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• Clinical Article •
Metabolic assessment of Parkinson disease by magnetic resonance spectroscopy
ZHANG You-qiao  WU Huan-ze  GUAN Ji-tian  YANG Jie-hua  ZHANG Qin-cheng  CHEN Wei 

DOI:10.12015/issn.1674-8034.2016.05.007.


[Abstract] Objective: To evaluate the brain metabolite with Parkinson's disease (PD) by proton magnetic resonance spectroscopy (1HMRS).Materials and Methods: Forty-two PD individuals and twenty healthy controls were enrolled in this study. All the subjects were tested with unified Parkinson disease rating scale (UPDRS) scale. Subsequently, individuals underwent MRI and 1HMRS using a GE signa 1.5 T MR, and the ratios of metabolites in the substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus were compared. Correlations, between brain metabolism with UPDRS the duration, in PD, were analyzed.Results: Significant remarkable declines in the NAA/Cr and NAA/Cho ratios in the bilateral substantia nigra, bilateral globus pallidus, bilateral prefrontal lobe, bilateral hippocampus, bilateral cuneus gyrus, and bilateral dorsal thalamus were found in the PD group (P<0.01). A significant increase of the Cho/Cr ratio in the right hippocampus, right cuneus gyrus, and right dorsal thalamus was also found (P<0.05). The NAA/Cho ratio in the bilateral substantia nigra (left r=-0.324, P=0.036, right r=-0.399, P=0.009), right globus pallidus (r=-0.353, P=0.022), left hippocampus (r= -0.388, P= 0.011) and left cuneus gyrus (r= -0.325, P= 0.036) were negatively associated with UPDRS scores (P<0.05). The NAA/Cr ratio in the left globus pallidus was positively associated with the duration (r=0.327, P=0.034).Conclusions: PD patients with extensive neuronal damage in the brain and some glial proliferation, the degree of damage is positively correlated with the clinical severity of the disease and gradually increased with the extension of the course of the disease.
[Keywords] Parkinson disease；Proton magnetic resonance spectroscopy；Metabolomics；Brain

ZHANG You-qiao Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

WU Huan-ze Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

GUAN Ji-tian Department of Radiology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

YANG Jie-hua Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

ZHANG Qin-cheng Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

CHEN Wei* Department of Neurology, the 2nd Affiliated Hospital Shantou University Medical College, Shantou 515041, China

*Correspondence to: Chen W, E-mail: chw7203@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by Clinical improvement project of Shantou University Medical College No. 201409
Received  2016-02-29
Accepted  2016-04-06
DOI: 10.12015/issn.1674-8034.2016.05.007
DOI:10.12015/issn.1674-8034.2016.05.007.

[1]
Rodríguez-Violante M, Cervantes-Arriaga A, González-Latapí P, et al. Proton magnetic resonance spectroscopy changes in Parkinson's disease with and without psychosis. Rev Invest Clin, 2015, 67(4): 227-234.
[2]
Levin BE, Katzen HL, Maudsley A, et al. Whole-brain proton MR spectroscopic imaging in Parkinson's disease. J Neuroimaging, 2012, 24(1): 39-44.
[3]
Modrego PJ, Fayed N, Artal J, et al. Correlation of findings in advanced MRI techniques withglobal severity scales in patients with Parkinson disease. Acad Radiol, 2011, 18(2): 235-241.
[4]
Weiduschat N, Mao X, Beal MF, et al. Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease. J Neuroimaging, 2015, 25(1): 105-110.
[5]
中华医学会神经病学分会运动障碍及帕金森病学组. 帕金森病的诊断. 中华神经科杂志, 2006, 39(6): 408-409.
[6]
Kickler N, Lacombe E, Chassain C, et al. Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo 1H-MRS study. NMR Biomed, 2009, 22(2): 207-212.
[7]
Broeders M, de Bie RM, Velseboer DC, et al. MD Evolution of mild cognitive impairment in Parkinson disease. Neurology, 2013, 81(4): 346-352.
[8]
陈薇，谢惠君，汪剑. 磁共振波谱分析在帕金森病早期诊断应用中的价值. 中国临床康复, 2004, 8(1): 34-35.
[9]
张尤桥，杨忠现，关计添, 等. 代谢综合征脑磁共振波谱喝弥散张量成像的相关性研究. 中国临床神经科学, 2013, 21(4): 381-388.
[10]
de Celis Alonso B, Hidalgo-Tobón SS, Menéndez-González M, et al. Magnetic resonance techniques applied to the diagnosis and treatment of Parkinson's disease. Front Neurol, 2015, 6: 146.
[11]
张莉，孔岩，徐斋, 等. 豆状核质子磁共振波谱对帕金森病的诊断价值. 临床荟萃, 2009, 24(13): 1115-1117.
[12]
方学文，胡涛，武玉华，等. 1H-MR检测早期帕金森病纹状体、黑质的功能代谢. 磁共振成像, 2015, 6(7): 481-485.
[13]
邱喜雄，刘品霓，刘立红, 等. 质子磁共振波谱在帕金森病患者纹状体中的应用研究. 深圳中西医结合杂志, 2011, 21(4): 204-207.
[14]
黄海东，杨春闽，赵凯, 等. 帕金森病患者纹状体质子磁共振波谱的变化及意义. 实用医学杂志, 2008, 28(16): 2785-2787.
[15]
彭帅，陈敏，李春媚, 等. 帕金森病静息态脑功能MRI研究. 磁共振成像, 2014, 5(5): 321-327.
[16]
麻少辉，张明，Rana N, 等. 1H-MRS观察帕金森病患者延髓及黑质代谢. 中国医学影像技术, 2011, 27(1): 127-131.

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