Share：
Share this content in WeChat
X
[Chinese][PDF]75093
• Clinical Article •
A primary fMRI study of the chinese language function: a free fluency paradigm
WANG Peng  YU Hong-mei  DU Fei-zhou  GU Ming  WANG Yang  HE Ci 

DOI:10.12015/issn.1674-8034.2016.04.008.


[Abstract] Objective: To design a stimulus task for Chinese free fluency, and explore the brains language function areas in Chinese people.Materials and Methods: Nineteen healthy Chinese volunteers underwent a BOLD-fMRI scan with a free fluency stimulus task, that was block design. All images were collected and processed by SPM 8, followed by a First- and Second-level analysis. The distribution, sizes(number of voxels), and peak intensity of activations were shown by Xjview.Results: All participants completed the language task in connection with chinese language functional areas located primarily in the right superior temporal gyrus. In this study, the left fusiform gyrus and left parahippocampal gyrus were not activated, and bilateral hippocampus with low-grade activations.Conclusion: This stimulus task effectively activated brain language areas relating to chinese free fluency. BOLD-fMRI located activated areas accurately, and quantified the size and peak intensity of activations. It was stable and reliable with good compliance from patients. This study shows that chinese free fluency.
[Keywords] Chinese language；Functional magnetic resonance imaging；Brain；Language function area；Free fluency

WANG Peng Department of Radiology, Chengdu Military General Hospital, Chengdu 610083, China

YU Hong-mei Department of Radiology, Chengdu Military General Hospital, Chengdu 610083, China

DU Fei-zhou Department of Radiology, Chengdu Military General Hospital, Chengdu 610083, China

GU Ming Department of Radiology, Chengdu Military General Hospital, Chengdu 610083, China

WANG Yang Department of Radiology, Chengdu Military General Hospital, Chengdu 610083, China

HE Ci* Department of Radiology, Chengdu Military General Hospital, Chengdu 610083, China

*Correspondence to: He C, E-mail: hecicd@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of China’s Postdoctoral Science Foundation No. 2013M542582 General program of Chengdu Military region during the 12th Five-Year Plan Period No. C12036 General program of Chengdu Military General Hospital No. 2013YG-B004
Received  2015-12-03
Accepted  2015-12-26
DOI: 10.12015/issn.1674-8034.2016.04.008
DOI:10.12015/issn.1674-8034.2016.04.008.

[1]
路俊锋. 汉语语言中枢的多模态技术研究及其在外科手术定位中的应用. 上海: 复旦大学, 2013.
[2]
宋无名，陈南圭．功能MRI：最先进方法的简要回顾和展望.磁共振成像, 2013, 4(5): 361-372.
[3]
Chiang S, Haneef Z. Graph theory findings in the pathophysiology of temporal lobe epilepsy. Clin Neurophysiol, 2014, 125(7): 1295-1305.
[4]
张志强, 许强, 卢光明, 等. 失神性癫痫的动态功能MRI研究.磁共振成像, 2013, 4(1): 3-7.
[5]
Comesana M, Fraga I, Moreira AJ, et al. Free associate norms for 139 European Portuguese words for children from different age groups. Behav Res Methods, 2014, 46(2): 564-574.
[6]
Marques JF, Nunes LD. The contributions of language and experience to the representation of abstract and concrete words: different weights but similar organizations. Mem Cognit, 2012, 40(8): 1266-1275.
[7]
Kenett YN, Kenett DY, Ben-Jacob E, et al. Global and local features of semantic networks: evidence from the Hebrew mental lexicon. PLoS One, 2011, 6(8): 23912.
[8]
Borge-Holthoefer J, Moreno Y, Arenas A. Modeling abnormal priming in Alzheimer's patients with a free association network. PLoS One, 2011, 6(8): 22651.
[9]
Simanova I, van Gerven MA, Oostenveld R, et al. Predicting the semantic category of internally generated words from neuromagnetic recordings. J Cogn Neurosci, 2015, 27(1): 35-45.
[10]
Nelson DL, Kitto K, Galea D, et al. How activation, entanglement, and searching a semantic network contribute to event memory. Mem Cognit, 2013, 41(6): 797-819.
[11]
Wende KC, Straube B, Stratmann M, et al. Neural correlates of continuous causal word generation. Neuroimage, 2012, 62(3): 1399-1407.
[12]
Wu CY, Ho MH, Chen SH. A meta-analysis of fMRI studies on Chinese orthographic, phonological, and semantic processing. Neuroimage, 2012, 63(1): 381-391.
[13]
Wende KC, Straube B, Stratmann M, et al. Neural correlates of continuous causal word generation. Neuroimage, 2012, 62(3): 1399-1407.
[14]
冯燕韻, 黄飚, 高明勇, 等. 语义、语法任务相关的脑功能磁共振成像. 中国医学影像技术, 2012, 28(5): 865-868.
[15]
Sheldon S, Romero K, Moscovitch M. Medial temporal lobe amnesia impairs performance on a free association task. Hippocampus, 2013, 23(5): 405-412.
[16]
Norris DG. Principles of magnetic resonance assessment of brain function. J Magn Reson Imaging, 2006, 23(6): 794-807.
[17]
Weber B, Wellmer J, Reuber M, et al. Left hippocampal pathology is associated with atypical language lateralization in patients with focal epilepsy. Brain, 2006, 129(Pt 2): 346-351.
[18]
蒋震, 张彩元, 贡志刚, 等. 两种语言任务脑功能区激活的功能磁共振成像比较. 苏州大学学报（医学版), 2008, 28(3): 449-451.
[19]
Deyne SD, Navarro DJ, Storms G. Better explanations of lexical and semantic cognition using networks derived from continued rather than single-word associations. Behav Res Methods, 2013, 45(2): 480-498.

PREV The discrimination between brain metastases from lung cancer and high-grade glioma with proton MR spectroscopy and its value for survival predictorsand
NEXT The features and diagnostic value of MRI for infant brachial plexus injury
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn