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• Clinical Article •
The value of diffusion-weighted imaging for clinical evaluation of chemoradiatiotherapy of non-surgical laryngeal and hypopharyngeal carcinoma patients
LI Yi-xia  CUI Yuan-yuan  CUI Bao  MA Lu  CHEN Si  YANG Na  ZHANG Ailian  CAI Jian-ming 

DOI:10.12015/issn.1674-8034.2016.03.005.


[Abstract] Objective: To investigate the value of the magnetic resonance diffusion weighted imaging combined with conventional MRI for predicting clinical effect of chemoradiotherapyin non-surgical laryngeal and hypopharyngeal carcinoma.Materials and Methods: A total of 25 cases of patients with non-surgical laryngeal and hypopharyngeal carcinoma, which was confirmed by biopsy or surgical pathology, were included. All patients underwent conventional MRI and DWI scan for pre- and post-treatment. The maximum cross sectional area and apparent diffusion coefficient (ADC) value (the mean, the highest and lowest ADC value) of the tumor were measured before treatment. The residual tumor size and ADC values were measured after treatment, and tumor regression rate was calculated. The differences of ADC values with complete response (CR) and non-CR before and after treatment were analyzed.Results: The maximum cross sectional area [2.42 (0—7.92) cm2] of the tumor after treatment was significantly reduced (P<0.05) than that from pre-treatment [4.81 (0.83—14.12) cm2]. The total tumor remission rate was 74.8% (6.0%—100%) and CR was in 11 (11/25, 44.0%) patients. Pre-treatment ADCmean and the highest ADC value were negatively correlated with the rate of tumor regression (r=-0.922, - 0.691, P<0.05), and post-treatment ADCmean value was positively correlated with the regression rate (P<0.05, r=0.678). Pre-treatment ADCmean and ADChigh values in non CR group were higher than those in the CR group. Post-treatment ADCmean value and differences of the ADC value between pre- and post-treatment of CR group were significantly higher than those of non CR group (P<0.05).Conclusions: The pre-treatment ADC values and the differences of the ADC value between pre- and post-treatment might be useful to predict and evaluate the response of radiotherapy and chemotherapy in the non-surgical laryngeal and hypopharyngeal carcinoma patients.
[Keywords] Laryngeal neoplasms；Hypopharyngeal neoplasms；Diffusion magnetic resonance imaging；Radiotherapy；Chemotherapy, adjuvant

LI Yi-xia Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

CUI Yuan-yuan Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

CUI Bao Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

MA Lu Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

CHEN Si Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

YANG Na Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

ZHANG Ailian Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

CAI Jian-ming* Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China; Department of Radiology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China

*Correspondence to: Cai JM, E-mail: beili12345@sina.cn

Conflicts of interest   None.

Received  2015-12-02
Accepted  2016-01-25
DOI: 10.12015/issn.1674-8034.2016.03.005
DOI:10.12015/issn.1674-8034.2016.03.005.

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