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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=201508</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[An expectable wave of clinical studies using quantitative dynamic contrast-enhanced MR imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.001</link>
<description><![CDATA[Quantitative dynamic contrast-enhanced MR imaging (dynamic contrast-enhanced MRI, DCE-MRI) using fast T1-weighted imaging is considered as a functional tool to non-invasively assess the microcirculation features of normal or diseased tissues. It can be used to assess tissue perfusion and microvessel permeability by means of qualitative, semi-quantitative and quantitative method. With inclusion of arterial input function and tissue concentration of contrast agents used, quantitative DCE-MRI is superior to either qualitative or semi-quantitative method with respect to accurate evaluation of tissue perfusion and microvessel permeability; and can avoid inconsistent analysis results between different researchers caused by individual scanning protocols used. Thus quantitative DCE-MRI is not only favorable to achieve an early diagnosis and improve accuracy of the differential diagnosis of various disease entities, but also helpful for implementation of a multicenter randomized control clinical trials to obtain evidence medicine data. To date, some obstacles are still present in DCE-MRI, such as the standardization of scanning protocols and data computation, particularly the application of appropriate hemodynamic models. Advanced software specialized designed for quantitative DCE-MRI can provide a standard and convenient platform for data analysis. With the help of such favorable platform, the progress of clinical application of DCE-MRI would be promoted and its application field would be extended.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[Dynamic contrast-enhanced MRI in the differential diagnosis of high grade glioma, low grade glioma and meningioma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.002</link>
<description><![CDATA[Objective: Through undergoing dynamic contrast-enhanced MRI (dynamic contrast-enhanced MRI, DCE-MRI) before operation to provide quantitative basis for the differential diagnosis of the three kinds of tumors. Materials and Methods: Nineteen cases of gliomas (7 with low grade, 12 with high grade) and 19 cases of meningiomas (13 with benign, 6 with malignant or anaplastic) were enrolled. The pharmacokinetic model of Extended Tofts Linear was used to calculate the datas, the tissue enhancement-time curve and pharmacokinetic parameters (volume transfer constant, Ktrans, extracellular extravascular volume fraction, Ve; and blood plasma fraction, Vp) of the lesion, solid components were obtained. Ktrans value, Ve value and Vp value were compared to judge whether there were significant differences between the three kinds of tumors. Results: The values of Ktrans and Ve in high grade glioma (HGG) were significantly higher than the low grade glioma(LGG) (P＜0.05); Vp values of high grade glioma were slightly higher than the low grade glioma, but the difference was not statistically significant; The values of Ktrans and Ve in meningiomas were significantly higher than the low grade gliomas (P＜0.05), but the difference of Vp values were not statistically significant; the differences of Ktrans, Ve, Vp of gliomas and meningiomas were not statistically significant (P＞0.05). Conclusion: DCE-MRI can effectively distinguish low grade glioma from high grade glioma and low grade glioma from meningioma, At the same time, DCE-MRI improves the diagnosis accuracy of glioma and invasive meningioma through the quantitative analysis .]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[The reproducibility study of the pharmacokinetic model extended tofts linear of the dynamic contrast-enhanced MRI in brain glioma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.003</link>
