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• Clinical Article •
The study of correlation between diffusion kurtosis imaging on cervical spinal cord and age in healthy
LI Dao-wei  WANG Xiao-ming 

DOI:10.12015/issn.1674-8034.2016.08.006.


[Abstract] Objective: To explore the change rule of the normal adult spinal cord diffusion kurtosis imaging (DKI) parameter values and its correlation with age, provide a reference for the quantitative diagnosis of spinal diseases.Materials and Methods: Gather 36 healthy adult volunteers with their age range from 18 to 65, Sheng jing Hospital, China Medical University, between August in 2015 and March in 2016. After divide into groups by age, carry out DKI sequence scanning on them and determine FA, MD and MK parameter values with MRI software ADW 4.6. Compare the differences of FA, MD and MK parameter value in different segments of intervertebral disc, and the correlation between above value and age change.Results: With the moving down of anatomic segment, the MD increased gradually, FA and MK gradually reduced. C2-3 level FA-GM and MD-WM with other level exists significant difference (F=10.01, P<0.05; F=16.94, P<0.05), the C6-7 level MK-GM and MD-GM also exists significant difference with other level (F=10.11, P<0.05; F=10.01, P<0.05). FA-WM negatively correlated with age (r=0.507, P<0.05); MK-GM and MK-WM age were positively correlated (r=0.436, P<0.01 and r=0.249, P<0.05). FA-WM and MK-GM exists significant difference in different groups(P<0.05).Conclusion: DKI is capable of reflect changes of the microstructure in healthy adult spinal cord grey and white matter, and correlation between age. MK may be the highly sensitive indexes to reflect nervous system complex microstructure and change after damage.
[Keywords] Spinal cord；Magnetic resonance imaging；Diffusion kurtosis imaging；Age

LI Dao-wei Department of Radiology, Sheng jing Hospital, China Medical University, Shenyang 110004, China

WANG Xiao-ming* Department of Radiology, Sheng jing Hospital, China Medical University, Shenyang 110004, China

*Correspondence to: Wang XM, E-mail: wangxm024@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Shengjing free researchers fund No. 2008-02
Received  2016-03-24
Accepted  2016-04-21
DOI: 10.12015/issn.1674-8034.2016.08.006
DOI:10.12015/issn.1674-8034.2016.08.006.

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