Share：
Share this content in WeChat
X
[Chinese][PDF]931181
• DWI Papers •
Measurement of diffusion tensor imaging in patients with mild cognitive impairment: a meta analysis
WANG Dong-dong  JIANG Chun-hui  WANG Jian 

DOI:10.12015/issn.1674-8034.2016.02.001.


[Abstract] Objective: To investigate the value of MR diffusion tensor imaging in diagnosis of mild cognitive impairment (MCI) with Meta-analysis.Materials and Methods: A search in computer databases such as PubMed, CNKI WanFang and VIP Data was performed, the relevant literature which are related to the MR diffusion tensor imaging in diagnosis of MCI were collected from the date of the above mentioned databases' establishment to January 31, 2015. The measured data of MCI and normal control (NC) was extracted from different brains (frontal lobe, parietal lobe, temporal lobe, occipital lobe, posterior cingulated fasciculus, hippocampus, parahippocampal gyrus, posterior limb of the internal capsule, fasciculus longitudinal superior, fasciculus longitudinal inferior, fornix, genu of corpus callosum, splenium of corpus callosum, uncinatus fasciculus), the relevant articles were analyzed with the Review Manager 5.3 to achieve weighted mean difference (WMD) with 95% confidence level CI.Results: Totally 47 articles including 30 English articles and 17 Chinese articles were collected. The outcome indicates the values of FA in the MCI group are lower than that in the NC group, and the WMD with 95% CI is -0.05[-0.05, 0.04], the values of FA of both the above metioned brains have significantly statistical difference except occipital lobe.Conclusion: The microstructural white matter in MCI group have been impaired, DTI can provide early diagnosis index of MCI.
[Keywords] Mild cognitive impairment；Diffusion tensor imaging；Meta-analysis；Parkinson disease

WANG Dong-dong MRI room of Imaging Center, the first affiliated hospital of Xinjiang Medical University, Urumqi 830054, China

JIANG Chun-hui MRI room of Imaging Center, the first affiliated hospital of Xinjiang Medical University, Urumqi 830054, China

WANG Jian* MRI room of Imaging Center, the first affiliated hospital of Xinjiang Medical University, Urumqi 830054, China

*Correspondence to: Wang J, E-mail: jeanw1265@sina.com

Conflicts of interest   None.

Received  2015-11-05
Accepted  2016-01-06
DOI: 10.12015/issn.1674-8034.2016.02.001
DOI:10.12015/issn.1674-8034.2016.02.001.