<description><![CDATA[Objective: Through repeatedly measuring the dynamic contrast- enhanced MRI (DCE-MRI) pharmacokinetic parameters-volume transfer constant, Ktrans; extracellular extravascular volume fraction, Ve; and blood plasma fraction, Vp of the glioma to determine whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably. Materials and Methods: Nineteen cases of gliomas (seven with low-grade, twelve with high-grade) were enrolled. All of the patients underwent DCE-MRI before operation. The pharmacokinetic model of Extended Tofts Linear was used to calculate the datas, the tissue enhancement–time curve and pharmacokinetic parameters (Ktrans, Ve and Vp) of the lesion, solid components were obtained. Ktrans value, Ve value and Vp value were compared to judge whether there were significant differences between the low-grade glioma and the high-grade glioma of the two groups (survey one and survey two), and whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably. Results: The values of  Ktrans, Ve and Vp in high-grade glioma were significantly higher than the low grade glioma in both groups (survey one and survey two), (P＜0.05); The intraclass correlation coefficient (ICC) values of Ktrans, Ve and Vp were 0.93, 0.809, 0.592, separately＞0.4. Conclusion: The reproducibility of the DCE-MRI Extended Tofts Linear is good.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[Microvascular permeability changes in ischemic stroke and prediction of hemorrhagic transformation]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.004</link>
<description><![CDATA[Objective: To evaluate the permeability changes in ischemic infarction in patients of acute stage and subacute stage and to predict the post-infarction hemorrhagic transformation. Materials and Methods: The data of 43 patients (10 acute stage and 33 subacute stage) who had routine MRI and DCE-MRI performed were retrospectively analyzed. Volume transitional co-efficiency (Ktrans) was measured with pharmacokinetic model. Statistical analysis of Ktrans was performed in the following different groups: infarcted tissue and contralateral normal tissue; hemorrhagic group and non- hemorrhagic group. The correlation of enhancement of different stages was analyzed by Fisher's test. Results: The Ktrans values of infarcted areas dramatically increased compared to those in the conterlateral’s in all cases (P＜0.05). Subsequent hemorrhage was found in all 10 cases of acute stage and 15 cases of subacute stage while not found in the rest 18 cases, which was statistically different with Fisher's test (P＜0.05). Ktrans values of cases with HT of acute stage were significantly higher than those with or without HT in subacute stage respectively (P＜0.05). However, there was no statistical difference in Ktrans values between HT group and non-HT group in subacute stage. Conclusion: The specificity was better in early parenchymal enhancement in predicting HT and the permeability was higher compared to later periods. Early parenchymal enhancement and subsequent HT is likely associated with injury of early capillary endothelial cells of tight dense connections and basement membranes. Parenchymal enhancement in later period and HT is likely associated with establishment of collateral circulation. DCE-MRI could quantitatively evaluate osmotic quantity. It is of great help for further research on HT category.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[The differential diagnosis value of DCE-MRI in brucellosis spondylitis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.005</link>
<description><![CDATA[Objective: To explore the value of dynamic contrast enhanced (DCE) MRI in differential diagnosis of brucellosis spondylitis. Materials and Methods: Sixteen cases with spinal lesions(proved  by clinically or histologically: 11 cases were brucellosis spondylitis, 2 cases were vertebral metastases, 3 cases were tuberculous spondylitis) received T1WI, T2WI, STIR and DCE-MRI examination. Morphological and MRI features were analyzed. Results: The lesions were mainly located in the lumbar vertebrae. In the MRI of brucellosis spondylitis, morphology of vertebral body was almost normal. Bone destruction and osteophyte were detected in the rim of vertebral body. The affected vertebral body showed hypointense on T1WI, hypointense, isointense, hyperintense or heterogeneous intense on T2WI and hyperintense on STIR. After injection of contrast media, signal of affected vertebral body was similar to or higher than that of adjacent vertebral body. There were significant differences between the different spinal lesions for Ktrans values and Ve values (P＜0.05). Conclusion: Brucellosis spondylitism has some MRI characteristics. DCE-MRI has significant value in the differential diagnosis of brucellosis spondylitis.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of DCE-MRI quantitative permeability parameter combined with ADC in differential diagnosis of benign and malignant lung lesions]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.006</link>
