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• DWI Papers •
Measurement of diffusion tensor imaging in patients with mild cognitive impairment: a meta analysis
WANG Dong-dong  JIANG Chun-hui  WANG Jian 

DOI:10.12015/issn.1674-8034.2016.02.001.


[Abstract] Objective: To investigate the value of MR diffusion tensor imaging in diagnosis of mild cognitive impairment (MCI) with Meta-analysis.Materials and Methods: A search in computer databases such as PubMed, CNKI WanFang and VIP Data was performed, the relevant literature which are related to the MR diffusion tensor imaging in diagnosis of MCI were collected from the date of the above mentioned databases' establishment to January 31, 2015. The measured data of MCI and normal control (NC) was extracted from different brains (frontal lobe, parietal lobe, temporal lobe, occipital lobe, posterior cingulated fasciculus, hippocampus, parahippocampal gyrus, posterior limb of the internal capsule, fasciculus longitudinal superior, fasciculus longitudinal inferior, fornix, genu of corpus callosum, splenium of corpus callosum, uncinatus fasciculus), the relevant articles were analyzed with the Review Manager 5.3 to achieve weighted mean difference (WMD) with 95% confidence level CI.Results: Totally 47 articles including 30 English articles and 17 Chinese articles were collected. The outcome indicates the values of FA in the MCI group are lower than that in the NC group, and the WMD with 95% CI is -0.05[-0.05, 0.04], the values of FA of both the above metioned brains have significantly statistical difference except occipital lobe.Conclusion: The microstructural white matter in MCI group have been impaired, DTI can provide early diagnosis index of MCI.
[Keywords] Mild cognitive impairment；Diffusion tensor imaging；Meta-analysis；Parkinson disease

WANG Dong-dong MRI room of Imaging Center, the first affiliated hospital of Xinjiang Medical University, Urumqi 830054, China

JIANG Chun-hui MRI room of Imaging Center, the first affiliated hospital of Xinjiang Medical University, Urumqi 830054, China

WANG Jian* MRI room of Imaging Center, the first affiliated hospital of Xinjiang Medical University, Urumqi 830054, China

*Correspondence to: Wang J, E-mail: jeanw1265@sina.com

Conflicts of interest   None.

Received  2015-11-05
Accepted  2016-01-06
DOI: 10.12015/issn.1674-8034.2016.02.001
DOI:10.12015/issn.1674-8034.2016.02.001.

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