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• Clinical Article •
MRI features of primary biliary cirrhosis and correlations with pathological staging
HAN Dan  YUAN Yan-wen  ZHANG Jie  XU Yan  JIN Er-hu  HE Wen 

DOI:10.12015/issn.1674-8034.2016.03.006.


[Abstract] Objective: To explore the features of primary biliary cirrhosis (PBC) on magnetic resonance imaging (MRI) and correlate them with pathological staging.Materials and Methods: MRI and pathologic findings of 50 patients with PBC (observation group) and 44 patients with other cirrhosis-causing liver diseases (control group) were analyzed, retrospectively. The severity of PBC was divided into stage Ⅰ—Ⅳ according to the histopathological changes. The MRI findings of the patients in the two groups were reviewed and compared, and the differences of MRI findings of PBC in different pathological stages were discussed.Results: The common MRI findings of PBC are the heterogeneous hyperintensity in the liver on T2WI, periportal long T2 signal intensity, periportal halo sign, decreased number and diameter of the intrahepatic bile ducts, liver parenchyma lace-like fibrosis, liver segmental atrophy or hypertrophy, abdominal lymphadenopathy, ascites and splenomegaly. The differences of the demonstrating frequencies on MRI were statistically significant in the periportal halo sign (χ2=6.887, P<0.05), decreased intrahepatic bile ducts (χ2= 5.537, P<0.05), and lymphadenopathy (χ2= 22.297, P<0.05) between the observation group and control group. Among the patients with PBC in varied histological stages, the demonstrating frequencies on MRI between stage II and stage III were significantly different in the periportal halo sign (P<0.05), and a decreased number and diameter of the intrahepatic bile ducts (P<0.05), but not in the lymphadenopathy (P>0.05).Conclusions: MRI findings of PBC were correlated with pathological staging, and the MRI examination was beneficial to evaluate the severity of the disease.
[Keywords] Liver Cirrhosis, Biliary；Magnetic resonance imaging；Pathology

HAN Dan Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

YUAN Yan-wen Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, China

ZHANG Jie Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

XU Yan Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

JIN Er-hu* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

HE Wen* Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Jin EH, E-mail: erhujin@263.net. He W, E-mail: hewen1724@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was supported by Beijing Talented Youth Cultivation Project No. 2013B008001000009
Received  2016-01-10
Accepted  2016-02-10
DOI: 10.12015/issn.1674-8034.2016.03.006
DOI:10.12015/issn.1674-8034.2016.03.006.

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