[1]
Ownby RL, Crocco E, Acevedo A, et al. Depression and risk for alzheimer’s disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry, 2006, 63(5): 530-538.
[2]
Bai F, Zhang Z, Watson DR, et al. Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment. J Neurol Sci, 2009, 278(1-2): 102-106.
[3]
Cho H, Yang DW, Shon YM, et al. Abnormal integrity of corticocortical tracts in mild cognitive impairment: a diffusion tensor imaging study. J Korean Med Sci, 2008, 23(3): 477-483.
[4]
Zhuang L, Wen W, Trollor JN, et al. Abnormalities of the fornix in mild cognitive impairment are related to episodic memory loss. J Alzheimers Dis, 2012, 29(3): 629-639.
[5]
Pievani M, Agosta F, Pagani E, et al. Assessment of white matter tract damage in mild cognitive impairment and alzheimer’s disease. Hum Brain Mapp, 2010, 31(12): 1862-1875.
[6]
Nowrangi MA, Okonkwo O, Lyketsos C, et al. Atlas-based diffusion tensor imaging correlates of executive function. J Alzheimers Dis, 2015, 44(2): 585-598.
[7]
Duffy SL, Paradise M, Hickie IB, et al. Cognitive impairment with and without depression history: an analysis of white matter microstructure. J Psychiatry Neurosci, 2014, 39(2): 135-143.
[8]
Fellgiebel A, Müller MJ, Wille P, et al. Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment. Neurobiol Aging, 2005, 26(8): 1193-1198.
[9]
Stricker NH, Salat DH, Foley JM, et al. Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning. J Int Neuropsychol Soc, 2013, 19(8): 925-937.
[10]
Müller MJ, Greverus D, Weibrich C, et al. Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI. Neurobiol Aging, 2007, 28(3): 398-403.
[11]
Shim YS, Yoon B, Shon YM, et al. Difference of the hippocampal and white matter microalterations in MCI patients according to the severity of subcortical vascular changes: neuropsychological correlates of diffusion tensor imaging. Clin Neurol Neurosurg, 2008, 110(6): 552-561.
[12]
Liu Y, Spulber G, Lehtimäki KK, et al. Diffusion tensor imaging and tract-based spatial statistics in alzheimer’s disease and mild cognitive impairment. Neurobiol Aging, 2011, 32(9): 1558-1571.
[13]
Zhang Y, Schuff N, Jahng GH, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and alzheimer’s disease. Neurology, 2007, 68(1): 13-19.
[14]
Bozoki AC, Korolev IO, Davis NC, et al. Disruption of limbic white matter pathways in mild cognitive impairment and alzheimer’s disease: a DTI/FDG-PET study. Hum Brain Mapp, 2012, 33(8): 1792-1802.
[15]
Ukmar M, Makuc E, Onor ML, et al. Evaluation of white matter damage in patients with alzheimer’s disease and in patients with mild cognitive impairment by using diffusion tensor imaging. Radiol Med, 2008, 113(6): 915-922.
[16]
Hong YJ, Yoon B, Lim SC, et al. Microstructural changes in the hippocampus and posterior cingulate in mild cognitive impairment and alzheimer’s disease: a diffusion tensor imaging study. Neurol Sci, 2013, 34(7): 1215-1221.
[17]
Choo IH, Lee DY, Oh JS, et al. Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and alzheimer’s disease. Neurobiol Aging, 2010, 31(5): 772-779.
[18]
Delano-Wood L, Stricker NH, Sorg SF, et al. Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment. J Alzheimers Dis, 2012, 29(3): 589-603.
[19]
Carter SF, Embleton KV, Anton-Rodriguez JM, et al. Regional neuronal network failure and cognition in late-onset sporadic alzheimer’s disease. AJNR Am J Neuroradiol, 2014, 35(6Suppl): 18-30.
[20]
Scrascia F, Curcio G, Ursini F, et al. Relationship among diffusion tensor imaging, EEG activity, and cognitive status in mild cognitive impairment and alzheimer’s disease patients. J Alzheimers Dis, 2014, 38(4): 939-950.
[21]
Goldstein FC, Mao H, Wang L, et al. White matter Integrity and episodic memory performance in mild cognitive impairment: a diffusion tensor imaging study. Brain Imaging Behav, 2009, 3(2): 132-141.
[22]
Kiuchi K, Morikawa M, Taoka T, et al. Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early alzheimer’s disease: a diffusion tensor tractography study. Brain Res, 2009, 1287(9): 184-191.
[23]
Huang J, Auchus AP. Diffusion tensor imaging of normal appearing white matter and its correlation with cognitive functioning in mild cognitive impairment and alzheimer’s disease. Ann N Y Acad Sci, 2007, 1097(1): 259-264.
[24]
Nishioka C, Poh C, Sun SW. Diffusion tensor imaging reveals visual pathway damage in patients with mild cognitive impairment and alzheimer’s disease. J Alzheimers Dis, 2015, 45(1): 97-107.
[25]
Zimny A, Szewczyk P, Bladowska J, et al. Quantitative evaluation of changes in the selected white matter tracts using diffusion tensor imaging in patients with alzheimer’s disease and mild cognitive impairment. Neuroradiol J, 2012, 25(3): 300-310.
[26]
