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• Clinical Article •
Study of brain structure in nomal plateau area adult with voxel-based morphometry
LI Chao-wei  BAO Hai-hua  KONG De-min  Li Wei-xia  YUAN Qiang 

DOI:10.12015/issn.1674-8034.2016.01.001.


[Abstract] Objective: The aim of the study was to investigate the brain structure volumes alterations in born and raised high altitude (HA) (>3000 m) normal adult by using voxel-based morphometry method (VBM).Materials and Methods: Two groups of adults participated in the study, including an HA group [8 males and 8 females, mean age=(21.81±2.07) years] and an age- and education-matched sea level (SL) group [7 males and 13 females, mean age=(21.85±1.90) years]. 3D-T1 structural images of all subjects who were underwent the whole brain scan were acquired. Then we used the VBM method to compare the whole brain GM and WM images differences between HA group and SL group.Results: HA acclimatization (vs. SL) showed increased gray matter volume in the left posterior cingulate, the left superior temporal gyrus,decreased GM volumes was found in the right insular lobe in highland group and we also found increased WM volumes in left thalamus, the right superior frontal gyrus, the lentiform nucleus, the left occipital lobe.Conclusions: The VBM method was applied to the analysis of the magnetic resonance structural images and it could objectively display the volume changes of specific brain areas in HA group and could get us a comprehensive evaluation of the impact of altitude hypoxia on brain structure.
[Keywords] Brain；Anthropometry；Altitude；Magnetic resonance imaging

LI Chao-wei The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xining 810001, China

BAO Hai-hua* The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xining 810001, China

KONG De-min The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xining 810001, China

Li Wei-xia The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xining 810001, China

YUAN Qiang The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xining 810001, China

*Correspondence to: Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 81060117 International cooperation project of science and Technology Department of Qinghai Province No. 2012-H-807
Received  2015-10-17
Accepted  2015-11-11
DOI: 10.12015/issn.1674-8034.2016.01.001
DOI:10.12015/issn.1674-8034.2016.01.001.

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