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• Original Article •
The feasibility study of 3D-PCASL evaluating the anti-angiogenesis of soft tissue tumor
YAN Li-yong  ZHA Yun-fei  XING Dong  WANG Ke-jun  GONG Wei  HU Lei  WANG Jiao  LIU Chang-sheng 

DOI:10.12015/issn.1674-8034.2016.09.010.


[Abstract] Objective: To investigate the feasibility of anti-angiogenesis of VX2 soft tissue tumor by 3D-PCASL and MVD.Materials and Methods: VX2 tumor was inoculated in the muscular tissue of lower section of femur of 24 New Zealand rabbits successfully. The experimental group and the control group contained 12 subjects, respectively injected in muscles around the tumor with Endostar solution (Endostar: saline ratio of 1.5 mg/8 ml) and 0.9% saline 8 ml, for a period of 14 days. BFASL values were respectively measured by arterial spin labeling (ASL) via selecting the tumor maximum level. BFASL values were compared with those parameters of pathology, which including MVD and VEGF.Results: The MVD values of the central and margin region of experimental group showed a positive correlation with BFASL values (r= 0.891, r= 0.626, P<0.05), the MVD values of the central and margin region of control group showed a positive correlation with BFASL values (r=0.960, r=0.917, P<0.05), they all corresponded to the expression of VEGF.Conclusions: The BFASL values and the MVD values showed a positive correlation in evaluation of anti-angiogenesis of VX2 soft tissue tumor. The 3D-PCASL might be feasible for evaluation of anti-angiogenesis of soft tissue tumor.
[Keywords] Magnetic resonance imaging；Soft tissue neoplasms；Angiostatins

YAN Li-yong Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yun-fei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

XING Dong Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

WANG Ke-jun Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

GONG Wei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

HU Lei Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

WANG Jiao Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

LIU Chang-sheng Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

*Correspondence to: ZHA Yun-fei, E-mail: zhayunfei999@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of natural science foundation of Hubei province No. 2013CFB242 scientific research project of health department of Hubei No. JX6B68
Received  2016-04-09
Accepted  2016-05-18
DOI: 10.12015/issn.1674-8034.2016.09.010
DOI:10.12015/issn.1674-8034.2016.09.010.

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