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• Clinical Article •
Metabolic assessment of Parkinson disease by magnetic resonance spectroscopy
ZHANG You-qiao  WU Huan-ze  GUAN Ji-tian  YANG Jie-hua  ZHANG Qin-cheng  CHEN Wei 

DOI:10.12015/issn.1674-8034.2016.05.007.


[Abstract] Objective: To evaluate the brain metabolite with Parkinson's disease (PD) by proton magnetic resonance spectroscopy (1HMRS).Materials and Methods: Forty-two PD individuals and twenty healthy controls were enrolled in this study. All the subjects were tested with unified Parkinson disease rating scale (UPDRS) scale. Subsequently, individuals underwent MRI and 1HMRS using a GE signa 1.5 T MR, and the ratios of metabolites in the substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus were compared. Correlations, between brain metabolism with UPDRS the duration, in PD, were analyzed.Results: Significant remarkable declines in the NAA/Cr and NAA/Cho ratios in the bilateral substantia nigra, bilateral globus pallidus, bilateral prefrontal lobe, bilateral hippocampus, bilateral cuneus gyrus, and bilateral dorsal thalamus were found in the PD group (P<0.01). A significant increase of the Cho/Cr ratio in the right hippocampus, right cuneus gyrus, and right dorsal thalamus was also found (P<0.05). The NAA/Cho ratio in the bilateral substantia nigra (left r=-0.324, P=0.036, right r=-0.399, P=0.009), right globus pallidus (r=-0.353, P=0.022), left hippocampus (r= -0.388, P= 0.011) and left cuneus gyrus (r= -0.325, P= 0.036) were negatively associated with UPDRS scores (P<0.05). The NAA/Cr ratio in the left globus pallidus was positively associated with the duration (r=0.327, P=0.034).Conclusions: PD patients with extensive neuronal damage in the brain and some glial proliferation, the degree of damage is positively correlated with the clinical severity of the disease and gradually increased with the extension of the course of the disease.
[Keywords] Parkinson disease；Proton magnetic resonance spectroscopy；Metabolomics；Brain

ZHANG You-qiao Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

WU Huan-ze Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

GUAN Ji-tian Department of Radiology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

YANG Jie-hua Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

ZHANG Qin-cheng Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

CHEN Wei* Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

*Correspondence to: Chen W, E-mail: chw7203@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by Clinical improvement project of Shantou University Medical College No. 201409
Received  2016-02-29
Accepted  2016-04-06
DOI: 10.12015/issn.1674-8034.2016.05.007
DOI:10.12015/issn.1674-8034.2016.05.007.

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