR scanner. The values of the relative cerebral blood volume (rCBV) and the relative cerebral blood flow (rCBF) on regions of infarct and contralateral in mirror areas were measured. The ratios (infarct/contralateral) of rrCBV and rrCBF were calculated. These ratios on 24 h and 48 h were compared to evaluate whether there were any statistical differences among Group A, B and C. Spearman correlation coefficients were calculated between the ratios rrCBV and rrCBF of Group B plus C and values of IL-1β, IL-6, IL-10 and TNF-α, respectively. Results: The values of rrCBV and rrCBF were significantly higher in group A than those in group B and C on 24 h and 48 h (P＜0.05). The values of rrCBV and rrCBF were significantly higher in group C than those in group B on 24 h and 48 h (P＜0.05). On 24 h, the values of rrCBV and rrCBF of group B plus C were significantly negatively correlated with the values of IL-1βand IL-6, and positively correlated with the values of IL-10 (P＜0.05). The values of rrCBV of group B plus C were significantly positively correlated with the values of TNF-α on 24 h (P＜0.05). On 48 h, the values of rrCBV and rrCBF of group B plus C were significantly negatively correlated with the values of IL-1β, and positively correlated with the values of IL-10 (P＜0.05). Conclusions: The blood supply of infarct areas during acute stage in pMCAO rats is improved on acupuncture by down-regulating the serum levels of IL-1β and IL-6 to reduce the inflammatory response and up-regulating the serum levels of IL-10 and TNF-α to increase the rrCBV and rrCBF in the infarct areas.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Combination of CBF and SWI for the changes of the vision areas with directional visual fatigue]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.017</link>
<description><![CDATA[Objective: Functional magnetic resonance imaging (fMRI) was applied to investigated the changes of the brain vision functional areas (the occipital lobe) of different vision states (directional vision, rest with closed eyes and free vision states). Materials and Methods: Selected twenty-one healthy volunteers in this experiment. All subjects underwent experimental training and test, and the data of test phase were used as the final evaluation indexes. The experiment test was conducted by three stages in order, directional vision, rest with closed eyes and free vision states. In the stage of directional vision, the visual fatigue time (VFT) of the subject was obtained, and which was taken as the beginning time of MRI test of the subject in the three visual states. Cerebral blood flow (CBF) and susceptibility weighted imaging (SWI) were combined to assess the changes of blood flow and oxygen saturation of the visual cortex in three visual states. Univariate ANOVA analysis was used to analyze the differences between the observed values of three groups. Results: After training, VFT was extended (35±15) s in training phase and (50±6) s in test phase (P=0.07). Taken the state of rest with closed eyes as the baseline, the free vision had an marked increased CBF of the visual cortex (P=0.05), but directional vision presented a significant decrease of CBF (P＜0.001). SWI phase value characteristically displayed an orderly increasing trend in three vision states of rest with closed eyes, free vision and directional vision. Directional vision presented a marked rise of averaged SWI phase value than free vision (P=0.03) and than rest with closed eyes (P=0.02). Conclusions: Quick decline of blood flow and oxygen saturation of the brain vision functional areas in directional visual state might be the physiological basis for its prone to fatigue.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Feasibility study on application of MAGiC sequence in sacroiliac joint of young volunteers]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.018</link>
<description><![CDATA[Objective: To explore the feasibility of applying magnetic resonance image compilation (MAGiC) sequence to MR examination of sacroiliac joint in young volunteers. Materials and Methods: All participants (14 male, 16 female) underwent conventional sequences and MAGiC sequence scanning. Image quality, atifacts, the signal to noise ratio (SNR) and the carrier to noise ratio (CNR) were assessed independently by two observers (a radiologist and a radiologic technologist) on both conventional sequences (T1WI-FSE, T2WI-FSE, STIR) and MAGiC sequences (T1WI, T2WI, STIR). Kappa (K) statistic was used to evaluate the consistency of observers. T2 value of subchondral bone were measured on MAGiC T2-mapping images. Results: Thirty young volunteers were performed MR examination (60 sacroiliac joints included). The image quality scores of conventional sequences T1WI, T2WI and STIR were 5 (0), 5 (0) and 5 (0), which