<description><![CDATA[Objective: To investigate the application value of quantitative assessment of pulmonary benign and malignant lesions by kinetic parameters of DCE-MRI imaging combined ADC. Materials and Methods: A total of 49 patients with pulmonary lesions (29 malignant lesions, 20 benign lesions) underwent CT contrast enhanced scanning, routine MR scanning, diffusion-weighted imaging MRI (DWI-MRI), and dynamic enhanced MRI. MRI dynamic enhanced scan with 3D rapid volumetric scanning technology. The ADC values of the lesions were calculated by MRI post-processing workstation, and the kinetic parameters such as Ktrans, Kep et al were calculated by the Omni-Kinetics software. Results: DCE-MRI and DWI-MRI technique for the differential diagnosis of benign and malignant nodules of lung nodules accuracy was 93.9%, ADC value combined with CT in the differential diagnosis of lung nodules accuracy was 85.7%, CT in the differential diagnosis of lung nodules accuracy was 75.5%, the accuracy of DCE-MRI combined with DWI-MRI for differentiating benign and malignant pulmonary nodules was significantly different from CT (P＜0.05). Conclusion: DCE-MRI hemodynamic parameters such as Ktrans and Kep combined with ADC values of pulmonary benign and malignant lesions were higher than that of CT, and can be used as a quantitative method of differential diagnosis. It should be widely used in clinical work.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[Evaluations of quantitative DCE-MRI parameters in breast lesions and correlations with histology]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.007</link>
<description><![CDATA[Objective: To evaluate the value of T1 quantitative parameters of Dynamic Contrast Enhanced MRI (DCE-MRI) at high temporal resolution in the diagnosis of breast lesions and analyze their correlations with MVD, VEGF for breast carcinoma. Materials and Methods: Sixty-seven patients with breast lesions were enrolled from Nov. 2014 to Feb. 2015 in one hospital, underwent the DCEMRI sequence using TWIST with 70 phases. All were confirmed with pathology within one week. Temporal resolution was 4.58 s per phase except for the first phase 17.3 s. And total scanning time was 5 min 33 s. The following quantitative parameters were calculated: volume transfer constant (Ktrans), rate constant (Kep) and extravascular extracellular volume fraction (Ve). The Ktrans, Kep and Ve among malignant, benign and normal glandular tissues, and all kinds of ductal carcinoma were calculated and compared by one-way ANOVA and LSD method. Additionally, the areas under the ROC curve of Ktrans, Kep and Ve between malignant and benign lesions were compared. The correlations between quantitative DCEMRI parameters and the microvessel density(MVD), vascular endothelial growth factor(VEGF)of malignant lesions were performed using Pearson correlation analysis. Results: The mean Ktrans, Kep and Ve of normal glandular tissue were (0.012±0.003) min-1, (0.439±0.083) min-1, (0.045±0.013). The mean Ktrans, Kep and Ve of benign lesions were (0.049±0.007) min-1, (0.588±0.073) min-1, (0.107±0.022). The mean Ktrans, Kep and Ve of malignant lesions was (0.187±0.045) min-1, (1.205±0.517) min-1, (0.133±0.049). The difference of Kep, Ktrans between malignant and benign lesions was statistically significant (P=0, P=0.041). The difference of Kep, Ktrans between malignant lesions and normal glandular was statistically significant (P=0, P=0.008). The sensitivity of Ktrans and Kep were 86.8% and 67.9%. The specificity of Kep and Ktrans were 94.7% and 89.5% using the maximum Youden’ index as the cut-off value. The area under the ROC curve of Ktrans and Kep were 0.931 and 0.819 respectively. The mean Ktrans, Kep and Ve of the 30 patients were (0.183±0.031) min-1, (1.192±0.063) min-1, (0.127±0.031). The amount of MVD was (34.96±9.86) and the score of VEGF was (5±1). The quantitative parameters Ktrans, Kep and Ve were positively correlated with MVD and VEGF (P＜0.05). Kep and Ktrans showed significantly statistical correlations with anti-VEGF (r=0.759, r=0.771) and anti-CD34 (r=0.613, r=0.607). Conclusion: The differential diagnosis of benign and malignant breast lesions by Ktrans, Kep were applicable. Ktrans, Kep of breast carcinoma were strongly correlated with MVD and VEGF. They could be used as non-invasive biomarkers to evaluate the microcirculation status of breast carcinoma in vivo.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of quantitative dynamic contrast enhanced MRI in differential diagnosis of renal clear cell carcinoma and renal angiomyolipomas with minimal fat]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.008</link>
