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<title>Chinese Journal of Magnetic Resonance Imaging RSS feed</title>
<link>http://med-sci.cn/cgzcx/en/contents_list.asp?issue=201709</link>
<language>zh-cn</language>
<copyright>An RSS feed for Chinese Journal of Magnetic Resonance Imaging</copyright>
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<title><![CDATA[The value of 3D-TOF-MRA for diagnosing rupturd intracranial aneurysm: a Meta analysis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.001</link>
<description><![CDATA[Objective: To evaluate the value of three-dimensional time of flight magnetic resonance angiography (3D-TOF-MRA) for diagnosing ruptured intracranial aneurysm (RIA) by Meta analysis. Materials and Methods: The studies concerning the diagnosis of RIA by 3D-TOF-MRA until December 2016 were searched in the databases such as CNKI, CBM, Wanfang data, VIP, the Cochrane Library, PubMed, Embase and Web of Science. Two reviewers independently screened literature, extracted data, and assessed risk of bias of included studies by using QUADAS-2 tool. Subsquently, Meta-analysis was performed through Stata 12.0 software. The pooled weighted sensitivity (SEN), specificity (SPE), Positive Likelihood (+LR), Negative Likelihood (-LR) and the diagnostic odds ratio (DOR) were calculated, summary receiver operating characteristic curve (SROC) was drawn. Results: A total of 13 articles consisting 15 studies were included, involving 1004 RIA patients and 1056 suspicious RIA cases. The results of Meta-analysis showed that, the pooled SEN, SPE, +LR, -LR, DOR and AUC of 3D-TOF-MRA for diagnosing RIA were Senmerge=0.94 [95% CI (0.91, 0.97)], Spemerge=0.94 [95% CI (0.87, 0.98)], +LRmerge=9.25 [95% CI (5.28, 16.20)], -LRmerge=0.07 [95% CI (0.05, 0.12)], DORmerge=151.90 [95%CI (70.27, 328.37)], AUC=0.98, respectively. Results of subgroup showed 3D-TOF-MRA had better Sen in 3.0 T in comparation with 1.5 T (P＜0.05), study type and study standard have no significant differences in RIA diagnosis (P＞0.05). Conclusions: 3D-TOF-MRA has definite efficiency for assessing RIA, especially in high field study.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparative study of IVIM and 3D pCASL in the clinical staging of nasopharyngeal carcinoma]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.002</link>
<description><![CDATA[Objective: To explore the application value of 3D pCASL (three-dimensional pseudo continuous arterial spin labeling) in the clinical staging of nasopharyngeal carcinoma with IVIM (intravoxel incoherent motion) double exponential model. Materials and Methods: We collected 36 cases of first diagnosed patients with nasopharyngeal carcinoma in our hospital. All patients underwent plain MR scan plus enhancement, multiple B diffusion weighted sequence and three-dimensional pseudo continuous arterial spin labeling sequence, and using Chinese 2008 staging system for staging, which was divided into high and low level group. The original data were sent to GEAW 4.6 workstation for post-processing to get D*, D, f and BFASL images, and the D*, D, f and BFASL values of the tumor parenchyma were measured. To compare the correlation between the parameters and the clinical stage of nasopharyngeal carcinoma. Results: In the BFASL and D* images, the tumors of the advanced group showed significantly high perfusion, while the low grade group showed a slightly higher or lower perfusion. In the total stage, T stage and N stage, the BFASL value and D* value of the advanced group were significantly higher than those of the lower level group, the f value was higher than that of the lower level group, and the D value was lower than that of the lower level group, which had statistical significance (P＜0.05). BFASL value, D* value and f value were positively correlated with the total stage, T stage and N stage, D value was negatively correlated with the total stage, T stage and N stage. BFASL value and D* value, f value has a good positive correlation. BFASL, D*, f and D values in each clinical stage have good diagnostic efficacy, in the clinical stage, T stage and N stage, the BFASL value is the best, the ROC area is about 0.96, 0.94, 0.97. Conclusions: 3D pCASL and IVIM imaging both are noninvasive functional magnetic resonance perfusion. They can be a good evaluation of nasopharyngeal carcinoma, and predict clinical staging before treatment of nasopharyngeal carcinoma. The diagnostic efficacy of 3D pCASL was higher than that of IVIM.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[An initial study using the quantitative parameters of dynamic contrast-enhanced MRI in differential diagnosis for parotid tumors with different pathological types]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.003</link>
