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• Technical Article •
Differential diagnosis of AIDS: study of multi b-value DWI double-exponential model
WU Wei-qing  WU Guang-yao  QUAN Hong 

DOI:10.12015/issn.1674-8034.2016.04.011.


[Abstract] Objective: To discuss how mono-exponential model and double-exponential model of multi-b value diffusion weighted imaging perform in HIV diagnosis.Materials and Methods: Multi-b value DWI(b=0, 50, 150, 200400, 600, 800) was performed to 23 teenagers, 15 of whom were HIV-positive and 8 of whom were HIV-negative. By fitting the images of mono-exponential model and double-exponential model, ADCs, ADCf, ADC values in frontal lobe were compared between HIV-positive subjects and HIV-negative subjects by statistical analysis.Results: For left frontal lobe, HIV-positive subjects have significantly lower ADCf values than HIV-negative subjects. While ADCs, ADC values are not significantly different.Conclusion: Double-exponential model of multi-b value diffusion weighted imaging, especially ADCf values can be a reference in AIDS diagnosis.
[Keywords] Multi-b value DWI；Mono-exponential model；Double-exponential model；Frontal lobe；Acquired immune deficiency syndrome

WU Wei-qing School of Physics and Technology, Wuhan University, Wuhan 430072, China

WU Guang-yao Zhongnan Hospital of Wuhan University, Wuhan 430071, China

QUAN Hong* School of Physics and Technology, Wuhan University, Wuhan 430072, China

*Correspondence to: Quan H, E-mail: csp6606@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 10875092 and Natural Science Foundation of Hubei Province No. 2012FKB04449
Received  2016-01-07
Accepted  2016-03-04
DOI: 10.12015/issn.1674-8034.2016.04.011
DOI:10.12015/issn.1674-8034.2016.04.011.

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