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• Clinical Article •
MRI of cerebral small vessel damage in sleep apnea syndrome(SAS)
YANG Lin  ZOU Li-qiu  WANG Niang-di  QI Yu-long  ZHENG Qi-wen  YU Lanfang  WANG Feng-qing 

DOI:10.12015/issn.1674-8034.2016.08.004.


[Abstract] Objective: A case-control study was designed to evaluate the brain magnetic resonance image (MRI) of cerebral small vessel damage in SAS. To deplore the characters of cerebral small vessel damage in SAS.Materials and Methods: Ninety-three snoring patients were enlisted and underwent polysomnograghy(PSG) . All patients were divided in 4 parts according to apnea hyponea index(AHI): 27 non- SAS, 23 mild SAS, 24 moderate SAS and 19 severe SAS group. All participants underwent MRI and the data of silent brain infarction(SBI), subcortical deep white matter hyperintensity (SDWMH) and periventricular hyperintensity(PVH) were collected. The results of MRI among 4 groups were compared by RC table chi-square test. The influence factors of small vessel damage were analyzed through binary logistic analysis.Results: SBI, SDWMH and PVH damage were increased along with the severity of SAS(P<0.05). AHI was the risk factor of SBI(OR 1.112, 95%CI 1.053—1.174, R2=0.387, χ2=29.009, P<0.001), SDWMH(OR 1.048, 95%CI 1.018—1.080, R2=0.193, χ2=13.056, P<0.001) and PVH (OR 1.043, 95%CI 1.015—1.073, R2=0.184, χ2=10.526, P=0.001). The cerebral small vessel damages in SAS were mostly found in basal ganglia(31% SBI) whereas frontal and parietal lobe(41%) in non-SAS group.Conclusion: SBI, SDWMH and PVH damage were increased along with the severity of SAS. AHI was the risk factor of SBI, SDWMH and PVH. Cerebral small vessel damage in SAS were mostly found in basal ganglia.
[Keywords] Magnetic resonance image；Cerebral small vessel disease；Sleep apnea syndrome；Apnea hyponea index

YANG Lin Department of Health Medicine, Shenzhen Hospital Peking University, Shenzhen 518036, China

ZOU Li-qiu* Department of Image, Nanshan Hospital of Shenzhen, Shenzhen 518001, China

WANG Niang-di Department of Health Medicine, Shenzhen Hospital Peking University, Shenzhen 518036, China

QI Yu-long Department of Image, Shenzhen Hospital Peking University, Shenzhen 518036, China

ZHENG Qi-wen Department of Health Medicine, Shenzhen Hospital Peking University, Shenzhen 518036, China

YU Lanfang Department of Health Medicine, Shenzhen Hospital Peking University, Shenzhen 518036, China

WANG Feng-qing Department of Health Medicine, Shenzhen Hospital Peking University, Shenzhen 518036, China

*Correspondence to: Zou LQ, E-mail: 13510331309@139.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Science and Technology Research and Development Fund Project of Shenzhen No. JCYJ20130402112459391
Received  2016-01-11
Accepted  2016-03-08
DOI: 10.12015/issn.1674-8034.2016.08.004
DOI:10.12015/issn.1674-8034.2016.08.004.

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