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• Clinical Article •
Correlation between myocardial iron deposit, liver iron concentration and serum ferritin in patients with thalassemia
DENG Xiao-qiang  HUANG Hai-bo  YiN Xiao-lin  ZHOU Ya-li  GUAN Jun  QIN Ming 

DOI:10.12015/issn.1674-8034.2016.09.006.


[Abstract] Objective: To quantify the myocardial iron overload and liver iron concentration (LIC) in thalassemia (TM) patients and discuss the relationships amongst myocardial iron overload, LIC and serun ferritin (SF).Materials and Methods: Study protocol was approved by local ethics committee, informed consent was obtained. A total of 134 patients with TM (Intermediate, 73. Major, 61) diagnosed by gene were enrolled. A multiple fast-field echo (mFFE) within a single breath-hold was performed using a 3.0 tesla MR unit to acquire 8 or 12 T2* weighted images in the heart or liver. T2*values of myocardium and liver were quantified based on mFFE-T2* protocol by a well-trained physician repectively, SF was obtained within 7 days before MRI. Spearman rank correlation was applied to analyse the relationships.Results: The median (range) of myocardial T2*, liver T2* and SF in 134 patients were 23.35 (1.88—36.17) ms, 1.33 (0.36—16.39) ms, 1235.3 (105.1—14673.0) μg/L, respectively. There was weakly correlation between myocardial T2* and liver T2* (rs=0.324, P=0.000), as well as myocardial T2* and SF (rs=-0.491, P=0.000), moreover, liver T2* and SF were moderately linear related (rs=-0.697, P=0.000). Furthermore, the median (range) of myocardial T2*, liver T2* and SF in 73 TM inter mediate were 26.18 (7.09—36.17) ms, 1.81 (0.37—16.39) ms, 622.8 (105.1—10807.0) μg/L, respecttively. There was no linear correlation between myocardial T2* and liver T2* (rs=0.059, P=0.619), likewise myocardial T2* and SF (rs=-0.166, P=0.161), however, liver T2*and SF was moderately related (rs=-0.583, P=0.000). The median (range) of myocardial T2*, liver T2* and SF in 61 TM major were 18.80 (1.88—33.11) ms, 0.72 (0.36—10.36) ms, 3310.0 (313.0—14673.0) μg/L, respectively. There was weak correlation between myocardial T2* and liver T2* (rs=0.365, P=0.004), and myocardial T2* and SF as well (rs=-0.359, P=0.004), in addition, liver T2*and SF was moderately related (rs=-0.707, P=0.000).Conclusions: Within a certain LIC limits, cardiac excess iron was weak or no linear correlation with LIC and SF, which might increase with condition worsed or its types, however, it showed a moderate negative relationship of LIC to SF.
[Keywords] Thalassemia；Iron；Ferritins；Serology；Magnetic resonance imaging

DENG Xiao-qiang Department of Radiology, Guangxi CAPE Hospital, Nanning 530003, China

HUANG Hai-bo* Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

YiN Xiao-lin Department of Haematology, 303rd Hospital of PLA, Nanning 530021, China

ZHOU Ya-li Department of Haematology, 303rd Hospital of PLA, Nanning 530021, China

GUAN Jun Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

QIN Ming Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

*Correspondence to: Huang HB, E-mail: jackie000528@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Guangxi Natural Science Foundation NO. 2014GXNSFBA118187, 2015GXNSFAA139164
Received  2016-06-23
Accepted  2016-08-12
DOI: 10.12015/issn.1674-8034.2016.09.006
DOI:10.12015/issn.1674-8034.2016.09.006.

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