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• Clinical Article •
The application of magnetic resonance spectroscopic imaging in thrombolytic therapy of hyperacute cerebral infarction
SHANG Wen-wen  YIN Xin-dao  XUE Hai-lin  FENG Yuan 

DOI:10.12015/issn.1674-8034.2016.05.008.


[Abstract] Objective: To investigate the application value of proton magnetic resonance spectroscopy (1H-MRS) in thrombolytic therapy of hyperacute cerebral infarction.Materials and Methods: According to the clinical treatment, patients with acute cerebral infarction were divided into thrombolysis group and non thrombolysis group. The two groups underwent conventional magnetic resonance (MRI) and 1H-MRS scans. Then we respectively compared the difference between the concentrations of Cr, Cho, NAA, the ratio of NAA/Cr, Cho/Cr, NAA/Cho in the infraction center, the border region, the normal region around the lesion and the contralateral area.Results: (1) In the thrombolysis group and non-thrombolysis group, the concentrations of Cr, Cho, NAA in the infraction center, the border region, the normal region around the lesion were significantly lower than the contralateral area (P<0.05), Lac increases compared with the contralateral area. (2) In the thrombolysis group, the concentrations of Cr and ratio of NAA/Cho in the infraction center and the border region were significantly lower than the non thrombolysis group (P<0.05), the concentrations of Lac and ratio of Lac/Cr in the border region were significantly lower than the non thrombolysis group (P<0.05). (3) In the thrombolysis group, the NAA, NAA/Cho in the infraction center were significantly negatively correlated with NIHSS score, the Lac in the infraction center was significantly positively correlated with NIHSS score. In the non-thrombolysis group, the Lac in the infraction center was also significantly positively correlated with NIHSS score.Conclusions: Multivoxel 1H-MRS can directly, accurately and comprehensively detect the recovery of cerebral injured neurons after thrombolytic therapy of cerebral infarction, it can objectively evaluate prognosis of cerebral infarction and the effect of clinical treatment, providing a foundation for clinical application.
[Keywords] Intracranial embolism and thrombosis；Emergencies；Thrombolytic therapy；Magnetic resonance spectroscopy；Comparative effectiveness research

SHANG Wen-wen Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China; School of Radiology, Yancheng Institute of Medical Science, Jiangsu Province, Yancheng 224000, China

YIN Xin-dao* Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

XUE Hai-lin Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

FENG Yuan Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

*Correspondence to: Yin XD, E-mail: y.163yy@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Nanjing health youth talent training project No. QRX11035 2015 annual science and technology development plan of Nanjing City No. 201503021
Received  2015-12-22
Accepted  2016-01-19
DOI: 10.12015/issn.1674-8034.2016.05.008
DOI:10.12015/issn.1674-8034.2016.05.008.

[1]
Yoon Y, Lee DH, Kang DW, et al. Single subcortical infarction and atherosclerotic plaques in the middle cerebral artery: high-resolution magnetic resonance imaging findings. Stroke, 2013, 44(9): 2462-2467.
[2]
Arnberg F, Lundberg J, Soderman M, et al. Image-guided method in the rat for inducing cortical or striatal infarction and for conteolling cerebral blood flow under MRI. Stroke, 2013, 43(9): 2437-2443.
[3]
姚志国，陈会生．磁共振技术指导超急性脑梗死溶栓的研究进展. 中华脑血管病杂志（电子版）, 2012, 6(4): 185-188.
[4]
延根，赵大威，戴卓智, 等. 评估量化超急性期缺血性脑卒中发病时间窗的研究. 磁共振成像, 2014, 5(1): 60-65.
[5]
Krishna A, Li An, Erica C, et al. Multivoxel MR spectroscopy in acute ischemic stroke comparison to the stroke protocol MRI. Stroke, 2012, 43(11): 2962-2967.
[6]
章桃，聂婷婷，贾岩龙, 等. 超急性脑卒中血脑屏障和相关脑代谢物变化的研究. 磁共振成像, 2014, 5(6): 473-478.
[7]
陈若伟，张海都，孔令梅. 急性脑梗死代谢物变化的磁共振波谱定量分析及其与预后的相关性研究．医学综述, 2013, 19(22): 4165-4167.
[8]
何玉洁，王学建，吴清华, 等. 急性脑梗死动脉溶栓治疗前后的质子磁共振波谱实验研究. 实用放射学杂志, 2007, 23(11): 1546-1551.
[9]
Dani KA, An L, Henning EC, et al. Multivoxel MR spectroscopy in acute ischemic stroke comparison to the stroke protocol MRI. Stroke, 2012, 43(11): 2962-2967.
[10]
黄刚，高幼奇，李明智, 等. 急性脑梗死患者脑组织磁共振波谱研究. 临床神经病学杂志, 2012, 25(1): 8-10.
[11]
Muñoz MS, Cvoro V, Armitage PA, et al. Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. Stroke, 2008, 39(9): 2467-2469.
[12]
姚于飞，高幼奇. 磁共振波谱分析在脑梗死中的研究进展. 中华脑血管病杂志（电子版）, 2010, 4(4): 293-299.
[13]
Graham GD, Kalvach P, Blamire AM, et al. Clinical correlates of proton magnetic resonance spectroscopy findings after acute cerebral infarction. Stroke, 1995, 26(2): 225-229.
[14]
Brouns R, Sheorajpanday R, Wauters A, et al. Evaluation of lactate as a marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA. Clin Chim Acta, 2008, 397(1-2): 27-31.
[15]
Li BS, Wang H, Gollell O. Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy. Magn Reson Imaging, 2003, 21(8): 923-928.
[16]
Jansen JF, Backes WH, Nicolay K, et al. 1H MR spectroscopy of the brain: absolute quantification of metabolites. Radiology, 2006, 240(2): 318-332.

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