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• Clinical Article •
The discrimination between brain metastases from lung cancer and high-grade glioma with proton MR spectroscopy and its value for survival predictorsand
CHEN Li-jian 

DOI:10.12015/issn.1674-8034.2016.04.007.


[Abstract] Objective: To investigate the clinical discrimination value of proton MR spectroscopy(1H-MRS) between brain metastasis from lung cancer and high-grade glioma, and access its prognostic value at the same time.Materials and Methods: Thirty-six patients of high-grade gliomas and forty-three patients of brain metastasis from lung cancer were studied. Thirty-six patients of high-grade gliomas and forty-three patients of brain metastasis from lung cancer were received 1H-MRS. The variety of metabolite peaks including n-acetylaspartate (NAA), choline (Cho) and creatine (Cr) were detected in different areas including tumor, peritumoral areas and the normal brain, at the same time the ratio of NAA/Cho, NAA/Cr and Cho/Cr were computed. Cox regression were performed for univariate and multivariate analyses to explore independent predictors influencing the survival of patients with lung cancer and brain metastases respectively.Results: Significant differences between peritumoral area of high-grade gliomas and brain metastasis from lung cancer were found in the ratios of Cho/Cr and Cho/NAA (P<0.05). The ratios of NAA/Cr, Cho/Cr and NAA/Cho were independent survival predictors in patients with lung cancer and brain metastasis as indicated by Cox proportional hazard model(P<0.05).Conclusion: The ratios of Cho/Cr and Cho/NAA in peritumoral area can be found in brain metastases from lung cancer with 1H-MRS, which is helpful in discrimination between lung cancer and high-grade gliomas. The ratios of Cho/Cr may be an independent survival predictors in patients with lung cancer and brain metastasis.
[Keywords] 1H magnetic resonance spectroscopy；Neoplasm metastasis；Brain metastases；High-grade glioma；Magnetic resonance imaging；N-acetylaspartate；Choline；Creatine

CHEN Li-jian* Department of radiology, tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535099, China

*Correspondence to: Chen LJ, E-mail: clj0066@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Qinzhou Municipal Science and Technology Bureau of self funding research project of Guangxi No. 20135801
Received  2015-09-21
Accepted  2015-12-30
DOI: 10.12015/issn.1674-8034.2016.04.007
DOI:10.12015/issn.1674-8034.2016.04.007.

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