of MAGiC reconstruction sequences were 5 (1), 5 (1) and 3 (2), with statistically significant differences (P＜0.05). The consistency check between observers showed K＞0.61. The SNR of T1WI sequence and MAGiC T1WI sequence were 12.61±0.37, 13.96±0.52 (t=-2.63, P＜0.05), the CNR of two sequences were 1.06±0.04, 1.18±0.28 (Z=-2.373，P＜0.05). The SNR of T2WI sequence and MAGiC T2WI sequence were 12.84±0.48, 112.63±0.45 (t=0.447，P＞0.05), the CNR of two sequences were 1.57±0.05, 1.54 (0.03)(Z=-1.486, P＞0.05). The SNR of STIR sequence and MAGiC STIR sequence were 8.36 (3.77), 5.73±0.52 (Z=-3.19, P＜0.05), the CNR of two sequences were -1.9 (10.29), 0.95±0.08 (Z=-1.46，P＞0.05). There was no statistical difference of artifact score between conventional sequences and MAGiC sequences [conventional sequences: 50 cases (83.3%, grade 1), 8 cases (13.3%, grade 2), 2 cases (3.3%, grade 3). MAGiC sequences: 34 cases (56.6%，grade 1), 18 cases (30%, grade 2), 8 cases (13.3%, grade 3), Z=-4.443, P＜0.001]. The mean T2 value was (83±8) ms, and the iliac side was slightly higher than sacral side (P＜0.05). Conclusions: Though the subjective image quality score of MAGiC sequence images are slightly lower than conventional sequences images, but with higher SNR and CNR, shorter scanning time, more quantitative parameters, MAGiC sequence can be used for MR examination of sacroiliac joint in young volunteers.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Value of DWI combined with MRS in glioma grade diagnosis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.019</link>
<description><![CDATA[Objective: To analyze the value of diffusion weighted imaging (DWI) combined with hydrogen proton magnetic resonance spectroscopy (MRS) in glioma grade diagnosis. Materials and Methods: Between January 2017 and December 2018, 92 patients with glioma were selected as subjects, and grouped according to the results of DWI and MRS, of which 45 patients with grade Ⅰ to Ⅱ were classified into low-grade glioma group and 47 patients with grade Ⅲ to Ⅳ were classified into high-grade glioma group. All patients received DWI and MRS examinations. Various indexes were compared between groups, including apparent diffusion coefficient (ADC) value, N-acetylaspartate (NAA), creatine (Cr) and choline (Cho). The diagnostic value of DWI combined with MRS in different grades of gliomas was analyzed. Results: The ADC [(11.52±1.0)×10-3 mm2/s] and NAA/Cr in the low-grade group were significantly higher than those in the high-grade group ADC [(8.69±1.11)×10-3 mm2/s] and NAA/Cr (t=12.332, P＜0.05; t=18.999, P＜0.05). The Cho/Cr and Cho/NAA in the highgrade group were significantly higher than those in the low-garde group (t=34.164, P＜0.05; t=40.962, P＜0.05). Taking pathological diagnosis as gold standard, the sensitivity, specificity and accuracy of DWI examination were 77.78%, 76.60%, and 77.17%, respectively; the sensitivity, specificity and accuracy of MRS examination were 86.67%, 80.85%, and 83.70%; the sensitivity, specificity and accuracy of DWI combined with MRS were 93.33%, 95.74% and 94.57% (P＜0.05). The diagnostic value of DWI and MRS was significantly lower than that of DWI combined with MRS (P＜0.05). Conclusions: DWI combined with MRS parameters have certain clinical guiding value in glioma grade diagnosis with high sensitivity and specificity, which can provide some reference for clinical treatment and prognosis.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[3.0 T MRI double-echo hydro-lipid separation Dixon technique for quantitative determination of liver fat in patients with nonalcoholic fatty liver disease]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.020</link>
<description><![CDATA[Objective: To study the liver fat content in patients with fatty liver by using magnetic resonance water-fat separation Dixon method, and to explore the feasibility and clinical value of the quantitative analysis of the liver fat in the non-alcoholic hepatic steatosis. Materials and Methods: Dixon technique (T1-VIBE-Dixon), a phase (in-phase, IP) and (out-phase, OP) and MRS image were obtained by using conventional liver MRI plain scan and double-echo water-fat separation Dixon technique (T1-VIBE-Dixon). The obtained sequence of Dixon scan obtained the fat fraction map by the software, and the fat score map and the magnetic resonance spectroscopy (MRS) sequence were statistically analyzed for their correlation by the fat fraction (FF) measured at the same position. Results: The correlation coefficient between the FF value measured by the T1-VIBE-Dixon sequence and the FF value measured by 1H-MRS is as high as 0.99637, which is highly correlated. Conclusions: It is feasible to use 3.0 T MRI double-echo water-fat separation Dixon technique in the quantitative analysis of the liver fat in non-alcoholic liver steatosis, and the result is valuable for the diagnosis, follow-up and monitoring of non-alcoholic fatty liver.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[MRI findings of adult-onset sporadic neuronal intranuclear inclusion disease: report of 3 cases and review of literature]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.021</link>
