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• Clinical Article •
Analysis of related parameters of magnetic resonance spectroscopy in the hippocampus of normal middle-aged group
LIANG jie  FAN Zi-jian  JU Wen-ping  MENG Fan-lian  WANG Xian-liang 

DOI:10.12015/issn.1674-8034.2016.09.003.


[Abstract] Objective: To discuss the changes of the brain metabolites on the bilateral hippocampus of different age groups and parts in normal chinese middle-aged group by using magnetic resonance spectroscopy (MRS), to provide reference for early clinical diagnosis and treatment of hippocampal-related diseases.Materials and Methods: From community healthy volunteers, we selected 276 according to the standards, who were divided into three groups according to age, A group: prime period, 41 to 48 years, B group: steady period, 49 to 55 years, C group: adjustment period, 56 to 65 years, with about 100 subjects for each, underwent conventional cerebral MR scans, bilateral hippocampal MRS scans. The parameters of NAA/Cr, Cho/Cr, NAA/(Cho+Cr) ratio were measured. To analyse the differences of the parameters between different genders, sides, groups and parts, and discuss the correlation between the parameters and age.Results: The ratios of NAA/Cr, Cho/Cr, NAA/(Cho+Cr) had no significant difference between genders and left-right sides (P>0.05). The ratios of metabolites had statistically significant difference among age groups (P<0.05), the ratio of NAA/Cr, NAA/(Cho+Cr) was higher in group A, B than that in group C (P<0.05), the ratio of Cho/Cr was lower in group A than that in group C (P<0.05). The ratio of NAA/Cr, Cho/Cr had statistically significant difference between different parts (P<0.05). But, the ratio of NAA/(Cho+Cr) had no significant difference (P>0.05). The ratios of NAA/Cr, NAA/(Cho+Cr) were negatively correlated with age (r value: -0.486, -0.653, P<0.05), the ratio of Cho/Cr was positively correlated with age (r value: 0.482, P<0.05).Conclusions: MRS could reflect varieties of hippocampal metabolites in normal chinese middle-aged people noninvasively, their combination could find potential changes in micro metabolism and micro structure of normal brain and provide references for early clinical diagnosis of various diseases associated with hippocampus.
[Keywords] Hippocampus；Metabolomics；Magnetic resonance spectroscopy；Adult

LIANG jie Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

FAN Zi-jian Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

JU Wen-ping Department of Medical Imaging of Weifang Medical University, Weifang 261053, China

MENG Fan-lian Department of Medical Imaging, the People's Hospital of Weifang, Weifang 261041, China

WANG Xian-liang* Department of Medical Imaging, the People's Hospital of Weifang, Weifang 261041, China

*Correspondence to: Wang XL, E-mail: wangxianliang2011@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Natural Science Foundation of Shandong Province No. ZR2009CM115
Received  2016-06-06
Accepted  2016-08-06
DOI: 10.12015/issn.1674-8034.2016.09.003
DOI:10.12015/issn.1674-8034.2016.09.003.

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