Share：
Share this content in WeChat
X
[Chinese][PDF]85787
• CEST Papers •
Research of chemical exchange saturation transfer in brain
YANG Yong-gui  SHEN Zhi-wei  WU Ren-hua  CHEN Zhong  CAI Cong-bo  GUO Gang 

DOI:10.12015/issn.1674-8034.2016.04.002.


[Abstract] Chemical exchange saturation transfer (CEST) imaging is a new method for magnetic resonance imaging theory of exchange in the magnetization transfer and chemical, the expansion of the new field of molecular magnetic resonance imaging, but it’s still in the research stage. The intracellular substances as an endogenous contrast agent, through the indirect detection of metabolite water signal information for tissue pH imaging and imaging of various metabolites. This paper mainly discusses the chemical and water exchange in the field of MRI saturation transfer phenomenon, expounds the principle, research status and the application in brain diseases used the different field strength clinical MRI scanner.
[Keywords] Chemical exchange saturation transfer；Amide proton transfer；pH value；Brain tumor；Stroke

YANG Yong-gui Department of medical imaging, The Second Hospital of Xiamen, Xiamen 361021, China

SHEN Zhi-wei Departmentof Radiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

WU Ren-hua Departmentof Radiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

CHEN Zhong Physical and mechanical and Electrical Engineering College of Xiamen University, Xiamen University, Department of Electronic Science, Fujian Province Key Laboratory of plasma and magnetic resonance, Xiamen 361005, China

CAI Cong-bo Physical and mechanical and Electrical Engineering College of Xiamen University, Xiamen University, Department of Electronic Science, Fujian Province Key Laboratory of plasma and magnetic resonance, Xiamen 361005, China

GUO Gang* Department of medical imaging, The Second Hospital of Xiamen, Xiamen 361021, China

*Correspondence to: Guo G, E-mail: guogangxm@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Science and Technology Department of Xiamen Huimin project in 2014 No. 3502Z20144052
Received  2016-01-04
Accepted  2016-03-11
DOI: 10.12015/issn.1674-8034.2016.04.002
DOI:10.12015/issn.1674-8034.2016.04.002.