Fujie S, Namiki C, Nishi H, et al. The role of the uncinate fasciculus in memory and emotional recognition in amnestic mild cognitive impairment. Dement Geriatr Cogn Disord, 2008, 26(5): 432-439.
[27]
Chen TF, Lin CC, Chen YF, et al. Diffusion tensor changes in patients with amnesic mild cognitive impairment and various dementias. Psychiatry Res, 2009, 173(1): 15-21.
[28]
Thillainadesan S, Wen W, Zhuang L, et al. Changes in mild cognitive impairment and its subtypes as seen on diffusion tensor imaging. Int Psychogeriatr, 2012, 24(9): 1483-1493.
[29]
Rogalski EJ, Murphy CM, deToledo-Morrell L, et al. Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: a diffusion tensor imaging study. Behav Neurol, 2009, 21(1): 51-61.
[30]
Sali D, Verganelakis DA, Gotsis E, et al. Diffusion tensor imaging (DTI) in the detection of white matter lesions in patients with mild cognitive impairment (MCI). Acta Neurol Belg, 2013, 113(4): 441-451.
[31]
Larroza A, Moratal D, D’Ocón AV, et al. Tractography of the uncinate fasciculus and the posterior cingulate fasciculus in patients with mild cognitive impairment and Alzheimer disease. Neurologia, 2014, 29(1): 11-20.
[32]
高光峰. Alzheimer病及轻度认知障碍磁共振扩散张量成像的研究. 天津: 天津医科大学, 2006.
[33]
王建华, 吕佩源, 王贺波, 等. DTI评价轻度认知障碍及轻中度阿尔茨海默病脑白质微细结构损害的研究. 中国神经免疫学和神经病学杂志, 2010, 17(3): 211-214.
[34]
吴婷, 刘文, 肖朝勇, 等. 阿尔茨海默病与轻度认知障碍弥散张量成像研究. 临床精神医学杂志, 2009, 19(4): 224-226.
[35]
陈皓, 洪楠, 于欣, 等. 磁共振扩散张量成像评价轻度认知障碍患者的脑白质变化. 中国医学影像技术, 2009, 25(8): 1358-1360.
[36]
常城, 李文彬, 谢文晖, 等. 扩散张量成像观察遗忘型轻度认知障碍患者联合纤维束. 中国医学影像技术, 2010, 26(1): 56-59.
[37]
嵇鸣，叶春涛，苗华栋，等．老年轻度认知功能障碍的高场MR脑DTI定量研究. 上海医学影像, 2011, 20(3): 200-204.
[38]
任庆云, 何丽, 刘斋, 等. 轻度认知功能障碍患者后扣带回的磁共振扩散张量成像研究．临床合理用药杂志, 2014, 7(2): 23-24.
[39]
任庆云, 何丽, 刘斋, 等. 轻度认知功能障碍患者在MR扩散张量成像中脑白质各向异性分数值的变化. 疑难病杂志, 2014, 13(1): 34-36, 39.
[40]
廖晶, 袁慧书, 朱玥, 等. 轻度认知功能障碍及阿尔茨海默病脑白质的MR扩散张量成像研究．中华放射学杂志, 2009, 43(5): 490-494.
[41]
何丽, 刘斋, 任庆云, 等. 轻度认知障碍的MR扩散张量成像研究. 实用放射学杂志, 2014, 30(8): 1255-1258.
[42]
黄婷婷, 刘鹏飞, 刘志兰, 等. 遗忘型轻度认知障碍的弥散张量成像研究. 中国临床医学影像杂志, 2012, 23(2): 77-80.
[43]
侯美丹, 范国光, 李松柏, 等. 遗忘型轻度认知障碍脑白质纤维束扩散张量成像研究．放射学实践, 2014, 29(12): 1392-1395.
[44]
吴娟, 顾红梅, 曹亮, 等. 遗忘型轻度认知障碍的脑白质纤维束成像研究. 实用放射学杂志, 2014, 30(11): 1787-1790, 1801.
[45]
凌茹晶, 倪秀石, 张琳, 等. 弥散张量成像与老年人认知功能的相关性. 中国临床神经科学, 2010, 18(6): 622-630.
[46]
杨延辉, 梁佩鹏, 秦文, 等. 轻度认知障碍患者背外侧前额叶白质的DTI研究. 临床放射学杂志, 2010, 29(4): 432-435.
[47]
郑慧鑫. 扩散峰度成像在轻度认知障碍及阿尔茨海默病中的应用价值. 太原: 山西医科大学, 2013.
[48]
赵强. 磁共振弥散张量成像在轻度认知功能障碍中的应用价值研究. 济南: 山东大学, 2012.
[49]
Sexton CE, Kalu UG, Filippini N, et al. A meta-analysis of diffusion tensor imaging in mild cognitive impairment and alzheimer’s disease. Neurobiol Aging, 2011, 32(12): 5-18.
[50]
李树金, 吴晓冰, 张绍伟, 等. 表观扩散系数鉴别良恶性软组织肿瘤价值的Meta分析. 磁共振成像, 2012, 3(4): 255-259.
[51]
Yoshiura T, Wu O, Zaheer A, et al. Highly diffusion-sensitized MRI of brain: dissociation of gray and white matter. Magn Reson Med, 2001, 45(5): 734-740.
[52]
Zimny A, Szewczyk P, Trypka E, et al. Multimodal imaging in diagnosis of alzheimer’s disease and amnestic mild cognitive impairment: value of magnetic resonance spectroscopy, perfusion, and diffusion tensor imaging of the posterior cingulate region. J Alzheimers Dis, 2011, 27(3): 591-601.
[53]
Zhang Y, Schuff N, Jahng GH, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and alzheimer’s disease. Neurology, 2007, 68(1): 13-19.
[54]
Mielke MM, Kozauer NA, Chan KC, et al. Regionally-specific diffusion tensor imaging in mild cognitive impairment and alzheimer’s disease. Neuroimage, 2009, 46(1): 47-55.
[55]
Nowrangi MA, Lyketsos CG, Leoutsakos JM, et al. Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and alzheimer’s disease. Alzheimers Dement, 2013, 9(5): 519-528.
[56]
Clerx L, Visser PJ, Verhey F, et al. New MRI markers for alzheimer’s disease: a meta-analysis of diffusion tensor imaging and a comparison with medial temporal lobe measurements. J Alzheimers Dis, 2012, 29(2): 405-429.
[57]
唐守现，戴建平．扩散张量成像和磁敏感加权成像在阿尔茨海默病海马的研究进展. 磁共振成像, 2015, 6(9): 699-703.
[58]
Elderkin-Thompson V, Ballmaier M, Hellemann G, et al. Executive function and MRI prefrontal volumes among healthy older adults. Neuropsychology, 2008, 22(5): 626-37.
[59]
Hamidi M, Tononi G, Postle BR. Evaluating frontal and parietal contributions to spatial working memory with repetitive transcranial magnetic stimulation. Brain Res, 2008, 1230(9): 202-210.
[60]
Pantel J, Schröder J, Jauss M, et al.Topography of callosal atrophy reflects distribution of regional cerebral volume reduction in alzheimer’s disease. Psychiatry Res, 1999, 90(3): 181-192.

PREV Progress of resting-state functional magnetic resonance imaging in bipolar disorder
NEXT Value of DWI to transplanted renals with early acute rejection: a preliminary study
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn