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• Clinical Article •
The correlation between iron deposition of deep gray nuclei and cerebral venous susceptibility of drainage veins in healthy people using susceptibility mapping
ZUO Chao  CHAI Chao  XIA Shuang 

DOI:10.12015/issn.1674-8034.2016.05.006.


[Abstract] Objective: To evaluate age-related changes of cerebral venous susceptibility and the relationship between iron deposition of deep gray nuclei and the susceptibility of cerebral drainage veins in healthy people using MR quantitative susceptibility mapping (QSM).Materials and Methods: Fifty-seven right-handed healthy individuals underwent SWI scanning to get phase images and magnitude images. QSM were reconstructed from the phase images and magnitude images using SMART software. The regions of interest include the bilateral cerebral veins (thalamostriate veins, septal veins, internal cerebral veins, basal veins) and the bilateral gray nuclei (caudate nucleus, globus pallidus, putamen, dorsal thalamus, substantia nigra, red nucleus) were drawn manually, and the susceptibility of cerebral gray nuclei and cerebral draining veins was measured using SPIN software.Results: There was no significant difference in susceptibility between the right and the left draining veins of cerebral gray nuclei in 57 healthy individuals (P>0.05). The susceptibility of right caudate nucleus, substantia nigra, red nucleus was higher than that of left sides (t value was 3.34, 5.12, 3.91, P<0.05). There was positive correlation between age and the susceptibility of right thalamostriate vein (r=0.33, P<0.05). There were positive correlation of susceptibility between left caudate nucleus and left internal cerebral vein, left putamen and left internal cerebral vein, red nucleus and left internal cerebral vein (r value was 0.29, 0.31, 0.28, P<0.05).Conclusions: The susceptibility of right thalamostriate vein increased with aging.There was no side-difference in susceptibility between bilateral cerebral veins. The susceptibility of some draining veins has positive correlation with iron deposition of some gray nuclei.
[Keywords] Quantitative magnetic susceptibility maping；Oxygen saturation；Iron deposition；Age distribution

ZUO Chao Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

CHAI Chao Tianjin First Center Hospital, Department of Radiology, Tianjin 300192, China

XIA Shuang* Tianjin First Center Hospital, Department of Radiology, Tianjin 300192, China

*Correspondence to: Xia S, E-mail: xiashuang77@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was supported by Grants the National Natural Science Foundation of China No. 81501457 Tianjin Municipal Health Bureau Key Research Fund No. 14KG103
Received  2015-12-22
Accepted  2016-01-25
DOI: 10.12015/issn.1674-8034.2016.05.006
DOI:10.12015/issn.1674-8034.2016.05.006.

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