Share：
Share this content in WeChat
X
[Chinese][PDF]1111272
• Clinical Article •
The value of "swallow tail" appearance of nigrosome on ESWAN at 3.0 T MR in the diagnosis of Parkinson’s disease
LIU Tai-yuan  BAI Yan  MA Xiao-yue  MA Lun  SHI Da-peng  DOU She-wei  WANG Mei-yun 

DOI:10.12015/issn.1674-8034.2016.04.005.


[Abstract] Objective: To explore the value of Enhanced gradient echo T2 star weighted angiography (ESWAN) findings of nigrosome at 3.0 T MR imaging in the diagnosis of Parkinson’s Disease (PD).Materials and Methods: The ESWAN findings of 58 patients with PD and 364 age-matched healthy control were retrospectively analyzed. All the subjects were divided into PD and non-PD group according to the presence or absence of nigrosome 1 on ESWAN imaging, e.g. "swallow tail" appearance, and the accuracy was evaluated.Results: Fifty-five (94.83%) of 58 PD patients did not show "swallow tail" appearance and the rest 3 were doubtful, while 344 (94.51%) of 364 non-PD patients did have this appearance. The sensitivity of "swallow tail" appearance in differentiating PD from non-PD patients was 95% and the specifity was 91%.Conclusion: The absence of "swallow tail" appearance in nigrosome on ESWAN imaging at 3.0 T MRI provides a new, easy and reliable tool for the diagnosis of PD.
[Keywords] Magnetic resonance imaging；Swallow tail；Parkinson's disease

LIU Tai-yuan Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, China

BAI Yan Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, China

MA Xiao-yue Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, China

MA Lun Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, China

SHI Da-peng Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, China

DOU She-wei Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, China

WANG Mei-yun* Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou 450003, China

*Correspondence to: Wang MY, E-mail: mywang@ha.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation No. 31470047, 81271565 Henan Province Scientific and Technological Innovation Talents Project
Received  2016-01-09
Accepted  2016-03-04
DOI: 10.12015/issn.1674-8034.2016.04.005
DOI:10.12015/issn.1674-8034.2016.04.005.

[1]
Fearnley JM, Lees AJ. Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain, 1991, 114(Pt5): 2283-2301.
[2]
Schapira AH. Etiology of Parkinson’s disease. Neurology, 2006, 66(10Suppl 4): 10-23.
[3]
彭帅, 陈敏, 李春媚, 等. 帕金森病静息态脑功能MRI研究. 磁共振成像, 2014, 5(5): 321-327.
[4]
Meijer FJ, Goraj B. Brain MRI in Parkinson’s disease. Frontiers in Bioscience, 2014, (6): 360-369.
[5]
Schwarz ST, Mohammed A, Morgan PS, et al. The 'swallow tail' appearance of the healthy nigrosome-a new accurate test of Parkinson's disease: a case-control and retrospective cross-sectional MRI study at 3 T. PLoS One, 2014, 9(4): e93814.
[6]
Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol, 1999, 56(1): 33-39.
[7]
Damier P, Hirsch EC, Agid Y, et al. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson’s disease. Brain J Neurol, 1999, 122(Pt 8): 1437-1448.
[8]
陈德强, 贺丹. 磁敏感加权成像技术原理及临床应用进展. 脑与神经病杂志, 2009, 17(2): 152-154.
[9]
Haines DE. Fundamental neuroscience for basic and clinical applications. Philadelphia: Churchill Livingstone Elsevier, 2006: 169-180.
[10]
Damier P, Hirsch EC, Agid Y, et al. The substantia nigra of the human brain. Brain, 1999, 122(Pt 8): 1421-1436.
[11]
Anna I, Blazejewska, Stefan T, et al. Visualization of nigrosome 1 and its loss in PD. Neurology, 2013, 81(6): 534-540.
[12]
Kwon DH, Kim JM, Oh SH, et al. Seven-Tesla magnetic resonance images of the substantia nigra in Parkinson disease. Ann Neurol, 2012, 71(2): 267-277.
[13]
Cosottini M, Frosini D, Pesaresi I, et al. Comparison of 3 T and 7 T susceptibility-weighted angiography of the substantia nigra in diagnosing parkinson disease. AJNR Am J Neuroradiol, 2015, 36(3): 461-466.
[14]
Zecca L, Casella L, Albertini A, et al. Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson’s disease. J Neurochem, 2008, 106(4): 1866-1875.
[15]
王波, 戴敏方. 帕金森病的MRI研究进展. 磁共振成像, 2013, 4(6): 459-462.
[16]
Bajaj N, Hauser RA, Grachev ID. Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes. J Neurol Neurosurg Psychiatry, 2013, 84(11): 1288-1295.
[17]
Massey LA, Micallef C, Paviour DC, et al. Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy. Mov Disord, 2012, 27(14): 1754-1762.
[18]
Meijer FJA, Bloem BR, Mahlknecht P, et al. Update on diffusion MRI in Parkinson’s disease and atypical parkinsonism. J Neurol Sci, 2013, 332(1-2): 21-29.

PREV Clinical applications of amide proton transfer magnetic resonance imaging
NEXT The functional connectivity of hypothalamus in T2DM patients: a resting-state fMRI study
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn