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• Technical Article •
Hemodynamic parameters comparison between 4D Flow MRI and computational fluid dynamics for intracranial aneurysms
CHEN Yu  ZHANG Yu  ZHOU Ze-chen  LIU Ai-hua  LIU Peng  LI Rui 

DOI:10.12015/issn.1674-8034.2016.08.011.


[Abstract] Objective: To compare the results of 4D Flow MRI and computational fluid dynamics (CFD).Materials and Methods: In this study, 4 patients with intracranial aneurysms (IA) were selected, all of whom underwent both 4D Flow MRI scan and CFD simulation. Two sets of velocity data were analyzed and compared. 3D pathlines were calculated and visualized based on velocity data. Mean velocity profiles at IAs' neck contour were obtained and normalized root mean squared error(NRMSE) as well as R-squared(R2) value were calculated and compared. At last, velocity distribution on maximum cross section slice were demonstrated.Results: This study shows 3D pathlines of 4D Flow MRI and CFD look similar to each other. Average velocity on IA’s neck contour are consistent. NRMSE values are 0.08992(0.10208, 0.10270, 0.04242, 0.11248). R2 values are 0.95958(0.9735, 0.9316, 0.9920, 0.9412). In maximum cross setion of IA, velocity distributions demonstrate similar features in general.Conclusion: There exists a strong linear correlation between 4D Flow MRI measurement and CFD simulation, but also some disagreements in detail. It’s necessary to undertake in vitro phantom experiments to investigate in detail.
[Keywords] Intracranial aneurysm；Hemodynamics；Magnetic resonance imaging；4D Flow MRI；Computational fluid dynamics

CHEN Yu Center for Biomedical Imaging Reseach, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China

ZHANG Yu Medical Center, Tsinghua University, Beijing 100084, China

ZHOU Ze-chen Center for Biomedical Imaging Reseach, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China

LIU Ai-hua Department of Neurosurgery, Beijing Tiantan Hospital, Captical Medical University, Beijing 100050, China

LIU Peng Department of Neurosurgery, Beijing Tiantan Hospital, Captical Medical University, Beijing 100050, China

LI Rui* Center for Biomedical Imaging Reseach, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China

*Correspondence to: Li R, E-mail: leerui@tsinghua.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Beijing science and technology project No. Z131100005213001 2015 annual independent research funding project of Tsinghua University No. 20141081265
Received  2016-05-09
Accepted  2016-07-30
DOI: 10.12015/issn.1674-8034.2016.08.011
DOI:10.12015/issn.1674-8034.2016.08.011.

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