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Review
The advantages and clinical value of high resolution MRI in evaluating the stability of carotid plaque
MA Yu-rong  ZHANG Tao  ZHANG Jing 

DOI:10.12015/issn.1674-8034.2016.08.015.


[Abstract] Carotid atherosclerotic plaque rupture and thrombosis are the independent risk factors of acute ischemic cerebrovascular disease. Timely identification of vulnerable plaque is helpful to prevent the occurrence of stroke, and it can provide the basis for clinical treatment. In recent years, high resolution MRI has become a hot spot in the research of carotid artery screening with its high soft tissue resolution and the advantage of safety. It can well show the important biological characteristics of the plaque, analyze the internal composition and morphology of the patch, identify vulnerable plaque, and evaluate the stability of the plaque. The purpose of this paper is to make a brief summary of the high resolution MR in the identification of vulnerable plaque and its clinical application.
[Keywords] Magnetic resonance imaging;Carotid artery atherosclerosis;Vulnerable plaque;Stroke

MA Yu-rong Gansu University of Traditional Chinese Medicine, Department of Nuclear Magnetic Resonance of the Second Hospital of Lanzhou University, Lanzhou 730000, China

ZHANG Tao Peopleˊs Hospital of Zhongwei, Zhongwei 755000, China

ZHANG Jing* Department of Nuclear Magnetic Resonance of the Second Hospital of Lanzhou University, Lanzhou 730000, China

*Correspondence to: Zhang J, E-mail: 260570874@qq.com

Conflicts of interest   None.

Received  2016-03-25
Accepted  2016-05-27
DOI: 10.12015/issn.1674-8034.2016.08.015
DOI:10.12015/issn.1674-8034.2016.08.015.

