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• Original Article •
Evaluation of microstructure remodeling after myocardial infarction using 3.0 T magnetic resonance imaging
YU Si-si  YIN Liang  LI Shu-hao  ZOU Qian  YU Yao-han  XIONG Fa-kui  GONG Liang-geng 

DOI:10.12015/issn.1674-8034.2016.07.008.


[Abstract] Objective: To detect myocardial microstructure remodeling dynamically in the core-infarction zone (CIZ), peri-infarction zone (PIZ) and non-infarction zone (NIZ) using 3.0 T diffusion tensor imaging, so as to find out the ventricular remodeling (VR) mechanism and heterogeneity.Materials and Methods: Fifty adult male rabbits were split into a normal group (n=5), a sham-operation group (n=5), and a myocardial infarction (MI) group (n=40), the MI group was further split into 5 subgroups at 1, 2, 4, 8 weeks, and 16 weeks after operation, while 33 survived and 7 died. The rabbit MI model was established by ligating the left ventricular branch of the coronary artery. The vitro heart specimens were gained to proceed the 3.0 T DTI. Fractional anisotropy (FA) and mean diffusion (MD) coefficient values were measured in the CIZ, PIZ and NIZ. DTI indicators were monitored dynamically.Results: (1)Both the FA values of the CIZ and PIZ significantly decreased in the 1st week, then decreased slowly, both reached the lowest values at the 4th week. Then the FA of the CIZ tended to be stable, while in the PIZ, they appeared a small increase and became stable at the 8th week. (2)The MD values in the CIZ increased rapidly and dramatically in the 4th week after operation, while those in the PIZ increased slowly and gradually, both reaching the peak at the 4th week synchronously. Subsequently, the MD of the CIZ stayed stable until the 8th week, then decreased slightly at the 16th week. The MD of the PIZ decreased slowly and became stable at the 8th week.Conclusions: Ventricular remodeling after myocardial infarction was a complex and dynamic process, the CIZ and PIZ remodeled very quickly and obviously in the 1st week, and reached the peak at the 4th week, which meant the tissue destruction was the most serious, then remodeling stayed stable until the 8th week. DTI can reveal the remodeling regularity in different areas and play an important role on the guidance for clinical treatment.
[Keywords] Magnetic resonance imaging；Myocardial infarction

YU Si-si Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

YIN Liang Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

LI Shu-hao Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

ZOU Qian Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

YU Yao-han Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

XIONG Fa-kui Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

GONG Liang-geng* Second Affiliated Hospital of Nanchang University- radiology department, Nanchang 330006, China

*Correspondence to: Gong LG, E-mail: gong111999@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 81360216 Science and Technology Support Program of Jiangxi Province No. 20121BBG70040 Natural Science Foundation of Jiangxi Province No. 20142BAB205061
Received  2016-03-18
Accepted  2016-05-20
DOI: 10.12015/issn.1674-8034.2016.07.008
DOI:10.12015/issn.1674-8034.2016.07.008.

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