<description><![CDATA[Objective: To investigate the value of the quantitative parameters of dynamic contrast-enhanced (DCE) MRI-derived parameters in differential diagnosis for parotid tumor with different pathologic types, in order to provide useful quantitative indicators for accurate preoperative diagnosis of parotid tumors. Materials and Methods: Forty-seven patients with different pathological types of parotid tumors were enrolled and performed DCE-MRI examinations. The region of interest was delineated around the tumor margin, time intensity curve (TIC) and quantitative parameters including Ktrans, Ve, Kep were calculated. The differences of TIC and DCE-MRI-derived quantitative parameters were analyzed among different pathologic type of parotid tumors. Results: (1) Among the 47 patients, the numbers of benign and malignant parotid tumor were 37 and 10. No significant difference was demonstrated about the TIC type between the benign (Type A, B, D: 20. Type C: 17) and malignant parotid tumor (Type A, B, D: 2. Type C: 8) (P＞0.05). (2) The Ktrans, Kep values of benign parotid tumor (not included adenolymphoma) were significantly lower than malignant parotid tumor, while the value of Ve was significantly higher than malignant parotid tumor (P＜0.05). The Ktrans, Kep values of mix parotid tumor were significantly lower than that of malignant parotid tumor and adenolymphoma (P＜0.05). The Ve values of mix parotid tumor were significantly higher than malignant parotid tumor and adenolymphoma (P＜0.05). The Ktrans, Kep values of adenolymphoma were significantly higher than malignant parotid tumor (P＜0.05). High diagnostic efficiency were demonstrated for Ktrans, Ve, Kep values in differential diagnosis of mix parotid tumor from malignant parotid tumor and adenolymphoma. Conclusions: DCE-MRI derived quantitative parameters can differentiate parotid tumors among different pathological types, especially provides a useful quantitative parameters for the differential diagnosis of parotid tumors which were lack of MRI feature.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[The value of MR intravoxel incoherent motion diffusion weighted imaging in evaluating the degree of liver fibrosis of chronic hepatitis B]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.004</link>
<description><![CDATA[Objective: To investigate the value of IVIM diffusion weighted imaging in the assessment of liver fibrosis in patients with chronic hepatitis B. Materials and Methods: Fifty-five cases of patients with chronic hepatitis B were divided into no and mild liver fibrosis group, moderate liver fibrosis group and severe liver fibrosis group according to liver biopsy pathology and selected 20 healthy volunteers as control group. All of the subjects have received 3.0 T magnetic resonance IVIM-DWI et al. The difference of sADC, D, D* and f value between the normal control group and the liver fibrosis group and between the liver fibrosis groups were statistically analyzed. Results: With the progression of liver fibrosis, the D, D* and f value of liver were gradually reduced. There was signicficant difference in D value between the normal control group and the liver fibrosis group. There was signicficant difference in D* and f value between the normal control group and the liver fibrosis group and between the liver fibrosis groups. The D, D* and f values in normal control group and liver fibrosis group respectively were (0.540±0.031)×10-3 mm2/s and (0.427±0.061)×10-3 mm2/s, (0.380±0.027)×10-1 mm2/s and (0.320±0.052)×10-1 mm2/s, (0.232±0.014) and (0.217±0.011). The D, D* and f values in no and mild liver fibrosis group respectively were (0.489±0.027)×10-3 mm2/s, (0.349±0.041)×10-1 mm2/s, (0.226±0.010). The D, D* and f values in moderate liver fibrosis group respectively were (0.398±0.035)×10-3 mm2/s, (0.317±0.040)×10-1 mm2/s, (0.214±0.008). The D, D* and f values in severe liver fibrosis group respectively were (0.370±0.048)×10-3 mm2/s, (0.269±0.055)×10-1 mm2/s, (0.206±0.006). Conclusions:  The parameters D, D* and f value of MR IVIM-DWI can approximately reflect the severity of liver fibrosis in patients with chronic hepatitis B, has potential value in clinical application, especially can be used for the noninvasive assessment of liver fibrosis in the early stage.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparison of apparent diffusion coefficient and intravoxel incoherent motion imaging in stratification of prostate cancer: based on three-dimensional whole-tumor histogram analysis]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.005</link>