[1]
Cai JM, Hatsukami TS, Ferguson MS, et al. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation, 2002, 106(11): 1368-1373.
[2]
Pende A, Dallegri F. Is the carotid plaque rupture a pivotal event in stroke pathogenesis? update on the role of the intraplaque inflammatory processes. Curr Vasc Pharmacol, 2015, 13(2): 173-181.
[3]
戴建平.重视MRI对易损斑块的研究.磁共振成像, 2010, 1(6): 406-407.
[4]
苑纯,赵锡海.易损斑块磁共振成像:共识与挑战.磁共振成像, 2010, 1(6): 429-431.
[5]
张娜,刘新,张元亭,等. MRI检测易损斑块的优势与不足.磁共振成像, 2010, 1(6): 415-421.
[6]
Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies:PartI. Circulation, 2003, 108(14): 1664-1672.
[7]
李红英.颈动脉易损斑块MRI表现与缺血性卒中的风险预测.磁共振成像, 2016, 7(1): 16-19.
[8]
赵世华.易损斑块的含义和诊断标准.磁共振成像, 2010, 1(6): 408-410.
[9]
Pedersen SF, Sandholt BV, Keller SH, et al. 64 Cu-DOTATATE PET/MRI for detection of activated macrophages in carotid atherosclerotic plaques: studies in patients undergoing endarterectomy. Arterioscler Thromb Vasc Biol, 2015, 35(7): 1696-1703.
[10]
Gijsen FJ, Nieuwstadt HA, Wentzel JJ, et al. Carotid plaque morphological classification compared with biomechanical cap stress: implications for a magnetic resonance imaging-based assessment. Stroke, 2015, 46(8): 2124-2128.
[11]
Kashiwazaki D, Akioka N, Kuwayama N, et al. Pathophysiology of acute cerebrovascular syndrome in patients with carotid artery stenosis: amagnetic resonance imaging/single-photon emission computed tomography study. Neurosurgery, 2015, 76(4): 427-433.
[12]
Yu XY, Zhou DL, Hao D, et al. Application of optical coherence tomography in detecting rabbit vulnerable abdominal artery plaques. Chin J Geriatr Heart Brain Vessel Dis, 2014, 16(12): 1265-1268.
[13]
雷云,丁里,任丽香,等. 3.0 T MRI对颈动脉粥样硬化斑块成分分析及分型的研究.磁共振成像, 2015, 6(6): 430-436.
[14]
Calcagno C, Mani V, Ramachandran S, et al. Dynamic contrast enhanced(DCE) magnetic resonance imaging(MRI)of atherosclerotic plaque angiogenesis. Angiogenesis, 2010, 13(2): 87-99.
[15]
Mauriello A, Sangiorgi GM, Virmani R, et al. A pathobiologic link between risk factors profile and morphological markers of carotid instability. Atherosclerosis, 2010, 208(2): 572-580.
[16]
Lenglet S, Mach F, Montecucco F. Role of matrix metalloproteinase-8 in atherosclerosis. Mediators of Inflammation, 2013, 2013(1): 105-114.
[17]
Qiao Y, Zeiler SR, Mirbagheri S, et al. Intracranial plaque enhancement in patients with cerebrovascular events on high spatial-resolution MR images. Radiology, 2014, 271(2): 534-542.
[18]
李明华,李梅.易损斑块的影像学检查方法.磁共振成像, 2010, 1(6): 411-414.
[19]
Simpson RJ, Akwei S, Hosseini AA, et al. MR imaging-detected carotid plaque hemorrhage is stable for 2 years and a marker for stenosis progression. AJNR Am J Neuroradiol, 2015, 36(6): 1171-1175.
[20]
杨利新,董莉,于薇.颈动脉斑块内出血的高分辨率MR成像临床应用及技术进展.磁共振成像, 2015, 6(9): 711-715.
[21]
Wong KK, Thavornpattanapong P, Cheung SC, et al. Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model. BMC Cardiovascular Disorders, 2012, 12(4): 7.
[22]
Li Z, U-King-Im J, Tang T, et al. Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm. J Vasc Surg, 2008, 47(5): 928-935.
[23]
Grimm JM, Schindler A, Freilinger T, et al. Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR. J Cardiovasc Magn Reson, 2013, 15(1): 44-53.
[24]
Zhao XQ, Dong L, Hatsukami T, et al. MR imaging of carotid plaque composition during lipid-lowering therapy:a prospective assessment of effect and time course. JACC Cardiovasc Imaging, 2011, 4(9): 977-986.
[25]
Moody AR, Murphy RE, Morgan PS, et al. Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia. Circulation, 2003, 107(24): 3047-3052.
[26]
Zhao X, Underhill HR, Zhao Q, et al. Discriminating carotid atherosclerotic lesion severity by luminal stenosis and plaque burden:a comparison utilizing high-resolution magnetic resonance imaging at 3.0 Tesla. Stroke, 2011, 42(2): 347-353.
[27]
Mono ML, Karameshev A, Slotboom J, et al. Plaque characteristics of asymptomatic carotid stenosis and risk of stroke. Cerebrovasc Dis, 2012, 34(5-6): 343-350.
[28]
Kurosaki Y, Yoshida K, Endo H, et al. Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events. Neurosurgery, 2011, 68(1): 62-67.
[29]
Lindsay AC, Biasiolli L, Lee JM, et al. Plaque features associated with increased cerebral infarction after minor stroke and TIA: A prospective, case-control, 3-T carotid artery MR imaging study. JACC Cardiovasc Imaging, 2012, 5(4): 388-396.
[30]
Freilinger TM, Schindler A, Schmidt C, et al. Prevalence of nonstenosing, complicated atherosclerotic plaques in cryptogenic stroke. JACC Cardiovasc Imaging, 2012, 5(4): 397-405.
[31]
中华医学会外科学分会血管外科学组.颅外段颈动脉狭窄治疗指南.中国实用外科杂志, 2008, 28(11): 913-915.
[32]
Yamada K, Yoshimura S, Kawasaki M, et al. Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging. Atherosclerosis, 2011, 215(2): 399-404.
[33]
赵红,胡云涛,陈彦菊,等.阿托伐他汀钙对急性脑梗死患者颈动脉粥样硬化斑块的影响.中国实用神经疾病杂志, 2011, 14(8): 6-8.
[34]
Zhao Y, Nicoll R, He YH, et al. The effect of statins therapy in aortic stenosis: Meta-analysis comparison data of RCTs and observationals. Data in Brief, 2016, 7: 357-361.
[35]
Zhao Y, Nicoll R, He YH, et al. The effect of statins on valve function andcalcification in aortic stenosis: A meta-analysis. Atherosclerosis, 2016, 246: 318-324.
[36]
Corti R, Fayad ZA, Fuster V, et al. Effects of lipid lowering by simvastatin on human atherosclerotic lesions: A longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation, 2001, 104(3): 249-252.
[37]
West AM, Anderson JD, Meyer CH, et al. The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline. Atherosclerosis, 2011, 218(1): 156-162.
[38]
Dong L, Kerwin W, Chen HJ, et al. Effect of intensive lipid therapy on atherosclerotic plaque inflammation: evaluation using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in carotid disease.Circulation, 2009(18): 342-343.
[39]
Tang TY, Howarth SP, Miller SR, et al. The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease. J Am Coll Cardiol, 2009, 53(22): 2039-2050.
[40]
Underhill HR, Hatsukami TS, Cai J, et al. A noninvasive imaging approach to assess plaque severity: the carotid atherosclerosis score. AJNR Am J Neuroradiol, 2010, 31(6): 1068-1075.
[41]
Makowski MR, Botnar RM. MR imaging of the arterial vessel wall: molecular imaging from bench to bedside. Radiology, 2013, 269(1): 34-51.
[42]
Witkiewicz W, Klimeczek P, Iwanowski W, et al. Dual source computed tomography in analysis of significance and morphology carotid plaques. Przegl Lek, 2013, 70(3): 118-122.

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