Share：
Share this content in WeChat
X
[Chinese][PDF]1402133
• Academic Debate •
The system applying and analyzing of Z spectrum in chemical exchange saturation transfer
BAI Shuai  HOU Yu-qing  HE Xiao-wei  XUE Xin-yu 

DOI:10.12015/issn.1674-8034.2016.04.010.


[Abstract] Objective: To create a simple and friendly software toolkit to display and analyze Z spectrum of Chemical Exchange Saturation Transfer (CEST), which is convenient for clinicians and researchers to apply and research.Materials and Methods: The data is collected by conventional CEST imaging method, and the system is made by MATLAB GUI. Fitting the Z spectrum of different region of interest (ROI) which are selected by taking the mouse, and also carrying on its analysis and comparison.Results: The different positions and different pixel values of image’s ROI, the Z spectrum are different, which reflect different biological information.Conclusion: Z spectrum directly determines the final CEST signal analysis and relates biomedical information extraction. The functions of this system mainly include CEST image denoising, the formation of asymmetric magnetization transfer rate (MTRasym) mapping, selecting ROI and fitting the Z spectrum. To fit the Z spectra of ROI which are selected by taking the mouse.
[Keywords] Chemical exchange saturation transfer；Region of interest；Z spectrum；Magnetic resonance imaging

BAI Shuai College of information science and technology, Northwest University, Xi'an 710127, China

HOU Yu-qing College of information science and technology, Northwest University, Xi'an 710127, China

HE Xiao-wei* College of information science and technology, Northwest University, Xi'an 710127, China

XUE Xin-yu College of information science and technology, Northwest University, Xi'an 710127, China

*Correspondence to: He XW, E-mail: hexw@nwu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of project of National Natural Science Foundation of China No. 61372046
Received  2016-01-07
Accepted  2016-03-31
DOI: 10.12015/issn.1674-8034.2016.04.010
DOI:10.12015/issn.1674-8034.2016.04.010.

[1]
Ward KM, Aletras AH, Balaban RS, et al. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). Magn Reson, 2000, 143(1): 79.
[2]
周智洋，刘得超．肛管和肛周疾病的MRI诊断．磁共振成像, 2015, 6(11): 868-875.
[3]
Friedman JI, Xia D, Regatte RR, et al. Transfer Rate Edited experiment for the selective detection of Chemical Exchange via Saturation Transfer (TRE-CEST). Journal of Magnetic Resonance, 2015, 256: 43-51.
[4]
Sagiyama K, Mashimo T, Togao O, et al. In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci U S A, 2014, 111(12): 4542-4547.
[5]
van Zijl P, Yadav NN. Chemical exchange saturation transfer (CEST): what is in a name and what isn't?. Magnetic Resonance in Medicine, 2011, 65(4): 927-948.
[6]
Singh A, Cai K, Haris M, et al. On B1 inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7 T. Magnetic Resonance in Medicine, 2013, 69(3): 818-824.
[7]
Zhou J, Tryggestad E, Wen Z, et al. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature medicine, 2011, 17(1): 130-134.
[8]
Togao O, Yoshiura T, Keupp J, et al. Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Neuro-oncology, 2014, 16(3): 441-448.
[9]
龚启勇, 吕粟. 功能磁共振成像临床应用及进展. 磁共振成像, 2014, 5（增刊1): 68-72.
[10]
Sun PZ, Xiao G, Zhou IY, et al. A method for accurate pH mapping with chemical exchange saturation transfer (CEST) MRI. Contrast media & molecular imaging, 2015 DOI: 10.1002/cmmi.1680.
[11]
白雪冬, 孙夕林, 王丹, 等. 动态对比增强MRI在鉴别胶质瘤复发及放射性脑损伤中的应用. 磁共振成像, 2014, 5(1): 1-6.
[12]
Woessner DE, Zhang S, Merritt ME, et al. Numerical solution of the bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magnetic Resonance in Medicine, 2005, 53(4): 790-799.
[13]
Li AX, Hudson RHE, Barrett JW, et al. Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents. Magnetic Resonance in Medicine, 2008, 60(5): 1197-1206.
[14]
Zaiss M, Schmitt B, Bachert P. Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. Journal of Magnetic Resonance, 2011, 211(2): 149-155.
[15]
Song X, Xu J, Xia S, et al. A multi-echo length and offset VARied saturation (MeLOVARS) method for improved CEST imaging. Magn Reson Med, 2015, 73(2):488-496.

PREV The features and diagnostic value of MRI for infant brachial plexus injury
NEXT Differential diagnosis of AIDS: study of multi b-value DWI double-exponential model
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn