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• Clinical Article •
Application value of DKI in grading of extrahepatic cholangiocarcinoma
XU Meng-lai  XING Chun-hua  CHEN Hong-wei  CUI Xing-yu 

DOI:10.12015/issn.1674-8034.2016.01.007.


[Abstract] Objective: To evaluate the application value of diffusion kurtosis imaging (DKI) based D, K parameters in grading extrahepatic cholangiocarcinoma (EHCC) and compare their diagnostic potential.Materials and Methods: Thirty-five consecutive patients surgically resected and pathologically confirmed EHCC were included in this study. All patients underwent upper abdomen magnetic resonance imaging, including traditional magnetic resonance imaging and diffusion kurtosis imaging. The DKI derived parameters D, K were calculated by using post-processing software. Compared with histologic grade (well-differentiated, moderately differentiated and poorly differentiated adenocarcinoma), evaluating the association and compare the diagnostic potential of parameters by using receiver operating characteristic (ROC) analysis.Results: Thirty-five cases of EHCC include: grade Ⅰ (well-differentiated adenocarcinoma) 11 cases, grade Ⅱ (moderately differentiated adenocarcinoma) 11 cases and grade Ⅲ (poorly differentiated adenocarcinoma) 13 cases. Grade Ⅰ group lesions parameter D, K values were (1.56±0.08) ×10-3 mm2/s, 0.38±0.07. Grade Ⅱ group were (1.47±0.09) ×10-3 mm2/s, 0.51±0.08. Grade Ⅲ group were (1.39±0.07) ×10-3 mm2/s, 0.66±0.08. D and K values were significantly different in well, moderately and poorly differentiated adenocarcinoma (P<0.001, <0.001). With the reduction of histological differentiation degree, D value decreased, while K value increased (r=0.672, 0.848). ROC analysis demonstrated a higher area under the ROC curve value for K than for D for differentiating different pathological grade of EHCC (0.860 VS 0.951).Conclusions: K value of EHCC showed significantly diagnostic performance in differentiating different grade EHCC, and are helpful of pathologic degree in preoperative diagnosis.
[Keywords] Cholangiocarcinoma；Bile ducts, extrahepatic；Magnetic resonance imaging；Pathology

XU Meng-lai Department of Radiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China

XING Chun-hua Department of Radiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China

CHEN Hong-wei* Department of Radiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China

CUI Xing-yu Department of Radiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China

*Correspondence to: Chen HW, E-mail: chw6312@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This project was supported by Jiangsu Province Nature Science Foundation No. BK2012541
Received  2015-07-16
Accepted  2015-09-10
DOI: 10.12015/issn.1674-8034.2016.01.007
DOI:10.12015/issn.1674-8034.2016.01.007.

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