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• fMRI Papers •
A fractional amplitude of low frequency fluctuation study of resting-state fMRI in stroke
WANG Xiang-min  ZHAO Zhi-yong  YIN Da-zhi  SUN Li-min  ZHENG Xiao-hui  JIA Jie  FAN Ming-xia 

DOI:10.12015/issn.1674-8034.2016.06.001.


[Abstract] Objective: To investigate the abnormal changes in baseline brain activity of the chronic stroke patients by using fractional amplitude of low frequency fluctuation (fALFF) of resting-state fMRI.Materials and Methods: Sixteen chronic stroke patients with left subcortical lesions and sixteen age and sex- matched healthy volunteers were performed resting-state fMRI scans. Values of fALFF were calculated in the frequency ranging from 0.01-0.08 Hz. Two-sample t-test was performed to compare the differences in fALFF between the two groups (P<0.05, corrected by AlphaSim).Results: Compared with the healthy controls, the areas where the fALFF values decreased in stroke patients mainly located in the ipsilesional thalamus and basal ganglia, of which, the fALFF values of the ipsilesional thalamus showed significantly positive correlation with the Fugl-Meyer Assessment (FMA) scores in stroke patients (r=0.54, P=0.03<0.05).Conclusion: The abnormal spontaneous neural activity of the stroke is closely related to lesions site and hand motor dysfunction. These findings help us to further understand the pathophysiological mechanisms of the motor dysfunction in stroke.
[Keywords] Stroke；Magnetic resonance imaging, functional；Frequency amplitude

WANG Xiang-min Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China

ZHAO Zhi-yong Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China

YIN Da-zhi Laboratory of Primate Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

SUN Li-min Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China

ZHENG Xiao-hui Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China

JIA Jie Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China

FAN Ming-xia* Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China

*Correspondence to: Fan MX, E-mail: mxfan@phy.ecnu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81471651 National Natural Science Foundation of China No. 81401859 the 12th Five-Year Plan supporting project of Ministry of Science and Technology of the People's Republic of China No. 2013BAI10B03
Received  2016-03-21
Accepted  2016-04-18
DOI: 10.12015/issn.1674-8034.2016.06.001
DOI:10.12015/issn.1674-8034.2016.06.001.

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