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• CEST Papers •
Principle and application progress of chemical exchange saturation transfer (CEST) technique
YAN Shuang  LI Ming-li  JIN Zheng-yu 

DOI:10.12015/issn.1674-8034.2016.04.001.


[Abstract] Hydrogen protons, a component of many biological macromolecules like protein, glycosaminoglycan and glycogen, could be saturated by pre-saturated radio frequency pulses and exchanged with those hydrogen protons in the water, and then the measurement of these water molecule signals could reflect their content in the human body. This mechanism is the principal of a technique called Chemical Exchange Saturation Transfer (CEST). Meanwhile, as there is a close relation between these molecules and the incidence of tumor and stroke, this technique could be used in the diagnosis and treatment. With regard to its noninvasive and nonradiative nature, CEST has become a research hotspot. Therefore, the purpose of this article was to review the principle and application progress of this technique.
[Keywords] Magnetic resonance imaging；Magnetization transfer；Chemical exchange saturation transfer；pH image；Amide proton transfer

YAN Shuang Chinese Academy of Medical Sciences, Peking Union Medical College, Department of Radiology of Peking Union Medical College Hospital, Beijing 100730, China

LI Ming-li Chinese Academy of Medical Sciences, Peking Union Medical College, Department of Radiology of Peking Union Medical College Hospital, Beijing 100730, China

JIN Zheng-yu* Chinese Academy of Medical Sciences, Peking Union Medical College, Department of Radiology of Peking Union Medical College Hospital, Beijing 100730, China

*Correspondence to: Jin ZY, E-mail: jin_zhengyu@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81171390 Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period No. 2012BAI23B06 Health Industry Special Scientific Research Project No. 201402019
Received  2016-01-20
Accepted  2016-03-15
DOI: 10.12015/issn.1674-8034.2016.04.001
DOI:10.12015/issn.1674-8034.2016.04.001.

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