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• Clinical Article •
The application of magnetic resonance spectroscopic imaging in thrombolytic therapy of hyperacute cerebral infarction
SHANG Wen-wen  YIN Xin-dao  XUE Hai-lin  FENG Yuan 

DOI:10.12015/issn.1674-8034.2016.05.008.


[Abstract] Objective: To investigate the application value of proton magnetic resonance spectroscopy (1H-MRS) in thrombolytic therapy of hyperacute cerebral infarction.Materials and Methods: According to the clinical treatment, patients with acute cerebral infarction were divided into thrombolysis group and non thrombolysis group. The two groups underwent conventional magnetic resonance (MRI) and 1H-MRS scans. Then we respectively compared the difference between the concentrations of Cr, Cho, NAA, the ratio of NAA/Cr, Cho/Cr, NAA/Cho in the infraction center, the border region, the normal region around the lesion and the contralateral area.Results: (1) In the thrombolysis group and non-thrombolysis group, the concentrations of Cr, Cho, NAA in the infraction center, the border region, the normal region around the lesion were significantly lower than the contralateral area (P<0.05), Lac increases compared with the contralateral area. (2) In the thrombolysis group, the concentrations of Cr and ratio of NAA/Cho in the infraction center and the border region were significantly lower than the non thrombolysis group (P<0.05), the concentrations of Lac and ratio of Lac/Cr in the border region were significantly lower than the non thrombolysis group (P<0.05). (3) In the thrombolysis group, the NAA, NAA/Cho in the infraction center were significantly negatively correlated with NIHSS score, the Lac in the infraction center was significantly positively correlated with NIHSS score. In the non-thrombolysis group, the Lac in the infraction center was also significantly positively correlated with NIHSS score.Conclusions: Multivoxel 1H-MRS can directly, accurately and comprehensively detect the recovery of cerebral injured neurons after thrombolytic therapy of cerebral infarction, it can objectively evaluate prognosis of cerebral infarction and the effect of clinical treatment, providing a foundation for clinical application.
[Keywords] Intracranial embolism and thrombosis；Emergencies；Thrombolytic therapy；Magnetic resonance spectroscopy；Comparative effectiveness research

SHANG Wen-wen Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China; School of Radiology, Yancheng Institute of Medical Science, Jiangsu Province, Yancheng 224000, China

YIN Xin-dao* Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

XUE Hai-lin Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

FENG Yuan Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

*Correspondence to: Yin XD, E-mail: y.163yy@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Nanjing health youth talent training project No. QRX11035 2015 annual science and technology development plan of Nanjing City No. 201503021
Received  2015-12-22
Accepted  2016-01-19
DOI: 10.12015/issn.1674-8034.2016.05.008
DOI:10.12015/issn.1674-8034.2016.05.008.

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