<description><![CDATA[Objective: To investigate the three-dimensional whole-tumor histogram analysis of apparent diffusion coefficients (ADCs) and IVIM-DWI in discriminating the Gleason grades of prostate cancer. Materials and Methods: A total of 57 patients with prostate cancer (PCa) underwent MRI before radical prostatectomy. DWI was acquired at 3.0 T using a single-shot echo-planar imaging sequence with 14 b values (0—1500 s/mm2). A volume of interest was drawn manually around every tumor visible on the images. The 10th, 25th, 50th, 75th , 90th, mean, min, kurtosis, skewness of ADC, D, D* and f were determined from a histogram that contained all voxels from all sections covering the entire tumor and correlated with the Gleason score (GS) by using the Spearman correlation coefficient (ρ). The patients were divided into GS≤3+4 and GS≥4+3 groups. The area under the receiver operating characteristic curve (AUC) was used to evaluate the ability of each parameter to differentiate the two groups. Results: GS≤3+4 in 23 cases (40.35%) and GS≥4+3 in 34 cases (59.65%). The 10th, 25th, 50th, 75th, 90th of ADC and D show a negative correlation with GS (ρ=-0.239—-0.411, P＜0.05), and ρ values increased in turn. All above metrics were significantly different between two groups (P＜0.05). The 90th ADC, 90th D show higher AUC (0.735 and 0.739, respectively) than mean ADC and mean D (0.719 and 0.698, respectively, P＞0.05) in differentiating GS≤3+4 from GS≥4+3. There was no statistically significant difference between any two AUC values of ADC and D histogram metrics. The kurtosis of ADC and D were positively correlated with GS (ρ=0.357, P=0.006; ρ=0.350, P=0.008), but skewness had no correlation with GS. D* and f had no statistically significant correlation with GS either. The volume of whole-tumor lesion was positively correlated with GS (ρ=0.419, P=0.001), and showed a higher discriminatory performance (AUC=0.783) than ADC and D in differentiating GS≤3+4 from GS≥4+3. Conclusions: The histogram parameters of ADC and D had similar performance for prostate cancer stratification. D* and f were unable to distinguish between the different Gleason grades. Tumor volume may be a good predictor of PCa aggressiveness.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Comparative analysis of T2-mapping, 3D-FSE-Cube and conventional sequence in the classification of knee cartilage injury in 3.0 T MRI]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.006</link>
<description><![CDATA[Objective: To evaluate the value of 3D-FSE-Cube, T2-Mapping and conventional MRI sequences in grading diagnosis of knee cartilage injury. Materials and Methods: In this retrospective study, 63 patients with knee joint trauma or osteoarthritis who underwent not only knee joint MRI but also arthroscopic surgery from March 2016 to December 2016 in our hospital were included. Each knee cartilage injury classification diagnosis was respectively obtained by T2-mapping, 3D-FSE-Cube, conventional sequences and arthroscopy. Taking the classification diagnostic results of arthroscopy as gold standards, the sensitivity and specificity of the three sequences for the knee cartilage injury were calculated and compared. Results: The total sensitivity, specificity and sensitivity of grade Ⅰ and Ⅱ injury for knee cartilage were evaluated among three kinds of MRI sequences, and the differences were statistically significant (P＜0.05). While the sensitivity of Ⅲ and Ⅳ grade injury had no significant differences (P＞0.05). Further analysis of the results between sequences, the sensitivity of T2-mapping sequence for grade Ⅰ knee cartilage injury was significantly higher than that of 3D-FSE-Cube sequence (P＜0.0125). There was no significant difference in total sensitivity, specificity and sensitivity of grade Ⅱ injury for knee cartilage between T2-mapping and 3D-FSE-Cube sequence (P＞0.0125). As for the total sensitivity and sensitivity of grade Ⅰ and Ⅱ injury, T2-mapping sequence and 3D-FSE-Cube sequence were both higher than that of the conventional sequence, while the specificity of T2-mapping sequence and 3D- FSE-Cube sequence in diagnosis of the knee cartilage injury was lower than that of conventional sequences, the differences were statistically significant (P＜0.0125). Conclusions:  In the evaluation of knee cartilage injury, the sensitivity of T2-mapping sequence and 3D-FSE-Cube sequence were higher than that of conventional sequence, and the specificity of the conventional sequences was higher than that of T2-mapping sequence and 3D-FSE-Cube sequence. The T2-mapping sequence can indicate early articular cartilage injury without morphology change, which has a high clinical value to diagnose and treat early cartilage injury.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Effects of different concentrations of magnetic probe on growth of adipose stem cells and T2*mapping imaging]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.007</link>