<description><![CDATA[Objective: To explore the differential diagnosis value of quantitative dynamic contrast-enhanced MRI(DCE-MRI) of renal clear cell carcinoma and renal angiomyolipomas with minimal fat. Materials and Methods: Twenty-six cases with renal clear cell carcinoma, twelve cases with renal angiomyolipomas with minimal fat confirmed by operation, underwent the examination of MRI conventional scanning, and DCE-MRI. ROI were drawn to record the quantitative parameters average values of Ktrans, Kep, Ve. Results were statistically treated with SPSS 13.0. Results: Twenty-six cases with renal clear cell carcinoma showed obvious enhancement in the early phase of DCE-MRI. The Ktrans, Kep, Ve average value of renal cell carcinoma was  (0.625±0.313) min-1, (1.764±1.105) min-1, (-0.341±0.207), and the Ktrans, Kep, Ve average value of renal angiomyolipomas with minimal fat was (0.061±0.023) min-1, (0.916±0.313) min-1, (-0.146±0.074). Ktrans value was statistically significant in the differences between renal cell carcinoma and renal angiomyolipomas with minimal fat. t value 4.063, P＜0.05. Kep, Ve value were not statistically significant in the differences between renal cell carcinoma and renal angiomyolipomas with minimal fat, t value 2.153, 0.5, P＞0.05. Conclusion: Quantitative DCE-MRI could differentiate renal clear cell carcinoma from renal angiomyolipomas with minimal fat.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[The preliminary value of DCE-MRI quantitative parameters in high intensity focused ultrasound (HIFU) ablation<sup><sup>,</sup></sup>s immediate effect for uterine fibroids]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.009</link>
<description><![CDATA[Objective: To evaluate the immediate value of dynamic contrast-enhanced MRI(DCE-MRI)quantitative parameters after HIFU treatment of uterine fibroids. Materials and Methods: Thirteen patients with uterine fibroids were scanned with DCE-MRI before and after HIFU ablation. They were grouped into two groups, the complete ablation group and the non-complete ablation group according to appearance of DCE-MRI. Mann-Whitney U test and Spearman's correlations were applied to find the association between quantitative parameters and grouping. Results: Ktrans(after treatment), Ve (after treatment) and Vp (after treatment) were positively correlated with the grouping, and correlation coefficents were 0.713 , 0.757 and 0.668 respectively. Ktrans(rate of change) and Ve (rate of change) were negatively correlated with the grouping，and correlation coefficients were both -0.802. Conclusion: DCE-MRI quantitative parameters have reference value in HIFU treatment's immediate effect evaluations for uterine fibroids.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[Quantitative diagnostic value of 3.0 T dynamic contrast-enhanced MRI in different diagnosis of prostate cancer and hyperplasia]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.010</link>
<description><![CDATA[Objective: To explore the diagnostic value of quantitative analysis parameters of DCE-MRI in prostate cancer diagnosis, and to evaluate the correlation between Ktrans, Kep and Ve and Gleason scores. Materials and Methods: Forty-three prostate diseases patients pathologically proved underwent conventional MRI and DCE-MRI examinations, including 27 patients with prostate cancer and 16 with prostate hyperplasia. The variations of the value of Ktrans, Kep and Ve between the prostate cancer and hyperplastic tissues were measured and compared, and the correlations between Ktrans, Kep and Ve and Gleason scores were studied. Results: The Ktrans, Kep and Ve values of cancerous area were (0.312±0.085) min-1, (0.818±0.098) min-1 and (0.379±0.031), while, for hyperplastic area were (0.213±0.046) min-1, (0.537±0.076) min-1 and (0.324±0.034). The values of Ktrans, Kep, Ve were significantly higher in prostate cancer than in hyperplastic tissues; and Ktrans, Kep, Ve values were not relevant with Gleason score. Conclusion: DCE-MRI quantitative analysis plays a significant role in prostate cancer diagnosis, and may help in differential diagnosis of prostate tumors. Ktrans, Kep and Ve values were not relevant with Gleason score.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[Correlation of contrast-enhanced dynamic MRI imaging semi-quantitative parameters with tumor tissue hypoxia and intravascular generate]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.011</link>
