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• DWI Papers •
Value of DWI to transplanted renals with early acute rejection: a preliminary study
LIANG Shi-wei  HUANG Hai-bo  HUANG Gui-xiong  GUAN Jun  YANG Jianjun  LIU Xu-yang 

DOI:10.12015/issn.1674-8034.2016.02.002.


[Abstract] Objective: To explore the value of DWI on transplanted renals with early acute rejection.Materials and Methods: Study protocol was approved by local ethics committee; informed consent was obtained. A total of 88 velunteers were enrolled and divided into three groups, as follows: Group A, 51 cases with healthy kidneys in situ; group B, 22 transplantation with stable renal function for at least 3 months after operating; and group C, 15 iliac allograft renals with early acute rejection from 1 week to 4 weeks after operating. T2W, T1W axial/coronal, and a transverse fat-saturated echo-planar DWI with 3 b-values(0, 100, 800 s/mm2) were performed on a 3.0 T scanner during normal breathing. EWS2.6.3 workstation was used to calculate the apparent diffusion coefficient(ADC) value of renal cortex, medulla, muscle respectively based on ADC0-800 maps. Receiver operating characteristic(ROC) curve was used to predict the kidneys with early acute rejection.Results: No statistic significances were found for gender, age, ADC0-800 of muscle among three groups(P>0.05), nor did ADC0-800 values reveal a significant difference for left and right kidneys in situ(P>0.05). It showed renal cortex mean(+/-SD) ADC0-800 values of (1.92±0.13), (1.93±0.15), (1.68±0.14)×10-3 mm2/s for group A, B and C, respectively. Group C was significantly higher than both group A and B(P<0.05); however no statistic significance was found between group A and B(P>0.05); Nor did medullary ADC0-800 values reveal a significant difference for 3 groups. While the difference between cortex and medulla was statistically significant for both groups A and B(P<0.05). With an ADC0-800 <1.76×10-3 mm2/s as diagnose critical points compared to biopsy, the sensibility was 86.7%, the specificity was 90.4%, and the accuracy was 0.942 in the prediction of the kidneys with early acute rejection.Conclusion: DWI is of important value in transplanted renals with early-stage acute rejection, it can provide reliable imaging evidence for treatment.
[Keywords] Kidney transplantation；Graft rejection；Diffusion magnetic resonance imaging；Diffusion weighted imaging

LIANG Shi-wei Department of Radiology, Guangxi CAPF Hospital, Nanning 530003, China

HUANG Hai-bo* Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

HUANG Gui-xiong Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

GUAN Jun Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

YANG Jianjun Department of Pathology, 303rd Hospital of PLA, Nanning 530021, China

LIU Xu-yang Department of Pathology, 303rd Hospital of PLA, Nanning 530021, China

*Correspondence to: Huang HB, E-mail: jackie000528@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Guangxi scientific research and technology development project No. GUIKEGONG1298003-8-6
Received  2015-11-01
Accepted  2015-12-23
DOI: 10.12015/issn.1674-8034.2016.02.002
DOI:10.12015/issn.1674-8034.2016.02.002.

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