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Magnetic resonance amide proton transfer (APT) imaging: description of technical principles and potential applications
WU Ren-hua 

DOI:10.12015/issn.1674-8034.2016.04.003.


[Abstract] Amide proton transfer (APT) imaging is related to chemical exchange saturation transfer (CEST) technique. This review focuses on description of APT technical principles, factors influencing APT imaging, and relationship between in vivo APT imaging and nuclear Overhauser effect (NOE). Potential clinical applications of APT technique, such as pH imaging, temperature imaging, as well as APT-weighted imaging for organs and tissues, are discussed.
[Keywords] Amide proton transfer；Chemical exchange saturation transfer；Nuclear Overhauser effect；pH imaging；Temperature imaging

WU Ren-hua* Department of Medical Imaging, the 2nd Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

*Correspondence to: Wu RH, E-mail: cjr.wurenhua@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81471730
Received  2016-02-17
Accepted  2016-04-03
DOI: 10.12015/issn.1674-8034.2016.04.003
DOI:10.12015/issn.1674-8034.2016.04.003.

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