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• Clinical Article •
Corticospinal tract injuries in subacute phase intracerebral hemorrhage: a diffusion tensor imaging study
HUANG Chang-yao  LIU Long-sheng  ZHOU Chun 

DOI:10.12015/issn.1674-8034.2016.01.002.


[Abstract] Objective: The aim of this study was to evaluate the impairment of corticospinal tract (CST) at basilar part of pons level and its relationship with function level using diffusion tensor imaging (DTI) obtained in subacute phase intracerebral hemorrhage (ICH) patients.Materials and Methods: Twenty-six basal ganglia hemorrhage patients in subacute phase (7—21 days after the onset of ICH) and Glasgow Coma Scale score >12 were recruited in the study. Function level of all patients was evaluated by the National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale (mRS), and Barthel Index (BI). DTI data were also obtained by 1.5 T MR scanner for the eigenvalues λ1、λ2、λ3 of CST at basilar part of pons. Fractional anisotropy (FA), mean diffusivity (MD) and λ23 were calculated according to these eigenvalues. Then we calculated the ratios of FA (rFA), MD (rMD), λ1 (rλ1) and λ23 (rλ23) between the affected and unaffected sides of the CSTs. Paired samples t test was applied for the comparisons of FA, MD, λ1 and λ23 between the affected and unaffected CSTs. Spearman correlation analysis was conducted between values of rFA, rMD, rλ, rλ23 and scores of NIHSS, mRS and BI. Statistical analysis was accomplished with SPSS 18.0 software.Results: The FA, MD and λ1 values of affected CST were significantly decreased (P<0.05) and λ23 did not show any significant difference between the two sides (P>0.05). The rFA was negatively correlated with NIHSS score (rs=-0.694, P=0.000) and mRS score (rs=-0.633, P=0.001), and positively correlated with BI score (rs=0.674, P=0.000).Conclusions: The integrity of affected CST of ICH patients in subacute phase was damaged, which was characterized by Wallerian degeneration. The index rFA of CSTs at basilar part of pons level could effectively evaluate the function impairment caused by CST damage.
[Keywords] Cerebral hemorrhage；Corticospinal tract；Diffusion tensor imaging

HUANG Chang-yao* Department of Neurosurgery, People's Hospital of Southwest Guizhou Province, Xingyi 562400, China

LIU Long-sheng Department of Neurosurgery, People's Hospital of Southwest Guizhou Province, Xingyi 562400, China

ZHOU Chun Department of Radiology, People's Hospital of Southwest Guizhou Province, Xingyi 562400, China

*Correspondence to: Huang CY, E-mail: HuangCY211@163.com

Conflicts of interest   None.

Received  2015-11-13
Accepted  2015-12-03
DOI: 10.12015/issn.1674-8034.2016.01.002
DOI:10.12015/issn.1674-8034.2016.01.002.

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