Share：
Share this content in WeChat
X
[Chinese][PDF]930110
• Original Article •
Evaluation of microstructure remodeling after myocardial infarction using 3.0 T magnetic resonance imaging
YU Si-si  YIN Liang  LI Shu-hao  ZOU Qian  YU Yao-han  XIONG Fa-kui  GONG Liang-geng 

DOI:10.12015/issn.1674-8034.2016.07.008.


[Abstract] Objective: To detect myocardial microstructure remodeling dynamically in the core-infarction zone (CIZ), peri-infarction zone (PIZ) and non-infarction zone (NIZ) using 3.0 T diffusion tensor imaging, so as to find out the ventricular remodeling (VR) mechanism and heterogeneity.Materials and Methods: Fifty adult male rabbits were split into a normal group (n=5), a sham-operation group (n=5), and a myocardial infarction (MI) group (n=40), the MI group was further split into 5 subgroups at 1, 2, 4, 8 weeks, and 16 weeks after operation, while 33 survived and 7 died. The rabbit MI model was established by ligating the left ventricular branch of the coronary artery. The vitro heart specimens were gained to proceed the 3.0 T DTI. Fractional anisotropy (FA) and mean diffusion (MD) coefficient values were measured in the CIZ, PIZ and NIZ. DTI indicators were monitored dynamically.Results: (1)Both the FA values of the CIZ and PIZ significantly decreased in the 1st week, then decreased slowly, both reached the lowest values at the 4th week. Then the FA of the CIZ tended to be stable, while in the PIZ, they appeared a small increase and became stable at the 8th week. (2)The MD values in the CIZ increased rapidly and dramatically in the 4th week after operation, while those in the PIZ increased slowly and gradually, both reaching the peak at the 4th week synchronously. Subsequently, the MD of the CIZ stayed stable until the 8th week, then decreased slightly at the 16th week. The MD of the PIZ decreased slowly and became stable at the 8th week.Conclusions: Ventricular remodeling after myocardial infarction was a complex and dynamic process, the CIZ and PIZ remodeled very quickly and obviously in the 1st week, and reached the peak at the 4th week, which meant the tissue destruction was the most serious, then remodeling stayed stable until the 8th week. DTI can reveal the remodeling regularity in different areas and play an important role on the guidance for clinical treatment.
[Keywords] Magnetic resonance imaging；Myocardial infarction

YU Si-si Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

YIN Liang Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

LI Shu-hao Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

ZOU Qian Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

YU Yao-han Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

XIONG Fa-kui Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

GONG Liang-geng* Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

*Correspondence to: Gong LG, E-mail: gong111999@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 81360216 Science and Technology Support Program of Jiangxi Province No. 20121BBG70040 Natural Science Foundation of Jiangxi Province No. 20142BAB205061
Received  2016-03-18
Accepted  2016-05-20
DOI: 10.12015/issn.1674-8034.2016.07.008
DOI:10.12015/issn.1674-8034.2016.07.008.

[1]
Heydari B, Abdullah SM, Coelho-Filho O, et al. Serial quantification of myocardial infarction tissue heterogeneity during infarct healing by cardiac MRI provides strong characterization of left ventricular remodeling (the NHLBI PROSPECTCMR Study). J Cardiovasc Magn Reson, 2010, 13(1): 1-2.
[2]
Angeli S, Befera N, Peyrat JM, et al. A high-resolution cardiovascular magnetic resonance diffusion tensor map from ex-vivo C57BL/6 murine hearts. J Cardiovasc Magn Reson, 2014, 16(1): 77.
[3]
龚良庚，夏黎明，任海波，等. MRI心功能参数对陈旧性心肌梗死左心室重构的评估价值．放射学实践, 2013, 28(11): 1136-1139.
[4]
Wu Y, Zhang LJ, Zou C, et al. Transmural heterogeneity of left ventricular myocardium remodeling in postinfarct porcine model revealed by MR diffusion tensor imaging. J Magn Reson Imaging, 2011, 34(1): 43-49.
[5]
Ganame J, Messalli G, Masci PG, et al. Time course of infarct healing and left ventricular remodeling in patients with reperfused ST segment elevation myocardial infarction using comprehensive magnetic resonance imaging. Eur Radiol, 2011, 21(4): 693-701.
[6]
Hu N, Sabey KH, Curtis HR, et al. Magnetic resonance imaging (MRI) assessment of ventricular remodeling after myocardial infarction in rabbits. Comp Med, 2012, 62(2): 116-123.
[7]
Mekkaoui C, Huang S, Chen HH, et al. Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation. J Cardiovasc Magn Reson, 2012, 14: 70.
[8]
Sosnovik DE, Wang R, Dai G, et al. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging, 2009, 2(3): 206-212.
[9]
Axel L. MRI of the microarchitecture of myocardial infarction: are we seeing new kinds of structures? Circ Cardiovasc Imaging, 2009, 2(3): 169-170.
[10]
Winklhofer S, Stoeck CT, Berger N, et al. Post-mortem cardiac diffusion tensor imaging: detection of myocardial infarction and remodeling of myofiber architecture. Eur Radiol, 2014, 24(11): 2810-2818.
[11]
Strijkers GJ, Bouts A, Blankesteijn WM, et al. Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse. NMR Biomed, 2009, 22(2): 182-190.
[12]
Jiang Y, Guccione JM, Ratcliffe MB, et al. Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging. Am J Physiol Heart Circ Physiol, 2007, 293(4): H2377-2384.
[13]
袁蕾蕾，赵斌．磁共振弥散张量成像的原理、参数及影响因素．医学影像学杂志. 2007, 17(5): 517-520.
[14]
Wu Y, Zou C, Liu W, et al. Effect of B-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging. Magn Reson Imaging, 2013, 31(6): 847-856.
[15]
Zornoff LA, Paiva SA, Duarte DR, et al. Ventricular remodeling after myocardial infarction: concepts and clinical implications. Arq Bras Cardiol, 2009, 92(2): 150-164.

PREV The diagnosis value of 3.0 tesila MRI on cystic-solid masses of appendix and the misdiagnosis reason anaiysis
NEXT Analysis on faults of Siemens Skyra 3.0 T MRI system: report of 2 case
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn