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• Clinical Article •
Changes of default mode network in patients with chronic mountain sickness: evidence from PCC functional connectivity
KONG De-min  BAO Hai-hua  LI Chao-wei  LI Wei-xia  WANG Fang-fang 

DOI:12015/j.issn.1674-8034.2016.02.005.


[Abstract] Objective: To explore the changes of default mode network (DMN) in CMS patients, to investigate the pathogenesis of brain lesions in patients with CMS.Materials and Methods: Twenty-four patients with clinically diagnosed CMS and age, sex, years of education, altitude matched 25 cases of normal volunteers underwent whole brain scan, and EPI images were acquired. The difference in DMN between the two groups was analyzed by defining posterior cingulate cortex (PCC) as seed region.Results: Compared with normal control group, posterior cingulate showed increased function connectivity with left parahippocampal gyrus, left angular gyrus, left medial frontal gyrus, right cerebellum 9 area and left cerebellum crus 2 area of CMS patients.Conclusion: CMS patients had changed functional connection in many regions, it might be associated with the pathogenesis of CMS patients .
[Keywords] Chronic mountain sickness；Resting state；Functional magnetic resonance imaging；Default mode network；Functional connection

KONG De-min Department of Radiology, Affiliated hospital of Qinghai University, Xi' ning 810001, China

BAO Hai-hua* Department of Radiology, Affiliated hospital of Qinghai University, Xi' ning 810001, China

LI Chao-wei Department of Radiology, Affiliated hospital of Qinghai University, Xi' ning 810001, China

LI Wei-xia Department of Radiology, Affiliated hospital of Qinghai University, Xi' ning 810001, China

WANG Fang-fang Department of Radiology, Affiliated hospital of Qinghai University, Xi' ning 810001, China

*Correspondence to: Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81060117 International cooperation project of Qinghai provincial science and Technology Department No. 2012-H-807
Received  2015-11-10
Accepted  2016-01-08
DOI: 12015/j.issn.1674-8034.2016.02.005
DOI:12015/j.issn.1674-8034.2016.02.005.

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