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The application of non-Gaussion DWI model in body diseases
WANG Ke  PAN Ting  ZHOU Xin  WU Guang-yao 

DOI:10.12015/issn.1674-8034.2016.01.014.


[Abstract] When perform diffusion-weighted imaging (DWI) at ultrahigh b-value, the standard monoexponential model analysis may not be suitable. Water molecules diffusion behaviors in the extracellular space away from Gaussian distribution, thus it is requiring a more sophisticated model for analysis the non-Gaussian behaviors of water. Diffusional kurtosis imaging (DKI) can describe this non-Gaussian diffusion effects of water and provide an additional parameter Kapp, which presumably reflects heterogeneity and irregularity of cellular microstructure, as well as the amount of interfaces within cellular tissue. A few studies have explored DKI outside the brain in rencent years. The most investigated organ is the prostate. Studies have shown that DKI can improve tumor detection and grading. A robust understanding of DKI is necessary for radiologists to better understand the meaning of DKI parameters in the context of different tumors and how these parameters vary between tumor types and in response to treatment. This article reviewed the basic principle, biological correlation, technique highlights and the clinical application in the body of DKI.
[Keywords] Non-Gaussian；Diffusion magnetic resonance imaging；Diffusional kurtosis imaging；Human Body

WANG Ke Department of Magnetic Resonance Imaging, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

PAN Ting Department of Magnetic Resonance Imaging, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

ZHOU Xin Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China

WU Guang-yao* Department of Magnetic Resonance Imaging, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

*Correspondence to: Wu GY, E-mail: Wuguangy2002@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China (NSFC) No. 81171315, 81227902
Received  2015-10-31
Accepted  2015-11-24
DOI: 10.12015/issn.1674-8034.2016.01.014
DOI:10.12015/issn.1674-8034.2016.01.014.

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