<description><![CDATA[Objective: To study the safe concentration of superparamagnetic iron oxide particles with poly-l-lysine (SPIO-PLL) labelling rabbit adipose stem cells (ADSCs) and quantative T2*mapping imaging. Materials and Methods: The cells labelled with 25, 50, 75 μg/ml SPIO-PLL were detected by Prussian blue staining and transmission electron microscopy (TEM). The cell cycle and apoptosis were analysed by flow cytometry (FCM). 1×106 cells unlabelled and 1×106 cells (labelled 1 d), 1×106 (labelled 3 d) and 5×105 (labelled 1 d) with 25 μg/ml SPIO-PLL were performed with GRE T2*WI and T2*mapping sequences scanning, then the relaxation time of each tube were measured. Results: The results of Prussian blue staining showed the labelled rate was nearly 100%, and TEM displayed particles existed in every cytoplasm. The blocking rate of cell cycle and the rate of cell apoptosis of cells labelled with 25 μg/ml SPIO-PLL had no significant difference compared with the blank group (P＞0.05), 25 μg/ml SPIO-PLL was the safe concentration. The signal intensity (SI) of 1×106 cells (labelled 1 d) was the lowest. The T2* relaxation time of each labelled groups had significant difference compared with the blank group (F=169.837, P＜0.01). Conclusions: ADSCs can be labelled safely and efficiently by 25 μg/ml SPIO-PLL and cell population can be scanned by MR. T2*mapping can be used to quantatively monitor the relaxation time of labelled cells.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[MR diffusion kurtosis imaging versus standard diffusion imaging: changes with radiation in uterine cervical carcinoma xenografts]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.008</link>
<description><![CDATA[Objective: To explore the changes of diffusion-kurtosis imaging (DKI) derived parameters after radiation treatment in cervical cancer xenografts, comparing with traditional apparent diffusion coefficient (ADC) values. Materials and Methods: HELA cell cervical cancer xenografts were built with one tumor in inguinal region and one tumor in contralateral side axillary cavity for each mouse. Radiation were performed on groin area with a single dose of 15 Gy, taking axillary tumors as non-treated contrast. MRI were performed before radiation (pre) and at the 7th day (post) after radiation on a 1.5 T scanner using phase-array animal coil. Maps of mean kurtosis (MK), mean diffusivity (MD) and ADC values were generated with in-house-made software developed in Matlab. Regions of interests covering whole tumor were drawn for each lesion. Average and median values of MK, MD and ADC, respectively, were acquired and the relationships were compared. Differences before and after radiation were compared within treated group and the contrast group using paired sample t test. Results: Strong negative relation of ADC and MK, and strong positive relation of ADC and MD were seen before radiation (r＞0.7). After radiation, treated tumors got increased ADC (ADCav 0.571±0.063×10-3 mm2/s v.s. 0.611±0.055×10-3 mm2/s, P=0.015. ADCm 0.543±0.052×10-3 mm2/s v.s. 0.587±0.041×10-3 mm2/s, P=0.013) and decreased MK (MK 1.14±0.12 v.s. 1.02±0.10, P=0.003. MKm 1.13±0.10 v.s. 1.14±0.10, P=0.003) while MD tended to increase but with no statistical significance (MDav 0.856±0.105×10-3 mm2/s v.s. 0.885±0.071× 10-3 mm2/s, P＞0.05. MDm 0.843±0.113×10-3 mm2/s v.s. 0.878±0.081×10-3 mm2/s, P＞0.05). The average changing rates were 9.4% for MK and 7.5% for MD. No differences were found in the contrast group. Conclusions: Both ADC and MK were able to change with radiation treatment for cervical cancer, in which MK got higher changing rate, thus making DKI hold the potential to use as a tool in therapy evaluation.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[A longitudinal study of changes of brain metabolites in vascular cognitive impairment rats using 3.0 T 1H-MRS]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.009</link>
<description><![CDATA[Objective: To explore the application of 3.0 T 1H-MRS in assessment of longitudinal changes of brain metabolites in vascular cognitive impairment (VCI) rats and its potential value in early diagnosis of VCI disease. Materials and Methods: Philips 3.0 T MR scanner combined with animal coil were applied to obtain 1H-MRS data of brain (mainly including the hippocampus) in VCI rats at different time points (2 weeks, 1 month, 3 months and 5 months), Morris Water maze test and pathologic examination (HE and Nissle staining) were also performed to evaluate the cognitive impairment and pathological changes. Results: Compared with controls, at 2 weeks, significantly cognitive impairment and deduction of Glu/tCr ratio (P＜0.05)were found. And reduction of NAA/tCr (P＜0.05) and increasing of mI/tCr (P＜0.05) were detected at 1 month, at 3 months, the increase of mI/tCr were kept, and also GPC/tCr (P＜0.05) and tCho/tCr (P＜0.05) were raised, at 5 months, all metabolites recovered to normal level besides mI/tCr. But, HE and Nissle stainings showed that cell structural and morphological changes can also exist in the hippocampus. Conclusions: The abnormal metabolites provided by 3.0 T 1H-MRS maybe can reflect the pathological changes in progression of VCI, objectively. Results from this study suggested that reduction of Glu/tCr at the onset and sustained rise of mI/tCr in the progress of VCI,  can be helpful for diagnosis of VCI at its early stage.