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• Clinical Article •
The relationship between DKI and pathological features of cervical cancer: a primary study
YAN kun  HU Sha-sha  YANG Pin  LI Jin-kui  ZHAI Ya-jun  LEI Jun-qiang 

DOI:10.12015/issn.1674-8034.2016.09.009.


[Abstract] Objective: To evaluate and contrast diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in differentiating cervical cancer pathological type and degree of differentiation.Materials and Methods: Collecting 39 patients with cervical cancer diagnosed by pathological examination, 31 were cervical squamous cell cancer (7 high, 19 medium and 5 low differentiation cervical squamous cell cancer), and the remaining 8 patients were cervical adenocarcinoma. Everyone underwent cervical magnetic resonance imaging (MRI) examination, the sequences included conventional, DWI and DKI. Compared mean value of ADC (apparent diffusion coefficient), MK (mean kurtosis) and MD (mean diffusion) of cervical squamous cell cancer, cervical adenocarcinoma and high, medium and low differentiation cervical squamous cell cancer. Evaluate the discriminability of ADC, MK and MD in cervical squamous cell cancer, cervical adenocarcinoma and high, medium and low differentiation cervical squamous cell cancer by receiver operating characteristics (ROC) curves.Results: (1) The mean values of ADC, MD were lower in cervical squamous cell carcinoma contrast to adenocarcinoma (P<0.001), but the mean values of MK in cervical squamous cell carcinoma were higher contrast to adenocarcinoma (P<0.001). When differentiating cervical squamous cell carcinoma from cervical adenocarcinoma, mean value of MK possessed a biggest AUC (0.968), followed MD (0.940) and ADC (0.915). (2) When differentiating poorly from medium, medium from high differentiated squamous cell carcinoma, the mean value of MK had best ability with largest AUC (0.905, P=0.003. 0.940, P<0.001), followed MD (AUC=0.884, P=0.009. AUC=0.887, P=0.002) and ADC (AUC=0.853, P=0.012. AUC=0.842, P=0.003).Conclusions: DKI is better than DWI on discriminating cervical squamous cell carcinoma, cervical adenocarcinoma and high, medium and low differentiated subtypes of cervical squamous carcinoma.
[Keywords] Uterine cervical neoplasms；Diffusion magnetic resonance imaging；Pathology

YAN kun Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

HU Sha-sha Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

YANG Pin Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

LI Jin-kui Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

ZHAI Ya-jun Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

LEI Jun-qiang* Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

*Correspondence to: Lei JQ, E-mail: leijq1990@163.com

Conflicts of interest   None.

Received  2016-04-09
Accepted  2016-05-26
DOI: 10.12015/issn.1674-8034.2016.09.009
DOI:10.12015/issn.1674-8034.2016.09.009.

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