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Clinical features and MRI findings of wernicke encephalopathy
ZHANG Shuang  PENG Ru-chen  XIN Rui-qiang  YANG Yan-hui  ZHENG Jing-li 

DOI:10.12015/issn.1674-8034.2016.02.010.


[Abstract] Objective: To investigate the clinical and MR imaging features of wernicke encephalopathy(WE).Materials and Methods: Retrospective analysis in February 2010 to June 2015, the clinical diagnosis of 10 cases of wernicke encephalopathy in patients with clinical and MRI image data.Results: Three of ten patients showed changes in consciousness and psychiatric syptoms, Three patients had ocular manifestations, and four had ataxia. On MR imaging, six patients had evidence of symmetric lesions in the medial thalami and in the periventricular region of the third or four ventricle, and in periaqueductal area. Two patients had evidence of mamillary bodies, column of the fornix; Two patient had evidence of tectal plate, mamillary bodies, periaqueductal area, bilateral signal-intensity alterations of the pre- and postcentral cortex. The imaging findings were hyperintensity on T2-weighted or T1-weighter and fluid-attenuated inversion recovery (FLAIR) images.Conclusion: Contrast enhancement in the mamillary bodies and thalamus is a typical finding of the disease in WE patients. MR imaging has a valuable diagnostic role in diagnosing early WE except for clinical symptoms.
[Keywords] Wernicke’s encephalopathy；Magnetic resonance imaging；Diffusion weighted imaging；Vit-B1

ZHANG Shuang Department of Radiology, BeiJing LuHe Hospital, Capital Medical University, Beijing 101100, China

PENG Ru-chen* Department of Radiology, BeiJing LuHe Hospital, Capital Medical University, Beijing 101100, China

XIN Rui-qiang Department of Radiology, BeiJing LuHe Hospital, Capital Medical University, Beijing 101100, China

YANG Yan-hui Department of Radiology, BeiJing LuHe Hospital, Capital Medical University, Beijing 101100, China

ZHENG Jing-li Department of Radiology, BeiJing LuHe Hospital, Capital Medical University, Beijing 101100, China

*Correspondence to: Peng RC, E-mail: 13501271260@163.com

Conflicts of interest   None.

Received  2015-11-23
Accepted  2016-01-04
DOI: 10.12015/issn.1674-8034.2016.02.010
DOI:10.12015/issn.1674-8034.2016.02.010.

[1]
戴建平，陈红艳．磁共振脉冲序列在中枢神经系统中的应用（一). 磁共振成像, 2010, 1(4): 220-226.
[2]
Pereira DB, Pereira ML, Gasparetto EL. Nonalcoholic Wernicke encephalopathy with extensive cortical involvement: cortical laminar necrosis and hemorrhage demonstrated with susceptibility-weighted MR phase images. AJNR Am J Neuroradiol, 2011, 32(2): 37-38.
[3]
张春礼, 谢寒冰, 余江涛, 等. 肠外瘘并发韦尼克脑病的诊治分析. 中华普通外科学杂志, 2012, 27(5): 714-720.
[4]
Rufa A, Rosini F, Cerase A, et al. Wernicke encephalopathy after gastrintestinal surgery for cancer: causes of diagnostic lailure or delay. Int J Neurosci, 2011, 121(4): 201-208.
[5]
Morishima T, Aoyama M, Iida Y, et al. Lactic acid incer ases aquaporin expression on the cell membrane of cultured rat astrocutes. Neurosci Res, 2008, 61(1): 8-16.
[6]
Wang D, Hazell AS. Microglial activation is a major contributor to neurologic dysfunction in thiamine deficiency. Biochem Biophys Res Commun, 2010, 402(1): 123-128.
[7]
Hazell AS, SheedyD, Oanea R, et al. Loss of astrocytic glutamate transporters in Wernicke encephalopathy. Glia, 2010, 58(2): 148-156.
[8]
Zuccoli G, Pipitone N. Neuroimaging findings in acute wernicke ncephalopathy: review of the literature. AJR Am J Roentgenol, 2009, 192(2): 501-508.
[9]
Ogershok PR, Rahman A, Nestor S, et al. Wernicke encephalopathy in nonalcoholic patients. Am J Med Sci, 2002, 323(2): 107-111.
[10]
韩顺昌, 浦传强, 黄旭升, 等. Wernicke脑病的临床影像学及病理学特点. 临床神经病学志, 2006, 19(3): 167-169.
[11]
李光, 高平, 刘焦枝, 等. Wernicke脑病的临床与MRI诊断. 放射学实践, 2012, 27(5): 502-504.
[12]
马林．加强多发性硬化的磁共振成像诊断及研究．磁共振成像, 2011, 2(4): 241-242.
[13]
冯逢．多发性硬化的常见MRI征象分析．磁共振成像, 2011, 2(4): 309-313.
[14]
戴世鹏, 庞军, 戴景儒. 高血压脑病的MRI表现及鉴别诊断. 磁共振成像, 2014, 5(1): 15-18.

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