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Arterial spin labeling application in brain：review of reproducibility and reliability]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.011</link>
<description><![CDATA[Arterial spin labeling (ASL) technique is an emerging technique MR cerebral perfusion technique which can measure the cerebral blood flow quantitatively and noninvasively in genuine. The reliability and reproducibility of the perfusion technique is essential before perfusion imaging data can be pooled from different times or from different scanners. However the reproducibility and reliability of data from ASL is not as robust as imagine. Some work has been done to assess the reproducibility and reliability of data from ASL. This work will have a review on it.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Advances of MR imaging on differential diagnosis between recurrence of glioma and radiation-induced brain injury]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.012</link>
<description><![CDATA[It remains challenging to distinguish radiation-induced brain injury from tumor recurrence in treated patients with high grade glioma (HGG) due to overlapping radiologic features. Both may present with new and/or increasing enhancing mass lesions and fulfill standard criteria for progression. Distinguishing radiation-induced brain injury from tumor recurrence is crucial for treatment planning. The purpose of this review is to outline the current MRI researches on differential diagnosis between tumor recurrence and radiation-induced brain injury.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Pathophysiology and imaging diagnosis of main pulmonary artery dilatation in patients with chronic mountain sickness]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.013</link>
<description><![CDATA[The mian causes of main pulmonary artery (MPA) dilatation in patients with chronic mountain sickness (CMS) is chronic plateau hypoxia, followed by cold. The combined action of both can affect the function of cardiovascular system. Imaging examination not only can effectively diagnose MPA dilatation, but also evaluate the relationship between MPA dilatation and pulmonary arterial hypertension or the effect of MPA dilatation on the heart. MRI plays an irreplaceable role in such examinations. This paper reviews the pathogenesis, clinical significance and imaging diagnosis of MPA dilatation in patients with CMS.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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<title><![CDATA[Distribution and deposition of magnetic resonance gadolinium contrast agents in body: current status]]></title>
<link>http://med-sci.cn/cgzcx/en/en_articlexml.asp?doi=10.12015/issn.1674-8034.2017.09.014</link>
<description><![CDATA[Contrast-enhanced Magnetic resonance imaging (CE-MRI) is widely used in diagnosis and differential diagnosis diseases due to the high relaxation rate of gadolinium contrast agent. In the United States, more than 10 million patients accounting for 40%—50% of all MRI examinations undergoing CE-MRI which is considered as a safety method. But many literatures have reported that gadolinium contrast agent administration have been associated with nephrogenic systemic fibrosis (NSF) in whom with severely compromised renal function, some found that gadolinium could deposite in the skin, some organs and bone tissues. Recently, more studies have shown obviously evidence that gadolinium may deposit in some specific brain structures who with nomal renal function, such as globus pallidus and dentate nucleus. After repeated CE-MRI examinations we could find higher signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images. However, its mechanism and clinical significances remain to be unclear. Therefore, this paper will review the literatures on the application of magnetic resonance gadolinium contrast agent, summarizing the classifications and risk levels, biodistribution and deposition, possible mechanism and clinical significance, providing a powerful reference in selection of gadolinium contrast in clinic.]]></description>
<pubDate>Wed,20 Sep 2017 00:00:00  GMT</pubDate>
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