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• DWI Papers •
Correlation between estimated glomerular filtration rate(eGFR) and apparent diffusion coefficient (ADC) values of the kidneys
ZHANG You-yuan  ZHA Yun-fei  LI Liang  XING Dong  GONG Wei  LIN Yuan  LIU Chang-sheng 

DOI:10.12015/issn.1674-8034.2016.08.002.


[Abstract] Objective: To determine the relationship between apparent diffusion coefficient (ADC) values of the kidney measured by diffusion-weighted MR imaging and the estimated glomerular filtration rate (eGFR).Materials and Methods: A total of 627 adult patients in Renmin Hospital of Wuhan University, apply for kidney DWI examination in our hospital between January 2013 and May 2015. Regions of interests (ROIs) were manually delineated in the parenchyma as large as possible at the level of the middle portion of the bilateral kidneys. The eGFR was calculated by an equation based on serum creatinine level. The patients were divided into 3 groups: eGFR< 30 mL/min/1.73m2; 30 mL/min/1.73 m2≤eGFR <60 mL/min/1.73m2; and eGFR≥ 60 mL/min/1.73m2. Differences between the 3 groups respect to the mean renal ADCs and the correlation of the renal ADC value and eGFR were analyzed.Results: The mean ADC values of the 3 groups were (1.72±0.10)×10-3 mm2/s for the group with eGFR< 30 mL/min/1.73 m2; (1.88±0.16)×10-3 mm2/s for those with 30 mL/min/1.73m2≤eGFR<60 mL/min/1.73m2; and (1.90±0.16)×10-3 mm2/s for those with eGFR≥ 60 mL/min/1.73m2. There was statistically significant difference in renal ADCs among the 3 groups (F=81.24, P<0.001). The ADC of kidney showed positive linear correlation with eGFR (r=0.613, P<0.05).Conclusion: ADC values can reflect kidney filtration function to some extent. DWI may be useful to evaluate renal function.
[Keywords] Kidney；Diffusion weighted imaging；Apparent diffusion coefficient；Glomerular filtration rate；Magnetic resonance imaging

ZHANG You-yuan Department of Radiology, People's Hospital of Jiangling County, Jingzhou 434100, China

ZHA Yun-fei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LI Liang* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

XING Dong Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

GONG Wei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIN Yuan Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIU Chang-sheng Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail: zhayunfei999@126.com Li L, E-mail: liliang_082@126.com

Conflicts of interest   None.

Received  2016-04-29
Accepted  2016-07-25
DOI: 10.12015/issn.1674-8034.2016.08.002
DOI:10.12015/issn.1674-8034.2016.08.002.

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