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• Technical Article •
Feasibility of multiple-echo GRE-R2* to renals at 3.0 T MRI
Huang Hai-bo  Huang Gui-xiong  Chen Yu-xiou  Li Da-chuang  Sun Xi-yong  Guan Jun  Qin Ming 

DOI:10.12015/issn.1674-8034.2016.01.012.


[Abstract] Objective: To explore the feasibility of multiple-echo GRE-R2* to renals at 3.0 T MRI.Materials and Methods: A MR phantom which includes fifteen vials containing 0.2—3.2 mmol/L manganese chloride in hydrochloric acid solution, 51 healthy vonlunteers (Group A) with kidneys in-situ and 22 normal renals (Group B) transplanted were scanned by 3.0 T MRI, repeated protocols to the phantom and group A with kidneys in-situ one month later. Both phantom and in-vivo renals R2* were quantified by a well-trained physician using a CMR tools after MRI.Results: Phantom R2* was linearly correlated with its concentration in vials (r=0.999, P=0.000). Through the regressions procedure,a slope of 0.008 and an intercept of -0.050 were found. No statistic differences were found for R2* value between the first and second scanning on phantom (P>0.05), The real and predicted concentration of phantom, R2* repeated scanning on phantom have a highly reliability respectively (ICCconcentration=1, ICCR2*=0.999). No statistic differences were found for gender and age between group A and B(P>0.05). No statistic differences were found for the cortical and medullary R2* between left and right renal (P>0.05). No statistic differences were found for kidneys R2* in group A between the first and second scanning (P>0.05), It showed a well reliability respectively (ICCcortex= 0.847, ICCmedullation= 0.915). No statistic differences were found for renal R2* between group A and B (P>0.05). However, renal R2* was dramatically higher in medullation than in cortex and there was statistic difference (P<0.05).Conclusions: With CMRtools, multiple-echo GRE protocol is feasible for evaluating oxygenation in kidneys at 3.0 T MRI, it could provide a reliable evidence for clinic application to renals.
[Keywords] Kidney；Magnetic resonance imaging；Diagnostic techniques and procedures

Huang Hai-bo Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

Huang Gui-xiong* Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

Chen Yu-xiou MR Room of Shanxi CAPF Hospital, Nanning 530003, China

Li Da-chuang Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

Sun Xi-yong Department of Transplantation, 303rd Hospital of PLA, Nanning 530021, China

Guan Jun Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

Qin Ming Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

*Correspondence to: Huang GX, E-mail: 303hgx@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Guangxi Scientific and Technological Plan No. GUIKEGONG1298003-8-6
Received  2015-09-28
Accepted  2015-11-09
DOI: 10.12015/issn.1674-8034.2016.01.012
DOI:10.12015/issn.1674-8034.2016.01.012.

[1]
Pedersen M, Dissing TH, Morkenborg J, et al. Validation of quantitative BOLD MRI measurements in kidney: application to unilateral ureteral obstruction. Kidney Int, 2005, 67(6): 2305-2312.
[2]
Neugarten J. Renal BOLD-MRI and assessment for renal hypoxia. Kidney Int, 2012, 81(7): 613-614.
[3]
杨正汉, 冯逢, 王霄英, DOI: . 磁共振成像技术指南. 北京: 人民军医出版社, 2014: 11.
[4]
Prasad PV, Edelman RR, Epstein FH. Noninvasive evaluation of intrarenal oxygenation with BOLD MRI. Circulation, 1996, 94(12): 3271-3275.
[5]
Gloviczki ML, Saad A, Textor SC. Blood oxygen level-dependent (BOLD) MRI analysis in atherosclerotic renalartery stenosis. Curr Opin Nephrol Hypertens, 2013, 22(5): 519-524.
[6]
张晓东, 米悦, 王晶, 等. 基于MRI技术定量测量单侧肾动脉狭窄动物模型肾脏氧摄取分数的初步研究. 放射学实践, 2015, 30(5): 519-524.
[7]
张莹莹, 徐荣天, 刘屹, 等. BOLD MRI分析肾癌及癌旁肾组织氧合状况. 中国医学影像技术, 2012, 28(4): 756-759.
[8]
蒋振兴, 王毓, 丁玖乐, 等. 血氧水平依赖MRI评估糖尿病肾病肾功能损伤的研究. 磁共振成像, 2015, 6(7): 524-528.
[9]
Djamali A, Sadowski EA, Samaniego-Picota M, et al. Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging. Transplantation, 2006, 82(5): 621-628.
[10]
Chou SY, Porush JG, Faubert PF. Renal medullary circulation: hormonal control. Kidney Int, 1990, 37(1): 1-13.
[11]
Prasad PV. Evaluation of intra-renal oxygenation by BOLD MRI. Nephron Clin Pract, 2006, 103(2): C58-C65.
[12]
Farman N, Corthesy-Theulaz I, Bonvalet JP, et al. Localization of alpha-isoforms of Na+-K+-ATP ase in rat kidney by in situ hybridization. Am J Physiol, 1991, 260(3Pt 1): C468-C474.
[13]
吴学东, 井远方, 裴夫瑜, 等. 磁共振成像（T2*)检测重型地中海贫血患者心脏、肝脏铁负荷及其临床意义. 南方医科大学学报, 2013, 33(2): 249-252.
[14]
黄璐, 韩瑞, 李志伟, 等. MRI有效驰豫时间图对兔心肌铁超负荷模型铁负荷定量的初步研究．中华放射学杂志, 2014, 48(3): 236-240.
[15]
黄海波, 周亚丽, 李致忠, 等. 前瞻性3.0 T MRI梯度多回波序列参数优化可行性研究. 磁共振成像, 2015, 6(7): 529-534.
[16]
龙莉玲, 彭鹏, 黄仲奎, 等. 铁超负荷兔模型3.0 T MRI定量肝铁沉积可行性研究. 磁共振成像, 2012, 3(6): 451-455.
[17]
王大丽, 周健, 李清海. 肾脏缺氧的血氧水平依赖性磁共振成像评估. 浙江临床医学, 2014, 16(10): 1565-1568.
[18]
石会兰, 郑振峰, 马慧, 等. 正常肾脏血氧依赖磁共振成像特点及与生理指标相关性研究. 天津医药, 2014, 42(6): 619-621.
[19]
刘静红, 刘爱连, 宁殿秀, 等. 正常志愿者肾脏血氧水平依赖MRI-1.5 T与3.0 T MRI对比．生物医学工程与临床, 2011, 15(3): 251-253.
[20]
Tumkur S, Vu A, Li L, et al. Evaluation of intrarenal oxygenation at 3.0 T using 3-dimensional multiple gradient-recalled echo sequence. Invest Radiol, 2006, 41(2): 81-184.
[21]
徐学勤, 李晓, 林晓珠, 等. 肾脏血氧水平依赖MRI的初步应用. 诊断学理论与实践, 2012, 11(2):136-140.
[22]
Xin LP, Xie JX, Liu JY, et al. A preliminary study of blood oxygen-level dependent MRI in patients with chronic kidney disease. Magn Reson Imaging, 2012, 30(3): 330-335.
[23]
吴刚, 余永强, 钱银锋. 肾脏BOLD功能磁共振成像基本原理与研究进展. 国际医学放射学杂志, 2010, 33(4): 336-339.

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