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• Clinical Article •
A quantitative study about iron content of the cerebral nucleus in patients with Parkinson's disease
TANG Shou-xian  ZUO Li-jun  ZHANG Wei  SHEN Hui-cong  DAI Jian-ping 

DOI:10.12015/issn.1674-8034.2016.09.002.


[Abstract] Objective: Aiming to measure and analyse the iron content in cerebral nucleus of the Parkinson's disease (PD) subjects.Materials and Methods: Forty PD subjects and 36 volunteers were recruited in the cross-sectional study. Susceptibility weighted images (SWI) was acquired for all participants. Phase values of globus pallidum (GP), putamen (PUT), substantia nigra (SN) were measured by SPIN software. Paired-sample t test was used to compare the phase values of nucleus, P<0.05 was considered to be statistically significant.Results: Phase values in SN of PD subjects were least (right, 2034.84. left, 2030.55). Phase values of bilateral GP (R, P=0.018. L, P=0.040) and bilateral SN (R, P=0.008. L, P=0.000) showed significantly statistical differences between PD subjects and volunteers. There were significantly statistical differences in phase values between right GP and SN (P=0.000), right PUT and SN (P=0.000), left PUT and SN (P=0.000) in PD subjects.Conclusions: SN showed highest iron content in patients with PD, iron content increased symmetrically in GP and SN of patients with PD. SWI provided information for the diagnosis of PD.
[Keywords] Parkinson disease；Magnetic resonance imaging；Iron

TANG Shou-xian Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

ZUO Li-jun Department of Geriatric, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

ZHANG Wei Department of Geriatric, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

SHEN Hui-cong Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

DAI Jian-ping* Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Dai JP, E-mail: daijianping_2008@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of the General Program of National Natural Science Foundation of China No. 81271541
Received  2016-06-01
Accepted  2016-08-10
DOI: 10.12015/issn.1674-8034.2016.09.002
DOI:10.12015/issn.1674-8034.2016.09.002.

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