<description><![CDATA[Objective: To investigate the MRI findings of adult-onset sporadic neuronal intranuclear inclusion disease (NIID). Materials and Methods: The clinical symptoms, MRI findings and dermatopathological features of adult-onset sporadic NIID were analyzed. Results: Three patients with clinical manifestations such as cognitive dysfunction, extrapyramidal symptoms, cerebellar ataxia, etc. Head MRI showed abnormal white matter signal in bilateral cerebral hemispheres. DWI showed high signals at the cerebral cortico-medullary junction, which persisted and progressive increase. Skin biopsy revealed eosinophilic intranuclear inclusion bodies in adipocytes, fibroblasts, and sweat gland cells which were diagnosed as NIID. Conclusions: NIID is a chronically progressive neurodegenerative disease. MRI-DWI of the head shows high signals at the cerebral corticomedullary junction, and dermatopathological findings of eosinophilic intranuclear inclusion bodies contribute to the diagnosis.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Research progress on the effect of type 2 diabetes on the brain microstructure and structural network]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.023</link>
<description><![CDATA[Type 2 diabetes Mellitus (T2DM) is a chronic metabolic disease with multiple system complications. In addition to the well-known renal, eye, foot, and cardiovascular complications, T2DM can cause central nervous system dysfunction, characterized by a multidisciplinary decline in cognitive function. Due to its insidious onset, the key of treatment is to early diagnosis and timely intervention. Diffusion tensor imaging (DTI) can non-invasively detect the changes of the microstructure of living tissue. In recent years, the application of this technique in neuroimaging of T2MD has made a lot of achievements, finding out the changes of the microstructure of many brain regions in patients with T2DM, and the changes of the microstructure of local brain regions have significant correlation with cognitive ability and clinical parameters. In addition, DTI combined with graph theory can provide a quantitative characterization of the changes in white matter connectivity, which provides a new insight into the pathogenesis of cognitive decline in patients with T2DM. Therefore, this article will review the progress of neuroimaging in patients with type 2 diabetes from the above two aspects.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Current progress in neuroimaging research on postpartum depression]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.024</link>
<description><![CDATA[Postpartum depression refers to the onset of depressive symptoms within twelve months postpartum. The pathogenesis of postpartum depression is unclear, especially the neurological pathogenesis. With the advances in neuroimaging technology represented by magnetic resonance imaging (MRI) in recent years, the study of the neural correlates of mental disorders has been increasingly approached using magnetic resonance techniques. In this review we synthesize the results from studies on postpartum depression in brain in the context of metabolism, functional and structural as a whole. This paper provides ideas and objective imaging basis for postpartum depression, so as to diagnose the disease early, intervene its occurrence and development, and improve the therapeutic effect.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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<title><![CDATA[Evaluation of plaque composition and stability in early vascular diseases based on CT and MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2020.07.025</link>
<description><![CDATA[Cardiovascular disease has become the first killer of human health, and atherosclerosis is the main cause of coronary heart disease and stroke. Numerous studies have shown that in addition to the degree of arterial lumen stenosis, the composition and stability of arterial plaque are more important reasons of the severity of atherosclerosis. There are many methods for detecting the composition and stability of arterial plaques in clinical practice, among which CT and MRI have important clinical value for early risk assessment of atherosclerosis patients because of their noninvasive and high-resolution characteristics.]]></description>
<pubDate>Mon,20 Jul 2020 00:00:00  GMT</pubDate>
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