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• CEST Papers •
Clinical applications of amide proton transfer magnetic resonance imaging
BAI Yan  MA Xiao-yue  SHI Da-peng  LIU Tai-yuan  Wang Mei-yun 

DOI:10.12015/issn.1674-8034.2016.04.004.


[Abstract] Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) method based on chemical exchange dependent saturation transfer technique that detects endogenous mobile proteins and peptides, and amide proton exchange rates in biological tissues. APT weighted image is calculated by the magnetization transfer asymmetry between ±3.5 ppm which respect to the water frequency on z-spectrum. In recent years, APT MRI has been increasingly used for the diagnosis of diseases. In this article, we reviewed the developments of APT MRI in the clinical applications and scientific researches.
[Keywords] Amide proton transfer；Magnetic resonance imaging；Chemical exchange dependent saturation transfer

BAI Yan Department of Radiology, The People’s Hospital of Zhengzhou University & Henan Provincial People’s Hospital, Zhengzhou 450003, China

MA Xiao-yue Department of Radiology, The People’s Hospital of Zhengzhou University & Henan Provincial People’s Hospital, Zhengzhou 450003, China

SHI Da-peng Department of Radiology, The People’s Hospital of Zhengzhou University & Henan Provincial People’s Hospital, Zhengzhou 450003, China

LIU Tai-yuan Department of Radiology, The People’s Hospital of Zhengzhou University & Henan Provincial People’s Hospital, Zhengzhou 450003, China

Wang Mei-yun* Department of Radiology, The People’s Hospital of Zhengzhou University & Henan Provincial People’s Hospital, Zhengzhou 450003, China

*Correspondence to: Wang MY, E-mail: marian9999@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81271565, 31470047
Received  2016-02-20
Accepted  2016-03-29
DOI: 10.12015/issn.1674-8034.2016.04.004
DOI:10.12015/issn.1674-8034.2016.04.004.

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