<description><![CDATA[Objective:  To investigate the correlation between various internal parameters of dynamic contrast-enhanced MR and the immunohistochemistry factor expression of revelevant site by biopsy. Materials and Methods: Thirty cases of newly diagnosed patients with osteosarcoma were choosen. All cases underwent dynamic contrast-enhanced MR scanning after injecting gadodiamide through the cubital vein. The regional enhancement curve and the characteristic parameters of the tumor were obtained. At the same time, we punctured the related region and measured the HIF- 1α, MVD and VEGF levels of the tissue biopsy site. The enhanced parameters and immunohistochemical factors were compared and studied. Results: The slope and Smax, SImax of the biopsy site was positively correlated with HIF-1α expression (γ were respectively 0.894, 0.832 and 0.681, P＜0.05), and with the MVD (γ were respectively 0.629, 0.739 and 0.663, P＜0.05). The slope and Smax, SImax of the biopsy site and VEGF expression was positively correlated (γ were respectively 0.876, 0.829 and 0.627, P＜0.05); Even more, T1 onset, TTP was negatively correlated with HIF-1α expression (γ were －0.692, －0.667, P＜0.05 ), and with MVD  (γ were －0.574, －0.835, P＜0.05).T1 onset, TTP and VEGF expression was negatively correlated  (γ were －0.907, －0.830, P＜0.05). Conclusion: MRI biopsy site osteosarcoma dynamic enhancement parameters are statistically correlated with the expression of three factors and significantly correlated with tissue hypoxia factor. Dynamic contrast-enhanced scans can provide a basis for the detection of hypoxia and angiogenesis in osteosarcoma tissue indirectly.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparison of HR-MRI, MRA and DSA in measuring intracranial aneurysm]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.013</link>
<description><![CDATA[Objective:  To investigate the application value of high-resolution magnetic resonance imaging(HR-MRI) in measuring intracranial aneurysm by a comparative analysis with three-dimensional digital subtraction angiography (3D-DSA), three-dimensional time of flight magnetic resonance angiography (3D-TOF MRA). Materials and Methods: A total of 25 patients diagnosed of intracranial aneurysm were enrolled in department of neurosurgery of our hospital from October 2013 to March 2015. Among them, 15 cases were male and 10 female, age 5-60 years old, median age 50.5 years. Firstly all of them underwent conventional MRI sequence to verify the location of intracranial aneurysm, then 3D-TOF MRA sequence was performed, thirdly we performed HR-MRI sequence according to 3D-TOF MRA images (one patient was excluded for poor image quality). And they underwent DSA examination in a week. We measured the maximum width of intracranial aneurysm on the images of 3D-TOF MRA, HR-MRI and 3D-DSA. Statistical analysis was performed using a paired sample Student’s t-test for the pairwise comparisons of the differences among HR-MRI, 3D-DSA and 3D-TOF MRA in measuring the maximum width of intracranial aneurysm. We assume the difference is significant statistically when P＜0.05. Results: In the aspect of measuring the maximum width of intracranial aneurysm, the differences between HR-MRI and 3D-DSA (the mean difference was 3.16±2.66 mm), HR-MRI and 3D-TOF MRA (the mean difference was 5.15±4.89 mm) were significant statistically (P1＜0.05, P2＜0.05), respectively, and there was no statistical significance between 3D-DSA and 3D-TOF MRA (the mean difference was 2.53±5.18 mm, P3＞0.05). Conclusion: There were differences between HR-MRI and 3D-DSA, HR-MRI and 3D-TOF MRA in measuring the maximum width of intracranial aneurysm, HR-MRI may have higher clinical application value in measuring the actual size of intracranial aneurysm accurately.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[The preliminary study of role of multi-echo GRE Dixon in the diagnosis of primary hepatocarcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.014</link>
<description><![CDATA[Objective: To clarify the significance of multi-echo GRE Dixon in the diagnosis of primary hepatocarcinoma. Materials and Methods: Twenty-two patients with hepatocarcinoma proved pathologically by surgery and biopsy underwent liver MRI scanning with a phase correction multi-echo GRE Dixon sequence. We analyze their imaging features of tumor in water only imaging, fat only imaging, water/fat phase mapping, R2* mapping and make a contrast with imaging of in-phase and opposed-phase, T2 weighted imaging and histopathological results. Results: Intrahepatic cholangiocarcinoma and hepatocellular carcinoma with fatty degeneration usually shows hypointensity on water only imaging and hepatocellular carcinoma without fatty degeneration shows isointensity on water only image. Most of the tumors can be seen more necrosis and hemorrhage on R2* mapping than T2 weighted imaging. The value of R2* of Intrahepatic cholangiocarcinoma is lower than that of Hepatocellular carcinoma and the P value is 0.003. R2* mapping has a lower contrast to noise ratio of tumor and hepatic tissue than T2 weighted imaging.  