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• Prostate Papers •
The value of diagnosis for prostate cancer by combining DWI with MRS
LU Yang  GE Shang  ZHU Yan  WANG Ya-ting  BO Gen-ji 

DOI:10.12015/issn.1674-8034.2016.05.002.


[Abstract] Objective: To investigate the value of diagnosis for prostate cancer (PCa) by combining diffusion weighted imaging (DWl) with magnetic resonance spectroscopy (MRS).Materials and Methods: Twenty-four cases of PCa and 30 cases of benign prostate hyperplasia (BPH) proved by pathology were examined by DWI and MRS. Apparent diffusion coefficient (ADC) values of cancerous regions and peripheral zone and central glands in BPH were measured. The chemical shift of citrate (Cit), choline (Cho), creatine (Cr) spectra, and the ratio of (Cho+Cr)/Cit were observed in MRS. The upper bound of 95 confidence interval of PCa ADC and (Cho+Cr)/Cit was set as the threshold value. The sensitivity, specificity and accuracy of DWI, MRS and DWI+MRS in the diagnosis of PCa were analyzed.Results: The ADC value of cancerous, peripheral zone and central glands in BPH were (0.83±0.12)×10-3 mm2/s, (1.82±0.26)×10-3 mm2/s, (1.46±0.16)×10-3 mm2/s (F=31.1, P<0.05). The (Cho+Cr)/Cit value of cancerousperipheral zone and central glands in BPH were 1.55±0.11, 0.53±0.16, 0.64±0.13 (F= 18.2, P<0.05). There were significant difference between cancerous and peripheral zone, central glands of BPH in the value of (Cho+Cr)/Cit respectively (P<0.05). There was no significant difference between peripheral zone and central glands of BPH in the value of (Cho+Cr)/Cit (P>0.05).The diagnostic sensitivity, specificity and accuracy of DWI were 79.17%, 80%, 79.63%, respectively. The diagnostic sensitivity, specificity and accuracy of MRS were 87.5%, 86.67%, 87.03%, respectively. The diagnostic sensitivity, specificity and accuracy of DWI+MRS were 91.67%, 93.33%, 92.59%, respectively.Conclusions: The combined application with DWI and MRS was better than DWl or MRS alone in the diagnosis for prostate cancer.
[Keywords] Prostatic neoplasms；Diffusion magnetic resonance imaging；Magnetic resonance spectroscopy

LU Yang Department of Medical Imaging, the First Pople's Hospital of Huaian, Affiliated to Nanjing Medical University, Huaian 223300, China

GE Shang Department of Medical Imaging, the First Pople's Hospital of Huaian, Affiliated to Nanjing Medical University, Huaian 223300, China

ZHU Yan Department of Medical Imaging, the First Pople's Hospital of Huaian, Affiliated to Nanjing Medical University, Huaian 223300, China

WANG Ya-ting Department of Medical Imaging, the First Pople's Hospital of Huaian, Affiliated to Nanjing Medical University, Huaian 223300, China

BO Gen-ji* Department of Medical Imaging, the First Pople's Hospital of Huaian, Affiliated to Nanjing Medical University, Huaian 223300, China

*Correspondence to: Bo GJ, E-mail: hybgj0451@163.com

Conflicts of interest   None.

Received  2016-02-21
Accepted  2016-03-26
DOI: 10.12015/issn.1674-8034.2016.05.002
DOI:10.12015/issn.1674-8034.2016.05.002.

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