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• Clinical Article •
The role of mean relative cerebral blood volume of MRI in differentiating recurrent glioma from radiation injury: a Meta-analysis
HONG Shun-ming  ZHANG Yu  LU Hao  WANG Peng-fei  LI Wen-han  ZHANG Chun-zhi 

DOI:10.12015/issn.1674-8034.2016.03.002.


[Abstract] Objective: This Meta-analysis is to evaluate the diagnostic accuracy of rCBVmean of MRI in distinguishing glioma recurrence from radiation injury.Material and Methods: PubMed, Embase and Chinese Biomedical database were systematically searched for studies (from January 2000 to August 2015) that evaluated the rCBVmean of MRI in differential diagnosis of glioma recurrence from radiation injury. Data were extracted from eligible studies and these studies were performed quality assessment. The Meta-analysis was performed by Stata13.0.Results: Fourteen studies involving 378 patients were eligible, and included in our Meta-analysis. The pooled SEN, SPE, PLR, NLR and DOR were 0.87 (95% CI: 0.80—0.91), 0.89 (95% CI: 0.81—0.94), 7.6 (95% CI: 4.3—13.4), 0.15 (95% CI: 0.10—0.23) and 50 (95% CI: 22—117), respectively. The area under the SROC was 0.93 (95% CI: 0.91—0.95).Conclusions: This Meta-analysis showed that the rCBVmean of MRI had good diagnostic accuracy in discriminating between glioma recurrence and radiation injury.
[Keywords] Glioma；Brain injuries；Radiotherapy side-effects；Magnetic resonance imaging

HONG Shun-ming The graduate school of Tianjin Medical University, Tianjin, 300070, China

ZHANG Yu Department of MRI, the General Hospital of CAPF, Beijing,100039, China

LU Hao Department of MRI, Tianjin Huanhu Hospital, Tianjin, 300060, China

WANG Peng-fei The graduate school of Tianjin Medical University, Tianjin, 300070, China

LI Wen-han The graduate school of Tianjin Medical University, Tianjin, 300070, China

ZHANG Chun-zhi* Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China

*Correspondence to: Zhang CZ, E-mail: zhchzh_6@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Public relations project of Tianjin Municipal Public Health Bureau No. 12KG113
Received  2015-12-14
Accepted  2016-01-05
DOI: 10.12015/issn.1674-8034.2016.03.002
DOI:10.12015/issn.1674-8034.2016.03.002.

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