[1]
Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson, 2000, 143(1): 79-87.
[2]
滕皋军，崔莹．磁共振分子影像学研究进展．磁共振成像, 2014, 5(S1): 31-36.
[3]
Zijl PCMV, Yadav NN. Chemical exchange saturation transfer (CEST): What is in a name and what isn't?. Magn Reson Med, 2011, 65(4): 927-948.
[4]
Zhou J, Payen JF, Wilson DA, et al. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med, 2003, 9(8): 1085-1090.
[5]
Zhou J, Lal B, Wilson DA, et al. Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med, 2003, 50(6): 1120-1126.
[6]
Sun PZ, Zhou J, Sun W, et al. Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab, 2006, 27(6): 1129-1136.
[7]
Sun PZ, Wang E, Cheung JS. Imaging acute ischemic tissue acidosis with pH-sensitive endogenous amide proton transfer (APT) MRI-Correction of tissue relaxation and concomitant RF irradiation effects toward mapping quantitative cerebral tissue pH. Neuroimage, 2012, 60(1): 1-6.
[8]
Jia G, Abaza R, Williams JD, et al. Amide proton transfer MR imaging of prostate cancer: A preliminary study. J Magn Reson Imaging, 2011, 33(3): 647-654.
[9]
Wang S, Jarso S, Van Zijl PC, et al. Role of amide proton transfer (APT)-MRI of endogenous proteins and peptides in brain tumor imaging. Functional Brain Tumor Imaging. Springer, 2014: 171-181.
[10]
Mori S, Eleff SM, Pilatus U, et al. Proton NMR spectroscopy of solvent-saturable resonances: A new approach to study pH effects in Situ. Magn Reson Med, 1998, 40(1): 36-42.
[11]
Wolff SD, Balaban RS. NMR imaging of labile proton exchange. J Magn Reson, 1990, 86(1): 164-169.
[12]
Sun PZ, Wang E, Cheung JS, et al. Simulation and optimization of pulsed radio frequency (RF) irradiation scheme for chemical exchange saturation transfer(CEST) MRI-demonstration of pH-weighted pulsed-amide proton CEST MRI in an animal model of acute cerebral ischemia. Magn Reson Med, 2011, 66(4): 1042-1048.
[13]
Sun PZ, Zhou J, Huang J, et al. Simplified quantitative description of amide proton transfer (APT) imaging during acute ischemia. Magn Reson Med, 2007, 57(2): 405-410.
[14]
Sun PZ, Murata Y, Lu J, et al. Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke. Magn Reson Med, 2008, 59(5): 1175-1182.
[15]
Sun PZ, Sorensen AG. Imaging pH using the chemical exchange saturation transfer (CEST)MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH. Magn Reson Med, 2008, 60(2): 390-397.
[16]
Aime S, Delli CD, Fedeli F, et al. A paramagnetic MRI-CEST agent responsive to lactate concentration. J Am Chem Soc, 2002, 124(32): 9364-9365.
[17]
Zhang S, Winter P, Wu K, et al. A novel europium (III)-based MRI contrast agent. J Am Chem Soc, 2001, 123(7): 1517-1518.
[18]
Ren J, Trokowski R, Zhang S, et al. Imaging the tissue distribution of glucose in livers using a paracest sensor. Magn Reson Med, 2008, 60(5): 1047-1055.
[19]
Gilad AA, Van Laarhoven HW, Mcmahon MT, et al. Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles. Magn Reson Med, 2009, 61(4): 970-974.
[20]
Aime S, Barge A, Delli Castelli D, et al. Paramagnetic Lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications. Magn Reson Med, 2002, 47(4): 639-648.
[21]
Ward K, Balaban R. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST). Magn Reson Med, 2000, 44(5): 799-802.
[22]
Dagher AP, Aletras A, Choyke P, et al. Imaging of urea using chemical exchange-dependent saturation transfer at 1.5 T. J Magn Reson Imaging, 2000, 12(5): 745-748.
[23]
Zhou J, Blakeley JO, Hua J, et al. Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging. Magn Reson Med, 2008, 60(4): 842-849.
[24]
Cai K, Haris M, Singh A, et al. Magnetic resonance imaging of glutamate. Nat Med, 2012, 18(2): 302-306.
[25]
Zhang S, Trokowski R, Sherry AD. A paramagnetic CEST agent for imaging glucose by MRI. J Am Chem Soc, 2003, 125(50): 15288-15289.
[26]
Van Zijl PC, Jones CK, Ren J, et al. MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci U S A, 2007, 104(11): 4359-4364.
[27]
Ling W, Regatte RR, Navon G, et al. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci U S A, 2008, 105(7): 2266-2270.
[28]
Aime S, Barge A, Cabella C, et al. Targeting cells with MR imaging probes based on paramagnetic Gd (III) chelates. Current pharmaceutical biotechnology, 2004, 5(6): 509-518.
[29]
Yoo B, Pagel MD. A PARACEST MRI contrast agent to detect enzyme activity. J Am Chem Soc, 2006, 128(43): 14032-14033.
[30]
Gilad AA, Mcmahon MT, Walczak P, et al. Artificial reporter gene providing MRI contrast based on proton exchange. Nature biotechnology, 2007, 25(2): 217-219.
[31]
Vinogradov E, Zhang S, Lubag A, et al. On-resonance low B1 pulses for imaging of the effects of paracest agents. J Magn Reson, 2005, 176(1): 54-63.
[32]
Zhang S, Zhu X, Chen Z, et al. Improvement in the contrast of CEST MRI via intermolecular double quantum coherences. Phys Med Biol, 2008, 53(14): 287-296.
[33]
Jin T, Autio J, Obata T, et al. Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons. Magn Reson Med, 2011, 65(5): 1448-1460.
[34]
Friedman JI, Mcmahon MT, Stivers JT, et al. Indirect detection of labile solute proton spectra via the water signal using frequency-labeled exchange (FLEX) transfer. J Am Chem Soc, 2010, 132(6): 1813-1815.
[35]
Sun PZ, Benner T, Kumar A, et al. Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner. Magn Reson Med, 2008, 60(4): 834-841.
[36]
Haris M, Singh A, Cai K, et al. MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer’s disease. J Neurosci Methods, 2013, 212(1): 87-93.
[37]
韦茂彬, 沈智威, 肖刚, 等. 基于pH值敏感的磁化传递技术在1.5 T磁共振成像上的研究. 磁共振成像, 2012, 3(1): 40-43.
[38]
Henkelman RM, Stanisz GJ, Graham SJ. Magnetization transfer in MRI: a review. NMR Biomed, 2001, 14(2): 57-64.
[39]
Mulkern RV, Williams ML. The general solution to the Bloch equation with constant rf and relaxation terms: application to saturation and slice selection. Med Phys, 1993, 20(1): 5-13.
[40]
Jin T, Wang P, Zong X, et al. MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear Overhauser effect at 9.4 T. Magn Reson Med, 2013, 69(3): 760-770.
[41]
Liu D, Zhou J, Xue R, et al. Quantitative characterization of nuclear overhauser enhancement and amide proton transfer effects in the human brain at 7 tesla. Magn Reson Med, 2013, 70(4): 1070-1081.
[42]
Liu G, Song X, Chan KW, et al. Nuts and bolts of chemical exchange saturation transfer MRI. NMR Biomed, 2013, 26(7): 810-828.

PREV Principle and application progress of chemical exchange saturation transfer (CEST) technique
NEXT Magnetic resonance amide proton transfer (APT) imaging:description of technical principles and potential applications
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn