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• Clinical Article •
Preliminary using multivoxel 1H-MRS to reveals the effect of CPAP treatment in moderate and severe OSAHS patients
MU Xin-nuan  WANG Bin  LIU Quan-yuan  SUN Yun-liang  LIU Jiang-hua  YANG Jia-bin  LIU Xin-jiang 

DOI:10.3969/issn.1674-8034.2016.02.004.


[Abstract] Objective: To investigate the variation of multivoxel 1H magnetic resonance spectroscopy(1H-MRS) after continuous positive airway pressure(CPAP) treatment in patients who are suffering from obstructive sleep apnea hypopnea syndrome(OSAHS).Materials and Methods: Twenty-five cases of moderate or severe OSAHS patients were performed brain multivoxel 1H-MRS examinations before and after CPAP treatment. The ratios of brain metabolites in frontal lobe was recorded and analyzed respectively. To observe whether the lactate(Lac) peak appeared or not.Results: In region of frontal lobe, the NAA/Cr, NAA/Cho of the patients after treatment 1 day (2.3140±0.3128 and 2.0164±0.4240, respectively) and 90 days (2.2812±0.2904 and 2.0180±0.4796) were increased compared with the patients before treatment (2.0212±0.2312 and 1.6088±0.2571), and the differences were statistically significant(P<0.05). Lac peak was not detected in all.Conclusion: Multivoxel 1H-MRS could demonstrate sensitively the changes of brain metabolism in patients with OSAHS before and after CPAP treatment, and may help clinical therapeutic effect and prognostic evaluation provide objective imaging evidence.
[Keywords] Obstructive sleep apnea hypopnea syndrome；Multivoxel 1H magnetic resonance spectroscopy；Cerebral metabolic；Continuous positive airway pressure

MU Xin-nuan Department of Radiology, Binzhou Medical University hospital, Binzhou 256600, China

WANG Bin* Department of Radiology, Binzhou Medical University hospital, Binzhou 256600, China

LIU Quan-yuan Department of Radiology, Binzhou Medical University hospital, Binzhou 256600, China

SUN Yun-liang Department of Radiology, Binzhou Medical University hospital, Binzhou 256600, China

LIU Jiang-hua Department of Radiology, Binzhou Medical University hospital, Binzhou 256600, China

YANG Jia-bin Department of Radiology, Binzhou Medical University hospital, Binzhou 256600, China

LIU Xin-jiang Department of Radiology, Binzhou Medical University hospital, Binzhou 256600, China

*Correspondence to: Wang B, E-mail: binwang001@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Founds No. 81171303 Shandong province science and technology development plan in 2014 No. 2014GSF118115
Received  2015-12-01
Accepted  2015-12-30
DOI: 10.3969/issn.1674-8034.2016.02.004
DOI:10.3969/issn.1674-8034.2016.02.004.

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