Conclusion: We can distinguish necrosis, hemorrhage, fatty degeneration and fibre in the liver tumor by phase correction multi-echo GRE Dixon, which plays an important role in the differential diagnosis of intrahepatic cholangiocarcinoma and hepatocarcinoma.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[A study on the best fitting model for diffusion-weighted magnetic resonance imaging of normal prostate tissue at different b-values]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.015</link>
<description><![CDATA[Objective: To compare the fitting behavior of biexponential diffusion model and diffusion kurtosis model (DKI) on diffusion-weighted imaging (DWI) of healthy prostate at different b-values at 1.5 T. Materials and Methods: T2-weighted imaging and DWI of prostate was performed on 11 healthy man with 31 b-values ranging from 0 to 3000 s/mm². The DWI signals were fitted into two diffusion models. The continuous b-values with smaller deviation between the signal intensities of fitted curves of one model and the acquired original data can be combined into one section. The best fitting model could be selected for the b-values sections. Results: The adjusted R² of the full b-values for biexponential diffusion model was bigger than that for DKI. The RMSE of DKI was smaller than biexponential model with b-values from 500 to 1000 s/mm², and the RMSE of biexponential diffusion model was smaller than DKI with b-values ranging from 0 to 500 s/mm² and from 1000 to 3000 s/mm². Conclusion: For DWI of prostate, biexponential diffusion model and DKI behaviors diversely on the goodness of fitting at different b-values. The different b-values sections can be fitted best with different diffusion models. It may potentially provide more help for clinical diagnosis when combining the biexponential diffusion model and DKI.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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<title><![CDATA[Study of region-of-interest choosing in measuring brain iron content by susceptibility weighted imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.3969/j.issn.1674-8034.2015.08.016</link>
<description><![CDATA[Objective:  To explore the influence of selecting different region of interest (the whole globus pallidus or a local mineral deposition area) on evaluating the iron content when mineral deposited abnormally in the globus pallidus. The present study might provide a convenient approach to choose the appropriate ROI and to measure the brain iron. Materials and Methods: There were 94 healthy volunteers underwent the routine MRI and SWI scan, and group A had 10 cases with abnormal mineral deposit in the region of globus pallidus, while another 10 cases with normal mineral deposition were group B. Group A was then sub-divided into group A1 or group A2 based on defining the region of the whole globus pallidus (A1) or the region of the only abnormal mineral deposition area as ROI, respectively. Pearson correlation analysis was applied to analyze the relationship between the different ROI on iron measurement and the abnormal mineral depositing content in the region of globus pallidus. Results: The correlation r value between the group A1 and group A2 was 0.827 (P＜0.05), which showed that the value of mineral depositing content was remarkably consistent between the two different ROIs measurement (ROI with whole globus pallidusor the local abnormal mineral deposition area). The correlation of r value between group B and group A1, or between group A2 was 0.183 (P＞0.05) and 0.344 (P＞0.05), respectively. The difference of the signal intensity in globus pallidus was significant between the cases with and without abnormal mineral deposition. Conclusion: We both choose the whole globus pallidus and the local abnormal mineral depositing area as ROI in analyzing the mineral deposition by SWI. Our results showed that these two different ROIs we selected had little influence on brain iron measurements. Therefore we conclude that taking the whole globus pallidus as ROI to measure brain iron content in the globus pallidus by SWI is reliable and much more convenient in comparison with the ROI drawn around the local abnormal mineral depositing area.]]></description>
<pubDate>Thu,20 Aug 2015 00:00:00  GMT</pubDate>
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