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• fMRI Papers •
First-episode depression resting state of brain function low frequency amplitude research
GUO Dong-ling  GAO Yang  NIU Guang-ming  XIE Sheng-hui 

DOI:10.12015/issn.1674-8034.2016.06.002.


[Abstract] Objective: We used the method of resting-state functional magnetic resonance imaging (rfMRI) to explore the abnormal brain activity under the basic status of patients with first-episode depression and its significance.Materials and Methods: Thirty patients with depression(the DSM-IV diagnostic criteria for depression) and thirty healthy volunteers matched with it were examined using resting-state functional MRI. Data analysis was processed by using the method of low-frequency amplitude (ALFF).Results: Intergroup analysis between depression and normal ALFF group: ALFF values of the parts of bilateral frontal lobes, temporal lobe and the cingulate gyrus and the right angular gyrus in depression groups are significantly higher than those in the control group; and ALFF values of bilateral medial prefrontal cortex, cuneus, precuneus, cerebellar hemisphere decreased.Conclusion: ALFF technology which can directly reflect the change of BOLD signal caused by abnormal metabolism of depressions with emotion disorder would contribute to exploration of the pathophysiological mechanisms of depression.
[Keywords] Depression；Magnetic resonance imaging, functional；Amplitude of low frequency fluctuation；Blood oxygen level dependent

GUO Dong-ling Room of MRI, Affiliated hospital of Inner Mongolia Medical University, Hohhot 010050, China

GAO Yang* Room of MRI, Affiliated hospital of Inner Mongolia Medical University, Hohhot 010050, China

NIU Guang-ming Room of MRI, Affiliated hospital of Inner Mongolia Medical University, Hohhot 010050, China

XIE Sheng-hui Room of MRI, Affiliated hospital of Inner Mongolia Medical University, Hohhot 010050, China

*Correspondence to: Gao Y, E-mail: 1390903990@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Science and technology support program of Inner Mongolia science and technology department in 2014 No. 2013002066
Received  2015-12-12
Accepted  2016-03-11
DOI: 10.12015/issn.1674-8034.2016.06.002
DOI:10.12015/issn.1674-8034.2016.06.002.

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