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• fMRI Papers •
A study of rest-stating functional magnetic resonance imaging in children with attention deficit hyperactivity disorder
XIE Na  SUN Long-wei  XU Shou-jun  ZENG Wei-bin 

DOI:10.12015/issn.1674-8034.2016.06.003.


[Abstract] Objective: To investigate the regional and network pattern of the dysfunctional brain in ADHD children using resting-state functional MRI.Materials and Methods: Resting-state functional brain MR images were acquired for 10 ADHD children and 10 matched healthy controls. Parametric maps of the amplitude of low frequency fluctuations (ALFF) were calculated and group comparison was performed using a voxel-based approach, then brain regions with differences in ALFF were extracted as seeds to calculate functional connectivity (FC) maps.Results: Compared with healthy controls, children with ADHD showed increased ALFF in bilateral anterior cingulate cortex (ACC), caudate and right mid and superior-frontal cortex. When using ACC as seed region, ADHD group showed FC increase in bilateral thalami, insula and posterior cingulate cortex; when the right frontal cluster was selected as seed, FC with the right precentral gyrus and superior temporal gyrus demonstrated reduced FC in ADHD; at last, when using caudate as seed region, bilateral mid-frontal regions showed FC decrease.Conclusion: We identified abnormalities in the regional spontaneous brain activities and inter-regional functional connectivity in ADHD, indicating its association with the developmental delay or deficits of cognitive and attention network.
[Keywords] Child；Attention deficit hyperactivity disorder；Magnetic resonance imaging；Functional connectivity；Amplitude of low-frequence fluctuation

XIE Na* Department of Radiology, Shenzhen Children’s Hospital, Shenzhen 518026, China

SUN Long-wei Department of Radiology, Shenzhen Children’s Hospital, Shenzhen 518026, China

XU Shou-jun Department of Radiology, Shenzhen Children’s Hospital, Shenzhen 518026, China

ZENG Wei-bin Department of Radiology, Shenzhen Children’s Hospital, Shenzhen 518026, China

*Correspondence to: Xie N, E-mail: xiena@139.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Shenzhen science and technology research and development fund project NO. JCYJ20130401114111467
Received  2016-04-15
Accepted  2016-05-17
DOI: 10.12015/issn.1674-8034.2016.06.003
DOI:10.12015/issn.1674-8034.2016.06.003.

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